ES2100462T3 - Procedimiento para separar anomeros de 2-desoxi-2,2-difluoro-d-ribofuranosilo alquilsulfonato. - Google Patents

Procedimiento para separar anomeros de 2-desoxi-2,2-difluoro-d-ribofuranosilo alquilsulfonato.

Info

Publication number
ES2100462T3
ES2100462T3 ES93304821T ES93304821T ES2100462T3 ES 2100462 T3 ES2100462 T3 ES 2100462T3 ES 93304821 T ES93304821 T ES 93304821T ES 93304821 T ES93304821 T ES 93304821T ES 2100462 T3 ES2100462 T3 ES 2100462T3
Authority
ES
Spain
Prior art keywords
desoxi
difluoro
ribofuranosilo
alquilsulfonato
anomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93304821T
Other languages
English (en)
Spanish (es)
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2100462T3 publication Critical patent/ES2100462T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES93304821T 1992-06-22 1993-06-21 Procedimiento para separar anomeros de 2-desoxi-2,2-difluoro-d-ribofuranosilo alquilsulfonato. Expired - Lifetime ES2100462T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
ES2100462T3 true ES2100462T3 (es) 1997-06-16

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93304821T Expired - Lifetime ES2100462T3 (es) 1992-06-22 1993-06-21 Procedimiento para separar anomeros de 2-desoxi-2,2-difluoro-d-ribofuranosilo alquilsulfonato.

Country Status (16)

Country Link
US (1) US5256797A (OSRAM)
EP (1) EP0576232B1 (OSRAM)
JP (1) JPH0656867A (OSRAM)
KR (1) KR100302087B1 (OSRAM)
AT (1) ATE149505T1 (OSRAM)
BR (1) BR9302426A (OSRAM)
CA (1) CA2098888C (OSRAM)
CY (1) CY2091B1 (OSRAM)
DE (1) DE69308391T2 (OSRAM)
DK (1) DK0576232T3 (OSRAM)
ES (1) ES2100462T3 (OSRAM)
GR (1) GR3023060T3 (OSRAM)
HU (1) HU217976B (OSRAM)
IL (1) IL106074A (OSRAM)
MX (1) MX9303714A (OSRAM)
TW (1) TW233300B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE153669T1 (de) * 1992-06-22 1997-06-15 Lilly Co Eli Verfahren zur herstellung von mit alpha-anomeren angereicherten 1-halogen-2-deoxy-2,2-difluor-d- ribofuranosyl-derivaten
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
MXPA04012802A (es) 2002-06-28 2005-04-19 Idenix Cayman Ltd Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004046331A2 (en) 2002-11-15 2004-06-03 Idenix (Cayman) Limited 2’-branched nucleosides and flaviviridae mutation
US7598373B2 (en) 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
BRPI0512360A (pt) * 2004-06-23 2008-03-11 Idenix Cayman Ltd derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3856477T2 (de) * 1987-08-28 2001-11-08 Eli Lilly And Co., Indianapolis Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
HK1006022A1 (en) 1999-02-05
IL106074A0 (en) 1993-10-20
EP0576232B1 (en) 1997-03-05
HUT64551A (en) 1994-01-28
KR100302087B1 (ko) 2001-10-22
DE69308391D1 (de) 1997-04-10
TW233300B (OSRAM) 1994-11-01
GR3023060T3 (en) 1997-07-30
CY2091B1 (en) 2002-04-05
IL106074A (en) 1998-02-22
CA2098888A1 (en) 1993-12-23
DK0576232T3 (da) 1997-07-21
MX9303714A (es) 1994-01-31
KR940000473A (ko) 1994-01-03
DE69308391T2 (de) 1997-07-17
HU217976B (hu) 2000-05-28
HU9301826D0 (en) 1993-09-28
JPH0656867A (ja) 1994-03-01
US5256797A (en) 1993-10-26
EP0576232A1 (en) 1993-12-29
BR9302426A (pt) 1994-01-11
CA2098888C (en) 2003-07-29
ATE149505T1 (de) 1997-03-15

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