ES2105926B1 - El uso de taxol para la fabricacion de una preparacion de infusion para el tratamiento del cancer. - Google Patents
El uso de taxol para la fabricacion de una preparacion de infusion para el tratamiento del cancer.Info
- Publication number
- ES2105926B1 ES2105926B1 ES09301618A ES9301618A ES2105926B1 ES 2105926 B1 ES2105926 B1 ES 2105926B1 ES 09301618 A ES09301618 A ES 09301618A ES 9301618 A ES9301618 A ES 9301618A ES 2105926 B1 ES2105926 B1 ES 2105926B1
- Authority
- ES
- Spain
- Prior art keywords
- taxol
- treatment
- infusion
- cancer
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229930012538 Paclitaxel Natural products 0.000 title abstract 7
- 238000001802 infusion Methods 0.000 title abstract 7
- 229960001592 paclitaxel Drugs 0.000 title abstract 7
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
EL USO DE TAXOL PARA LA FABRICACION DE UNA PREPARACION DE INFUSION PARA EL TRATAMIENTO DEL CANCER. LA PRESENTE INVENCION SE REFIERE AL USO DE TAXOL PARA LA FABRICACION DE UNA PREPARACION DE INFUSION PARA EL TRATAMIENTO DEL CANCER, EN COMBINACION CON UN AGENTE PARA EL TRATAMIENTO DE UNA REACCION DE TIPO ANAFILACTICO Y/O UN AGENTE PARA REDUCIR LA MIELOTOXICIDAD, DE ACUERDO CON UN PROTOCOLO DE INFUSION QUE COMPRENDE UNA DURACION DE LA INFUSION NO SUPERIOR A 6 HORAS Y UNA DOSIS DE PACLITAXEL DE ENTRE 135 MG/M2 A 275 MG/M2. EN UNA REALIZACION PREFERIDA SE FABRICA UNA PREPARACION DE INFUSION DE TAXOL CAPAZ DE INFUNDIR UNA DOSIS DE 135 A 275 MG/M2 DE TAXOL EN 3 HORAS. LA INFUSION DE TAXOL PUEDE EFECTUARSE EN REGIMEN AMBULATORIO A PACIENTES QUE NO REQUIEREN HOSPITALIZACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92362892A | 1992-08-03 | 1992-08-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2105926A1 ES2105926A1 (es) | 1997-10-16 |
ES2105926B1 true ES2105926B1 (es) | 1998-07-01 |
Family
ID=25448992
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09301618A Expired - Fee Related ES2105926B1 (es) | 1992-08-03 | 1993-07-19 | El uso de taxol para la fabricacion de una preparacion de infusion para el tratamiento del cancer. |
ES93401978T Expired - Lifetime ES2101261T3 (es) | 1992-08-03 | 1993-07-29 | Uso de taxol para la fabricacion de un medicamento para el tratamiento del cancer. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93401978T Expired - Lifetime ES2101261T3 (es) | 1992-08-03 | 1993-07-29 | Uso de taxol para la fabricacion de un medicamento para el tratamiento del cancer. |
Country Status (23)
Country | Link |
---|---|
US (5) | US5641803A (es) |
EP (3) | EP0783886A3 (es) |
JP (1) | JP2848760B2 (es) |
AT (1) | ATE152910T1 (es) |
AU (3) | AU641894B3 (es) |
BE (1) | BE1006497A5 (es) |
CA (1) | CA2086874E (es) |
CH (1) | CH686868A5 (es) |
DE (2) | DE69310634T2 (es) |
DK (2) | DK65293A (es) |
ES (2) | ES2105926B1 (es) |
FR (1) | FR2694192B1 (es) |
GB (1) | GB9311740D0 (es) |
GR (2) | GR1001617B (es) |
IE (1) | IE80620B1 (es) |
IL (1) | IL105879A (es) |
IT (1) | IT1276041B1 (es) |
MY (1) | MY109862A (es) |
NL (1) | NL9301086A (es) |
NZ (1) | NZ245795A (es) |
PT (1) | PT101289A (es) |
SE (1) | SE513082C2 (es) |
ZA (1) | ZA93686B (es) |
Families Citing this family (91)
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MX347225B (es) | 2010-06-04 | 2017-04-19 | Abraxis Bioscience Llc * | Metodos de tratamiento contra el cancer pancreatico. |
KR20220025946A (ko) | 2014-03-21 | 2022-03-03 | 애브비 인코포레이티드 | 항-egfr 항체 및 항체 약물 접합체 |
US20200338209A1 (en) | 2016-06-08 | 2020-10-29 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
BR112018075630A2 (pt) | 2016-06-08 | 2019-03-19 | Abbvie Inc. | anticorpos anti-cd98 e conjugados de fármaco de anticorpo |
BR112018075644A2 (pt) | 2016-06-08 | 2019-04-09 | Abbvie Inc. | anticorpos anti-cd98 e conjugados de anticorpo e fármaco |
EP3468993A1 (en) | 2016-06-08 | 2019-04-17 | AbbVie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
EP3458479B1 (en) | 2016-06-08 | 2020-11-04 | AbbVie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
CN109562073B (zh) | 2016-09-29 | 2021-11-09 | 四川科伦药物研究院有限公司 | 白蛋白药物组合物及其制备方法 |
UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
WO1992019765A1 (en) * | 1991-05-08 | 1992-11-12 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method for designing cancer treatment regimens and methods and pharmaceutical compositions for the treatment of cancer |
FR2678833B1 (fr) * | 1991-07-08 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes. |
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1993
- 1993-01-07 CA CA002086874A patent/CA2086874E/en not_active Expired - Fee Related
- 1993-01-29 AU AU32102/93A patent/AU641894B3/en not_active Ceased
- 1993-01-29 AU AU32168/93A patent/AU3216893A/en not_active Abandoned
- 1993-01-29 NZ NZ245795A patent/NZ245795A/xx not_active IP Right Cessation
- 1993-02-01 ZA ZA93686A patent/ZA93686B/xx unknown
- 1993-02-02 MY MYPI93000157A patent/MY109862A/en unknown
- 1993-06-02 IL IL10587993A patent/IL105879A/en not_active IP Right Cessation
- 1993-06-04 DK DK065293A patent/DK65293A/da not_active Application Discontinuation
- 1993-06-07 GB GB939311740A patent/GB9311740D0/en active Pending
- 1993-06-08 SE SE9301951A patent/SE513082C2/sv not_active IP Right Cessation
- 1993-06-08 IE IE930433A patent/IE80620B1/en not_active IP Right Cessation
- 1993-06-10 GR GR930100239A patent/GR1001617B/el not_active IP Right Cessation
- 1993-06-15 PT PT101289A patent/PT101289A/pt not_active Application Discontinuation
- 1993-06-22 NL NL9301086A patent/NL9301086A/nl not_active Application Discontinuation
- 1993-07-15 JP JP5174994A patent/JP2848760B2/ja not_active Expired - Lifetime
- 1993-07-19 ES ES09301618A patent/ES2105926B1/es not_active Expired - Fee Related
- 1993-07-29 DE DE69310634T patent/DE69310634T2/de not_active Revoked
- 1993-07-29 ES ES93401978T patent/ES2101261T3/es not_active Expired - Lifetime
- 1993-07-29 EP EP97104512A patent/EP0783886A3/en not_active Withdrawn
- 1993-07-29 AT AT93401978T patent/ATE152910T1/de not_active IP Right Cessation
- 1993-07-29 DK DK93401978.7T patent/DK0584001T3/da active
- 1993-07-29 EP EP93401978A patent/EP0584001B1/en not_active Revoked
- 1993-07-29 EP EP97104511A patent/EP0783885A3/en not_active Withdrawn
- 1993-07-29 FR FR9309372A patent/FR2694192B1/fr not_active Expired - Fee Related
- 1993-07-29 IT IT93MI001714A patent/IT1276041B1/it active IP Right Grant
- 1993-07-30 BE BE9300800A patent/BE1006497A5/fr active
- 1993-08-02 DE DE4325927A patent/DE4325927B4/de not_active Revoked
- 1993-08-03 CH CH02325/93A patent/CH686868A5/de not_active IP Right Cessation
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1995
- 1995-10-18 US US08/544,594 patent/US5641803A/en not_active Expired - Lifetime
- 1995-11-20 US US08/559,890 patent/US5621001A/en not_active Expired - Lifetime
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1996
- 1996-01-19 AU AU42070/96A patent/AU704393C/en not_active Ceased
- 1996-09-19 US US08/715,914 patent/US5670537A/en not_active Expired - Lifetime
- 1996-11-22 US US08/755,740 patent/US5665761A/en not_active Expired - Lifetime
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1997
- 1997-08-13 GR GR970402058T patent/GR3024415T3/el unknown
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2000
- 2000-02-07 US US09/499,373 patent/US6414014B1/en not_active Expired - Fee Related
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