TW233300B - - Google Patents

Info

Publication number
TW233300B
TW233300B TW082104993A TW82104993A TW233300B TW 233300 B TW233300 B TW 233300B TW 082104993 A TW082104993 A TW 082104993A TW 82104993 A TW82104993 A TW 82104993A TW 233300 B TW233300 B TW 233300B
Authority
TW
Taiwan
Prior art keywords
anomeric mixture
countersolvent
ribofuranosyl
alkylsulfonates
deoxy
Prior art date
Application number
TW082104993A
Other languages
English (en)
Chinese (zh)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of TW233300B publication Critical patent/TW233300B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW082104993A 1992-06-22 1993-06-22 TW233300B (OSRAM)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
TW233300B true TW233300B (OSRAM) 1994-11-01

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082104993A TW233300B (OSRAM) 1992-06-22 1993-06-22

Country Status (16)

Country Link
US (1) US5256797A (OSRAM)
EP (1) EP0576232B1 (OSRAM)
JP (1) JPH0656867A (OSRAM)
KR (1) KR100302087B1 (OSRAM)
AT (1) ATE149505T1 (OSRAM)
BR (1) BR9302426A (OSRAM)
CA (1) CA2098888C (OSRAM)
CY (1) CY2091B1 (OSRAM)
DE (1) DE69308391T2 (OSRAM)
DK (1) DK0576232T3 (OSRAM)
ES (1) ES2100462T3 (OSRAM)
GR (1) GR3023060T3 (OSRAM)
HU (1) HU217976B (OSRAM)
IL (1) IL106074A (OSRAM)
MX (1) MX9303714A (OSRAM)
TW (1) TW233300B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE153669T1 (de) * 1992-06-22 1997-06-15 Lilly Co Eli Verfahren zur herstellung von mit alpha-anomeren angereicherten 1-halogen-2-deoxy-2,2-difluor-d- ribofuranosyl-derivaten
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
MXPA04012802A (es) 2002-06-28 2005-04-19 Idenix Cayman Ltd Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004046331A2 (en) 2002-11-15 2004-06-03 Idenix (Cayman) Limited 2’-branched nucleosides and flaviviridae mutation
US7598373B2 (en) 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
BRPI0512360A (pt) * 2004-06-23 2008-03-11 Idenix Cayman Ltd derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3856477T2 (de) * 1987-08-28 2001-11-08 Eli Lilly And Co., Indianapolis Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
HK1006022A1 (en) 1999-02-05
IL106074A0 (en) 1993-10-20
EP0576232B1 (en) 1997-03-05
HUT64551A (en) 1994-01-28
KR100302087B1 (ko) 2001-10-22
DE69308391D1 (de) 1997-04-10
GR3023060T3 (en) 1997-07-30
CY2091B1 (en) 2002-04-05
IL106074A (en) 1998-02-22
ES2100462T3 (es) 1997-06-16
CA2098888A1 (en) 1993-12-23
DK0576232T3 (da) 1997-07-21
MX9303714A (es) 1994-01-31
KR940000473A (ko) 1994-01-03
DE69308391T2 (de) 1997-07-17
HU217976B (hu) 2000-05-28
HU9301826D0 (en) 1993-09-28
JPH0656867A (ja) 1994-03-01
US5256797A (en) 1993-10-26
EP0576232A1 (en) 1993-12-29
BR9302426A (pt) 1994-01-11
CA2098888C (en) 2003-07-29
ATE149505T1 (de) 1997-03-15

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees