ES2100212T3 - Procedimiento para la purificacion de mezclas que contienen ibuprofeno. - Google Patents
Procedimiento para la purificacion de mezclas que contienen ibuprofeno.Info
- Publication number
- ES2100212T3 ES2100212T3 ES91308177T ES91308177T ES2100212T3 ES 2100212 T3 ES2100212 T3 ES 2100212T3 ES 91308177 T ES91308177 T ES 91308177T ES 91308177 T ES91308177 T ES 91308177T ES 2100212 T3 ES2100212 T3 ES 2100212T3
- Authority
- ES
- Spain
- Prior art keywords
- ibuprofen
- crystallization
- purification
- ibuprophen
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ESTA INVENCION PERTENECE AL METODO DE PURIFICACION DE MEZCLAS DE PRODUCTOS DE REACCION QUE COMPRENDEN IBUPROFENO. EL METODO DE PURIFICACION SE BASA EN LA CRISTALIZACION DEL IBUPROFENO DESDE UN DISOLVENTE DE HIDROCARBUROS Y EL DESCUBRIMIENTO DE QUE EXISTEN COMPLEJOS IMPUROS EN LAS MEZCLAS DE PRODUCTOS DE REACCION QUE COMPRENDEN IBUPROFENO, QUE NO PUEDEN RETIRARSE POR LA CRISTALIZACION DESDE UN DISOLVENTE DE HIDROCARBUROS. EL METODO DE LA INVENCION INCLUYE AL MENOS UN PASO EN EL QUE EL COMPLEJO DE IMPUREZAS EN UNA PRIMERA MEZCLA QUE COMPRENDE IBUPROFENO SE DESESTABILIZA O SE ROMPE, SEGUIDO DE LA CRISTALIZACION DEL IBUPROFENO DESDE UNA SEGUNDA SOLUCION O MEZCLA QUE COMPRENDE LA PRIMERA MEZCLA DE IBUPROFENO, DONDE LAS IMPUREZAS QUE SE FORMARON EN COMPLEJOS PREVIAMENTE, PODRAN SER REMOVIDAS DEL IBUPROFENO POR LA CRISTALIZACION DEL MISMO POR UN DISOLVENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/579,427 US5151551A (en) | 1990-09-06 | 1990-09-06 | Method for purification of ibuprofen comprising mixtures |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2100212T3 true ES2100212T3 (es) | 1997-06-16 |
Family
ID=24316864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91308177T Expired - Lifetime ES2100212T3 (es) | 1990-09-06 | 1991-09-06 | Procedimiento para la purificacion de mezclas que contienen ibuprofeno. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5151551A (es) |
EP (1) | EP0474509B1 (es) |
AT (1) | ATE149995T1 (es) |
BR (1) | BR9103858A (es) |
CA (1) | CA2050709C (es) |
DE (1) | DE69125073T2 (es) |
DK (1) | DK0474509T3 (es) |
ES (1) | ES2100212T3 (es) |
GR (1) | GR3022805T3 (es) |
MX (1) | MX9100983A (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5300301A (en) * | 1992-12-02 | 1994-04-05 | Hoechst Celanese Corporation | Isolation of ibuprofen from tablets |
WO2004096747A1 (en) * | 2003-04-28 | 2004-11-11 | Basf Aktiengesellschaft | Process for the separation of palladium catalyst from crude reaction mixtures of aryl acetic acids obtained by carbonylation |
WO2015163832A1 (en) | 2014-04-25 | 2015-10-29 | Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. | An ibuprofen and famotidine combined composition having improved stability |
CN112433016A (zh) * | 2020-12-11 | 2021-03-02 | 青岛科技大学 | 检测重排酯含量的液相色谱分析方法 |
CN114195633A (zh) * | 2021-12-24 | 2022-03-18 | 浙江新和成股份有限公司 | 一种布洛芬杂质f的合成方法 |
CN115286501A (zh) * | 2022-08-10 | 2022-11-04 | 浙江新和成股份有限公司 | 一种布洛芬结晶母液的综合利用方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2646792C2 (de) * | 1975-10-23 | 1985-05-09 | Mitsubishi Petrochemical Co., Ltd., Tokio/Tokyo | Verfahren zur Herstellung einer α-(arylsubstituierten)-Propionsäure und/oder eines Esters derselben |
US4476248A (en) * | 1983-02-28 | 1984-10-09 | The Upjohn Company | Crystallization of ibuprofen |
US4694100A (en) * | 1984-07-14 | 1987-09-15 | Nippon Petrochemicals Company, Ltd. | Method for producing α-(p-isobutylphenyl)propionic acid or its alkyl esters |
CA1286316C (en) * | 1986-02-08 | 1991-07-16 | Isoo Shimizu | Method for refining 2-(aryl substituted)-propionic acid or its salt |
JPH064560B2 (ja) * | 1986-02-08 | 1994-01-19 | 日本石油化学株式会社 | 2−(p−イソブチルフエニル)プロピオン酸またはその塩の回収方法 |
JPH0657670B2 (ja) * | 1986-06-14 | 1994-08-03 | 日本石油化学株式会社 | 粗イブプロフエンの精製方法 |
US4981995A (en) * | 1987-03-20 | 1991-01-01 | Varadaraj Elango | Method for producing ibuprofen |
DE3802619C1 (es) * | 1988-01-29 | 1989-09-07 | Hoechst Ag, 6230 Frankfurt, De | |
JPH02152945A (ja) * | 1988-12-02 | 1990-06-12 | Daicel Chem Ind Ltd | 2−(4−ヒドロキシフェノキシ)プロピオン酸エステルの精製法 |
-
1990
- 1990-09-06 US US07/579,427 patent/US5151551A/en not_active Expired - Lifetime
-
1991
- 1991-09-05 CA CA002050709A patent/CA2050709C/en not_active Expired - Fee Related
- 1991-09-06 AT AT91308177T patent/ATE149995T1/de not_active IP Right Cessation
- 1991-09-06 EP EP91308177A patent/EP0474509B1/en not_active Expired - Lifetime
- 1991-09-06 ES ES91308177T patent/ES2100212T3/es not_active Expired - Lifetime
- 1991-09-06 BR BR919103858A patent/BR9103858A/pt not_active Application Discontinuation
- 1991-09-06 DK DK91308177.4T patent/DK0474509T3/da active
- 1991-09-06 DE DE69125073T patent/DE69125073T2/de not_active Expired - Lifetime
- 1991-09-06 MX MX9100983A patent/MX9100983A/es not_active IP Right Cessation
-
1997
- 1997-03-13 GR GR970400327T patent/GR3022805T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2050709C (en) | 2002-08-20 |
BR9103858A (pt) | 1992-05-26 |
DE69125073D1 (de) | 1997-04-17 |
DK0474509T3 (da) | 1997-05-12 |
GR3022805T3 (en) | 1997-06-30 |
MX9100983A (es) | 1992-05-04 |
DE69125073T2 (de) | 1997-06-19 |
ATE149995T1 (de) | 1997-03-15 |
EP0474509A3 (en) | 1993-07-07 |
CA2050709A1 (en) | 1992-03-07 |
EP0474509B1 (en) | 1997-03-12 |
EP0474509A2 (en) | 1992-03-11 |
US5151551A (en) | 1992-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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