DE3687224D1 - Hemmung vom 5-lipoxygenase-weg. - Google Patents

Hemmung vom 5-lipoxygenase-weg.

Info

Publication number
DE3687224D1
DE3687224D1 DE8686309673T DE3687224T DE3687224D1 DE 3687224 D1 DE3687224 D1 DE 3687224D1 DE 8686309673 T DE8686309673 T DE 8686309673T DE 3687224 T DE3687224 T DE 3687224T DE 3687224 D1 DE3687224 D1 DE 3687224D1
Authority
DE
Germany
Prior art keywords
lipoxygenase
inhibition
way
diaryl
imidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686309673T
Other languages
English (en)
Other versions
DE3687224T2 (de
Inventor
Henry Martin Sarau
Don Edgar Griswold
Nabil Hanna
Paul Elliot Bender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE3687224D1 publication Critical patent/DE3687224D1/de
Publication of DE3687224T2 publication Critical patent/DE3687224T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8686309673T 1985-12-12 1986-12-11 Hemmung vom 5-lipoxygenase-weg. Expired - Fee Related DE3687224T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80839585A 1985-12-12 1985-12-12
US06/856,927 US4686231A (en) 1985-12-12 1986-04-28 Inhibition of 5-lipoxygenase products

Publications (2)

Publication Number Publication Date
DE3687224D1 true DE3687224D1 (de) 1993-01-14
DE3687224T2 DE3687224T2 (de) 1993-04-08

Family

ID=27123119

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686309673T Expired - Fee Related DE3687224T2 (de) 1985-12-12 1986-12-11 Hemmung vom 5-lipoxygenase-weg.

Country Status (7)

Country Link
US (1) US4686231A (de)
EP (1) EP0236628B1 (de)
AT (1) ATE82968T1 (de)
AU (1) AU586907B2 (de)
DE (1) DE3687224T2 (de)
DK (1) DK593886A (de)
PT (1) PT83902B (de)

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DE69426415T2 (de) * 1993-01-29 2001-07-26 Aradigm Corp., Hayward Intrapulmonares hormonabgabesystem
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
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US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US20030050330A1 (en) * 1997-01-10 2003-03-13 G.D. Searle & Co. 4,5-subtstituted imdazolyl compounds for the treatment of inflammation
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
NZ501714A (en) 1997-06-12 2001-09-28 Rhone Poulenc Rorer Ltd Imidazolyl-cyclic acetal derivatives, resins and intermediates thereof and use as TNF inhibitors
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US6610695B1 (en) 1997-06-19 2003-08-26 Smithkline Beecham Corporation Aryloxy substituted pyrimidine imidazole compounds
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CA2306077A1 (en) 1997-10-08 1999-04-15 Smithkline Beecham Corporation Novel cycloalkenyl substituted compounds
US6335340B1 (en) 1997-12-19 2002-01-01 Smithkline Beecham Corporation compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
CZ20004339A3 (cs) 1998-05-22 2001-10-17 Smithkline Beecham Corporation Nové 2-alkylem substituované imidazolové sloučeniny
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
ES2221426T3 (es) * 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
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US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
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US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
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US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
DK1333833T3 (da) * 2000-10-23 2011-12-12 Glaxosmithkline Llc Ny trisubstitueret 8H-pyridol[2,3-d]pyrimidin-7-on-forbindelse til behandling af CSBP/RK/p38-kinnasemedierede sygdomme
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US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US7329401B2 (en) * 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
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Also Published As

Publication number Publication date
ATE82968T1 (de) 1992-12-15
AU6645286A (en) 1987-06-18
EP0236628B1 (de) 1992-12-02
PT83902B (en) 1988-10-31
PT83902A (en) 1987-01-01
DE3687224T2 (de) 1993-04-08
DK593886D0 (da) 1986-12-10
US4686231A (en) 1987-08-11
EP0236628A1 (de) 1987-09-16
DK593886A (da) 1987-06-13
AU586907B2 (en) 1989-07-27

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Legal Events

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8339 Ceased/non-payment of the annual fee