ES2097918T3 - Agentes antihelminticos de benzoimidazol. - Google Patents
Agentes antihelminticos de benzoimidazol.Info
- Publication number
- ES2097918T3 ES2097918T3 ES92915486T ES92915486T ES2097918T3 ES 2097918 T3 ES2097918 T3 ES 2097918T3 ES 92915486 T ES92915486 T ES 92915486T ES 92915486 T ES92915486 T ES 92915486T ES 2097918 T3 ES2097918 T3 ES 2097918T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- group
- pct
- benzimidazole compounds
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN DERIVADO DE BENCIMIDAZOL DE FORMULA (IA) O (IB) O UNA SAL NO TOXICA DE ESTE, EN LA QUE R, QUE ESTA EN LOS COMPUESTOS (IA) ESTA EN LA POSICION 6 LOXI, FENILTIO, FENILSULFINILO, FENILSULFONILO, FENILSUFONILOXI, ALQUILO C1-C6, ALCOXI C1-C6, ALQUILSULFINLO C1-C6, ALQUISULFONILO C1-C6, O CARBONILO CICLOALQUILO C3-C7, DICHO GRUPO FENILO, Y LA PARTE FENILO DE DICHO GRUPO BENZOILO, QUE TIENE OPCIONALMENTE 1 A 3 SUSTITUYENTES CADA UNO ELEGIDO INDEPENDIENTEMENTE ENTRE HALO, ALQUILO C1-C4, HALOALQUILO C1-C4, ALCOXI C1-C4, ALQUILTIO C1-C4, ALQUILSULFINILO C1-C4, ALQUILSULFONILO C1-C4, ALCANOILO C2-C4, ISOCIANATO, Y CIANO,. O (II) UN GRUPO DE FORMULA (1A) DONDE X ES O, S, SO, SO2 O NR4 EN EL QUE R4 ES HIDROGENO; ALQUILO C1-C4 FENILO, O ALQUILFENILO C1-C4, DICHOS GRUPOS FENILOS ESTANDO OPCIONALMENTE SUSTITUIDOS POR 1 O 2 SUSTITUYENTES CADA UNO ELEGIDO ENTRE ALQUILO C1-C4, HALO, HIDROXI, Y ALCOXI C1-C4; Y R5 ES H, ALQUILO C1-C4, HALO, HIDROXI O ALCOXI C1C4; (1B) (1C) (1D) DONDE R6 ES ALQUILO C1-C4, ALILO, O FENILO, (1E) (1F) O (1G); Y CUALQUIER (A) R1 ES UN GRUPO 1-(ALCANOILOXIC2C6) ALQUILO C1-C4 O (B) R1 ES H Y R2 ES UN GRUPO 1-(ALCANOILOXI C2-C6) ALQUILOC1-C4, Y R3 ES UN GRUPO ALQUILO C1-C4.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919115273A GB9115273D0 (en) | 1991-07-15 | 1991-07-15 | Benzimidazole anthelmintics |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097918T3 true ES2097918T3 (es) | 1997-04-16 |
Family
ID=10698394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92915486T Expired - Lifetime ES2097918T3 (es) | 1991-07-15 | 1992-07-13 | Agentes antihelminticos de benzoimidazol. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5459155A (es) |
EP (1) | EP0594726B1 (es) |
JP (1) | JP2918690B2 (es) |
AT (1) | ATE148461T1 (es) |
CA (1) | CA2113566C (es) |
DE (1) | DE69217225T2 (es) |
DK (1) | DK0594726T3 (es) |
ES (1) | ES2097918T3 (es) |
GB (1) | GB9115273D0 (es) |
GR (1) | GR3022839T3 (es) |
IE (1) | IE922286A1 (es) |
PT (1) | PT100683B (es) |
WO (1) | WO1993002059A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ335166A (en) | 1999-04-14 | 2001-11-30 | Ashmont Holdings Ltd | Anthelmintic composition containing triclabendazole in at least one solvent |
GB9205368D0 (en) * | 1992-03-12 | 1992-04-22 | Pfizer Ltd | Benzimidozole anthelmintic agents |
US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
IL150929A0 (en) * | 2000-01-28 | 2003-06-24 | Rohm & Haas | Pharmaceutical compounds comprising a pharmaceutically active moiety and a moiety comprising a substituent that enhances its properties |
US20060222692A1 (en) * | 2005-03-31 | 2006-10-05 | Fairfield Clinical Trials Llc | Method and compositions for transdermal administration of antimicrobial medications |
WO2007014846A1 (en) * | 2005-07-28 | 2007-02-08 | Intervet International B.V. | Novel benzimidazole (thio) carbamates with antiparasitic activity and the synthesis thereof |
JP5406022B2 (ja) * | 2006-06-12 | 2014-02-05 | スミス アンド ネフュー インコーポレーテッド | 脛骨切除システム、方法、及び装置 |
EP2037914B1 (en) | 2006-06-14 | 2013-10-23 | Intervet International BV | A suspension comprising benzimidazole carbamate and a polysorbate |
CA3090691A1 (en) * | 2018-02-08 | 2019-08-15 | The Johns Hopkins University | Mebendazole prodrugs with enhanced solubility and oral bioavailability |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2933502A (en) * | 1958-02-12 | 1960-04-19 | Du Pont | Benzimidazolone derivatives |
US3010968A (en) * | 1959-11-25 | 1961-11-28 | Du Pont | Process for manufacture of certain alkyl esters of benzimidazole carbamic acids |
USRE28403E (en) * | 1964-08-04 | 1975-04-29 | Butyl and n-propoxy-z-carbo- methoxyaminobenzimidazoles | |
US4032536A (en) * | 1976-07-22 | 1977-06-28 | Janssen Pharmaceutica N.V. | (1h-benzimidazol-2-yl)carbamates |
DE2840927A1 (de) * | 1978-09-20 | 1980-04-10 | Bayer Ag | 3,4-dihydroisochinoline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4512998A (en) * | 1980-10-20 | 1985-04-23 | Schering Corporation | Anthelmintic benzimidazole carbamates |
DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4826862A (en) * | 1988-02-12 | 1989-05-02 | Janssen Pharmaceutica, N.V. | Anthelminthic [(5(6) (1H-azole-1-ylmethyl)benzimidazole]carbamates |
NZ232785A (en) * | 1989-03-15 | 1991-03-26 | Janssen Pharmaceutica Nv | 5-(1,2 benzisoxazol-, benzimidazol and benzisothiazol-3- yl)-1h-benzimadazol-2-yl carbamic acid ester derivatives preparatory processes, intermediates and anthelmintic compositions |
-
1991
- 1991-07-15 GB GB919115273A patent/GB9115273D0/en active Pending
-
1992
- 1992-07-13 JP JP4512058A patent/JP2918690B2/ja not_active Expired - Lifetime
- 1992-07-13 ES ES92915486T patent/ES2097918T3/es not_active Expired - Lifetime
- 1992-07-13 PT PT100683A patent/PT100683B/pt not_active IP Right Cessation
- 1992-07-13 AT AT92915486T patent/ATE148461T1/de not_active IP Right Cessation
- 1992-07-13 US US08/185,997 patent/US5459155A/en not_active Expired - Fee Related
- 1992-07-13 DE DE69217225T patent/DE69217225T2/de not_active Expired - Fee Related
- 1992-07-13 CA CA002113566A patent/CA2113566C/en not_active Expired - Fee Related
- 1992-07-13 WO PCT/EP1992/001579 patent/WO1993002059A1/en active IP Right Grant
- 1992-07-13 EP EP92915486A patent/EP0594726B1/en not_active Expired - Lifetime
- 1992-07-13 DK DK92915486.2T patent/DK0594726T3/da active
- 1992-07-14 IE IE228692A patent/IE922286A1/en not_active Application Discontinuation
-
1995
- 1995-06-06 US US08/469,408 patent/US5521204A/en not_active Expired - Fee Related
-
1997
- 1997-03-17 GR GR970400514T patent/GR3022839T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE148461T1 (de) | 1997-02-15 |
US5521204A (en) | 1996-05-28 |
GB9115273D0 (en) | 1991-08-28 |
US5459155A (en) | 1995-10-17 |
CA2113566C (en) | 1997-04-08 |
JPH06509066A (ja) | 1994-10-13 |
PT100683B (pt) | 1999-06-30 |
JP2918690B2 (ja) | 1999-07-12 |
CA2113566A1 (en) | 1993-02-04 |
IE922286A1 (en) | 1993-01-27 |
DE69217225T2 (de) | 1997-05-15 |
EP0594726A1 (en) | 1994-05-04 |
WO1993002059A1 (en) | 1993-02-04 |
DE69217225D1 (de) | 1997-03-13 |
DK0594726T3 (da) | 1997-04-01 |
GR3022839T3 (en) | 1997-06-30 |
PT100683A (pt) | 1993-08-31 |
EP0594726B1 (en) | 1997-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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