ES2101079T3 - Marcadores analiticos para el cancer, principalmente para el cancer de seno. - Google Patents
Marcadores analiticos para el cancer, principalmente para el cancer de seno.Info
- Publication number
- ES2101079T3 ES2101079T3 ES92901155T ES92901155T ES2101079T3 ES 2101079 T3 ES2101079 T3 ES 2101079T3 ES 92901155 T ES92901155 T ES 92901155T ES 92901155 T ES92901155 T ES 92901155T ES 2101079 T3 ES2101079 T3 ES 2101079T3
- Authority
- ES
- Spain
- Prior art keywords
- cancer
- mainly
- breast cancer
- understands
- analytical markers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 206010006187 Breast cancer Diseases 0.000 title 1
- 208000026310 Breast neoplasm Diseases 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 208000030776 invasive breast carcinoma Diseases 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN GEN QUE CODIFICA UN NUEVO ELEMENTO DE LA FAMILIA DE LAS METALOPROTEINAS QUE HA SIDO DESCUBIERTO POR ESTAR ESPECIFICAMENTE ASOCIADO AL CANCER DE MAMA INVASIVO, ASI COMO A PROCESOS DE DIAGNOSTICO PARA TAL CANCER QUE COMPRENDE LA DETECCION DEL MARCADOR O DE SU SECUENCIA NUCLEOTIDICA, Y AL TRATAMIENTO O LA PROFILAXIS POR INHIBICION, EN PARTICULAR, MODIFICACION DE LA ACTIVIDAD O ENLACE DEL MARCADOR, O POR PERTURBACION DE SU SINTESIS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9025326A GB2250993B (en) | 1990-11-21 | 1990-11-21 | Stromelysin-3 and its application in the diagnosis and treatment of malignant breast cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2101079T3 true ES2101079T3 (es) | 1997-07-01 |
Family
ID=10685753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92901155T Expired - Lifetime ES2101079T3 (es) | 1990-11-21 | 1991-11-21 | Marcadores analiticos para el cancer, principalmente para el cancer de seno. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5236844A (es) |
EP (1) | EP0513316B1 (es) |
JP (1) | JP3516448B2 (es) |
AT (1) | ATE152179T1 (es) |
CA (1) | CA2073860A1 (es) |
DE (1) | DE69125824T2 (es) |
DK (1) | DK0513316T3 (es) |
ES (1) | ES2101079T3 (es) |
GB (1) | GB2250993B (es) |
GR (1) | GR3023560T3 (es) |
HU (1) | HU215165B (es) |
IE (1) | IE914056A1 (es) |
NZ (2) | NZ240688A (es) |
PT (1) | PT99562B (es) |
WO (1) | WO1992009701A1 (es) |
ZA (1) | ZA919219B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994012645A2 (en) * | 1992-11-25 | 1994-06-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | cDNA CLONE FOR HUMAN INDUCIBLE NITRIC OXYDE SYNTHASE AND PROCESS FOR PREPARING SAME |
WO1995003428A1 (en) * | 1993-07-20 | 1995-02-02 | University Of Massachusetts Medical Center | In vivo nucleic acid hybridization method |
US6825024B1 (en) | 1993-11-30 | 2004-11-30 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Metalloproteinase and encoding DNA therefor |
EP0685557B1 (en) * | 1993-11-30 | 1998-08-12 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Novel metalloprotease and dna coding for the same |
JPH07303482A (ja) | 1993-11-30 | 1995-11-21 | Fuji Yakuhin Kogyo Kk | 新規なメタロプロテアーゼおよびそれをコードするdna |
US5753441A (en) * | 1994-08-12 | 1998-05-19 | Myriad Genetics, Inc. | 170-linked breast and ovarian cancer susceptibility gene |
US5710001A (en) * | 1994-08-12 | 1998-01-20 | Myriad Genetics, Inc. | 17q-linked breast and ovarian cancer susceptibility gene |
US5709999A (en) * | 1994-08-12 | 1998-01-20 | Myriad Genetics Inc. | Linked breast and ovarian cancer susceptibility gene |
US5747282A (en) * | 1994-08-12 | 1998-05-05 | Myraid Genetics, Inc. | 17Q-linked breast and ovarian cancer susceptibility gene |
US5763415A (en) | 1995-08-03 | 1998-06-09 | John Hopkins University School Of Medicine | Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer |
US5883241A (en) * | 1995-09-05 | 1999-03-16 | Celltech Therapeutics Limited | DNA sequences coding for a human metalloproteinase and variants thereof |
US5905027A (en) * | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
ATE331786T1 (de) * | 1996-04-25 | 2006-07-15 | Takeda Pharmaceutical | Matrix-metalloprotease |
DE69737788T2 (de) * | 1996-10-31 | 2008-03-13 | Abbott Laboratories, Abbott Park | Reagenzien und methoden zum nachweis von erkrankungen der brust |
US20050202499A1 (en) * | 1996-10-31 | 2005-09-15 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
US20050153373A1 (en) * | 1996-10-31 | 2005-07-14 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
US20030165971A1 (en) * | 1996-10-31 | 2003-09-04 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
WO1998024935A1 (en) * | 1996-12-06 | 1998-06-11 | Urocor, Inc. | Diagnosis of disease state using mrna profiles |
WO1998040475A1 (en) * | 1997-03-11 | 1998-09-17 | Abbott Laboratories | Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same |
EP0969868A2 (en) | 1997-03-18 | 2000-01-12 | Ortho-Mcneil Pharmaceutical, Inc. | Methods and kits for treating and diagnosing leiomyomas |
US6190857B1 (en) | 1997-03-24 | 2001-02-20 | Urocor, Inc. | Diagnosis of disease state using MRNA profiles in peripheral leukocytes |
US7332270B1 (en) | 1997-03-24 | 2008-02-19 | Urocor, Inc. | Diagnosis of disease state using mRNA profiles in peripheral leukocytes |
US20040072210A1 (en) * | 1997-07-07 | 2004-04-15 | Billing-Medel Patricia A. | Reagents and methods useful for detecting diseases of the breast |
WO1999002714A1 (en) * | 1997-07-07 | 1999-01-21 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
CA2309756A1 (en) * | 1997-11-17 | 1999-05-27 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
US5972615A (en) * | 1998-01-21 | 1999-10-26 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
US6600057B2 (en) | 2000-12-29 | 2003-07-29 | Kimberly-Clark Worldwide, Inc. | Matrix metalloproteinase inhibitors |
US7041787B2 (en) * | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
US20040219551A1 (en) * | 2001-07-09 | 2004-11-04 | Petersen Ole William | Epsti1, a novel gene induced by epithelial-stromal interaction in human breast cancer |
US20030119073A1 (en) * | 2001-12-21 | 2003-06-26 | Stephen Quirk | Sensors and methods of detection for proteinase enzymes |
DE10217254A1 (de) | 2002-04-15 | 2003-10-23 | Proteosys Ag | Verwendung von Substanzen zur Behandlung von Tumoren |
US20060088899A1 (en) * | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
US20050193432A1 (en) * | 2003-11-18 | 2005-09-01 | Whitehead Institute For Biomedical Research | Xenograft model of functional normal and malignant human breast tissues in rodents and methods thereof |
US7667001B1 (en) * | 2004-01-27 | 2010-02-23 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
US7569662B2 (en) * | 2004-01-27 | 2009-08-04 | Compugen Ltd | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
US20090191543A1 (en) * | 2005-05-27 | 2009-07-30 | Theregents Of The University Of California | Identification of rac1b as a marker and mediator of metalloproteinase-induced malignancy |
BRPI0912683A2 (pt) | 2008-05-15 | 2016-01-26 | Transmolecular Inc | tratamento de tumores metastáticos |
EP2531206B1 (en) | 2010-02-04 | 2017-05-31 | Morphotek, Inc. | Chlorotoxin polypeptides and conjugates and uses thereof |
CN106957356B (zh) | 2010-05-11 | 2021-05-25 | 弗雷德哈钦森癌症研究中心 | 氯毒素变体、缀合物及其使用方法 |
KR101313184B1 (ko) * | 2010-06-24 | 2013-09-30 | 한국표준과학연구원 | 질병 지표 검출 키트 및 질병 지표 검출 방법 |
RU2015126650A (ru) | 2012-12-10 | 2017-01-12 | Фред Хатчинсон Кэнсер Рисёрч Сентер | Партнеры липокалина по слиянию |
US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0269724A1 (en) * | 1986-06-17 | 1988-06-08 | Celltech Limited | Process for the production of a protein |
-
1990
- 1990-11-21 GB GB9025326A patent/GB2250993B/en not_active Expired - Fee Related
-
1991
- 1991-11-20 PT PT99562A patent/PT99562B/pt not_active IP Right Cessation
- 1991-11-21 IE IE405691A patent/IE914056A1/en unknown
- 1991-11-21 NZ NZ240688A patent/NZ240688A/en not_active IP Right Cessation
- 1991-11-21 US US07/794,393 patent/US5236844A/en not_active Expired - Fee Related
- 1991-11-21 NZ NZ260705A patent/NZ260705A/en not_active IP Right Cessation
- 1991-11-21 DK DK92901155.9T patent/DK0513316T3/da active
- 1991-11-21 WO PCT/FR1991/000924 patent/WO1992009701A1/fr active IP Right Grant
- 1991-11-21 DE DE69125824T patent/DE69125824T2/de not_active Expired - Fee Related
- 1991-11-21 ZA ZA919219A patent/ZA919219B/xx unknown
- 1991-11-21 AT AT92901155T patent/ATE152179T1/de not_active IP Right Cessation
- 1991-11-21 HU HU9202368A patent/HU215165B/hu unknown
- 1991-11-21 CA CA002073860A patent/CA2073860A1/en not_active Abandoned
- 1991-11-21 JP JP50118892A patent/JP3516448B2/ja not_active Expired - Fee Related
- 1991-11-21 EP EP92901155A patent/EP0513316B1/fr not_active Expired - Lifetime
- 1991-11-21 ES ES92901155T patent/ES2101079T3/es not_active Expired - Lifetime
-
1997
- 1997-05-26 GR GR970401211T patent/GR3023560T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IE914056A1 (en) | 1992-06-03 |
HU215165B (hu) | 1998-10-28 |
AU9089691A (en) | 1992-06-25 |
PT99562B (pt) | 1999-04-30 |
EP0513316A1 (fr) | 1992-11-19 |
GB2250993B (en) | 1995-02-15 |
CA2073860A1 (en) | 1992-05-22 |
AU646914B2 (en) | 1994-03-10 |
DE69125824D1 (de) | 1997-05-28 |
EP0513316B1 (fr) | 1997-04-23 |
ATE152179T1 (de) | 1997-05-15 |
PT99562A (pt) | 1992-10-30 |
GR3023560T3 (en) | 1997-08-29 |
WO1992009701A1 (fr) | 1992-06-11 |
HUT65373A (en) | 1994-05-02 |
JP3516448B2 (ja) | 2004-04-05 |
GB2250993A (en) | 1992-06-24 |
JPH05505530A (ja) | 1993-08-19 |
ZA919219B (en) | 1992-10-28 |
US5236844A (en) | 1993-08-17 |
DE69125824T2 (de) | 1997-08-07 |
HU9202368D0 (en) | 1992-10-28 |
GB9025326D0 (en) | 1991-01-02 |
NZ260705A (en) | 1997-05-26 |
NZ240688A (en) | 1994-09-27 |
DK0513316T3 (da) | 1997-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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