ES2099066T3 - Antigenos a partir de adn sintetico derivado del virus de la inmunodeficiencia humana (hiv-1). - Google Patents

Antigenos a partir de adn sintetico derivado del virus de la inmunodeficiencia humana (hiv-1).

Info

Publication number
ES2099066T3
ES2099066T3 ES89121513T ES89121513T ES2099066T3 ES 2099066 T3 ES2099066 T3 ES 2099066T3 ES 89121513 T ES89121513 T ES 89121513T ES 89121513 T ES89121513 T ES 89121513T ES 2099066 T3 ES2099066 T3 ES 2099066T3
Authority
ES
Spain
Prior art keywords
hiv
proteins
antigens
virus
human immunodeficiency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89121513T
Other languages
English (en)
Inventor
Sushil G Devare
Suresh M Desai
James M Casey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2099066T3 publication Critical patent/ES2099066T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION PROVEE UN METODO DE SINTETIZADOR DE GENES UNICOS CODIFICADO HIV-1 Y PROTEINAS ENVOLVENTES HIV-2 Y FRAGMENTOS QUE PERMITEN LA SOBRE-EXPRESION DE ESTAS PROTEINAS EN E. COLI. LAS PROTEINAS ENVOLVENTES HIV Y SUS FRAGMENTOS, HAN SIDO EXPRESADAS A ALTOS NIVELES COMO PROTEINAS INDIVIDUALES O EN FUSION CON OTRAS PROTEINAS. LAS PROTEINAS ENVOLVENTES HIV ASI EXPRESADAS EN E. COLI, PUEDEN SER USADAS PARA LA DETECCION DE LA EXPRESION AL HIV Y TAMBIEN COMO DISCRIMINACION DEL HIV1 Y HIV2.
ES89121513T 1988-11-23 1989-11-21 Antigenos a partir de adn sintetico derivado del virus de la inmunodeficiencia humana (hiv-1). Expired - Lifetime ES2099066T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27530988A 1988-11-23 1988-11-23

Publications (1)

Publication Number Publication Date
ES2099066T3 true ES2099066T3 (es) 1997-05-16

Family

ID=23051743

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95114545T Expired - Lifetime ES2238071T3 (es) 1988-11-23 1989-11-21 Antigenos recombinantes de vih-2 derivados de adn sintetico.
ES89121513T Expired - Lifetime ES2099066T3 (es) 1988-11-23 1989-11-21 Antigenos a partir de adn sintetico derivado del virus de la inmunodeficiencia humana (hiv-1).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95114545T Expired - Lifetime ES2238071T3 (es) 1988-11-23 1989-11-21 Antigenos recombinantes de vih-2 derivados de adn sintetico.

Country Status (9)

Country Link
US (3) US5859193A (es)
EP (2) EP0370458B1 (es)
JP (2) JP3073752B2 (es)
AT (2) ATE147758T1 (es)
AU (1) AU628108B2 (es)
CA (1) CA2003383A1 (es)
DE (2) DE68927665T2 (es)
ES (2) ES2238071T3 (es)
GR (1) GR3022850T3 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939074A (en) * 1986-12-30 1999-08-17 The United States Of America As Represented By The Department Of Health And Human Services Multideterminant peptide antigens
FR2676071B1 (fr) * 1991-05-02 1994-11-18 Transgene Sa Nouveau variant gp160 non-clivable, soluble, de forme hybride.
AU665023B2 (en) * 1991-08-29 1995-12-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Multideterminant peptide antigens that stimulate helper T lymphocyte response to HIV in a range of human subjects
GB9208428D0 (en) * 1992-04-16 1992-06-03 Proteus Molecular Design Synthetic polypeptides
EP0572737B1 (en) * 1992-06-04 2001-02-28 The Research Foundation For Microbial Diseases Of Osaka University HIV Gag-env fusion antigen
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
US6846905B2 (en) * 1997-08-15 2005-01-25 Abbott Laboratories Antigen constructs useful in the detection and differentiation of antibodies to HIV
AU2487300A (en) 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
EP1141313A2 (en) * 1998-12-31 2001-10-10 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
WO2000039303A2 (en) 1998-12-31 2000-07-06 Chiron Corporation Modified hiv env polypeptides
CA2378539A1 (en) 1999-07-06 2001-01-11 Merck & Co., Inc. Adenovirus carrying gag gene hiv vaccine
US20030096778A1 (en) * 2002-06-13 2003-05-22 Shiver John W Polynucleotide vaccines expressing codon optimized hiv-1 nef and modified hiv-1 nef
US20040063653A1 (en) * 2000-12-21 2004-04-01 Shiver John W. Polynucleotide vaccines expressing codon optimized hiv-1 pol and modified hiv-1 pol
US6733993B2 (en) * 2000-09-15 2004-05-11 Merck & Co., Inc. Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications
US20040101957A1 (en) * 2001-09-14 2004-05-27 Emini Emilio A. Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol.nef and modifications
DK1402015T3 (da) * 2001-06-22 2011-12-05 Hoffmann La Roche Opløseligt kompleks omfattende et retroviralt overfladeglycoprotein og FkpA eller SlyD
US7101683B2 (en) 2001-06-26 2006-09-05 Abbott Laboratories Methods for the simultaneous detection of HCV antigens and HCV antibodies
WO2003020876A2 (en) * 2001-08-31 2003-03-13 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
US6852491B2 (en) * 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US7825233B2 (en) * 2004-06-30 2010-11-02 Allergan, Inc. Optimizing expression of active Botulinum Toxin type E
EP1773874B1 (en) * 2004-08-04 2012-10-24 Allergan, Inc. Optimizing expression of active botulinum toxin type a
WO2007141650A2 (en) * 2006-01-17 2007-12-13 Instituto De Medicina Molecular Compositions and methods for diagnosing hiv-2 infection
US8112229B2 (en) * 2007-05-31 2012-02-07 Abbott Laboratories Method for determining the order of execution of assays of a sample in a laboratory automation system
US8188250B2 (en) * 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
EP2550362B1 (en) 2010-03-25 2017-01-04 Oregon Health&Science University Cmv glycoproteins and recombinant vectors
WO2011163558A1 (en) 2010-06-25 2011-12-29 Abbott Laboratories Materials and methods for assay of anti-hepatitis c virus (hcv) antibodies
PT2691530T (pt) 2011-06-10 2018-05-10 Univ Oregon Health & Science Glicoproteínas e vectores recombinantes cmv
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
US9689873B2 (en) 2012-05-30 2017-06-27 Bio-Rad Innovations Method for diagnosing and differentiating HIV-2 infections
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (en) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2028287A (en) 1931-01-02 1936-01-21 William F Leicester Process of making glued up plywood
EP0001931A3 (en) * 1977-11-08 1979-06-13 Genentech, Inc. Synthetic dna, process for preparing it and recombinant microbial cloning vehicle containing such dna
CA1341423C (en) * 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
EP0187041B1 (en) * 1984-12-24 1996-05-15 Genentech, Inc. Fusions of AIDS-related polypeptides
DK171119B1 (da) * 1985-04-19 1996-06-17 Hoffmann La Roche AIDS-viruskappeprotein, ekspressionsvektor bærende viruskappeproteinet, transformanter transformeret med ekspressionsvektoren, fremgangsmåde til fremstilling af viruskappeproteinet, fremgangsmåde til detektion af AIDS-antistoffer, fremgangsmåde til bestemmelse af AIDS-virus, vaccine mod AIDS, antistoffer mod viruskappeproteinet samt anvendelse af dette til fremstilling af en vaccine og til testnin
JP2564268B2 (ja) * 1985-08-28 1996-12-18 協和醗酵工業株式会社 融合抗原ポリペプチド
US5079342A (en) 1986-01-22 1992-01-07 Institut Pasteur Cloned DNA sequences related to the entire genomic RNA of human immunodeficiency virus II (HIV-2), polypeptides encoded by these DNA sequences and use of these DNA clones and polypeptides in diagnostic kits
US4753873A (en) 1986-02-03 1988-06-28 Cambridge Bioscience Corporation Peptides for the diagnosis of HTLV-III antibodies, their preparation and use
US4925784A (en) 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
HUT50875A (en) * 1986-11-01 1990-03-28 Oxford Gene Systems Ltd Process for producing particular hybrid hiv antigenes
ES2104556T3 (es) * 1987-01-16 1997-10-16 Pasteur Institut Peptidos que tienen propiedades inmunologicas de hiv-2.
US4861707A (en) * 1987-02-02 1989-08-29 E. I. Du Pont De Nemours And Company Human immunodeficiency virus antigen
US5124255A (en) * 1988-03-11 1992-06-23 Abbott Laboratories CKS method of protein synthesis
JPH04502760A (ja) * 1988-10-03 1992-05-21 レプリゲン・コーポレーション エイズの診断，予防および治療に有効な新規ｈｉｖ蛋白質およびペプチド
EP0400245B1 (en) * 1989-05-31 1995-12-20 Institut Pasteur Proteins and glycoproteins of the HIV-2 EHO retrovirus antibodies directed against them - application for the diagnosis

Also Published As

Publication number Publication date
JP3073752B2 (ja) 2000-08-07
AU628108B2 (en) 1992-09-10
US5859193A (en) 1999-01-12
ES2238071T3 (es) 2005-08-16
DE68929529T2 (de) 2005-12-29
CA2003383A1 (en) 1990-05-23
AU4545889A (en) 1990-07-05
DE68927665T2 (de) 1997-07-17
DE68929529D1 (de) 2005-02-17
EP0370458A2 (en) 1990-05-30
GR3022850T3 (en) 1997-06-30
ATE286978T1 (de) 2005-01-15
JPH02273187A (ja) 1990-11-07
US6538127B1 (en) 2003-03-25
EP0717109A1 (en) 1996-06-19
ATE147758T1 (de) 1997-02-15
EP0370458B1 (en) 1997-01-15
EP0370458A3 (en) 1991-11-06
EP0717109B1 (en) 2005-01-12
DE68927665D1 (de) 1997-02-27
US6153377A (en) 2000-11-28
JPH11313671A (ja) 1999-11-16

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