AU605920B2 - Morpholinyl silanes and use for control of plant diseases caused by fungi - Google Patents

Description

AUSTRALIA

Patents Act UZI/5E2f COMPLETE SPECIFICATION

(ORIGINAL)

Glass Int. Class Application Number: Lodged: Complete Specification Lodged: Accepted: Published: Priority Related Art: This documnent contains the amndments mpade under Section 49 and is correct for Iprinting.

*a a 0 0 .0 0. 0 Name(s) of Applicant(s): THE DOW CHEMICAL APPLICANT'S REF.: Dow Case 35,858-F ATOr-C-M Q)t-t MLC/- COMPANY AND -M&T-C-HEM1-AS-3N-.

Address(es) of Applicant(s): 2030 Dow Center, Abbott Road, Midland, Michigan 48640, United States of America Q~ie-Wedride-eenter 7 Un:ted-Sba-es-of-Areriea Actual Inventor(s): Chrislyn M. Carson, Leonard G. Copping, Robert J. Ehr, Melvin H. Gitlitz, Maynard W. McNeil, Peter F.S. Street, John W. Leibeschuetz o oo 0 04 0 00 0 0 a as 00 0 0 0 0 0 00 040000 0 0 o 000 Address for Service is: PHILLIPS, ORMONDE AND FITZPATRICK Patent and Trade Mark Attorneys 367 Collins Street Melbourne, Australia, 3000 Complete Specification for the invention entitled: MORPHOLINYL SILANES AND USE FOR CONTROL OF PLANT DISEASES CAUSED BY FUNGI The following statement is a full description of this invention, including the best method of performing it known to applicant(s): P 19/3/84 -1- MORPHOLINYL SILANES AND USE FOR CONTROL OF PLANT DISEASES CAUSED BY FUNGI This invention relates to certain novel aryl substituted morpholinyl silanes, compositions containing said compounds and to their use as agricultural fungicides.

Various aminosilanes are disclosed in the chemical literature. The invivo fungicidal activity of several aminosilanes containing a substituted phenyl 10 group or an N-morpholinopropyl group bonded to silicon is discussed in an article by E. Lukevics et al. [Latv.

PSRZinat.Akad. Vestis, Kin. Serv. 3, 343-349 (1978)].

These compounds exhibit at most only moderate activity S° against wheat rust, tomato late blight and cucumber 15 t o powdery mildew. None of the compounds disclosed in this reference contain both a substituted aryl group and an aminoalkyl group wherein the nitrogen atom is part of a morpholine ring.

S" 20 European Patent Application No. 0241429 1 discloses interalia certain silicon morpholino compounds ,o which may be represented by the formula: 35,835-F -1(r ~1 i I i-2- I-2-

R

(CH2)n- Si--R 1

N

Am

CH

3

O

CH

3

(A)

in which: A may be hydrogen, C 1

-C

10 alkyl, C 3

-C

7 cycloalkyl, phenyl or trimethylsilyl; R may be alkyl, cycloalkyl or alkoxy; n is 1; and

R

1 is methylene or substituted methylene.

20 The biological activity of compounds structurally related to those patents disclosed in EP Application No. 0241429 (above) is discussed in an article by E.H. Pommer [Pesticide Sci. 15, 285-295 S(1984)]. In this article on page 291, line 1, the 1125 author observes that it was firmly believed ("known") S' in 1984 that for compounds of this general type, the "alkyl chain length must have less than 4 members. The "alkyl chain length" to which he refers corresponds to the length of the chain -CH 2 -Si-R 1 in Formula A above, Ssince Pommer is concerned with the carbon-containing S, analogues of the silicon-containing compounds of Formula A.

This belief that the maximum permissible chain length in the group linking phenyl and morpholine 4 t i 35,835-F -2- -3should be no more than 3 has been widely held, as is illustrated by EP Patent Application No. 0241429 (above).

Surprisingly, it has now been found that compounds of Formula A above in which R1 is an npropylene or an n-butylene group, optionally substutited with 1 or 2 methyl groups, show unexpected fungicidal activity. Accordingly, the present invention provides aryl substituted morpholinyl silanes of the formula: R CH 3 (CH2)n--Si-- R 1 N 0 Am R

CH

3 wherein: S, each A independently represents halogen,

C

1

-C

4 alkyl, CI-C 4 alkoxy, phenyl, phenoxy or ,halomethyl; each R independertly represents C 1

-C

4 alkyl; R1 represents an n-propylene or n-butylene 30 group, optionally substituted with 1 or 2 methyl groups; .a n represents the integer 0, 1 or 2; and 35 m represents the integer 0 to i 35,835-F -3- _r -4- In the present specification and claims, the terms "C1-C 4 alkyl" and "CI-C 4 alkoxy" are employed to designate straight or branched chain alkyl or alkoxy groups of 1 to 4 carbon atoms.

The term "halomethyl" as used in the present specification and claims designate a methyl radical containing from 1 up to 3 halogen atoms, which may be the same or different.

The term "halogen" represents Br, Cl or F.

Preferred compounds of the invention are those on which A is trifluoromethyl, CI-C 4 alkyl, Cl or F.

More preferred compounds are those where R1 is npropylene or n-butylene.

All the organic and inorganic acids which form stable physiologically-acceptable salts are suitable for salt formation with compounds of Formula Examples of such salts are chlorides, bromides, iodides, sulphates, phosphates, acetates, oxalates, fumarates, malonates, alkylsulphonates, arylsulphonates, alkylarylsulphonates, octanoates and S; 25 oleates.

The salts are obtained by mixing the corresponding acid with the free amine of Formula if necessary in an inert solvent, distilling off the solvent and recrystallizing the residue as necessary.

Alternately, water soluble salts such as phosphates and acetates may be prepared as aqueous solutions, for ease 4 4 of formulation, by neutralization of the free amine in an equimolar amount of the acid. Oil soluble acid t .4-1 3 t 1 9 1 35,835-F -e derivatives such as the oleate may also be prepared by a similar means in an organic solvent such as xylene.

The compounds of Formula effectively control a variety of undesirable fungi which infest useful plant crops. Many of the compounds are particularly effective against organisms such as Erysiphe graminis which cause powdery mildew of grains, particularly barley and wheat, Psuedocercosporella (eye sport on wheat and barley), and Pyricularia (rice blast).

Compositions containing the compounds of Formula (I) together with a carrier can be applied to the roots, seeds or foliage of the barley or other plants and will kill or control the growth of various fungi without damaging the commercial value of said plants. Many of these compositions are unique because of their systemic action and because of the very low levels of chemical required to control powdery mildew.

20 20 These chemicals may be prepared as dusts, granular formulations, wettable powders, flowable concentrates, or emulsifiable concentrates.

I

The invention includes within its scope a method for the killing or controlling of fungus diseases which attack plants or plant parts which comprises applying to the plants or plant parts a fungicidally effective aomount of a compound of Formula or a composition in accordance with the invention.

Another advantage of the present invention is that a single application of the compositions can provide a residual control of powdery mildew diseases 35 over an extended period. Also, the compounds can be effective in eliminating established barley powdery f.

35,835-F r, -6mildew infestation. Furthermore, many compounds have been found to be translocated in plants and, thus, can provide a systemic protection against powdery mildew.

5 The method of the present invention comprises contacting plants, especially cereal grain plants, with a fungicidal amount of one or more of the compounds of Formula The present invention also embraces the employment of a liquid, powder, dust or granular composition containing one or more of the active compounds of Formula in intimate admixture with inert, non-phytotoxic materials, known in the art as agricultural adjuvants and/or carriers, in solid or liquid form. Thus, for example, the active compound(s) can be admixed with one or more additives including organic solvents, petroleum distillates, water or other liquid carriers, surface active dispersing agents, and finely divided inert solids. In such compositions, the active ingredients are present in a concentration from 2 to 95 percent by weight, preferably 10 to 95 percent by weight, and most advantageously 10 to 75 percent by weight of the morpholinyl silane compound. The compound of Formula can be employed in the form of diluted flowable compositions or a wettable powder composition containing 2 to 10,000 ppm of morpholinyl silane compound, preferably 10 to 600 ppm are employed.

When the carrier contains a surface active agent, from 0.1 to 20 percent by weight of the active ingredient is advantageously employed. Depending upon the concentration in the composition, such augmented compositions are adapted to be employed for the control of the undesirable fungi or employed as concentrates Sand subsequently diluted with additional inert carrier, e.g. water, to produce the ultimate treating 383--6 35,835-F -6- -i -1 a _I -7compositions. In general, good results can be obtained with liquid compositions containing from 0.0001 to percent by weight of the toxicant in the final diluted form. With dusts, good results can usually be obtained with compositions containing from 0.1 to 2.0 percent or more by weight of toxicant. Where the compositions are to be applied to foliage of plants, it is preferred that the toxicant be present in an amount not to exceed about 0.8 percent in liquid compositions and about percent in dusts. In terms of hectarage application, good controls of powdery mildews can be obtained when the active ingredients are applied to growing plants at a dosage of from 0.004 to 4 kg/hectare. When employed dS fungicides for the treatment of seeds or non-living substrates, from 0.1 to 1 gram of morpholinyl silane per kilogram of substrate is an effective dose.

In the preparation of dust, or wettable powder compositions, the toxicant products can be compounded with any of the finely divided solids as a carrier, such as prophyllite, talc, chalk, gypsum, fuller's earth, bentonite, attapulgite, starch, casein, gluten, or the like. In such operations, the finely divided carrier is ground or mixed with the toxicant or wet with a solution of the toxicant in a volatile organic solvent. Also, such compositions when employed as concentrates can be dispersed in water, with or without 3 the aid of dispersing agents to form spray mixtures.

Dust compositions are advantageously employed when treating seeds.

It Granular formulations are usually prepared by 8:48": impregnating a solution of the toxicant in a volatile lo 35,835-F -7- 35,835-F -7-

_I

-8organic solvent onto a bed of coarsely divided attapulgite, bentonite, diatomite, or the like.

Similarly, the toxicant products can be compounded with a suitable water-immiscible inert Sorganic liquid and a surface active dispersing agent to i produce an emulsifiable concentrate which can be further diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions which may optionally contain water miscible organic co-solvents to improve the physical properties of the formulation. In such compositions, the carrier comprises an aqueous emulsion, a mixture of inert water-immiscible solvent and optional water miscible organic co-solvent, emulsifying agent, and water.

Emulsifiers which can be advantageously employed herein can be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a blend of two or more emulsifiers. Examples of nonionic emulsifiers useful in preparing the emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxide or mixtures of ethylene and propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters solubilized with the polyol or polyoxyalkylene. Cationic emulsifiers Sinclude quaternary ammonium compounds and fatty amines.

Anionic emulsifiers include the oil-soluble salts calcium) of alkylaryl sulphonic acids, oil s'3 soluble salts of sulphated polyglycol ethers and appropriate salts of phosphated polyglycol ether.

35,835-F -8- 35,835-F -8- L -9- The preferred emulsifiers will depend upon the nature of the emulsifiable concentrate. For example, an emulsifiable concentrate of a compound of Formula containing 200 g/l of the compound in xylene may require a blend of an ethoxylated nonyl phenol and calcium dodecyl benzene sulphonate to function effectively whereas a similar emulsifiable concentrate of the oleate salt of a compound of Formula soluble in an aliphatic organic solvent will require a considerably different emulsification system.

Representative organic liquids which can be employed in preparing the emulsifiable concentrates of the present invention are the aromatic liquids such as xylene; propyl benzene fractions; or mixed naphthalene fractions; mineral oils substituted aromatic organic liquids such as dioctyl phthalate; kerosene; butene; dialkyl amides of various fatty acids, particularly the dimethyl amides of fatty glycols and glycol derivatives such as the n-butyl ether, ethyl ether or methyl ether of diethylene glycol, the methyl ether of triethylene glycol. Mixtures of two or more organic liquids are also often suitably employed in the preparation of the emulsifiable concentrate. The preferred organic liquids are xylene, and propyl benzene fractions, with xylene being most preferred. The surface active dispersing agents are usually employed in liquid compositions and in the amount of from 0.1 to percent by weight of the combined weight of the dispersing agent and active compound. The active compositions can also contain other compatible additaments, for example, plant growth regulators and Sother biologically active compounds used in agriculture.

35,835-F -9- L" i L_ Especially, these active compositions may contain adjuvant surfactants to enhance the deposition, wetting and penetration of the composition onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will vary from 0.01 to 1.0 percent v/v based on a spray-volume of water, preferably 0.05 to percent. Suitable adjuvant surfactants include 10 ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts of the esters of sulphosuccinic Sacids, ethoxylated organosilicones, ethoxylated fatty i amines and blends of surfactant with mineral or 15 vegetable oils.

i In such embodiments, the compounds of the i present invention or compositions containing the same, can be advantageously employed in combination with one or more additional pesticidal compounds. Such i additional pesticidal compounds may be insecticides, nematicides, miticides, arthropodicides, or bactericides that are compatible with the compounds of the present invention in the medium selected for i 25 application and not antagonistic to the activity of the I present compounds. Accordingly, in such embodiments, the pesticidal compound is employed as a supplemental I toxicant for the same or for a different pesticidal use or as an additament. The compounds in combination can generally be present in a ratio of from 1 to 100 parts of the compound of Forumula with from 100 to 1 part of the additional compound(s).

The exact amount of the active material to be 3 applied is dependent not only on the specific active material being applied, but also on the particular 35,835-F r -11action desired, the fungal species to be controlled and the stage of growth thereof as well as the part of the plant to be contacted with the toxic active ingredient.

Thus, all of the active ingredients of the present invention and compositions containing the same may not be equally effective at similar concentrations or against the same fungal species.

The organosilanes employed in this invention can be prepared using known synthetic procedures. As an example, dimethylchlorosilane,

CH

3 Cl-Si-H

(VIII)

CH

3 may be reacted with allyl chloride to form dimethylchloropropylchlorosilane,

CH

3 Cl-Si-(CH 2 3 -Cl

(IX)

CH3 This product may then be reacted with an appropriate phenyl magnesium halide such as p-chlorophenyl magnesium bromide, to yield

CH

Cl Si-(CH 2 3 -Cl (x)

CH

3 35,835-F -11- -12- The reacti.on of this product with 2,6-dimethylmorpholine yields dimethyl 3-(2,6--dimethyl-l4-morpholino)propyl-p-ohlorophenyls ilane CR 3 Si-(CH 2 3

N

CH

3

CH

3

(XI)

CR

3 The following equations represent general methods for preparing the organosilanes of the present invention.

II I 35,835-F -2 -12-

I

Z-Si-C1 C1Mg-'N

I

(II)

1 CH 3 CH 3 R 1 0 Z-S-R-N 0 MgC1 2 3

(III)

CH 3 2.

R

Z-Si-B -CI-.2 HN

(IV)

CH 3

R

0 Z-Si-B -N C H 3 0 +HClo HN CH 3 CH3 \-4CH3 CR3 (IVa)

R

Z-SiH 0H 2

=CHCH

2

-N

I

(V)

CH

3 CH 3 0 +Z-Si(CH- 2 3

-N

CH3

CH

3 (Va) CH 3

CH=CH

2 +H-Si-B-N 0 R

CH

3

CH

3

R

CH

2

CH

2 -Si-R-N 0 CH 3 Am

(VI)

(VII)

In the foregoing formulae, Z is (CH2)n and A, m, n, R and RI are as previously defined.

The silanes employed as starting materials in the foregoing equations are either commercially available, particularly in those instances when A represents methyl, or can be synthesized using known preparative methods. Some of these methods are described in the following examples.

2,6-Dimethylmorpholine employed as a starting material and its cis- and trans- stereoisomers are well known and can be obtained commercially.

In the following examples, all parts and percentages are by weight unless otherwise specified.

I 4% 4 1 1 111 35,835-F i i 4 -16- Example 1 Dimethyl-3-(2,6-dimethyl-4-morpholino)- -propyl-4-chlorophenethylsilane

CCHH

3 CH3 3 Cl (CH 2 2 -Si-(CH 2 3 -N 0 (I)

CH

3

CH

3 Step A: Preparation of 3-(2,6-dimethyl-4- -morpholino)propyl magnesium chloride

CH

3 ClMg-(CH 2 3 -N 0 (III)

CH

3 A glass reactor equipped with a motor driven agitator, a thermometer and a water-cooled reflux condenser was charged with 315 g (2 mol) of 1-chloro-3-bromopropane. The contents of the reactor were heated to 50 0 C and 461 g (4 mol) of 2,6-dimethyl- -morpholine was gradually added. The temperature of the reaction mixture was maintained between 40 and 50 0

C

for 1 hours, at which time heating was discontinued and the reaction mixture was allowed to cool to ambient temperature. A 500 ml portion of water and 500 ml of S hexane were then added to the reaction mixture, followed by 90 g of sodium hydroxide. The organic phase of the resultant two-phase liquid was separated I and retained. The aqueous phase was shaken together 35,835-F -16-

A

-17with 500 ml chloroform and the chloroform phase was separated and combined with the initial organic phase.

The aqueous phase was discarded and the water present in the organic phase was removed using anhydrous magnesium sulfate. The solvents present in the liquid phase were evaporated under the reduced pressure supplied by a water aspirator. The residue was distilled under a pressure of 15 mm of mercury. The fraction boiling from 103 to 111°C (vapor temperature) was collected and weighed 366.5 g. Analysis of this fraction by vapor phase chromatography indicated that it was 95 percent pure 4-(3-chloropropyl)-2,6-dimethylmorpholine.

A glass reactor was filled with nitrogen and charged with 2 g of magnesium chips, 25 ml of anhydrous tetrahydrofuran and a few drops of methyl iodide and ethylene dibromide. When a reaction initiated a small portion of a solution containing 192 g of the product obtained above in and one liter of anhydrous tetrahydrofuran was added gradually until the reaction became self-sustaining. A 22 g portion of magnesium was then added to the reactor, following which the remainder of the aforementioned solution of 4-(3-chloropropyl)-2,6-dimethylmorpholine in tetrahydrofuran was gradually added with slow agitation. External heating was employed as required to sustain the reaction. Following completion of the i 30 Saddition, the contents of the reactor were heated to the boiling point for two hours. The reaction mixture ,i was allowed to cool under a nitrogen atmosphere. 1.7 g Sof magnesium was recovered, indicating that the reaction was 92 percent completed.

S

3 4 i 35,835-F -17- -18- Step B: Preparation of dimethyl-3-(2,6-dimethyl-4- -morpholino)propylsilane

H--

HSi-(CH 2 3 -N 0 (VII) CH3 J

CH

3 To a glass reactor, fitted with a motor driven agitator, thermometer, dropping funnel and water-cooled condenser, was added 29.2 g dimethylchlorosilane and 100 ml diethyl ether. While cooling the reactor with San ice-bath, 0.3 moles of the Grignard reagent prepared in above was added dropwise via the dropping funnel over a period of two hours while keeping the reactor temperature between 10 and 20 0 C. The reaction mixture was allowed to stir overnight. To the reaction mixture 20 was then added 300 ml of a 10 percent aqueous solution of citric acid with vigorous stirring. The mixture was transferred to a separatory funnel and the organic layer separated and evaporated to constant weight, leaving 68.0 g of a golden yellow liquid. On distil- 25 lation of this liquid under vacuum, 60.9 g (93 percent) of a light yellow liquid boiling at 47-500C at 0.2 mm was obtained. Infrared spectroscopy showed the presence of strong Si-H absorption and the NMR spectrum was consistent with the expected structure.

Step C: Reaction of p-chlorostyrene with dimethyl-3- -(2,6-dimethyl-4-morpholino)propylsilane To a glass reactor fitted with a magnetic Sstirrer, thermometer and water-cooled reflux condenser was charged with 10.0 g of dimethyl-3-(2,6-dimethyl-4n~r .:I .5835 3-F 18effective in eliminating established barley powdery 35,835-F i -19- -morpholino)propylsilane, 6.4 g of p-chlorostyrene and 0.1 g chloroplatinic acid in 1 ml isopropanol. The reaction mass was heated to 1000C with stirring and kept at 100-108C for half an hour, then cooled to room temperature. Low boiling impurities and unreacted starting materials were removed by distillation at 0.2 mm in an oil bath at 128'C. The residue was a light brown liquid and weighed 15.0 g. Analysis showed the compound to contain 8.0 percent silicon, 9.2 percent and 3.5 percent nitrogen.(Tecluad values Of silicon, chlorine and nitrogen for the compound are 7.9 percent, 10.0 percent and 3.9 percent, respectively.) The NMR spectrum was consistent with expected structure (Compound 1).

.4 t 35,835-F -19- I I I Example 2 Dimethyl-3-(2,6-dimethyl-4-morpholino)propyl- -4-t-butylphenylsilane -CH3

(CH

3 3 C--Q Si-(CH 2 3

-N

0

C

C

r-K 0

H

3 l 3 ~CH3.* 466444 o ar 4 41

I

Do 4 0 61 o 4 4I 4 4 1 61 4 I 64 4 Step A: Preparation of 3-chloropropyldimethylchlorosilane CH3 C1-Si-(CH 2 3 Cl

CH

3 To a glass reactor equipped with a mechanically-driven stirrer, thermometer and dropping funnel was added 25 ml of a mixture of 1 ml of a 20 percent solution of chloroplatinic acid, 189.2 g dimethylchlorosilane and 157 g allyl chloride. The reaction mass was heated to 100°C and the remainder of the chlorosilane/allyl chloride mixture was added dropwise over a period of two hours while maintaining the reaction mass at 80 0 C. After the addition was complete, the reaction mass was stirred for one hour at 80 0 C and allowed to cool to room temperature.

The product was distilled at atmospheric pressure and the fraction boiling at 165-175°C was collected. It weighed 167.7 g and was a colorless, 35,835-F -21mobile liquid. Its NMR spectrum was consistent with the expected product.

Step B: Preparation of 4-t-butylphenyl-3-chloropropyldimethylsilane CH3

(CH

3 Si-(CH) 3 Cl1 (IV) i CH 3 ii I 15 To a glass reactor fitted with a motor-driven stirrer, a thermometer, water-cooled reflux condenser i! and dropping funnel was charged 0.5 moles of 4-t-butyli phenylmagnesium bromide in THF (prepared in the usual manner from 4-t-butylbromobenzene, magnesium chips and tetrahydrofuran). While maintaining an atmosphere of nitrogen in the reactor, 64.0 g of 3-chloropropyldimethylchlorosilane (prepared in Step A above) was added dropwise to the reactor over a period of minutes, keeping the temperature between 35-40cC. After the addition was complete, the mixture was stirred for one hour while allowing the reaction temperature to drop to ~30 0 C. To this mixture was added 400 ml of a percent aqueous ammonium chloride solution. The organic layer was separated and dried over magnesium 4 sulfate. After evaporation of solvent, the residue, weighing 113.6 g, was distilled under vacuum. The fraction boiling at 110-120°C at 0.5 mm was collected.

It weighed 93.2 g and was a colorless, oily liquid of refractive index 1.5088 at 23°C. Analysis showed the compound to contain 67.4 percent carbon, 9.2 percent 35,835-F -21- -u -22hydrogen and 13.0 percent chlorine. Theory for the compound is 67.0 percent carbon, 9.4 percent hydrogen and 13.2 percent chlorine. Gas chromatography showed the compound to be -90 percent pure.

Step C: Reaction of 4-t-butylphenyl-3-chloropropyldimethylsilane with 2,6-dimethylmorpholine 15.0 G 4-t-butylphenyl-3-chloropropyldimethylsilane (prepared in Step B above) and 13.0 g 2,6-dimethylmorpholine were charged to a glass reactor fitted with a reflux condenser, mechanical stilrer and thermometer. The mixture was refluxed for three hours, then cooled to room temperature. A solution containing 5 g sodium hydroxide in 50 ml water was added, followed by 25 ml diethyl ether with vigorous stirring. The organic phase was separated and dried over anhydrous magnesium sulfate. After evaporation of the solvent, the crude product was distilled under vacuum. The product fraction boiling at 163-168 0 C at 0.4 mm was collected. It was a yellow, oily liquid of refractive index 1.5017 and weighed 15.7 g. Analysis showed it to contain 72.8 percent carbon, 10.7 percent hydrogen and S 25 3.8 percent nitrogen. Theory for the compound is 72.6 i i percent carbon, 10.7 percent hydrogen and 4.0 percent nitrogen. Gas chromatography showed the product to be percent pure. Its NMR spectrum was consistent with the expected structure (Compound 2).

35,835-F -22- 3tF 35,835-F -22rl -23- Example 3 Dimethyl-3-(2,6-dimethyl-4-morpholino)propyl- -3, 4 -dichlorophenylsilane C C3CH3 Cl Si-(CH 2 3 -N 0 (I)

CH-

CH

3 i Preparation of 3-(2,6-dimethyl-4-morpholino)i propyl magnesium chloride 1 A glass reactor equipped with a motor driven agitator, a thermometer and a water-cooled reflux Icondenser was charged with 315 g (2 moles) of 1-chloro- -3-bromopropane. The contents of the reactor were Sheated to 50 0 C and 461 g (4 moles) of 2,6-dimethylmorpholine was gradually added. The temperature of the reaction mixture was maintained between 40 and 500C for 1- hours, at which time heating was discontinued and 25 the reaction mixture allowed to cool to ambient i temperature. A 500 ml portion of water and 500 ml of hexane were then added to the reaction mixture, S|followed by 90 g of sodium hydroxide. The organic Sphase of the resultant two-phase liquid was separated and retained. The aqueous phase was shaken together with 500 ml chloroform and the chloroform phase was separated and combined with the initial organic phase.

1 The aqueous phase was discarded and the water present in the organic phase was removed using anhydrous magnesium sulfate. The solvents present in the liquid phase were evaporated under the reduced pressure 35,835-F -23-

I~

applied is dependent not only on the specific active material being applied, but also on the particular 35,835-F i 7t -24supplied by a water aspirator. A solid precipitate formed in the residual liquid. The solid was removed by filtration and the filtrate was shaken together with an aqueous solution of sodium hydroxide. The aqueous layer was then separated, discarded and the water present in the organic layer was removed using anhydrous magnesium sulfate. The volatile materials were removed from the liquid phase by evaporation and the residue was distilled under a pressure of 15 to 41 mm of mercury. The fraction, boiling from 103 to 111°C (vapor temperature), was collected and weighed 366.5 g.

Analysis of this fraction by vapor phase chromatography indicated that it was 95 percent pure.

15 A glass reactor was filled wih nitrogen and charged with 2 g of magnesium chips, 25 ml of anhydrous tetrahydrofuran and a few drops of methyl iodide and ethylene dibromide. When a reaction initiated, a small portion of a solution containing 192 g of the product obtained as described in the first paragraph of this example and one liter of anhydrous tetrahydrofuran were added gradually until the reaction became self-sustaining. A 22 g portion of magnesium was then added to the reactor, following which the remainder of the aforementioned solution of N-(3-chloropropyl)-2,6-dimethylmorpholine in tetrahydrofuran was gradually added with slow agitation. External heating was employed as required to sustain the reaction. Following completion 30 of the addition, the contents of the reactor were heated to the boiling point for two hours without agitation. The reaction mixture was allowed to cool and then stored under a nitrogen atmosphere. A 1.7 g portion of magnesium was recovered, indicating that the reaction was 92 percent completed.

35,835-F -24- 35,835-F -11- 4i t Preparation of dimethyl(3,4-dichlorophenyl)bromosilane

OH

3 Cl Si-Br CH3 charged with 11 g (0.45 mole) of magnesium chips. A solution containing 100 g (0.44 mole) of 4-bromo-1,2- -dichlorobenzene and 300 ml anhydrous diethyl ether was gradually added at a rate which maintained the reaction mixture at the boiling point. Following completion of the addition, external heating was applied to the reactor for one hour to maintain the reaction mixture at the boiling point. The mixture was then allowed to cool to ambient temperature and stored for about 16 hours, at which time 50 ml (0.45 mole) of dimethylchlorosilane were gradually added. An exothermic reaction accompanied the addition, following which the reaction mixture was stirred for 20 minutes at ambient temperature. The reaction product was then hydrolyzed using an aqueous solution of ammonium chloride and the aqueous phase of the resultant two-phase liquid was separated and discarded. The water present in the organic layer was removed using anhydrous magnesium sulfate, following which the organic solvents were removed from the liquid phase by evaporation under reduced pressure. The residue was then distilled under a pressure of from 0.1 to 0.2 mm of mercury and the fraction, boiling from 48 to 60°C (vapor temperature), was collected. This fraction weighed 83.2 g (equivalent to a yield of 92 percent) and was found to 35,835-F i, 1 -26contain 47.56 percent carbon, 5.02 percent hydrogen and 33.60 percent chlorine. The calculated values for the expected product, dimethyl(3,4-dichlorophenyl)silane, are 46.8 percent, 4.9 percent and 34.6 percent, respectively.

A glass reactor was charged with 19.1 g (0.093 Smole) of dimethyl(3,4-dichlorophenyl)silane and 200 ml of petroleum ether. This mixture was cooled to at which time a solution containing 14.9 g (0.093 mole) of bromine and 200 ml petroleumn ether was gradually added, with agitation, to the reaction mixture. A decolorization of the bromine was observed. The cooling bath was removed as the bromine addition Sprogressed. The resultant reaction mixture was stirred for one hour at ambient temperature following completion of the bromine addition. The volatile materials present in the reaction mixture were removed 20 by evaporation under reduced pressure. The residue weighed 26.3 g, which is equivalent to a yield of 100 percent.

Reaction of dimethyl-3,4-dichlorophenylbromosilane with 3-,(2,6-dimethylmorpholino)propyl- Smagnesium chloride A glass reactor was charged with .he Grignard reagent prepared as described in part of this example under a nitrogen atmosphere. A 50 ml portion of anhydrous tetrahydrofuran was added to the reactor, followed by the gradual addition of the bromosilane Sprepared as described in part of this example.

Upon completion of this addi in, the contents of the reactor were stirred and maintained under ambient conditions for about 64 hours, at which time an aqueous 35,835-F -26- -27solution of ammonium chloride was added to the contents of the reactor. The organic phase was then separated, the water present therein was removed using anhydrous magnesium sulfate and the volatile solvents were evaporated under reduced pressure. The residue, which weighed 40.8 g, was then distilled under a pressure of 0.15 mm of mercury and the fraction, boiling from 150 to 157°C (vapor temperature), was collected and analyzed. This fraction was found to contain 56.49 percent carbon, 7.59 percent hydrogen and 19.52 percent chlorine. The calculated values for the expected product, represented by the formula CH3 -Si-I CH3

CH

3 CH2) 3 -N 0 (I)

CH

3 are 56.7 percent, 7.5 percent and 19.7 percent, respectively (Compound 3).

tt i 4 404.448 4 I 1 t 35,835-F -27i -28- Example 4 Dimethyl-4-(2,6-dimethyl-4-morpholino)-butyl- 4 -chlorobenzylsilane CH3

CH

3 C 3 Cl CH 2 -Si-(CH 2 4 -N 0 (I) CCH3

C

3

CH

3 Step A: Preparation of 4-chlorobenzyldimethyl-4chlorobutylsilane

CH

3 Cl

CH

2 -Si-(CH2) 4 -C

(IV)

CH

3 In a 500 ml glass reactor fitted with a mechanically driven stirrer, thermometer, nitrogen inlet, dropping funnel and water-cooled reflux condenser was charged 7.9 g magnesium chip. Via the dropping funnel was added a solution of 47.5 g 4-chlorobenzyl chloride in 200 ml diethyl ether with stirring over a period of half an hour. After the addition was complete, the reaction was refluxed for hour, then cooled to room temperature. To the Grignard reagent was added a solution of 31.0 g 3 chlorodimethyl-4-chlorobutylsilane (Petrarch Systems Inc., Bristol, PA) in 50 ml ether. The reaction mixture was refluxed for one hour after the addition was complete, then cooled to room temperature. A solution of 10 g citric acid in 200 ml water was added to hydrolyze the reaction. The organic layer was 35,835-F -28d 1 ii I -29separated, dried over magnesium sulfate and the solvent removed at room temperature under vacuum. Low boiling impurities were removed by distillation at 150°C under mm vacuum. The residue was a yellow oil. Vapor phase chromatography showed the compound to be about percent pure. Its NMR spectrum was consistent with the expected compound.

Step B: Reaction of 4-chlorobenzyldimethyl-4-chlorobutylsilane with 2,6-dimethyl morpholine In a 250 ml glass reactor equipped with a magnetic stirrer, water-cooled reflux condenser and thermometer was charged 30.0 g 4-chlorobutyldimethyl-4- -chlorobenzylsilane and 8.3 g 2,6-dimethylmorpholine.

The mixture was heated with stirring to 80 0 C and held at this temperature for 1 hour. The temperature was raised to 1000C for 4 hours, then to 120 0 C for 2 hours, followed by an additional 3 hours heating at 160°C. On 2 cooling to room temperature, the product partially solidified. To the mixture 500 ml diethyl ether was added with vigorous stirring. The mixture was filtered and the solid residue was resuspended in 300 ml of ethyl ether and cooled to 15°C. To the stirred ether suspension, 250 ml of a 3 percent aqueous solution of sodium hydroxide was added over 15 minutes. The organic phase was separated, dried over magnesium sulfate and the solvent evaporated off, leaving 10.3 g of a brownish oil. The product contained 8.7 percent chlorine by combustion analysis. Theory for the Scompound is 10.0 percent. Gas phase chromatography Sshowed the compound to be about 92 percent pure. The NMR spectrum was consistent with the expected product (Compound 4).

35,835-F -29-

S

cl 1 I Example 5 Dimethyl-3-(2,6-dimethyl-4-morpholino)- -propyl-3-(trifluoromethyl)phenylsilane.

CF

3

CH

3 -Si-(CH 2 3

-N

CH3 0 (I)

CH

3

CH

3 Step A: Preparation of 3-(trifluoromethyl)phenyl-3- -chloropropyldimethylsilane.

S 4 4 4 a4i

CH

3 -Si-

CH

3

(IV)

,4 To a solution of 3-(trifluoromethyl)phenyl- S 25 magnesium bromide (prepared from 40.5 g 3-bromobenzotrifluoride, 3.8 g magnesium chips and 100 ml tetrahydrofuran) contained in a glass reactor fitted with a mechanical stirrer, water-cooled reflux condenser, thermometer and dropping funnel, was added dropwise with stirring 25.0 g 3-chloropropyldimethylchlorosilane (prepared as in 2 above) while maintaining the temperature of the reaction at 35 0 C. On completion of the addition, the reaction mixture was refluxed for 1 hour, then cooled to room temperature.

35 S To the reaction mixture was added 300 ml of a percent aqueous solution of citric acid with 1 35,835-F -31vigorous stirring. The organic layer was separated, dried and evaporated to leave 55.6 g of yellow oil.

Distillation of this crude product under vacuum yielded 35.0 g of a colorless liquid boiling at 77-91 0 C at 0.4 mm of index of refraction 1.4714 at 23°C. The product contained 50.9 percent carbon, 5,6 percent hydrogen and 12.4 percent chlorine. Theory for the expected compound is 51.3 percent carbon, 5.7 percent hydrogen and 12.6 percent chlorine. The product was about 93 percent pure by gas chromatography.

Step B: Reaction of 3-(trifluoromethyl)phenyl-3- -chloropropyldimethylsilane with 2,6-dimethyl morpholine.

To a glass reactor fitted with a magnetic stirrer, water-cooled reflux condenser and thermometer was added 15.5 g of m-(trifluoromethyl)phenyl-3- -chloropropyldimethylsilane and 15.0 g 2,6-dimethylo 0 20 o. morpholine. The mixture was refluxed for 1 hour, then cooled to room temperature. To the brown mixture was Sadded a solution of 5 g sodium hydroxide in 50 ml water, followed by 50 ml hexane. The organic phase was separated, dried and the solvent removed at room temperature under vacuum. The residue, a brown oil, was distilled under vacuum and the fraction boiling at 112-129 0 C at 0.35 mm was collected. It was a light yellow liquid of refractive index 1.4735 at 230C. Gas chromatography showed the compound to be greater than percent pure. It contained 60.9 percent carbon, 8.1 percent hydrogen and 3.8 percent chlorine by 4 T' analysis. Theory for the compound is 60.1 percent carbon, 7.8 percent hydrogen and 3.9 percent chlorine.

35,835-F -31- I I -32- The NMR spectrum was consistent with the expected structure (Compound Example 6 Dimethyl 3-(2,6-dimethyl-4-morpholino)propyl-4-chlorophenylsilane I_ CH3 rC 3 Cl i-(CH 2 3 -N 0 (I)

CH

3 CH3 A glass reactor was filled with nitrogen and charged with 281 g (0.485 mole) of p-chlorophenylmagnesium chloride prepared by reacting p-chlorobromop: benzene with magnesium chips using anhydrous diethyl 20 ether as the reaction medium. An 83 g portion of dimethylchloro-3-chloropropylsilane, prepared as described in the preceding Example 2 wa3 gradually added to the reaction. Following completion of the 0 9 S 25 addition, the contents of the reactor were heated to the boiling point until most of the diethyl ether was removed by distillation. A 150 ml portion of anhydrcus tetrahydrofuran was added to the reactor and the S resultant mixture was heated at the boiling point for S 30 one hour. The reaction mixture was then combined with a stoichiometric excess of an aqueous ammonium chloride o solution, the organic phase was removed and the aqueous S phase was extracted with 200 ml of hexane. The hexane layer was combined with the original organic layer and the water present was removed using anhydrous magnesium sulfate. The solvents and other volatile materials 35,835-F -32- -33were removed under reduced pressure and the residue was distilled under a pressure of 0.1 mm of mercury. The fraction, boiling from 90° to 102°C, was collected.

This fraction, which weighed 95.1 g, was found to contain 52.84 percent carbon, 6.62 percent hydrogen and 28.15 percent chlorine. The calculated values for the expected product, 3-chloropropyl-4-chlorophenyldimethylsilane, are 53.42 percent, 6.51 percent and 28.71 percent, respectively. A 10 g portion of this material and 25 g of 2,6-dimethylmorpholine were charged into a glass reactor and heated to a temperature of from 120 to 130°C for 3- hours. After the contents of the flask had cooled to ambient temperature, a small amount of diethyl ether was added to dissolve the material in the reactor. The resultant solution was evaporated under reduced pressure to remove the diethyl ether and the residue was distilled under a pressure of 0.3 mm of mercury. The fraction, boiling from 127 to 150°C (vapor temperature), was collected. This portion, which weighed 9.7 g, was found to contain 62.7 percent carbon, 8.58 percent hydrogen and 10.33 percent chlorine. The calculated values for the expected 4 product, dimethyl-3-(2,6-dimethyl-4-morpholino)propyl- -4-chlorophenylsilane, are 62.6 percent, 8.7 percent and 10.9 percent, respectively (Compound 6).

35,835-F -33- A c CII""11~.14X~XUY-)-lyli lli*;ili-it*C -34- Employing the above procedures and the appropriate starting materials, the following compounds were prepared: Compound No.

7 dimethyl-3-(2,6-dimethyl-4- -morpholino)propyl-2,6dichlorobenzylsilane 8 dimethyl-3-(2,6-dimethyl-4- -morpholino)propyl-2chlorobenzylsilane 9 3-(2,6-dimethyl-4-morpholino)propyldimethylphenylsilane dimethyl-3-(2,6-dimethyl-4- -morpholino)propyl-4chlorobenzylsilane 11 dimethyl-3-(2,6-dimethyl-4- -morpholino)propyl-4- -phenoxyphenylsilane 12 dimethyl-3-(2,6-dimethyl-4- -morpholino)propyl-4methoxyphenylsilane 0 0 o 000 0 0 o o 0 0 0 o 0 0 0 00 0 0" 030 0 00 0 00 The organosilanes disclosed in the preceding examples were evaluated for fungicidal activity by applying the test compound, in diluted form, to a host plant. The plants were inoculated with the fungus (in spore form) and stored in a greenhouse or other controlled environment until untreated plants, used as controls, became infested with the fungus. The treated plants were then visually inspected and assigned a rating based on the percentage of total leaf area that had not become infested.

I* i p S0 0 0 0 0 000 00 0 0 0 0 000 35,835-F -34- Formulations containing the test compounds were prepared from concentrates in acetone. The silane compound (0.04 g) was dissolved in 10 ml of acetone and ml of water and 2 drops of a wetting agent were added to form a 400 ppm solution of the morpholinyl silane for application to leaves or roots.

The specific procedures employed invivo to evaluate the test compounds against particular fungi are described in the following paragraphs.

Procedure A Barley Powdery Mildew Foliar and Soil Drench Test Approximately 10 barley seeds (cv. Golden Promise) were sown at a depth of 4 inch (1.2 cm) into a 3-inch (7.6 cm) plastic pot containing sterilized loam soil. The pots were maintained under greenhouse conditions until the barley had germinated and reached a height of 3 to 5 inches (7.6 to 11.7 cm). The foliage was then sprayed with a 400 ppm solution of the test chemical and 10 ml of the same chemical applied as 2 a soil drench at a concentration of 400 ppm to each S 25 pot. The treated plants were held under greenhouse conditions for 24 hours and then inoculated with conidia of Erysiphegraminishordeii by brushing the foliage with heavily sporulating plants.

30 The plants were assessed for disease levels after 5 to 8 days when the treated, inoculated tests S showed good disease levels.

35,835-F I I 1 i- ir I-36- SProcedure B Barley Powdery Mildew Eradicant Test, Foliar Application i Barley was grown as for the foliar and soil 4 I drench test. Plants were inoculated by dry dusting of 4 spores from heavily infested plants and then maintained under greenhouse conditions for 3 days. They were then sprayed with a 100 ppm solution of the test chemical onto the leaves. The plants were maintained under i greenhouse conditions and the symptoms assessed 5 to 8 days later by comparing the sporulation on plants i treated with experimental chemical to untreated but Suninoculated plants.

-i i Procedure C Rice Blast Foliar and Soil Drench Test Approximately 10 seeds of barley (cv. Golden Promise) were sown at a depth of inch (1.2 cm) into a 3-inch (7.6 cm) plastic pot containing sterilized loam.

i The pots were maintained under greenhouse conditions i until the plants had germinated and reached a height of 25 3-5 inches (7.6 to 11.7 cm). The foliage was then ,i sprayed with a tcit chemical at a 400 ppm concentration in solution and 10 ml of this same solution was poured Sonto the soil of each pot. The treated plants were held in a greenhouse for 24 hours and then inoculated with 1 x 106 conidia per ml of Pyriculariaoryzae (rice iblast) by spraying the spores onto the leaves. The plants were placed into a chamber with 100 percent S relative humidity for 48 hours and then removed and held in a greenhouse for 5 to 7 days and assessed when 35,835-F -36i -37symptoms of the disease appeared on the untreated, inoculated plants.

The results of test of procedures A, B and C are set forth hereinafter in Table 1.

I

:4: 35,835-F -37-j TABLE 1 INVIVO BIOLOGICAL EVALUATION PERCENT EFFICACY OF THE COMPOUNDS INVIVO COMPOUND BARLEY POWDERY BARLEY POWDERY RICE BLAST COMPOUND RICE BLAST MILDEW MILDEW NUMBER (PROCEDURE C) NUMBER (PROCEDURE A) (PROCEDURE B) (PROCEDURE C) 1 100 90 100 2 100 NT NT 4 97 NT NT 100 NT NT 8 100 90 100 9 93 NT NT 100 75 100 11 100 NT NT NT Not Tested .i

I

s= crrv 1 1: q r

I

-39- Procedure D invitro test against 8 organisms Test chemicals were added to liquid potato dextrose agar in plastic petri dishes at a final concentration of 40 ppm and then the agar allowed to cool and set to a solid. Discs of actively growing fungi of the following plants pathogenic species: Alternaria brassisicola (leaf spot), Pyriculariaoryzae, Fusarium oxysporum f. sp. phaseolicola, Pyrenophorateres (net blotch), Phytophthora citricola, Rhizoctonia cerealis, Colletotrichum coffeanum and Verticilliumalbo-atrum were placed onto the chemical incorporated agar. Radial growth of the fungi was measured after 3-5 days when growth of the fungi on the untreated agar had reached a maximum. The results of 1 said test are set forth hereinafter in Table 2.

6 at 35,835-F -39ii TABLE 2 IN VITRO BIOLOGICAL EVALUATION PERCENT EFFICACY OF THE COMPOUNDS (PROCEDURE D) j j PSUEDOCERC- COMPOUND ALTERNARIA PYRICULARIA FUSARIUM PYRENOPHORA PHYTOPHTHORA RHIZOCTONIA COU L1-TOTRICHUM VERTICILLIUM OSPORELLA EXAMPLE BRASSISICOLA ORYZAE OXYSPORUM TERES PARASITICA CEREALIS C4.A;FEANUM ALBO-ATRIJM HERPOTRICH-

QIDES

1 100 1 100 70 100 59 100 79 100 100 2 88 100 68 93 87 96 45 90 NT 4 96 100 73 100 93 96 82 90 NT 96 100 27 100 20 86 39 1 100 93 8 100 100 26 80 0 100 33 100 ioo 9 80 100 0 77 7 39 9 81 NT 100 100 40 100 12 100 49 100 96 11 63 100 68 81 80 71 7033 NT -41- In other invivo tests, compound numbers 1, 4, 8, 9, 10 and 11 were found to give at 400 ppm at least percent kill and control of Erysiphegraminiswhen plants were sprayed with the test compound prior to inoculation with spores of the fungal organism. In other Lests, compound numbers 1, 4, 8 and 10 at 400 ppm gave at least percent kill and control of Pucciniarecondita when the plants were inoculated with spores of the fungal organism prior to being sprayed with the test compound.

When some of the compounds were applied at dosage levels of between 2 and 400 ppm, they had the ability to kill, inhibit or otherwise control one or more fungal diseases of plants.

II

35,835-F -41-

Claims (10)

1. A compound having the formula R (CH2)n--Si-R 1 -N R CH 3 0 O CH 3 wherein: each A independently represents halogen, C 1 C 4 alkyl, Ci-C 4 alkoxy, aryloxy or halomethyl; each R independently represents CI-C 4 alkyl; R 1 represents an n-propylene or n-butylene group, optionally substituted with 1 or 2 methyl groups; n is the integer 0, 1 or 2; and m is the integer 0 to 5 inclusive. 35,835-F -42- i .I

2. Formula (I) Any one of the following compounds of as claimed in Claim 1 wherein n is 0: dimethyl-[3-( 2, 6-dimethyl-)4-morpholino)- propyliphenylsi lane, dimethyl-3-( 2, 6-dimethyl-'l-morpholino) propyl- 1

4-methoxyphenylsilane, dimethyl-3-( 2,6-dimethyl-'4-morpholino)- propyl-L4-phenoxyphenylsilane, dimethyl-3-(2, 6-dimethyl-J4-morpholino) propyl- 1 4-chlorophenylsilane, dimethyl-3- 6-dimethyl-4-morpholino) propyl-3, 4-dichlorophenylsilane. dimethyl-3-(2, 6-dimethyl-4-morpholino)- propyl-4-t-butylphenylsilane, or dimethyl-3-(2, 6-dimethyl-4- -morpholino)propyl-3-( trifluoromeVthyl)- phenylsilane. 3. formula (I) Any one of the following compounds of as claimed in Claim 1 wherein n is 1: dimethyl-4-(2 ,6-dimethyl- 1 4-morpholino)butyl- 4-chlorobenzylsilane, dimethyl-3-[2,6-dimethyl-3-(2,6-dimeth,-4- morphol ino) propyl]-2-chlorobenzyl s ilane, dimethyl-3- 6-dimethyl-4-morpholino) propyl-LI-chlorobenzylsilane, or 35,835-F -44- dimethyl-3-(2,6-dimethyl-4-morpholino)- propyl)-2,6-dichlorobenzylsilane. 4. A compound of Formula as claimed in Claim 1 wherein n is 2; namely, dimethyl-3-(2,6-dimethyl-4-morpholino)- propyl-4-chlorophenethylsilane. A fungicidal composition which comprises at least one of a compound as claimed in any one of claims 1 through 4, together with a carrier.

6. A composition as defined in Claim 5 which i is in the form of a dust, an emulsifiable concentrate, I 15 a flowable concentrate, a wettable powder or a granular formulation.

7. A composition as defined in Claim 6 which i contains from 2 to 95 percent by weight of the 20 morpholinyl silane compound.

8. A composition as defined in Claim 6 which is in the form of a wettable powder containing from 2 to 10,000 ppm of the morpholinyl silane compound. -4 525 i25 9. A method for the killing or controlling of Sfungi which attack plants or plant parts which E comprises applying to the plants or plant parts a i fungicidally effective amount of a compound as claimed in any one of Claims 1 through 4, or a composition as claimed in any one of Claims 5 through 8. A process for preparing a compound of Formula as defined in Claim 1, which comprises reacting a compound of the formula 35,835-F -4 35,835-F -44- i (CH 2 Si-- Cl I (II) wherein: A, m, n and R are each defined as in Claim 1, with a compound of the formula CH 3 C1Mg-R N 0 CH3 (III) i. -I -i 111 wherein: R 1 is defined as in Claim 1.

11. A process for preparing a compound of Formula as defined in Claim 1, which comprises reacting a compound of the formula 35,835-F I -46- R (CH2) n Si-- R--R C1 (IV) wherein: Claim 1, A, m, n, R and R 1 are each defined as in with 2,6-dimethylmorpholine.

12. A process for preparing a compound of Formula as defined in Claim 1 wherein A, R, n and m are each defined as in Claim 1 and R1 is n-propylene, which comprises reacting a compound of the formula Si (V) wherein: A, m, n and R are each defined as in Claim 1, with 4-(2-propenyl)-2,6-dimethylmorpholine.

13. A process for preparing a compound of Formula as defined in Claim 1 wherein A, R, R 1 and m are each defined as in Claim 19 and n is 2, which comprises reacting a compound of the formula 35,835-F 1" CHz H 2 (VI) wherein: A and m are each defined as in Claim 1, with a compound of the formula H-S i-RI- (CH 3 q OH 3 (VII) wherein: R 1 is defined as above and R is defined as in Claim 1 4 4, 4 4 44~ 44 4 4 PHILLIPS OPNONDE FITZPATRICK -48-

14. A compound as claimed in claim 1 substantially as hereinbefore described with reference to any one of the examples. A process as claimed in any one of claims 10 to 13 substantially as hereinbefore described with reference to any one of the examples. DATED: 24 October 1990 alzakpz;d 92 9F 9 AU C 0 9 0' PHILLIPS ORMONDE FITZPATRICK Patent Attorneys for: THE DOW CHEMICAL COMPANY and ATOCHEM NORTH AMERICA, INC. 1843U n. i, II j I