ES2099282T3 - Derivados de beta-aminoacidos substituidos utiles como inhibidores de la agregacion de plaquetas. - Google Patents

Derivados de beta-aminoacidos substituidos utiles como inhibidores de la agregacion de plaquetas.

Info

Publication number
ES2099282T3
ES2099282T3 ES92921348T ES92921348T ES2099282T3 ES 2099282 T3 ES2099282 T3 ES 2099282T3 ES 92921348 T ES92921348 T ES 92921348T ES 92921348 T ES92921348 T ES 92921348T ES 2099282 T3 ES2099282 T3 ES 2099282T3
Authority
ES
Spain
Prior art keywords
radicals
derivatives
beta
inhibitors
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921348T
Other languages
English (en)
Inventor
Philippe Roger Bovy
Joseph Gerace Rico
Thomas Edward Rogers
Foe Siong Tjoeng
Jeffery Alan Zablocki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2099282T3 publication Critical patent/ES2099282T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SON PROVISTOS NUEVOS DERIVADOS DE ACIDO AMINO-BETA SUSTITUIDOS QUE TIENEN LA FORMULA GENERAL (Y) EN EL QUE, POR EJEMPLO, R2 ES SELECCIONADO DEL GRUPO QUE CONSTA DE HIDROGENO, RADICALES ALQUIL REBAJADOS, RADICALES ALQUENIL REBAJADOS, RADICALES ALQUINIL REBAJADOS, RADICALES DE HIDROCARBONO ALICICLICOS, RADICALES DE HIDROCARBONO AROMATICOS, EN DONDE LOS RADICALES SON OPCIONALMENTE SUSTITUIDOS CON HIDROXI, ALCOXI REBAJADO, ALQUIL REBAJADO, HALOGENO, NITRO, CIANO, AZIDO, UREIDO, UREILENO, CARBOXIL O DERIVADOS CARBONIL, TRIFLUOROMETIL, ACILOXI, ALQUILTIO, ARILTIO, ALQUILSULFENIL, ARILSULFENIL, ALQUILSULFONIL, ARILSULFONIL, AMINO, ALQUILAMINO, TRIALQUILSILIL, AMINOSULFONIL, DIALQUILAMINO, ALCANOILAMINO, AROILAMINO, FENIL, NAFTIL, ALQUINIL REBAJADO QUE SON SUSTITUIDOS OPCIONALMENTE CON UNO O MAS DE LOS SIGUIENTES: HALOGENO, NITRO, ALCOXI REBAJADO, ALQUIL REBAJADO, TRIALQUILSILIL, AZIDA Y FENIL; EL INVENTO TAMBIEN RELACIONA LAS COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN TALES DERIVADOS.
ES92921348T 1991-10-15 1992-10-06 Derivados de beta-aminoacidos substituidos utiles como inhibidores de la agregacion de plaquetas. Expired - Lifetime ES2099282T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77781191A 1991-10-15 1991-10-15
US07/866,933 US5239113A (en) 1991-10-15 1992-04-10 Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof

Publications (1)

Publication Number Publication Date
ES2099282T3 true ES2099282T3 (es) 1997-05-16

Family

ID=27119358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921348T Expired - Lifetime ES2099282T3 (es) 1991-10-15 1992-10-06 Derivados de beta-aminoacidos substituidos utiles como inhibidores de la agregacion de plaquetas.

Country Status (13)

Country Link
US (4) US5239113A (es)
EP (2) EP0614360B1 (es)
JP (1) JP2813462B2 (es)
KR (1) KR100250629B1 (es)
AT (1) ATE150302T1 (es)
AU (1) AU661724B2 (es)
CA (1) CA2115432C (es)
DE (1) DE69218453T2 (es)
DK (1) DK0614360T3 (es)
ES (1) ES2099282T3 (es)
GR (1) GR3023173T3 (es)
PT (1) PT542708E (es)
WO (1) WO1993007867A1 (es)

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Also Published As

Publication number Publication date
JPH07500111A (ja) 1995-01-05
US5703125A (en) 1997-12-30
EP0542708A1 (en) 1993-05-19
US5239113A (en) 1993-08-24
EP0542708B1 (en) 2001-05-30
PT542708E (pt) 2001-11-30
GR3023173T3 (en) 1997-07-30
EP0614360B1 (en) 1997-03-19
AU661724B2 (en) 1995-08-03
AU2760892A (en) 1993-05-21
DE69218453D1 (de) 1997-04-24
EP0614360A1 (en) 1994-09-14
US5973003A (en) 1999-10-26
JP2813462B2 (ja) 1998-10-22
ATE150302T1 (de) 1997-04-15
CA2115432C (en) 2003-06-03
DE69218453T2 (de) 1997-06-26
DK0614360T3 (da) 1997-08-04
US5344957A (en) 1994-09-06
CA2115432A1 (en) 1993-04-16
WO1993007867A1 (en) 1993-04-29
KR100250629B1 (ko) 2000-04-01

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