ES2103906T3 - Evaluacion de la fragilidad osea y prediccion del riesgo de fracturas osteoporoticas utilizando una determinacion cuantitativa de osteocalcina subcarboxilada circulante. - Google Patents

Evaluacion de la fragilidad osea y prediccion del riesgo de fracturas osteoporoticas utilizando una determinacion cuantitativa de osteocalcina subcarboxilada circulante.

Info

Publication number
ES2103906T3
ES2103906T3 ES92400517T ES92400517T ES2103906T3 ES 2103906 T3 ES2103906 T3 ES 2103906T3 ES 92400517 T ES92400517 T ES 92400517T ES 92400517 T ES92400517 T ES 92400517T ES 2103906 T3 ES2103906 T3 ES 2103906T3
Authority
ES
Spain
Prior art keywords
subcarboxylated
osteocalcine
circulating
evaluation
quantitative determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92400517T
Other languages
English (en)
Inventor
Pierre Delmas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EN RHUMATOLOGIE CENTRE RECH
Original Assignee
EN RHUMATOLOGIE CENTRE RECH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EN RHUMATOLOGIE CENTRE RECH filed Critical EN RHUMATOLOGIE CENTRE RECH
Application granted granted Critical
Publication of ES2103906T3 publication Critical patent/ES2103906T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA LA COMPROBACION DE LA FRAGILIDAD DE LOS HUESOS Y LA DETERMINACION DEL RIESGO DE FRACTURAS OSTEOPOROTICAS QUE SE CARACTERIZA POR: NA MUESTRA DE FLUIDO BIOLOGICO TAL COMO EL SUERO, EL PLASMA O LA ORINA; CARBOXILADA EN LA MUESTRA DE PRUEBA CON LA CONCENTRACION DE UNA MUESTRA DE CONTROL QUE CONTIENE NIVELES DE OSTEOCALCINA CARBOXILADA REPRESENTATIVOS DEL LIMITE SUPERIOR DE LA BANDA NORMAL, LAS CONCENTRACIONES POR ENCIMA DE ESTE LIMITE SUPERIOR SON INDICATIVAS DEL RIESGO INCREMENTADO DE FRACTURA EN LOS HUESOS.
ES92400517T 1992-02-27 1992-02-27 Evaluacion de la fragilidad osea y prediccion del riesgo de fracturas osteoporoticas utilizando una determinacion cuantitativa de osteocalcina subcarboxilada circulante. Expired - Lifetime ES2103906T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92400517A EP0557663B1 (en) 1992-02-27 1992-02-27 Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under-carboxylated osteocalcin

Publications (1)

Publication Number Publication Date
ES2103906T3 true ES2103906T3 (es) 1997-10-01

Family

ID=8211618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92400517T Expired - Lifetime ES2103906T3 (es) 1992-02-27 1992-02-27 Evaluacion de la fragilidad osea y prediccion del riesgo de fracturas osteoporoticas utilizando una determinacion cuantitativa de osteocalcina subcarboxilada circulante.

Country Status (5)

Country Link
EP (1) EP0557663B1 (es)
JP (1) JP3053503B2 (es)
AT (1) ATE152525T1 (es)
DE (1) DE69219451T2 (es)
ES (1) ES2103906T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0739439B2 (ja) * 1989-03-16 1995-05-01 寳酒造株式会社 モノクローナル抗体及びその使用方法
JPH0792165A (ja) * 1993-09-21 1995-04-07 Hoechst Japan Ltd 骨粗鬆症診断剤
DE4340597C2 (de) * 1993-11-29 1995-11-30 Brahms Diagnostica Gmbh Verfahren zur Verhinderung des Abbaus von Osteocalcin in humanem Serum oder Plasma f}r seine nachfolgende Bestimmung sowie Instrumente und Probengef{ße zur Durchf}hrung dieses Verfahrens
EP0946180A4 (en) * 1996-10-07 2003-07-23 Smithkline Beecham Corp METHODS FOR STIMULATING BONE FORMATION
FI973371A0 (fi) * 1997-08-15 1997-08-15 Jukka Hellman Nya isolerade peptider
AUPP547398A0 (en) * 1998-08-26 1998-09-17 Medvet Science Pty. Ltd. Predictive assessment of certain skeletal disorders
FI990693A0 (fi) 1999-03-29 1999-03-29 Kaekoenen Sanna Maria Menetelmä luunmurtumien ennustamiseksi osteokalsiinimääritysten avulla
DE10020880C2 (de) * 1999-04-28 2002-11-28 Pe Diagnostik Gmbh Verfahren zur Ermittlung signifikanter Knochendichteverluste
DE19919982C2 (de) * 1999-04-30 2001-06-28 Pe Diagnostik Gmbh Verfahren zur Ermittlung osteoporotischer Prozesse
US7534419B2 (en) 2001-01-19 2009-05-19 Depuy Mitek, Inc. Methods of diagnosis and treatment of osteoporosis
GB0107393D0 (en) * 2001-03-23 2001-05-16 Osteometer Biotech As A method of assaying osteocalcin fragments in body fluids a test kit and means for carrying out the method and use of the method to monitor bone resorption
NZ575804A (en) 2006-09-13 2012-01-12 Univ Columbia Undercarboxylated/uncarboxylated osteocalcin increases beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases fat mass

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0739439B2 (ja) * 1989-03-16 1995-05-01 寳酒造株式会社 モノクローナル抗体及びその使用方法

Also Published As

Publication number Publication date
ATE152525T1 (de) 1997-05-15
JP3053503B2 (ja) 2000-06-19
JPH0678788A (ja) 1994-03-22
DE69219451T2 (de) 1997-10-23
DE69219451D1 (de) 1997-06-05
EP0557663A1 (en) 1993-09-01
EP0557663B1 (en) 1997-05-02

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