ES2106025T3 - Analogos de gangliosidos semisinteticos. - Google Patents

Analogos de gangliosidos semisinteticos.

Info

Publication number
ES2106025T3
ES2106025T3 ES90402139T ES90402139T ES2106025T3 ES 2106025 T3 ES2106025 T3 ES 2106025T3 ES 90402139 T ES90402139 T ES 90402139T ES 90402139 T ES90402139 T ES 90402139T ES 2106025 T3 ES2106025 T3 ES 2106025T3
Authority
ES
Spain
Prior art keywords
acil
semi
derived
groups
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402139T
Other languages
English (en)
Inventor
Valle Francesco Della
Aurelio Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2106025T3 publication Critical patent/ES2106025T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lead Frames For Integrated Circuits (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

SE PRESENTAN N-ACIL-N,N''-DILISOGANGLIOSIDOS EN LOS QUE LOS GRUPOS ACIL SE DERIVAN DE ACIDOS ALIFATICOS INSUBSTITUIDOS QUE TIENEN ENTRE 1 Y 11 ATOMOS DE CARBONO, Y N''-ACIL-N, N''-DILISOGANGLIOSIDOS Y N, N'' CUALES LOS GRUPOS ACIL SE DERIVAN DE ACIDOS HALIFATICOS INSUBSTITUIDOS QUE TIENEN ENTRE 1 Y 24 ATOMOS DE CARBONO (CON LA EXCEPCION DE CIERTOS DERIVADOS DEL ACETIL Y DEL DIACETIL). LOS COMPUESTOS DEL INVENTO EXHIBEN UNA ACCION INHIBIDORA SOBRE LA ACTIVACION C DE LA PROTEINA KINASA Y DE ESTA FORMA, PUEDEN UTILIZARSE EN TERAPIAS DE VARIAS PATOLOGIAS DEL SISTEMA NERVIOSO, TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS Y UTILIDADES TERAPEUTICAS DE LOS DERIVADOS DILISOGANGLIOSIDOS.
ES90402139T 1989-07-27 1990-07-25 Analogos de gangliosidos semisinteticos. Expired - Lifetime ES2106025T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8948246A IT1232175B (it) 1989-07-27 1989-07-27 Analoghi semisintetici di gangliosidi

Publications (1)

Publication Number Publication Date
ES2106025T3 true ES2106025T3 (es) 1997-11-01

Family

ID=11265466

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402139T Expired - Lifetime ES2106025T3 (es) 1989-07-27 1990-07-25 Analogos de gangliosidos semisinteticos.

Country Status (16)

Country Link
US (1) US5484775A (es)
EP (1) EP0410881B1 (es)
JP (1) JPH0358995A (es)
KR (1) KR910002887A (es)
AT (1) ATE158297T1 (es)
AU (1) AU5982990A (es)
CA (1) CA2022138A1 (es)
DE (1) DE69031448T2 (es)
ES (1) ES2106025T3 (es)
FI (1) FI903753A0 (es)
HU (1) HU210923B (es)
IL (1) IL95169A0 (es)
IT (1) IT1232175B (es)
NO (1) NO903333L (es)
NZ (1) NZ234649A (es)
PL (1) PL165209B1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1232176B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IT1239060B (it) * 1990-05-04 1993-09-20 Fidia Spa Processo per la modulazione selettiva dell'espressione e della funzione di un determinante sulla superficie cellulare attraverso appropriati agenti chimici
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
DE4204907A1 (de) * 1992-02-14 1993-08-19 Reutter Werner Neuartige glykokonjugate mit n-substituierten neuraminsaeuren als mittel zur stimulierung des immunsystems
CA2457794A1 (en) 2001-08-29 2003-03-06 Neose Technologies, Inc. Novel synthetic ganglioside derivatives and compositions thereof
EP1603932B1 (en) 2003-03-06 2012-10-03 Seneb Biosciences Inc. Methods and compositions for the enzymatic synthesis of gangliosides
WO2010111530A1 (en) * 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease
WO2017062632A1 (en) 2015-10-09 2017-04-13 Tensar Corporation, Llc Geogrid made from a coextruded multilayered polymer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593091A (en) * 1981-08-04 1986-06-03 Fidia, S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4476119A (en) * 1981-08-04 1984-10-09 Fidia S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4716223A (en) * 1981-08-04 1987-12-29 Fidia, S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
JPH06795B2 (ja) * 1985-04-02 1994-01-05 理化学研究所 アシアロガングリオシド関連化合物の製造方法
US5010059A (en) * 1987-06-26 1991-04-23 Solco Basel Ag Pharmaceutical products and lactosyl compounds
IT1212041B (it) * 1987-11-02 1989-11-08 Fidia Farmaceutici Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche
CA1339488C (en) * 1988-02-12 1997-10-07 Taeko Dohi De-n-acetyl-syalic acid and their applications as modifiers of cell physiology
IT1235161B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisogangliosidi
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi

Also Published As

Publication number Publication date
NZ234649A (en) 1992-01-29
DE69031448D1 (de) 1997-10-23
PL286249A1 (en) 1991-08-26
HU210923B (en) 1995-09-28
NO903333L (no) 1991-01-28
AU5982990A (en) 1991-01-31
FI903753A0 (fi) 1990-07-27
KR910002887A (ko) 1991-02-26
IL95169A0 (en) 1991-06-10
IT1232175B (it) 1992-01-25
HUT54173A (en) 1991-01-28
ATE158297T1 (de) 1997-10-15
EP0410881A3 (en) 1993-01-20
JPH0358995A (ja) 1991-03-14
HU904640D0 (en) 1991-01-28
EP0410881B1 (en) 1997-09-17
DE69031448T2 (de) 1998-02-26
CA2022138A1 (en) 1991-01-28
IT8948246A0 (it) 1989-07-27
NO903333D0 (no) 1990-07-26
US5484775A (en) 1996-01-16
EP0410881A2 (en) 1991-01-30
PL165209B1 (pl) 1994-11-30

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