ES2097652T3 - Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso. - Google Patents
Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso.Info
- Publication number
- ES2097652T3 ES2097652T3 ES94915514T ES94915514T ES2097652T3 ES 2097652 T3 ES2097652 T3 ES 2097652T3 ES 94915514 T ES94915514 T ES 94915514T ES 94915514 T ES94915514 T ES 94915514T ES 2097652 T3 ES2097652 T3 ES 2097652T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- triazolo
- compounds
- optionally substituted
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
DERIVADOS DE TRIAZOLO[1,2,4] Y QUINOXALINA[4,3- A ] DE FORMULA (I) EN LA QUE UNO DE R{SUP,1} Y R{SUP,2} ES UN ANILLO QUE CONTIENE N, HETEROCICLICO, DE 5 O 6 MIEMBROS, OPCIONALMENTE SUSTITUIDO, O UN SISTEMA DE ANILLOS FUNDIDOS QUE CONTIENE UN ANILLO QUE CONTIENE N, HETEROCICLICO, DE 5 O 6 MEIMBROS, OPCIONALMENTE SUSTITUIDO, Y EL OTRO DE LA PAREJA R{SUP,1} Y R{SUP,2} ES H, ALQUILO, ALCOXILO, HALOGENO, NO{SUB,2}, NH{SUB,2}, CN, CF{SUB,3}, COC{SUB,1-6} ALQUILO O SO{SUB,2}NR''R'''', DONDE R'' Y R'''' SON INDEPENDIENTEMENTE H O ALQUILO, X ES O O S; Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE TIENEN AFINIDAD HACIA LOS RECEPTORES AMPA Y SON ANTAGONISTAS EN CONEXION CON ESTE TIPO DE RECEPTORES, LOS QUE LES HACE UTILES EN EL TRATAMIENTO DE LOS AFECCIONES SISTEMA NERVIOSO CENTRAL, ESPECIALMENTE EN EL TRATAMIENTO DE LAS NUMEROSAS INDICACIONES CAUSADAS POR LA HIPERACTIVIDAD Y LOS AMINOACIDOS EXCITANTES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK53593A DK53593D0 (da) | 1993-05-06 | 1993-05-06 | Oe1,2,4aatriazolooe4,3-aaaquinoxalinonforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse |
DK128793A DK128793D0 (es) | 1993-11-12 | 1993-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097652T3 true ES2097652T3 (es) | 1997-04-01 |
Family
ID=26064177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94915514T Expired - Lifetime ES2097652T3 (es) | 1993-05-06 | 1994-04-28 | Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5532236A (es) |
EP (1) | EP0698024B1 (es) |
JP (1) | JPH08509747A (es) |
KR (1) | KR100304177B1 (es) |
CN (1) | CN1041931C (es) |
AT (1) | ATE148120T1 (es) |
AU (1) | AU683062B2 (es) |
CA (1) | CA2162023A1 (es) |
DE (1) | DE69401583T2 (es) |
DK (1) | DK0698024T3 (es) |
ES (1) | ES2097652T3 (es) |
FI (1) | FI955304A0 (es) |
GR (1) | GR3023001T3 (es) |
HU (1) | HUT73983A (es) |
IL (1) | IL109530A (es) |
NO (1) | NO305516B1 (es) |
NZ (1) | NZ266127A (es) |
TW (1) | TW377354B (es) |
WO (1) | WO1994026746A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE190616T1 (de) * | 1994-09-16 | 2000-04-15 | Novo Nordisk As | (1,2,4)triazolo(4,3-a)chinoxylinonderivate, ihre darstellung und verwendung als antagonisten von ampa-rezeptoren |
CA2200056A1 (en) * | 1994-09-16 | 1996-03-21 | Novo Nordisk A/S | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use |
DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
CZ295565B6 (cs) | 1996-05-15 | 2005-08-17 | Pfizer Inc. | 2,3-Disubstituované 4(3H)-chinazolinony, jejich použití a farmaceutické kompozice na jejich bázi |
AU5704898A (en) * | 1996-12-16 | 1998-07-15 | Warner-Lambert Company | Tricyclic quinoxaline derivatives as neuroprotective agents |
US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
US6323208B1 (en) | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
AU9651198A (en) | 1997-11-11 | 1999-05-31 | Ono Pharmaceutical Co. Ltd. | Fused pyrazine compounds |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
WO2016199943A1 (en) * | 2015-06-11 | 2016-12-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
SI3823971T1 (sl) * | 2018-07-20 | 2022-10-28 | Gruenenthal Gmbh | Substituirani derivati triazolokinoksalina |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4400382A (en) * | 1980-05-09 | 1983-08-23 | Usv Pharmaceutical Corporation | Thiazoloquinoxalin-1,4-diones for treating allergy |
DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
-
1994
- 1994-04-28 WO PCT/DK1994/000170 patent/WO1994026746A1/en active IP Right Grant
- 1994-04-28 JP JP6524834A patent/JPH08509747A/ja not_active Ceased
- 1994-04-28 AT AT94915514T patent/ATE148120T1/de not_active IP Right Cessation
- 1994-04-28 NZ NZ266127A patent/NZ266127A/en unknown
- 1994-04-28 CN CN94192501A patent/CN1041931C/zh not_active Expired - Fee Related
- 1994-04-28 CA CA002162023A patent/CA2162023A1/en not_active Abandoned
- 1994-04-28 EP EP94915514A patent/EP0698024B1/en not_active Expired - Lifetime
- 1994-04-28 ES ES94915514T patent/ES2097652T3/es not_active Expired - Lifetime
- 1994-04-28 DE DE69401583T patent/DE69401583T2/de not_active Expired - Fee Related
- 1994-04-28 AU AU67200/94A patent/AU683062B2/en not_active Ceased
- 1994-04-28 DK DK94915514.7T patent/DK0698024T3/da active
- 1994-04-28 KR KR1019950704895A patent/KR100304177B1/ko not_active IP Right Cessation
- 1994-04-28 HU HU9503157A patent/HUT73983A/hu unknown
- 1994-05-03 US US08/237,518 patent/US5532236A/en not_active Expired - Fee Related
- 1994-05-03 IL IL10953094A patent/IL109530A/xx not_active IP Right Cessation
- 1994-05-04 TW TW083104020A patent/TW377354B/zh active
-
1995
- 1995-11-03 NO NO954402A patent/NO305516B1/no not_active IP Right Cessation
- 1995-11-06 FI FI955304A patent/FI955304A0/fi unknown
-
1997
- 1997-04-01 GR GR970400675T patent/GR3023001T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5532236A (en) | 1996-07-02 |
DK0698024T3 (da) | 1997-07-28 |
NO954402L (no) | 1996-01-05 |
EP0698024A1 (en) | 1996-02-28 |
KR960701877A (ko) | 1996-03-28 |
IL109530A0 (en) | 1994-08-26 |
EP0698024B1 (en) | 1997-01-22 |
DE69401583D1 (de) | 1997-03-06 |
ATE148120T1 (de) | 1997-02-15 |
GR3023001T3 (en) | 1997-07-30 |
AU683062B2 (en) | 1997-10-30 |
DE69401583T2 (de) | 1997-06-12 |
WO1994026746A1 (en) | 1994-11-24 |
KR100304177B1 (ko) | 2001-11-22 |
FI955304A (fi) | 1995-11-06 |
JPH08509747A (ja) | 1996-10-15 |
NO305516B1 (no) | 1999-06-14 |
AU6720094A (en) | 1994-12-12 |
FI955304A0 (fi) | 1995-11-06 |
HU9503157D0 (en) | 1996-01-29 |
TW377354B (en) | 1999-12-21 |
IL109530A (en) | 1997-01-10 |
HUT73983A (en) | 1996-10-28 |
CN1125446A (zh) | 1996-06-26 |
NO954402D0 (no) | 1995-11-03 |
NZ266127A (en) | 1997-11-24 |
CN1041931C (zh) | 1999-02-03 |
CA2162023A1 (en) | 1994-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2097652T3 (es) | Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso. | |
EA199800478A1 (ru) | N-([1,2,4]триазолазинил)бензолсульфонамиды и пиридинсульфонамиды и их применение в качестве гербицидов | |
YU47969B (sh) | Postupak za dobijanje derivata pirimidinona kao kalcijum nezavisnih camp inhibitora fosfordiesteraze | |
EA199800908A1 (ru) | Производные индола, полезные в качестве антагонистов рецептора эндотелина | |
NO940927D0 (no) | Kondenserte tricykliske nitrogenholdige heterocykler som substans-P-reseptor-antagonister | |
AU533295B2 (en) | Triazolo (4,3-a)pyridines | |
TR199902848T2 (xx) | Ergolin t�revleri ve bunlar�n somatostatin resept�r antagonist olarak kullan�mlar� | |
FI963130A (fi) | Heterosykliset yhdisteet sekä niiden valmistus ja käyttö | |
DE69509888T2 (de) | IMIDAZO[1,2-a]INDENO [1,2-e] PYRAZINONE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN | |
IL109076A (en) | 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
DE3769333D1 (de) | Acylaminomethylimidazo(1,2-a)pyrimidinderivate, ihre herstellung und therapeutische verwendung. | |
EA199800720A1 (ru) | Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора | |
NO305439B1 (no) | Pyrido(1,2,3-de)kinoksalinderivater og legemidler inneholdende disse |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 698024 Country of ref document: ES |