ES2097188T3 - Derivados organosilanos, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. - Google Patents
Derivados organosilanos, composiciones farmaceuticas que los contienen y procedimiento para su preparacion.Info
- Publication number
- ES2097188T3 ES2097188T3 ES91306934T ES91306934T ES2097188T3 ES 2097188 T3 ES2097188 T3 ES 2097188T3 ES 91306934 T ES91306934 T ES 91306934T ES 91306934 T ES91306934 T ES 91306934T ES 2097188 T3 ES2097188 T3 ES 2097188T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- sub
- formula
- pharmaceutical compositions
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 206010006002 Bone pain Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000002038 Muscle Hypertonia Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000001282 organosilanes Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000001148 spastic effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS ORGANOSILANOS REPRESENTADOS POR LA FORMULA (I) EN DONDE M ES 1, 2 O 3; R ELEVADO 1 Y/O R (AL CUADRADO) REPRESENTA HIDROGENO, UN GRUPO ALQUILO C SUB 1-4 EN LINEA O RAMIFICADO, ALCOXI C SUB 1-4, CICLOALQUILO C SUB 5-7 O HALOGENO; B REPRESENTA UN GRUPO HETEROCICLICO DE 5 O 6 MIEMBROS SATURADO O INSATURADO QUE CONTIENE UNO O MAS ATOMOS DE NITROGENO Y OPCIONALMENTE UN ATOMO DE OXIGENO O DE AZUFRE ADICIONAL O UN GRUPO -NH O -NR, EN DONDE R REPRESENTA UN GRUPO DE ALQUILO C SUB 1-5 O UN GRUPO DE (C SUB 1-5 ALQUIL) CARBONILO, ESTANDO DICHO GRUPO HETEROCICLICO ENLAZADO MEDIANTE UN ATOMO DE NITROGENO AL GRUPO (CH SUB 2) SUB M Y SIENDO OPCIONALMENTE SUSTITUIDO POR UN GRUPO DE ALQUILO C SUB 1-4 O DE (C SUB 1-4 ALCOXI) CARBONILO; Y SALES DE ADICION ACIDAS DE LOS MISMOS. LOS COMPUESTOS DE LA FORMULA (I) PRESENTAN UN GRAN EFECTO RELAJANTE DE MUSCULOS Y PROPIEDADES ANTIPARQUINSONICAS; POR TANTO SON UTILES PARA EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, ESPASTICO, DE HIPERTONICIDAD MUSCULAR RIGIDA, DE GOLPES, LESIONES DEL SISTEMA NERVIOSO, ESCLEROSIS MULTIPLE, RAQUIALGIA O DOLORES PARTICULARES. TAMBIEN SE DESCRIBEN UN PROCESO PARA LA PREPARACION DEL COMPUESTO DE LA FORMULA (I) Y COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU904647A HU206725B (en) | 1990-07-27 | 1990-07-27 | Process for producing new organosilane derivatives and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2097188T3 true ES2097188T3 (es) | 1997-04-01 |
Family
ID=10968569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91306934T Expired - Lifetime ES2097188T3 (es) | 1990-07-27 | 1991-07-29 | Derivados organosilanos, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5198446A (es) |
| EP (1) | EP0468825B1 (es) |
| JP (1) | JPH04270293A (es) |
| KR (1) | KR0150218B1 (es) |
| AT (1) | ATE147392T1 (es) |
| DE (1) | DE69124025T2 (es) |
| DK (1) | DK0468825T3 (es) |
| ES (1) | ES2097188T3 (es) |
| GR (1) | GR3023066T3 (es) |
| HU (2) | HU206725B (es) |
| IL (1) | IL98912A (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206725B (en) * | 1990-07-27 | 1992-12-28 | Richter Gedeon Vegyeszet | Process for producing new organosilane derivatives and pharmaceutical compositions containing them |
| US5451563A (en) * | 1994-03-16 | 1995-09-19 | Rohm And Haas Company | Silyl heterocyclic fungicides |
| DE19923801C1 (de) * | 1999-05-19 | 2001-07-05 | Andras Varga | Neue substituierte Disiloxane, Verfahren zu ihrer Herstellung und ihre Verwendung zur Umkehrung der Multidrugresistenz (Mdr) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4224317A (en) * | 1979-08-27 | 1980-09-23 | Sandoz, Inc. | Substituted 1-oxa-4-aza-2,6-disilacyclohexanes and use thereof |
| DE3141860A1 (de) * | 1981-10-22 | 1983-05-05 | Bayer Ag, 5090 Leverkusen | Trifluormethyl-phenoxy-phenyl-silicium-derivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide und pflanzenwuchsregulatoren |
| US4762826A (en) * | 1986-04-11 | 1988-08-09 | Ciba-Geigy Corporation | Microbicides |
| CA1341025C (en) * | 1987-05-08 | 2000-06-13 | Daniel Schirlin | Substituted silyl alkylene amines |
| US4927812A (en) * | 1987-10-21 | 1990-05-22 | Atochem North America, Inc. | Morpholinyl silanes and use for control of plant diseases caused by fungi |
| AU605920B2 (en) * | 1987-10-21 | 1991-01-24 | Atochem North America, Inc. | Morpholinyl silanes and use for control of plant diseases caused by fungi |
| AT389702B (de) * | 1988-02-01 | 1990-01-25 | Agrolinz Agrarchemikalien | Neue azolylmethylsilane |
| HU206725B (en) * | 1990-07-27 | 1992-12-28 | Richter Gedeon Vegyeszet | Process for producing new organosilane derivatives and pharmaceutical compositions containing them |
-
1990
- 1990-07-27 HU HU904647A patent/HU206725B/hu not_active IP Right Cessation
-
1991
- 1991-07-22 IL IL9891291A patent/IL98912A/xx active IP Right Grant
- 1991-07-27 KR KR1019910012976A patent/KR0150218B1/ko not_active IP Right Cessation
- 1991-07-29 AT AT91306934T patent/ATE147392T1/de not_active IP Right Cessation
- 1991-07-29 DK DK91306934.0T patent/DK0468825T3/da active
- 1991-07-29 DE DE69124025T patent/DE69124025T2/de not_active Expired - Fee Related
- 1991-07-29 ES ES91306934T patent/ES2097188T3/es not_active Expired - Lifetime
- 1991-07-29 JP JP3276052A patent/JPH04270293A/ja active Pending
- 1991-07-29 US US07/736,962 patent/US5198446A/en not_active Expired - Fee Related
- 1991-07-29 EP EP91306934A patent/EP0468825B1/en not_active Expired - Lifetime
-
1992
- 1992-12-18 US US07/993,139 patent/US5340823A/en not_active Expired - Fee Related
-
1995
- 1995-06-27 HU HU95P/P00444P patent/HU211833A9/hu unknown
-
1997
- 1997-04-08 GR GR970400734T patent/GR3023066T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69124025T2 (de) | 1997-05-15 |
| US5340823A (en) | 1994-08-23 |
| HU904647D0 (en) | 1991-01-28 |
| HUT58339A (en) | 1992-02-28 |
| DE69124025D1 (de) | 1997-02-20 |
| DK0468825T3 (da) | 1997-06-23 |
| KR920002619A (ko) | 1992-02-28 |
| IL98912A0 (en) | 1992-07-15 |
| IL98912A (en) | 1997-01-10 |
| EP0468825B1 (en) | 1997-01-08 |
| KR0150218B1 (ko) | 1998-10-15 |
| ATE147392T1 (de) | 1997-01-15 |
| HU211833A9 (en) | 1995-12-28 |
| EP0468825A1 (en) | 1992-01-29 |
| GR3023066T3 (en) | 1997-07-30 |
| HU206725B (en) | 1992-12-28 |
| US5198446A (en) | 1993-03-30 |
| JPH04270293A (ja) | 1992-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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