GB201016403D0 - Novel interaction between staphylococcus aureus Sbi and C3d protiens - Google Patents
Novel interaction between staphylococcus aureus Sbi and C3d protiensInfo
- Publication number
- GB201016403D0 GB201016403D0 GB201016403A GB201016403A GB201016403D0 GB 201016403 D0 GB201016403 D0 GB 201016403D0 GB 201016403 A GB201016403 A GB 201016403A GB 201016403 A GB201016403 A GB 201016403A GB 201016403 D0 GB201016403 D0 GB 201016403D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- sbi
- staphylococcus aureus
- protiens
- interaction
- novel interaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
The invention relates to the Sbi protein of Staphylococcus aureus, and in particular to the interaction between Sbi and the complement protein C3d. The crystal structure of the Sbi-C3d complex reveals an unexpected interaction between Sbi and the convex surface of C3d, which suggests that particular fragments and variants of Sbi may have utility as inhibitors of the alternative complement pathway. The invention provides novel peptides and their use in the inhibition of inflammatory conditions characterised by undesirable activation of the complement pathway.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201016403A GB201016403D0 (en) | 2010-09-29 | 2010-09-29 | Novel interaction between staphylococcus aureus Sbi and C3d protiens |
PCT/GB2011/001414 WO2012042213A1 (en) | 2010-09-29 | 2011-09-29 | Novel interaction between staphylococcus aureus sbi and c3d proteins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201016403A GB201016403D0 (en) | 2010-09-29 | 2010-09-29 | Novel interaction between staphylococcus aureus Sbi and C3d protiens |
Publications (1)
Publication Number | Publication Date |
---|---|
GB201016403D0 true GB201016403D0 (en) | 2010-11-10 |
Family
ID=43128179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB201016403A Ceased GB201016403D0 (en) | 2010-09-29 | 2010-09-29 | Novel interaction between staphylococcus aureus Sbi and C3d protiens |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB201016403D0 (en) |
WO (1) | WO2012042213A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112023017749A2 (en) | 2021-03-04 | 2023-10-03 | Helix Nanotechnologies Inc | COMPOSITIONS INCLUDING SBI ADJUVANTS AND METHODS OF USE THEREOF |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0134215B1 (en) | 1982-08-27 | 1989-10-25 | EKINS, Roger Philip | Measurement of analyte concentration |
ATE86385T1 (en) | 1986-08-06 | 1993-03-15 | Multilyte Ltd | DETERMINING ANALYTE CONCENTRATION WITH TWO LABELS. |
GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
WO1993008472A1 (en) | 1991-10-15 | 1993-04-29 | Multilyte Limited | Binding assay employing labelled reagent |
GB9326450D0 (en) | 1993-12-24 | 1994-02-23 | Multilyte Ltd | Binding assay |
GB9326451D0 (en) | 1993-12-24 | 1994-02-23 | Multilyte Ltd | Binding assay |
GB9404709D0 (en) | 1994-03-11 | 1994-04-27 | Multilyte Ltd | Binding assay |
EP2021087B1 (en) | 2006-05-30 | 2010-09-15 | Iknowledge Ltd. | Method and apparatus for televising a card game |
GB0610776D0 (en) * | 2006-05-31 | 2006-07-12 | Univ Bath | Novel applications for staphylococcus aureus Sbi protein |
-
2010
- 2010-09-29 GB GB201016403A patent/GB201016403D0/en not_active Ceased
-
2011
- 2011-09-29 WO PCT/GB2011/001414 patent/WO2012042213A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2012042213A1 (en) | 2012-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AT | Applications terminated before publication under section 16(1) |