ES2101906T3 - Procedimiento para la obtencion de l-ascorbato-2-fosfato de calcio. - Google Patents
Procedimiento para la obtencion de l-ascorbato-2-fosfato de calcio.Info
- Publication number
- ES2101906T3 ES2101906T3 ES93112314T ES93112314T ES2101906T3 ES 2101906 T3 ES2101906 T3 ES 2101906T3 ES 93112314 T ES93112314 T ES 93112314T ES 93112314 T ES93112314 T ES 93112314T ES 2101906 T3 ES2101906 T3 ES 2101906T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- piridine
- auri
- transformation
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229910000389 calcium phosphate Inorganic materials 0.000 title 1
- 239000001506 calcium phosphate Substances 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 4
- 230000009466 transformation Effects 0.000 abstract 3
- 240000006409 Acacia auriculiformis Species 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 159000000007 calcium salts Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- CIWBSHSKHKDKBQ-UHFFFAOYSA-N 2-(1,2-dihydroxyethyl)-3,4-dihydroxy-2h-furan-5-one Chemical compound OCC(O)C1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-UHFFFAOYSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- RCJVRSBWZCNNQT-UHFFFAOYSA-N dichloridooxygen Chemical compound ClOCl RCJVRSBWZCNNQT-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER LAS SALES DE CALCIO DE MONOFOSFATO-2ASCORBILO DE MEZCLAS ACUOSO ALCALINAS SE OBTIENE EN LA TRANSFORMACION DE ACIDO ASCORBINICO CON UN EXCESO MOLAR DE OXICLORURO DE FOSFORO EN PRESENCIA DE UNA AMINA TERCIARIA Y CON MANTENIMIENTO DE UN VALOR DE PH DURANTE LA REACCION MEDIANTE UNA LEJIA ACUOSA , SE CARACTERIZA PORQUE A) SE PARTE DE UNA MEZCLA DE REACCION QUE SE OBTIENE A TRAVES DE LA TRANSFORMACION DE ACIDO ASCORBINICO CON OXICLORURO DE FOSFORO,EN PRESENCIA DE PIRIDINA MANTENIENDO UN VALOR DE PH ENTRE 12 Y 13 MEDIANTE UNA LEJIA ACUOSA ,B) LOS IONES DEL ACIDO FOSFORICO FORMADOS EN LA TRANSFORMACION PRECIPITAN A TRAVES DE CLORURO MAGNESICO EN UNA CANTIDAD QUIZAS DE UN MOL DE IONES POR MOL DE IONES DE ACIDO FOSFORICO COMO FOSFATO MAGNESICO POTASICO ,C) SE SEPARA EL FOSFATO MAGNESICO POTASICO ,D) SE DESTILA DE LA SOLUCION ACUOSA QUE PERMANECE , LA PIRIDINA CONJUNTAMENTE CON UNA PARTE DE AGUA ,E) SE HACE REACCIONAR LA SOLUCION ACUOSA OBTENIDA CON CLORURO CALCICO Y F) SE AISLA LA SAL CALCICA DEL MONOFOSFATO-2-ASCORBILO YA QUE EN LA CONEXION DE LAS ETAPAS DEL PROCEDIMIENTO A) PRIMERAMENTE SE EFECTUA LA MEZCLA PIRIDINA-AGUA CON ARREGLO A LA ETAPA DEL PROCEDIMIENTO ,D) SEPARACION Y DESPUES SE EFECTUAN LAS ETAPAS DE PROCEDIMIENTO B) ,C) , E) Y F)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4226625A DE4226625A1 (de) | 1992-08-12 | 1992-08-12 | Verfahren zur Herstellung von Calcium-L-ascorbat-2-phosphat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2101906T3 true ES2101906T3 (es) | 1997-07-16 |
Family
ID=6465358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93112314T Expired - Lifetime ES2101906T3 (es) | 1992-08-12 | 1993-07-31 | Procedimiento para la obtencion de l-ascorbato-2-fosfato de calcio. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5420302A (es) |
| EP (1) | EP0582924B1 (es) |
| JP (1) | JPH06184173A (es) |
| CN (1) | CN1032539C (es) |
| CA (1) | CA2101658A1 (es) |
| DE (2) | DE4226625A1 (es) |
| ES (1) | ES2101906T3 (es) |
| NO (1) | NO301716B1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2230774C (en) * | 1997-03-18 | 2007-06-26 | F. Hoffmann-La Roche Ag | Manufacture of ascorbyl monophosphates |
| JPH11349595A (ja) * | 1998-06-05 | 1999-12-21 | Showa Denko Kk | Ｌ−アスコルビン酸−２−リン酸エステルカリウム塩結晶およびその製造方法 |
| US6271397B1 (en) | 1998-06-05 | 2001-08-07 | Showa Denko Kabushiki Kaisha | L-ascorbic acid-2-phosphoric acid potassium crystal and method for producing the same |
| DE19831056A1 (de) * | 1998-07-13 | 2000-01-20 | Basf Ag | Verfahren zur Herstellung von Salzen von Ascorbyl-2-phosphorsäureestern |
| DE60000844T2 (de) | 1999-06-07 | 2003-09-04 | Hoffmann La Roche | Verfahren zur Reinigung L-Ascorbyl 2-monophosphat |
| JP2001097982A (ja) * | 1999-07-29 | 2001-04-10 | Showa Denko Kk | アスコルビン酸−２−リン酸エステル塩の製造方法 |
| US6344567B1 (en) | 1999-07-29 | 2002-02-05 | Showa Denko Kabushiki Kaisha | Process for producing ascorbic acid-2-phosphoric ester salts |
| JP3957195B2 (ja) * | 2001-01-24 | 2007-08-15 | ブライトスマイル プロフェッショナル インク． | 局所用口腔ケア組成物 |
| KR100532573B1 (ko) * | 2002-11-21 | 2005-12-01 | 주식회사 엔지켐 | 엘-아스코빌-2-인산에스테르마그네슘염의 제조방법 |
| EP1633201B1 (en) * | 2003-06-16 | 2011-10-05 | DSM IP Assets B.V. | Pet food composition |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1489249A (fr) * | 1965-06-19 | 1967-07-21 | Takeda Chemical Industries Ltd | Sels métalliques de l'acide ascorbique phosphorylé et produits cosmétiques obtenus à partir de ces sels |
| DE3909198A1 (de) * | 1989-03-21 | 1990-09-27 | Basf Ag | Verfahren zur herstellung von ascorbinsaeure-2-phosphat sowie von 5,6-isorpropyliden-ascorbinsaeure als ausgangsprodukt |
| JP3206602B2 (ja) * | 1990-03-07 | 2001-09-10 | エフ・ホフマン―ラ ロシユ アーゲー | アスコルビン酸の誘導体の製造方法 |
| US5149829A (en) * | 1991-01-14 | 1992-09-22 | Hoffmann-La Roche Inc. | Method of preparing dry, concentrated salts of ascorbate 2-polyphosphate |
| US5110950A (en) * | 1991-06-12 | 1992-05-05 | Kansas State University Research Foundation | Method of preparing 2-phosphorylated compounds of ascorbic acid |
-
1992
- 1992-08-12 DE DE4226625A patent/DE4226625A1/de not_active Withdrawn
-
1993
- 1993-07-30 CA CA002101658A patent/CA2101658A1/en not_active Abandoned
- 1993-07-31 DE DE59306642T patent/DE59306642D1/de not_active Expired - Lifetime
- 1993-07-31 ES ES93112314T patent/ES2101906T3/es not_active Expired - Lifetime
- 1993-07-31 EP EP93112314A patent/EP0582924B1/de not_active Expired - Lifetime
- 1993-08-06 US US08/102,745 patent/US5420302A/en not_active Expired - Fee Related
- 1993-08-09 JP JP5197223A patent/JPH06184173A/ja not_active Withdrawn
- 1993-08-11 NO NO932860A patent/NO301716B1/no unknown
- 1993-08-12 CN CN93108823A patent/CN1032539C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0582924B1 (de) | 1997-06-04 |
| DE59306642D1 (de) | 1997-07-10 |
| NO301716B1 (no) | 1997-12-01 |
| NO932860L (no) | 1994-02-14 |
| JPH06184173A (ja) | 1994-07-05 |
| CN1087344A (zh) | 1994-06-01 |
| NO932860D0 (no) | 1993-08-11 |
| EP0582924A1 (de) | 1994-02-16 |
| US5420302A (en) | 1995-05-30 |
| DE4226625A1 (de) | 1994-02-17 |
| CA2101658A1 (en) | 1994-02-13 |
| CN1032539C (zh) | 1996-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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