ES2106173T3 - Virus vegetales modificados como vectores. - Google Patents
Virus vegetales modificados como vectores.Info
- Publication number
- ES2106173T3 ES2106173T3 ES92907583T ES92907583T ES2106173T3 ES 2106173 T3 ES2106173 T3 ES 2106173T3 ES 92907583 T ES92907583 T ES 92907583T ES 92907583 T ES92907583 T ES 92907583T ES 2106173 T3 ES2106173 T3 ES 2106173T3
- Authority
- ES
- Spain
- Prior art keywords
- peptide
- vectors
- plant viruses
- viruses modified
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 239000013598 vector Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 239000002245 particle Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/18011—Comoviridae
- C12N2770/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32711—Rhinovirus
- C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
LA INVENCION ES RELATIVA A PARTICULAS UNIDAS DE UN VIRUS VEGETAL QUE CONTIENE UNA PEPTIDA AJENA PREDETERMINADA COMO PARTE DE LA PROTEINA DE CUBIERTA DEL VIRUS, Y UN METODO PARA SU PRODUCCION. LA PEPTIDA AJENA ES PREFERIBLEMENTE UNA PEPTIDA BIOLOGICAMENTE FUNCIONAL, LA APLICACION BIOLOGICA DE LA CUAL REQUIERE O SE MEJORA POR PRESENTACION DE LA PEPTIDA EN ASOCIACION CON UNA MOLECULA DE PARTICULA LARGA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919108386A GB9108386D0 (en) | 1991-04-19 | 1991-04-19 | Modified plant viruses as vectors |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2106173T3 true ES2106173T3 (es) | 1997-11-01 |
ES2106173T5 ES2106173T5 (es) | 2001-08-01 |
Family
ID=10693567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92907583T Expired - Lifetime ES2106173T5 (es) | 1991-04-19 | 1992-04-02 | Virus vegetales modificados como vectores. |
Country Status (16)
Country | Link |
---|---|
US (4) | US6110466A (es) |
EP (1) | EP0580635B2 (es) |
JP (1) | JP3236614B2 (es) |
AR (1) | AR248426A1 (es) |
AT (1) | ATE154635T1 (es) |
AU (1) | AU661479B2 (es) |
CA (1) | CA2108777C (es) |
DE (1) | DE69220485T3 (es) |
DK (1) | DK0580635T4 (es) |
ES (1) | ES2106173T5 (es) |
GB (1) | GB9108386D0 (es) |
GR (2) | GR3024739T3 (es) |
HU (1) | HU218010B (es) |
NZ (1) | NZ242430A (es) |
WO (1) | WO1992018618A1 (es) |
ZA (1) | ZA922604B (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6846968B1 (en) | 1988-02-26 | 2005-01-25 | Large Scale Biology Corporation | Production of lysosomal enzymes in plants by transient expression |
US7033835B1 (en) | 1988-02-26 | 2006-04-25 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
US6660500B2 (en) | 1988-02-26 | 2003-12-09 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
GB9108386D0 (en) | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
US5484719A (en) | 1991-08-26 | 1996-01-16 | Edible Vaccines, Inc. | Vaccines produced and administered through edible plants |
US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
EP0787193A1 (en) * | 1994-10-18 | 1997-08-06 | Scottish Crop Research Institute | Method of producing a chimeric protein |
CA2232023A1 (en) * | 1995-09-15 | 1997-03-20 | John A. Howard | Expression cassettes and methods for delivery of animal vaccines |
US6042832A (en) * | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
US7393529B2 (en) * | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
CA2329074A1 (en) * | 1998-10-30 | 2000-05-11 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using plant virus vectors |
GB9921337D0 (en) * | 1999-09-09 | 1999-11-10 | Axis Genetics Plc | Modified plant viruses |
GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
GB9924352D0 (en) * | 1999-10-14 | 1999-12-15 | Hellendoorn Koen | Methods,compositions and applications relating to the generation of novel plant viral particles |
US7135282B1 (en) * | 1999-10-14 | 2006-11-14 | The Dow Chemical Company | Viral particles with exogenous internal epitopes |
CA2414396A1 (en) * | 2000-06-26 | 2002-01-03 | The United States Of America, As Represented By The Secretary Of Agricul Ture | Production of vaccines using transgenic plants |
US6800748B2 (en) | 2001-01-25 | 2004-10-05 | Large Scale Biology Corporation | Cytoplasmic inhibition of gene expression and expression of a foreign protein in a monocot plant by a plant viral vector |
CA2486118A1 (en) * | 2002-06-07 | 2003-12-18 | Large Scale Biology Corporation | Flexible vaccine assembly and vaccine delivery platform |
US20040170606A1 (en) * | 2002-06-07 | 2004-09-02 | Palmer Kenneth E. | Production of peptides in plants as viral coat protein fusions |
CA2497798A1 (en) | 2002-09-03 | 2004-04-22 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
AU2003287622A1 (en) * | 2002-11-06 | 2004-06-03 | Fraunhofer Usa | Expression of foreign sequences in plants using trans-activation system |
US7683238B2 (en) * | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
US8148608B2 (en) | 2004-02-20 | 2012-04-03 | Fraunhofer Usa, Inc | Systems and methods for clonal expression in plants |
US7692063B2 (en) * | 2002-11-12 | 2010-04-06 | Ibio, Inc. | Production of foreign nucleic acids and polypeptides in sprout systems |
ES2531125T3 (es) | 2003-02-03 | 2015-03-10 | Ibio Inc | Sistema para la expresión de genes en plantas |
CN101151272A (zh) * | 2003-12-01 | 2008-03-26 | 陶氏环球技术公司 | 在假单胞菌中生产重组二十面体病毒样颗粒 |
JP2007528727A (ja) | 2004-02-27 | 2007-10-18 | ザ ダウ ケミカル カンパニー | 植物細胞における高効率ペプチド生産 |
WO2005091753A2 (en) * | 2004-03-25 | 2005-10-06 | Large Scale Biology Corporation | Flexible vaccine assembly and vaccine delivery platform |
WO2005108564A2 (en) * | 2004-03-25 | 2005-11-17 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusion |
US8715923B2 (en) * | 2004-07-30 | 2014-05-06 | The United States Of America, As Represented By The Secretary Of The Navy | Protein scaffolds and viral particles for detecting analytes |
US20060216238A1 (en) * | 2005-02-28 | 2006-09-28 | Marianne Manchester | Compositions and methods for targeting or imaging a tissue in a vertebrate subject |
WO2006107954A2 (en) * | 2005-04-05 | 2006-10-12 | Pioneer Hi-Bred International, Inc. | Methods and compositions for designing nucleic acid molecules for polypeptide expression in plants using plant virus codon-bias |
BRPI0611336A2 (pt) * | 2005-06-01 | 2010-08-31 | Dow Global Technologies Inc | método para produzir uma partìcula multivalente semelhante a vìrus, partìcula multivalente semelhante a vìrus, método de aumentar a solubilidade de uma partìcula multivalente semelhante a vìrus e vacina |
BRPI0613625A2 (pt) * | 2005-07-19 | 2011-01-18 | Dow Global Technologies Inc | vacinas da gripe recombinantes |
EP2025762A3 (en) | 2006-01-17 | 2009-09-30 | Health Research Inc. | Heteroduplex tracking assay |
US7618815B2 (en) * | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
US7923823B2 (en) * | 2007-01-23 | 2011-04-12 | Infineon Technologies Ag | Semiconductor device with parylene coating |
CN101784655A (zh) * | 2007-04-27 | 2010-07-21 | 菲尼克斯股份有限公司 | 可溶性重组二十面体病毒样颗粒的改良生成和体内装配 |
AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
LT2691530T (lt) | 2011-06-10 | 2018-08-10 | Oregon Health & Science University | Cmv glikoproteinai ir rekombinantiniai vektoriai |
US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
KR102134815B1 (ko) | 2012-09-05 | 2020-07-17 | 메디카고 인코포레이티드 | 식물에서 피코르나바이러스-유사 입자 생산 |
US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
JP6789823B2 (ja) | 2014-04-15 | 2020-11-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 両末端peg化インテグリン結合性ペプチドおよびその使用方法 |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4407956A (en) * | 1981-03-13 | 1983-10-04 | The Regents Of The University Of California | Cloned cauliflower mosaic virus DNA as a plant vehicle |
CA1192510A (en) * | 1981-05-27 | 1985-08-27 | Lawrence E. Pelcher | Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom |
US4593002A (en) * | 1982-01-11 | 1986-06-03 | Salk Institute Biotechnology/Industrial Associates, Inc. | Viruses with recombinant surface proteins |
US5173410A (en) | 1984-02-15 | 1992-12-22 | Lubrizol Genetics Inc. | Transfer vector |
US4885248A (en) | 1984-02-15 | 1989-12-05 | Lubrizol Genetics, Inc. | Transfer vector |
GB8421282D0 (en) * | 1984-08-22 | 1984-09-26 | Connaught Lab | Multispecific antigenic proteins |
US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
CA1288073C (en) * | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
DE3686633T2 (de) * | 1985-10-25 | 1993-04-15 | David Matthew Bisaro | Pflanzenvektoren. |
GB8608850D0 (en) * | 1986-04-11 | 1986-05-14 | Diatech Ltd | Packaging system |
ATE108828T1 (de) * | 1987-02-09 | 1994-08-15 | Lubrizol Genetics Inc | Hybrides rns-virus. |
US5316931A (en) * | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
DE68929521T2 (de) * | 1988-02-26 | 2006-02-23 | Large Scale Biology Corp., Vacaville | Nicht-nukleare chromosomale Transformation |
CA1339841C (en) * | 1988-07-15 | 1998-04-28 | Robert L. Erwing | Synthesis of stereospecific enzyme by non-chromosomal transformation a host |
US5596132A (en) * | 1990-03-12 | 1997-01-21 | Cornell Research Foundation, Inc. | Induction of resistance to virus diseases by transformation of plants with a portion of a plant virus genome involving a read-through replicase gene |
WO1991013994A1 (en) | 1990-03-13 | 1991-09-19 | Commonwealth Scientific And Industrial Research Organisation | Gene expression |
WO1991015587A1 (en) | 1990-04-06 | 1991-10-17 | Commonwealth Scientific And Industrial Research Organisation | Self-polymerising expression system based on modified potyvirus coat proteins |
AU639088B2 (en) * | 1990-04-13 | 1993-07-15 | Digital Equipment Corporation | Telecommunications network with plesiochronous transfer mode |
GB9108386D0 (en) * | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
JPH07503361A (ja) | 1991-08-01 | 1995-04-13 | バイオソース テクノロジーズ インコーポレイティド | 組み換え植物ウィルス核酸 |
US5437976A (en) * | 1991-08-08 | 1995-08-01 | Arizona Board Of Regents, The University Of Arizona | Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA |
AU1838495A (en) | 1994-02-03 | 1995-08-21 | Scripps Research Institute, The | Method for using tobacco mosaic virus to overproduce peptides and proteins |
GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
-
1991
- 1991-04-19 GB GB919108386A patent/GB9108386D0/en active Pending
-
1992
- 1992-04-02 US US08/137,032 patent/US6110466A/en not_active Expired - Fee Related
- 1992-04-02 HU HU9302954A patent/HU218010B/hu not_active IP Right Cessation
- 1992-04-02 AT AT92907583T patent/ATE154635T1/de not_active IP Right Cessation
- 1992-04-02 JP JP50696092A patent/JP3236614B2/ja not_active Expired - Lifetime
- 1992-04-02 AU AU14479/92A patent/AU661479B2/en not_active Ceased
- 1992-04-02 DK DK92907583T patent/DK0580635T4/da active
- 1992-04-02 CA CA002108777A patent/CA2108777C/en not_active Expired - Lifetime
- 1992-04-02 DE DE69220485T patent/DE69220485T3/de not_active Expired - Lifetime
- 1992-04-02 EP EP92907583A patent/EP0580635B2/en not_active Expired - Lifetime
- 1992-04-02 ES ES92907583T patent/ES2106173T5/es not_active Expired - Lifetime
- 1992-04-02 WO PCT/GB1992/000589 patent/WO1992018618A1/en active IP Right Grant
- 1992-04-09 ZA ZA922604A patent/ZA922604B/xx unknown
- 1992-04-20 AR AR92322168A patent/AR248426A1/es active
- 1992-04-22 NZ NZ242430A patent/NZ242430A/xx not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/471,048 patent/US5874087A/en not_active Expired - Lifetime
-
1997
- 1997-09-17 GR GR970402384T patent/GR3024739T3/el unknown
-
1999
- 1999-05-05 US US09/304,967 patent/US6884623B1/en not_active Expired - Fee Related
-
2000
- 2000-05-30 US US09/580,704 patent/US7208655B1/en not_active Expired - Fee Related
-
2001
- 2001-03-05 GR GR20010400362T patent/GR3035521T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0580635B2 (en) | 2001-02-21 |
AU661479B2 (en) | 1995-07-27 |
US6110466A (en) | 2000-08-29 |
DK0580635T4 (da) | 2001-03-19 |
WO1992018618A1 (en) | 1992-10-29 |
DE69220485T3 (de) | 2001-06-07 |
JPH06506583A (ja) | 1994-07-28 |
CA2108777C (en) | 2000-07-18 |
JP3236614B2 (ja) | 2001-12-10 |
GR3024739T3 (en) | 1997-12-31 |
ATE154635T1 (de) | 1997-07-15 |
ZA922604B (en) | 1992-12-30 |
GR3035521T3 (en) | 2001-06-29 |
EP0580635A1 (en) | 1994-02-02 |
HUT65554A (en) | 1994-06-28 |
DE69220485T2 (de) | 1997-10-09 |
AU1447992A (en) | 1992-11-17 |
HU9302954D0 (en) | 1994-01-28 |
NZ242430A (en) | 1993-06-25 |
HU218010B (hu) | 2000-05-28 |
GB9108386D0 (en) | 1991-06-05 |
DE69220485D1 (de) | 1997-07-24 |
CA2108777A1 (en) | 1992-10-20 |
US7208655B1 (en) | 2007-04-24 |
DK0580635T3 (da) | 1998-01-19 |
US6884623B1 (en) | 2005-04-26 |
AR248426A1 (es) | 1995-08-18 |
US5874087A (en) | 1999-02-23 |
EP0580635B1 (en) | 1997-06-18 |
ES2106173T5 (es) | 2001-08-01 |
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