IL109076A - 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- IL109076A IL109076A IL109076A IL10907694A IL109076A IL 109076 A IL109076 A IL 109076A IL 109076 A IL109076 A IL 109076A IL 10907694 A IL10907694 A IL 10907694A IL 109076 A IL109076 A IL 109076A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- alkyl
- hydrogen
- dihydroimidazolo
- quinoxalin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
An excitatory amino acid antagonist imidazolo £1, 2-a| quinoxalinone of the formula R5A-R5 R4NN R3R2R1 NHO where A is an alkylene or alkenylene group with up to 5 C atoms or a bond, R1 is hydrogen; R2 and R3 are identical or different and are each trifluoromethyl, cyano or nitro; R4 is hydrogen; R5 is hydrogen, C1-C5-alkyl or phenyl which is unsubstituted or substituted by chlorine, fluorine, trifluoromethyl or C1-C4-alkyl; and R6 is a carboxyl group which can be in the form of its salt with a physiologically tolerated amine or metal cation or the radical COOR7 where R7 is C1-C8-alkyl.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4310521 | 1993-03-31 | ||
DE4329970A DE4329970A1 (en) | 1993-03-31 | 1993-09-04 | New imidazolo-quinoxalinones, their manufacture and use |
Publications (2)
Publication Number | Publication Date |
---|---|
IL109076A0 IL109076A0 (en) | 1994-06-24 |
IL109076A true IL109076A (en) | 1997-06-10 |
Family
ID=25924528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL109076A IL109076A (en) | 1993-03-31 | 1994-03-22 | 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0691970B1 (en) |
JP (1) | JPH08508271A (en) |
CN (1) | CN1041928C (en) |
AT (1) | ATE173263T1 (en) |
AU (1) | AU6428294A (en) |
BR (1) | BR9406034A (en) |
CA (1) | CA2158167A1 (en) |
CZ (1) | CZ246495A3 (en) |
FI (1) | FI954614A (en) |
HR (1) | HRP940210A2 (en) |
HU (1) | HUT73970A (en) |
IL (1) | IL109076A (en) |
NO (1) | NO953892D0 (en) |
NZ (1) | NZ263552A (en) |
PL (1) | PL310950A1 (en) |
SI (1) | SI9420023A (en) |
WO (1) | WO1994022865A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995021842A1 (en) * | 1994-02-11 | 1995-08-17 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
FR2722789B1 (en) * | 1994-07-20 | 1996-08-23 | Rhone Poulenc Rorer Sa | IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
IT1276167B1 (en) * | 1995-11-24 | 1997-10-27 | Foscama Biomed Chim Farma | IMIDAZO (1,2-ALPHA) QUINOSSALIN-4-AMINE ACTIVE AS ADENOSINE ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND COMPOSITIONS |
FR2743363A1 (en) * | 1996-01-10 | 1997-07-11 | Rhone Poulenc Rorer Sa | 5H, 10H-IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZINE-A-ONES SUBSTITUTED IN POSITION 2, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
US6271418B1 (en) * | 2000-02-22 | 2001-08-07 | Nippon Kayaku Co., Ltd. | Process for preparing (hetero) aromatic substituted benzene derivatives |
GB0017518D0 (en) * | 2000-07-17 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
GB0018473D0 (en) * | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
CN100386326C (en) * | 2003-10-22 | 2008-05-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 1-methylolimidazole [1,2-alpha] quinoxaline compound and its application |
EP2103613B1 (en) | 2006-12-13 | 2016-02-17 | ASKA Pharmaceutical Co., Ltd. | Quinoxaline derivative |
FR2921927B1 (en) * | 2007-10-03 | 2012-10-12 | Univ De Montpellier 1 | IMIDAZO® 1,2-A! QUINOXALINS AND DERIVATIVES FOR THE TREATMENT OF CANCER |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2043064B (en) * | 1979-02-09 | 1983-04-13 | Roussel Lab Ltd | Oximidazoquinoxaline derivatives |
US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
US5182386A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands |
-
1994
- 1994-03-19 HU HU9502848A patent/HUT73970A/en unknown
- 1994-03-19 EP EP94911932A patent/EP0691970B1/en not_active Expired - Lifetime
- 1994-03-19 CZ CZ952464A patent/CZ246495A3/en unknown
- 1994-03-19 WO PCT/EP1994/000871 patent/WO1994022865A1/en active IP Right Grant
- 1994-03-19 NZ NZ263552A patent/NZ263552A/en unknown
- 1994-03-19 AT AT94911932T patent/ATE173263T1/en not_active IP Right Cessation
- 1994-03-19 SI SI9420023A patent/SI9420023A/en unknown
- 1994-03-19 CN CN94191613A patent/CN1041928C/en not_active Expired - Fee Related
- 1994-03-19 AU AU64282/94A patent/AU6428294A/en not_active Abandoned
- 1994-03-19 BR BR9406034A patent/BR9406034A/en not_active Application Discontinuation
- 1994-03-19 JP JP6521617A patent/JPH08508271A/en active Pending
- 1994-03-19 CA CA002158167A patent/CA2158167A1/en not_active Abandoned
- 1994-03-19 PL PL94310950A patent/PL310950A1/en unknown
- 1994-03-22 IL IL109076A patent/IL109076A/en not_active IP Right Cessation
- 1994-03-30 HR HRP4329970.9A patent/HRP940210A2/en not_active Application Discontinuation
-
1995
- 1995-09-28 FI FI954614A patent/FI954614A/en not_active Application Discontinuation
- 1995-09-29 NO NO953892A patent/NO953892D0/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL310950A1 (en) | 1996-01-08 |
IL109076A0 (en) | 1994-06-24 |
SI9420023A (en) | 1996-04-30 |
FI954614A0 (en) | 1995-09-28 |
JPH08508271A (en) | 1996-09-03 |
NZ263552A (en) | 1997-06-24 |
AU6428294A (en) | 1994-10-24 |
FI954614A (en) | 1995-09-28 |
WO1994022865A1 (en) | 1994-10-13 |
HRP940210A2 (en) | 1996-12-31 |
ATE173263T1 (en) | 1998-11-15 |
CN1120336A (en) | 1996-04-10 |
BR9406034A (en) | 1996-01-02 |
CZ246495A3 (en) | 1996-03-13 |
NO953892L (en) | 1995-09-29 |
EP0691970B1 (en) | 1998-11-11 |
HU9502848D0 (en) | 1995-11-28 |
HUT73970A (en) | 1996-10-28 |
CN1041928C (en) | 1999-02-03 |
NO953892D0 (en) | 1995-09-29 |
CA2158167A1 (en) | 1994-10-13 |
EP0691970A1 (en) | 1996-01-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HK | Corrigendum |
Free format text: JOURNAL NO. 3/97 PAGE 740 IN THE NOTICE UNDER SECTION 26 OF THE PATENTS LAW 5727-1967 IN RELATION TO PATENT APPLICATION NO. 109076: THE DETAILS OF THE SECOND PRIORITY CLAIM ARE: P4329970.9 4.9.1993 DE |
|
FF | Patent granted | ||
KB | Patent renewed | ||
RH | Patent void |