ES2095809A1 - Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. - Google Patents
Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales.Info
- Publication number
- ES2095809A1 ES2095809A1 ES09501512A ES9501512A ES2095809A1 ES 2095809 A1 ES2095809 A1 ES 2095809A1 ES 09501512 A ES09501512 A ES 09501512A ES 9501512 A ES9501512 A ES 9501512A ES 2095809 A1 ES2095809 A1 ES 2095809A1
- Authority
- ES
- Spain
- Prior art keywords
- salts
- carboxylic acids
- naphthyridine
- preparing
- aminopyrrolidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 naphthyridine carboxylic acids Chemical class 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WUWFMDMBOJLQIV-UHFFFAOYSA-N 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Chemical compound C1C(N)CCN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1=CC=C(F)C=C1F WUWFMDMBOJLQIV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940124307 fluoroquinolone Drugs 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000005054 naphthyridines Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229950008187 tosufloxacin Drugs 0.000 abstract 1
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 abstract 1
- 229960000497 trovafloxacin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ACIDOS NAFTIRIDIN CARBOXILICOS Y SUS SALES. LA PRESENTE INVENCION TIENE POR OBJETO UN PROCEDIMIENTO PARA LA OBTENCION DE NAFTIRIDINAS DE FORMULA GENERAL 1, EN LAS QUE R ES IGUAL A 3-AMINOPIRROLIDIN-1-ILO (TOSUFLOXACINO O ACIDO (RS) - 7 (3-AMINOPIRROLIDIN-1-IL) -6-FLUORO-1- (2,4-DIFLUOROFENIL) -1,4- DIHIDRO-4-OXO-1,8 -NAFTIRIDIN-3-CARBOXILICO (1A) O A (1AL,5AL,6AL) - 6-AMINO-3-AZABICICLO [3.1.0] HEX-3-ILO (TROVAFLOXACINO O ACIDO 7-[(1AL,5AL,6AL) - 6 AMINO-3- AZABICICLO [3.1.0] HEX-3-IL) -6-FLUORO-1- (2,4-DIFLUOROFENIL) - 1,4-DIHIDRO-4-OXO-1,8 -NAFTIRIDIN-3-CARBOXILICO (1B)] Y SUS HIDRATOS Y SALES RESPECTIVAS, COMPUESTOS DE SINTESIS CON INTERESANTES PROPIEDADES TERAPEUTICAS QUE PERTENECEN A LA FAMILIA DE LAS FLUOROQUINOLONAS DE ACCION ANTIBACTERIANA.
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09501512A ES2095809B1 (es) | 1995-07-27 | 1995-07-27 | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. |
NO962906A NO962906L (no) | 1995-07-27 | 1996-07-10 | Fremgangsmåte til fremstilling av naftyridinkarboksylsyrer og deres salter |
CZ962047A CZ204796A3 (en) | 1995-07-27 | 1996-07-10 | Process for preparing naphthyridinecarboxylic acids and salts thereof |
GR960100244A GR960100244A (el) | 1995-07-27 | 1996-07-12 | Μεθοδος για την παρασκευη ναφθυριδινοκαρβοξυλικων οξεων και των αλατων τους. |
FI962852A FI962852A (fi) | 1995-07-27 | 1996-07-15 | Menetelmä naftyridiinikarboksyylihappojen ja niiden suolojen valmistamiseksi |
ARP960103597A AR002848A1 (es) | 1995-07-27 | 1996-07-16 | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales particularmente utiles por su accion antibacteriana. |
SK923-96A SK92396A3 (en) | 1995-07-27 | 1996-07-16 | Process for the preparation of naphtyridinecarboxylic acids and their salts |
PT101897A PT101897B (pt) | 1995-07-27 | 1996-07-18 | Processo para a preparacao de acidos naftiridinocarboxilicos e seus sais |
CO96038187A CO4700471A1 (es) | 1995-07-27 | 1996-07-19 | Procedimiento para la preparacion de acidos naftiridin car- boxilicos y sus sales |
MX9602953A MX9602953A (es) | 1995-07-27 | 1996-07-23 | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. |
KR1019960030206A KR970006303A (ko) | 1995-07-27 | 1996-07-25 | 나프티리딘카복실산 및 이의 염의 제조방법 |
HU9602071A HUP9602071A3 (en) | 1995-07-27 | 1996-07-26 | New process for preparing naphthridinecarboxilic acids and their salts |
PL96315423A PL315423A1 (en) | 1995-07-27 | 1996-07-26 | Method of obtaining naphtyridinocarboxylic acids and their salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09501512A ES2095809B1 (es) | 1995-07-27 | 1995-07-27 | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2095809A1 true ES2095809A1 (es) | 1997-02-16 |
ES2095809B1 ES2095809B1 (es) | 1997-12-16 |
Family
ID=8291178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09501512A Expired - Lifetime ES2095809B1 (es) | 1995-07-27 | 1995-07-27 | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. |
Country Status (13)
Country | Link |
---|---|
KR (1) | KR970006303A (es) |
AR (1) | AR002848A1 (es) |
CO (1) | CO4700471A1 (es) |
CZ (1) | CZ204796A3 (es) |
ES (1) | ES2095809B1 (es) |
FI (1) | FI962852A (es) |
GR (1) | GR960100244A (es) |
HU (1) | HUP9602071A3 (es) |
MX (1) | MX9602953A (es) |
NO (1) | NO962906L (es) |
PL (1) | PL315423A1 (es) |
PT (1) | PT101897B (es) |
SK (1) | SK92396A3 (es) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0302372A1 (en) * | 1987-08-04 | 1989-02-08 | Abbott Laboratories | Naphthyridine antianaerobic compounds |
ES2006994A6 (es) * | 1987-06-24 | 1989-05-16 | Chinoin Gyogyszer Es Vegyeszet | Procedimiento para la preparacion de derivados de los acidos quinolincarboxilicos. |
ES2020786A6 (es) * | 1990-07-19 | 1991-09-16 | Inke Sa | Procedimiento para la obtencion del acido (+-)-7-(3-amino-1-pirrolidinil)-1-(2-4-difluorofenil)-6-fluoro-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilico y sus sales. |
US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
WO1995019361A1 (en) * | 1994-01-18 | 1995-07-20 | Pfizer Inc. | Process and intermediates for preparing naphthyridonecarboxylic acid salts |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ224150A (en) * | 1987-04-08 | 1990-11-27 | Chinoin Gyogyszer Es Vegyeszet | Preparation of piperazinyl-substituted quinoline derivatives |
HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
-
1995
- 1995-07-27 ES ES09501512A patent/ES2095809B1/es not_active Expired - Lifetime
-
1996
- 1996-07-10 CZ CZ962047A patent/CZ204796A3/cs unknown
- 1996-07-10 NO NO962906A patent/NO962906L/no not_active Application Discontinuation
- 1996-07-12 GR GR960100244A patent/GR960100244A/el unknown
- 1996-07-15 FI FI962852A patent/FI962852A/fi unknown
- 1996-07-16 AR ARP960103597A patent/AR002848A1/es unknown
- 1996-07-16 SK SK923-96A patent/SK92396A3/sk unknown
- 1996-07-18 PT PT101897A patent/PT101897B/pt not_active IP Right Cessation
- 1996-07-19 CO CO96038187A patent/CO4700471A1/es unknown
- 1996-07-23 MX MX9602953A patent/MX9602953A/es unknown
- 1996-07-25 KR KR1019960030206A patent/KR970006303A/ko active IP Right Grant
- 1996-07-26 HU HU9602071A patent/HUP9602071A3/hu unknown
- 1996-07-26 PL PL96315423A patent/PL315423A1/xx unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2006994A6 (es) * | 1987-06-24 | 1989-05-16 | Chinoin Gyogyszer Es Vegyeszet | Procedimiento para la preparacion de derivados de los acidos quinolincarboxilicos. |
EP0302372A1 (en) * | 1987-08-04 | 1989-02-08 | Abbott Laboratories | Naphthyridine antianaerobic compounds |
US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
ES2020786A6 (es) * | 1990-07-19 | 1991-09-16 | Inke Sa | Procedimiento para la obtencion del acido (+-)-7-(3-amino-1-pirrolidinil)-1-(2-4-difluorofenil)-6-fluoro-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilico y sus sales. |
WO1995019361A1 (en) * | 1994-01-18 | 1995-07-20 | Pfizer Inc. | Process and intermediates for preparing naphthyridonecarboxylic acid salts |
Non-Patent Citations (1)
Title |
---|
ROSEN, T. y col. Asymmetric Synthesis and Properties of the Enantiomers of the Antibacterial Agent 7-(3-Aminopyrrolidin-1- yl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8- naphthyridine-3-carboxylic Acid Hydrochloride. J. Med. Chem., 1988, Vol. 31, N 8, pßginas 1586-90 * |
Also Published As
Publication number | Publication date |
---|---|
HUP9602071A3 (en) | 2000-03-28 |
HUP9602071A2 (en) | 1997-03-28 |
HU9602071D0 (en) | 1996-09-30 |
SK92396A3 (en) | 1997-06-04 |
PL315423A1 (en) | 1997-02-03 |
PT101897A (pt) | 1997-06-30 |
CO4700471A1 (es) | 1998-12-29 |
MX9602953A (es) | 1997-06-28 |
AR002848A1 (es) | 1998-04-29 |
NO962906L (no) | 1997-01-28 |
CZ204796A3 (en) | 1997-02-12 |
KR970006303A (ko) | 1997-02-19 |
FI962852A0 (fi) | 1996-07-15 |
NO962906D0 (no) | 1996-07-10 |
FI962852A (fi) | 1997-01-28 |
GR960100244A (el) | 1997-03-31 |
ES2095809B1 (es) | 1997-12-16 |
PT101897B (pt) | 1999-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970216 Kind code of ref document: A1 Effective date: 19970216 |