ES2111570T3 - Aislamiento y purificacion de la proteina de agente tensioactivo pulmonar. - Google Patents

Aislamiento y purificacion de la proteina de agente tensioactivo pulmonar.

Info

Publication number
ES2111570T3
ES2111570T3 ES91913203T ES91913203T ES2111570T3 ES 2111570 T3 ES2111570 T3 ES 2111570T3 ES 91913203 T ES91913203 T ES 91913203T ES 91913203 T ES91913203 T ES 91913203T ES 2111570 T3 ES2111570 T3 ES 2111570T3
Authority
ES
Spain
Prior art keywords
protein
isolation
purification
lung surface
aliphatic alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913203T
Other languages
English (en)
Inventor
Bradley J Benson
Douglas Buckley
David Lesikar
Asha Naidu
Katie Baptie Silverness
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Application granted granted Critical
Publication of ES2111570T3 publication Critical patent/ES2111570T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/848—Lungs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE PRESENTAN METODOS PARA EL AISLAMIENTO Y LA PURIFICACION DE UNA PROTEINA SURFACTANTE DE PULMON RECOMBINANTE. EL METODO CONSISTE EN UN PROCESO DE MULTIPLES PASOS QUE INCLUYE LA EXTRACCION CON UN ALCOHOL ALIFATICO C SUB 1-C SUB 4 Y LOS PASOS DE PURIFICACION CROMATOGRAFICA QUE EMPLEAN UN ALCOHOL ALIFATICO C SUB 1-C SUB 4 COMO ELUYENTE. TAMBIEN SE DESCRIBEN PROTEINAS PURIFICADAS OBTENIDAS QUE UTILIZAN DICHOS PASOS DE PURIFICACION Y DE AISLAMIENTO.
ES91913203T 1990-07-10 1991-07-10 Aislamiento y purificacion de la proteina de agente tensioactivo pulmonar. Expired - Lifetime ES2111570T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/551,524 US5258496A (en) 1990-07-10 1990-07-10 Isolation and purification of lung surfactant protein

Publications (1)

Publication Number Publication Date
ES2111570T3 true ES2111570T3 (es) 1998-03-16

Family

ID=24201618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913203T Expired - Lifetime ES2111570T3 (es) 1990-07-10 1991-07-10 Aislamiento y purificacion de la proteina de agente tensioactivo pulmonar.

Country Status (11)

Country Link
US (2) US5258496A (es)
EP (1) EP0491033B1 (es)
JP (1) JP3056525B2 (es)
AT (1) ATE159534T1 (es)
CA (1) CA2065323C (es)
DE (1) DE69128022T2 (es)
DK (1) DK0491033T3 (es)
ES (1) ES2111570T3 (es)
GR (1) GR3025929T3 (es)
HK (1) HK1004336A1 (es)
WO (1) WO1992000993A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE433460T1 (de) * 1990-04-04 2009-06-15 Novartis Vaccines & Diagnostic Protease von hepatitis c virus
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein
KR950701934A (ko) * 1993-04-30 1995-05-17 아사이 잇뻬이 소수성 폴리펩티드의 정제방법(purification method for hydrophobic polypeptide)
WO1996017942A1 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of peptides using recombinant fusion protein constructs
WO1996017941A2 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
US6020307A (en) * 1997-04-25 2000-02-01 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
WO1997041155A2 (en) * 1996-04-26 1997-11-06 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins sp-b and sp-c
WO1997043313A1 (en) * 1996-05-15 1997-11-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Process for separating and analyzing hydrophobic proteins using thin layer chromatography
JP2001526061A (ja) * 1997-12-23 2001-12-18 イーライ・リリー・アンド・カンパニー β−リポトロピンおよびその使用
JPH11335392A (ja) * 1998-05-26 1999-12-07 Hsp Kenkyusho:Kk 可溶性タンパク質の回収方法
US20100273983A1 (en) * 2007-04-05 2010-10-28 The University Of Queensland Method of purifying peptides by selective precipitation
EP2197459B1 (en) * 2007-09-14 2016-01-06 Marcus Larsson A lung-surfactant product

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
EP0240550A4 (en) * 1985-09-26 1989-09-19 Genetics Inst LUNG SURFACE ACTIVE PROTEINS.
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
AU1294888A (en) * 1987-01-29 1988-08-24 California Biotechnology, Inc. Recombinant alveolar surfactant protein
EP0368857B1 (en) * 1987-05-11 1997-08-06 Chiron Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
WO1989004326A1 (en) * 1987-11-04 1989-05-18 California Biotechnology Inc. Alveolar surfactant proteins
EP0320126A1 (en) * 1987-11-12 1989-06-14 Unilever Plc Stability of liquid automatic dish-washing detergents
CH677879A5 (es) * 1988-07-22 1991-07-15 Pentapharm Ag
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
ATE201880T1 (de) * 1989-07-11 2001-06-15 Genentech Inc Oberflächenaktive zusammensetzungen und verfahren
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein

Also Published As

Publication number Publication date
WO1992000993A1 (en) 1992-01-23
EP0491033A1 (en) 1992-06-24
HK1004336A1 (en) 1998-11-20
DK0491033T3 (da) 1998-07-20
CA2065323A1 (en) 1992-01-11
EP0491033A4 (es) 1994-03-30
US5403915A (en) 1995-04-04
ATE159534T1 (de) 1997-11-15
GR3025929T3 (en) 1998-04-30
DE69128022D1 (de) 1997-11-27
CA2065323C (en) 2003-06-10
US5258496A (en) 1993-11-02
DE69128022T2 (de) 1998-05-20
JP3056525B2 (ja) 2000-06-26
JPH05502888A (ja) 1993-05-20
EP0491033B1 (en) 1997-10-22

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