IL109076A - 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IL109076A
IL109076A IL109076A IL10907694A IL109076A IL 109076 A IL109076 A IL 109076A IL 109076 A IL109076 A IL 109076A IL 10907694 A IL10907694 A IL 10907694A IL 109076 A IL109076 A IL 109076A
Authority
IL
Israel
Prior art keywords
substituted
alkyl
hydrogen
dihydroimidazolo
quinoxalin
Prior art date
Application number
IL109076A
Other versions
IL109076A0 (en
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4329970A external-priority patent/DE4329970A1/en
Application filed by Basf Ag filed Critical Basf Ag
Publication of IL109076A0 publication Critical patent/IL109076A0/en
Publication of IL109076A publication Critical patent/IL109076A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

An excitatory amino acid antagonist imidazolo £1, 2-a| quinoxalinone of the formula R5A-R5 R4NN R3R2R1 NHO where A is an alkylene or alkenylene group with up to 5 C atoms or a bond, R1 is hydrogen; R2 and R3 are identical or different and are each trifluoromethyl, cyano or nitro; R4 is hydrogen; R5 is hydrogen, C1-C5-alkyl or phenyl which is unsubstituted or substituted by chlorine, fluorine, trifluoromethyl or C1-C4-alkyl; and R6 is a carboxyl group which can be in the form of its salt with a physiologically tolerated amine or metal cation or the radical COOR7 where R7 is C1-C8-alkyl.
IL109076A 1993-03-31 1994-03-22 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL109076A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4310521 1993-03-31
DE4329970A DE4329970A1 (en) 1993-03-31 1993-09-04 New imidazolo-quinoxalinones, their manufacture and use

Publications (2)

Publication Number Publication Date
IL109076A0 IL109076A0 (en) 1994-06-24
IL109076A true IL109076A (en) 1997-06-10

Family

ID=25924528

Family Applications (1)

Application Number Title Priority Date Filing Date
IL109076A IL109076A (en) 1993-03-31 1994-03-22 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (17)

Country Link
EP (1) EP0691970B1 (en)
JP (1) JPH08508271A (en)
CN (1) CN1041928C (en)
AT (1) ATE173263T1 (en)
AU (1) AU6428294A (en)
BR (1) BR9406034A (en)
CA (1) CA2158167A1 (en)
CZ (1) CZ246495A3 (en)
FI (1) FI954614A (en)
HR (1) HRP940210A2 (en)
HU (1) HUT73970A (en)
IL (1) IL109076A (en)
NO (1) NO953892D0 (en)
NZ (1) NZ263552A (en)
PL (1) PL310950A1 (en)
SI (1) SI9420023A (en)
WO (1) WO1994022865A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021842A1 (en) * 1994-02-11 1995-08-17 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
FR2722789B1 (en) * 1994-07-20 1996-08-23 Rhone Poulenc Rorer Sa IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
IT1276167B1 (en) * 1995-11-24 1997-10-27 Foscama Biomed Chim Farma IMIDAZO (1,2-ALPHA) QUINOSSALIN-4-AMINE ACTIVE AS ADENOSINE ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND COMPOSITIONS
FR2743363A1 (en) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa 5H, 10H-IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZINE-A-ONES SUBSTITUTED IN POSITION 2, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
US6271418B1 (en) * 2000-02-22 2001-08-07 Nippon Kayaku Co., Ltd. Process for preparing (hetero) aromatic substituted benzene derivatives
GB0017518D0 (en) * 2000-07-17 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0018473D0 (en) * 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
CN100386326C (en) * 2003-10-22 2008-05-07 中国人民解放军军事医学科学院毒物药物研究所 1-methylolimidazole [1,2-alpha] quinoxaline compound and its application
EP2103613B1 (en) 2006-12-13 2016-02-17 ASKA Pharmaceutical Co., Ltd. Quinoxaline derivative
FR2921927B1 (en) * 2007-10-03 2012-10-12 Univ De Montpellier 1 IMIDAZO® 1,2-A! QUINOXALINS AND DERIVATIVES FOR THE TREATMENT OF CANCER

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2043064B (en) * 1979-02-09 1983-04-13 Roussel Lab Ltd Oximidazoquinoxaline derivatives
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands

Also Published As

Publication number Publication date
PL310950A1 (en) 1996-01-08
IL109076A0 (en) 1994-06-24
SI9420023A (en) 1996-04-30
FI954614A0 (en) 1995-09-28
JPH08508271A (en) 1996-09-03
NZ263552A (en) 1997-06-24
AU6428294A (en) 1994-10-24
FI954614A (en) 1995-09-28
WO1994022865A1 (en) 1994-10-13
HRP940210A2 (en) 1996-12-31
ATE173263T1 (en) 1998-11-15
CN1120336A (en) 1996-04-10
BR9406034A (en) 1996-01-02
CZ246495A3 (en) 1996-03-13
NO953892L (en) 1995-09-29
EP0691970B1 (en) 1998-11-11
HU9502848D0 (en) 1995-11-28
HUT73970A (en) 1996-10-28
CN1041928C (en) 1999-02-03
NO953892D0 (en) 1995-09-29
CA2158167A1 (en) 1994-10-13
EP0691970A1 (en) 1996-01-17

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Legal Events

Date Code Title Description
HK Corrigendum

Free format text: JOURNAL NO. 3/97 PAGE 740 IN THE NOTICE UNDER SECTION 26 OF THE PATENTS LAW 5727-1967 IN RELATION TO PATENT APPLICATION NO. 109076: THE DETAILS OF THE SECOND PRIORITY CLAIM ARE: P4329970.9 4.9.1993 DE

FF Patent granted
KB Patent renewed
RH Patent void