AU6428294A - Imidazoloquinoxalinone derivatives as eaa antagonists - Google Patents

Imidazoloquinoxalinone derivatives as eaa antagonists

Info

Publication number
AU6428294A
AU6428294A AU64282/94A AU6428294A AU6428294A AU 6428294 A AU6428294 A AU 6428294A AU 64282/94 A AU64282/94 A AU 64282/94A AU 6428294 A AU6428294 A AU 6428294A AU 6428294 A AU6428294 A AU 6428294A
Authority
AU
Australia
Prior art keywords
imidazoloquinoxalinone
derivatives
preparation
eaa antagonists
eaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU64282/94A
Inventor
Berthold Behl
Hans Peter Hofmann
Hans-Joerg Treiber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4329970A external-priority patent/DE4329970A1/en
Application filed by BASF SE filed Critical BASF SE
Publication of AU6428294A publication Critical patent/AU6428294A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Described are imidazoloquinoxalinones of the formula (I) in which A and R1 to R6 are as defined in the description, plus their preparation. The compounds described can be used in the preparation of drugs for use in the treatment of neurodegenerative ailments and neurotoxic disorders of the central nervous system as well as in the preparation of spasmolytics, anti-epileptics, anxiolytics and anti-depressants.
AU64282/94A 1993-03-31 1994-03-19 Imidazoloquinoxalinone derivatives as eaa antagonists Abandoned AU6428294A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4310521 1993-03-31
DE4310521 1993-03-31
DE4329970A DE4329970A1 (en) 1993-03-31 1993-09-04 New imidazolo-quinoxalinones, their manufacture and use
DE4329970 1993-09-04
PCT/EP1994/000871 WO1994022865A1 (en) 1993-03-31 1994-03-19 Imidazoloquinoxalinone derivatives as eaa antagonists

Publications (1)

Publication Number Publication Date
AU6428294A true AU6428294A (en) 1994-10-24

Family

ID=25924528

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64282/94A Abandoned AU6428294A (en) 1993-03-31 1994-03-19 Imidazoloquinoxalinone derivatives as eaa antagonists

Country Status (17)

Country Link
EP (1) EP0691970B1 (en)
JP (1) JPH08508271A (en)
CN (1) CN1041928C (en)
AT (1) ATE173263T1 (en)
AU (1) AU6428294A (en)
BR (1) BR9406034A (en)
CA (1) CA2158167A1 (en)
CZ (1) CZ246495A3 (en)
FI (1) FI954614A (en)
HR (1) HRP940210A2 (en)
HU (1) HUT73970A (en)
IL (1) IL109076A (en)
NO (1) NO953892L (en)
NZ (1) NZ263552A (en)
PL (1) PL310950A1 (en)
SI (1) SI9420023A (en)
WO (1) WO1994022865A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970701192A (en) * 1994-02-11 1997-03-17 안네 섹커 Heterocyclic compounds and their preparation and use
FR2722789B1 (en) * 1994-07-20 1996-08-23 Rhone Poulenc Rorer Sa IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
IT1276167B1 (en) * 1995-11-24 1997-10-27 Foscama Biomed Chim Farma IMIDAZO (1,2-ALPHA) QUINOSSALIN-4-AMINE ACTIVE AS ADENOSINE ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND COMPOSITIONS
FR2743363A1 (en) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa 5H, 10H-IMIDAZO (1,2-A) INDENO (1,2-E) PYRAZINE-A-ONES SUBSTITUTED IN POSITION 2, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
US6271418B1 (en) * 2000-02-22 2001-08-07 Nippon Kayaku Co., Ltd. Process for preparing (hetero) aromatic substituted benzene derivatives
GB0017518D0 (en) * 2000-07-17 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0018473D0 (en) 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
CN100386326C (en) * 2003-10-22 2008-05-07 中国人民解放军军事医学科学院毒物药物研究所 1-methylolimidazole [1,2-alpha] quinoxaline compound and its application
US8299080B2 (en) * 2006-12-13 2012-10-30 Aska Pharmaceutical Co., Ltd. Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor
FR2921927B1 (en) * 2007-10-03 2012-10-12 Univ De Montpellier 1 IMIDAZO® 1,2-A! QUINOXALINS AND DERIVATIVES FOR THE TREATMENT OF CANCER

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2043064B (en) * 1979-02-09 1983-04-13 Roussel Lab Ltd Oximidazoquinoxaline derivatives
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands

Also Published As

Publication number Publication date
NZ263552A (en) 1997-06-24
HUT73970A (en) 1996-10-28
PL310950A1 (en) 1996-01-08
CN1120336A (en) 1996-04-10
BR9406034A (en) 1996-01-02
FI954614A0 (en) 1995-09-28
JPH08508271A (en) 1996-09-03
NO953892D0 (en) 1995-09-29
EP0691970B1 (en) 1998-11-11
WO1994022865A1 (en) 1994-10-13
HRP940210A2 (en) 1996-12-31
IL109076A (en) 1997-06-10
SI9420023A (en) 1996-04-30
CZ246495A3 (en) 1996-03-13
FI954614A (en) 1995-09-28
IL109076A0 (en) 1994-06-24
NO953892L (en) 1995-09-29
ATE173263T1 (en) 1998-11-15
HU9502848D0 (en) 1995-11-28
CA2158167A1 (en) 1994-10-13
CN1041928C (en) 1999-02-03
EP0691970A1 (en) 1996-01-17

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