ES2112430T3 - Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. - Google Patents

Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.

Info

Publication number
ES2112430T3
ES2112430T3 ES93920214T ES93920214T ES2112430T3 ES 2112430 T3 ES2112430 T3 ES 2112430T3 ES 93920214 T ES93920214 T ES 93920214T ES 93920214 T ES93920214 T ES 93920214T ES 2112430 T3 ES2112430 T3 ES 2112430T3
Authority
ES
Spain
Prior art keywords
sulfonilalcanoylamine
hydroxyethylamine
protease inhibitors
retroviral protease
sulfonamides useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93920214T
Other languages
English (en)
Inventor
Michael L Vazquez
Richard A Mueller
John J Talley
Daniel Getman
Gary A Decrescenzo
John N Freskos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2112430T3 publication Critical patent/ES2112430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Abstract

COMPUESTOS DE HIDROXIETILAMINA QUE CONTIENEN SULFONAMIDA, REPRESENTADOS POR LA FORMULA (I) EN DONDE R, R1, R2, R3, R4, R6, R20, R21, Y, T Y X SON COMO SE DEFINEN EN LA REIVINDICACION 1, SON EFECTIVOS COMO INHIBIDORES DE PROTEASA RETROVIRICA, Y EN PARTICULAR COMO INHIBIDORES DE PROTEASA HIV.
ES93920214T 1992-08-25 1993-08-24 Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. Expired - Lifetime ES2112430T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93507192A 1992-08-25 1992-08-25

Publications (1)

Publication Number Publication Date
ES2112430T3 true ES2112430T3 (es) 1998-04-01

Family

ID=25466549

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93920214T Expired - Lifetime ES2112430T3 (es) 1992-08-25 1993-08-24 Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.

Country Status (15)

Country Link
US (7) US5521219A (es)
EP (1) EP0656888B1 (es)
JP (1) JP4091654B2 (es)
KR (1) KR100296462B1 (es)
AT (1) ATE161828T1 (es)
AU (1) AU669223B2 (es)
CA (1) CA2140928C (es)
DE (1) DE69316223T2 (es)
DK (1) DK0656888T3 (es)
ES (1) ES2112430T3 (es)
FI (1) FI120343B (es)
GR (1) GR3025958T3 (es)
NO (1) NO303540B1 (es)
RU (1) RU2146668C1 (es)
WO (1) WO1994004493A1 (es)

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US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
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Also Published As

Publication number Publication date
RU95106996A (ru) 1996-11-20
DE69316223T2 (de) 1998-05-28
DK0656888T3 (da) 1998-02-09
AU5082093A (en) 1994-03-15
FI950651A (fi) 1995-02-14
US5639769A (en) 1997-06-17
NO303540B1 (no) 1998-07-27
GR3025958T3 (en) 1998-04-30
US6147117A (en) 2000-11-14
CA2140928A1 (en) 1994-02-26
US5760064A (en) 1998-06-02
JP4091654B2 (ja) 2008-05-28
NO950550L (no) 1995-02-14
US5510388A (en) 1996-04-23
FI120343B (fi) 2009-09-30
US5521219A (en) 1996-05-28
KR950702961A (ko) 1995-08-23
FI950651A0 (fi) 1995-02-14
US5965588A (en) 1999-10-12
KR100296462B1 (ko) 2001-10-24
AU669223B2 (en) 1996-05-30
WO1994004493A1 (en) 1994-03-03
EP0656888B1 (en) 1998-01-07
CA2140928C (en) 2008-01-29
JPH08500825A (ja) 1996-01-30
RU2146668C1 (ru) 2000-03-20
US5508294A (en) 1996-04-16
EP0656888A1 (en) 1995-06-14
ATE161828T1 (de) 1998-01-15
DE69316223D1 (de) 1998-02-12
NO950550D0 (no) 1995-02-14

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