GR3023173T3 - Substituted -g(b)-amino acid derivatives useful as platelet aggregation inhibitors. - Google Patents
Substituted -g(b)-amino acid derivatives useful as platelet aggregation inhibitors.Info
- Publication number
- GR3023173T3 GR3023173T3 GR970400830T GR970400830T GR3023173T3 GR 3023173 T3 GR3023173 T3 GR 3023173T3 GR 970400830 T GR970400830 T GR 970400830T GR 970400830 T GR970400830 T GR 970400830T GR 3023173 T3 GR3023173 T3 GR 3023173T3
- Authority
- GR
- Greece
- Prior art keywords
- radicals
- amino acid
- substituted
- acid derivatives
- lower alkyl
- Prior art date
Links
- -1 Substituted Chemical class 0.000 title abstract 3
- 229940127218 antiplatelet drug Drugs 0.000 title 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004647 alkyl sulfenyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000005239 aroylamino group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 150000001576 beta-amino acids Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77781191A | 1991-10-15 | 1991-10-15 | |
| US07/866,933 US5239113A (en) | 1991-10-15 | 1992-04-10 | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| PCT/US1992/008512 WO1993007867A1 (en) | 1991-10-15 | 1992-10-06 | SUBSTITUTED β-AMINO ACID DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3023173T3 true GR3023173T3 (en) | 1997-07-30 |
Family
ID=27119358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970400830T GR3023173T3 (en) | 1991-10-15 | 1997-04-18 | Substituted -g(b)-amino acid derivatives useful as platelet aggregation inhibitors. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US5239113A (el) |
| EP (2) | EP0614360B1 (el) |
| JP (1) | JP2813462B2 (el) |
| KR (1) | KR100250629B1 (el) |
| AT (1) | ATE150302T1 (el) |
| AU (1) | AU661724B2 (el) |
| CA (1) | CA2115432C (el) |
| DE (1) | DE69218453T2 (el) |
| DK (1) | DK0614360T3 (el) |
| ES (1) | ES2099282T3 (el) |
| GR (1) | GR3023173T3 (el) |
| PT (1) | PT542708E (el) |
| WO (1) | WO1993007867A1 (el) |
Families Citing this family (85)
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| US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| US5625093A (en) * | 1991-10-15 | 1997-04-29 | G. D. Searle & Co. | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors |
| WO1993018058A1 (en) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Peptides mimics useful as platelet aggregation inhibitors |
| US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
| US5409939A (en) * | 1993-02-12 | 1995-04-25 | G. D. Searle & Co. | Phenyl amidine thio derivatives useful as platelet aggregation inhibitors |
| US6268380B1 (en) * | 1993-02-19 | 2001-07-31 | G. D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
| WO1994020457A1 (en) * | 1993-03-02 | 1994-09-15 | G.D. Searle & Co. | N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors |
| WO1994021602A1 (en) * | 1993-03-15 | 1994-09-29 | G.D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| CZ250995A3 (en) * | 1993-03-29 | 1996-01-17 | Zeneca Ltd | Pyridine derivatives, process of their preparation and intermediates employed in this process as well as pharmaceutical compositions containing thereof |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| US5563141A (en) * | 1993-03-29 | 1996-10-08 | Zeneca Limited | Heterocyclic compounds |
| US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
| GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| US5430043A (en) * | 1993-08-24 | 1995-07-04 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| AU677481B2 (en) * | 1993-11-24 | 1997-04-24 | Du Pont Pharmaceuticals Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
| US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
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| DE19516483A1 (de) * | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
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| JP5497431B2 (ja) | 2006-05-03 | 2014-05-21 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヒストンデアセチラーゼおよびチューブリンデアセチラーゼ阻害剤 |
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| US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
| US5254573A (en) * | 1991-10-15 | 1993-10-19 | Monsanto Company | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
| US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
| WO1993018058A1 (en) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Peptides mimics useful as platelet aggregation inhibitors |
| US5272162A (en) * | 1992-07-02 | 1993-12-21 | G. D. Searle & Co. | Platelet aggregation inhibitors |
-
1992
- 1992-04-10 US US07/866,933 patent/US5239113A/en not_active Expired - Lifetime
- 1992-10-06 CA CA002115432A patent/CA2115432C/en not_active Expired - Fee Related
- 1992-10-06 KR KR1019940701090A patent/KR100250629B1/ko not_active IP Right Cessation
- 1992-10-06 DE DE69218453T patent/DE69218453T2/de not_active Expired - Fee Related
- 1992-10-06 DK DK92921348.6T patent/DK0614360T3/da active
- 1992-10-06 AT AT92921348T patent/ATE150302T1/de not_active IP Right Cessation
- 1992-10-06 AU AU27608/92A patent/AU661724B2/en not_active Ceased
- 1992-10-06 JP JP5507711A patent/JP2813462B2/ja not_active Expired - Fee Related
- 1992-10-06 US US07/953,601 patent/US5344957A/en not_active Expired - Lifetime
- 1992-10-06 WO PCT/US1992/008512 patent/WO1993007867A1/en active IP Right Grant
- 1992-10-06 EP EP92921348A patent/EP0614360B1/en not_active Expired - Lifetime
- 1992-10-06 ES ES92921348T patent/ES2099282T3/es not_active Expired - Lifetime
- 1992-10-14 EP EP92870167A patent/EP0542708B1/en not_active Expired - Lifetime
- 1992-10-14 PT PT92870167T patent/PT542708E/pt unknown
-
1995
- 1995-05-31 US US08/455,612 patent/US5703125A/en not_active Expired - Lifetime
-
1997
- 1997-04-18 GR GR970400830T patent/GR3023173T3/el unknown
- 1997-09-26 US US08/938,856 patent/US5973003A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2099282T3 (es) | 1997-05-16 |
| EP0614360A1 (en) | 1994-09-14 |
| AU661724B2 (en) | 1995-08-03 |
| US5703125A (en) | 1997-12-30 |
| AU2760892A (en) | 1993-05-21 |
| US5344957A (en) | 1994-09-06 |
| CA2115432C (en) | 2003-06-03 |
| DE69218453D1 (de) | 1997-04-24 |
| US5239113A (en) | 1993-08-24 |
| PT542708E (pt) | 2001-11-30 |
| US5973003A (en) | 1999-10-26 |
| EP0542708A1 (en) | 1993-05-19 |
| KR100250629B1 (ko) | 2000-04-01 |
| JPH07500111A (ja) | 1995-01-05 |
| WO1993007867A1 (en) | 1993-04-29 |
| EP0614360B1 (en) | 1997-03-19 |
| JP2813462B2 (ja) | 1998-10-22 |
| EP0542708B1 (en) | 2001-05-30 |
| DE69218453T2 (de) | 1997-06-26 |
| CA2115432A1 (en) | 1993-04-16 |
| ATE150302T1 (de) | 1997-04-15 |
| DK0614360T3 (da) | 1997-08-04 |
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