ES2095310T3 - Procedimiento de control de la alimentacion de reactivo en un espectrofotometro de barrido. - Google Patents

Procedimiento de control de la alimentacion de reactivo en un espectrofotometro de barrido.

Info

Publication number
ES2095310T3
ES2095310T3 ES91901116T ES91901116T ES2095310T3 ES 2095310 T3 ES2095310 T3 ES 2095310T3 ES 91901116 T ES91901116 T ES 91901116T ES 91901116 T ES91901116 T ES 91901116T ES 2095310 T3 ES2095310 T3 ES 2095310T3
Authority
ES
Spain
Prior art keywords
reagent
dye
concentration
reaction mixture
spectral region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901116T
Other languages
English (en)
Inventor
Richard Cornelius Driscoll
Timothy J Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2095310T3 publication Critical patent/ES2095310T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Plasma & Fusion (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

UN METODO PARA MEDIR LA CONCENTRACION DE UN REACTIVO EN UNA MEZCLA DE REACCION QUE INCLUYE LOS PASOS DE: AÑADIR COLORANTE A UN REACTIVO HASTA QUE EL COLORANTE TENGA UNA CONCENTRACION DADA EN EL REACTIVO; MEZCLAR EL REACTIVO CON UN ESPECIMEN PARA FORMAR UNA MEZCLA DE REACCION, DONDE EL ESPECIMEN COMPRENDE UN COMPONENTE QUE REACCIONA CON EL REACTIVO PARA FORMAR UN PRODUCTO DE REACCION; MEDIR LA FORMACION DEL PRODUCTO DE REACCION EN UNA PRIMERA ZONA ESPECTRAL; MEDIR LA CONCENTRACION DE COLORANTE EN LA MEZCLA DE REACCION EN UNA SEGUNDA ZONA ESPECTRAL EN LA QUE EL COLORANTE TIENE UNA CARACTERISTICA OPTICA, TAL COMO ABSORCION O FLUORESCENCIA, SIENDO LA SEGUNDA ZONA ESPECTRAL DIFERENTE DE LA PRIMERA ZONA ESPECTRAL; Y DETERMINAR LA CONCENTRACION DEL REACTIVO EN LA MEZCLA DE REACCION EN BASE A LA CONCENTRACION DE LA CANTIDAD DE COLORANTE. EN OTRO ASPECTO POSTERIOR DE LA INVENCION, SE PROPORCIONA UN REACTIVO QUE CONTIENE UN COLORANTE UTIL PARA EL METODO ANTERIOR.
ES91901116T 1989-12-01 1990-12-03 Procedimiento de control de la alimentacion de reactivo en un espectrofotometro de barrido. Expired - Lifetime ES2095310T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/443,953 US5068181A (en) 1989-12-01 1989-12-01 Method of monitoring reagent delivery in a scanning spectrophotometer

Publications (1)

Publication Number Publication Date
ES2095310T3 true ES2095310T3 (es) 1997-02-16

Family

ID=23762872

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901116T Expired - Lifetime ES2095310T3 (es) 1989-12-01 1990-12-03 Procedimiento de control de la alimentacion de reactivo en un espectrofotometro de barrido.

Country Status (14)

Country Link
US (1) US5068181A (es)
EP (1) EP0502983B1 (es)
JP (1) JP2902108B2 (es)
KR (1) KR100210736B1 (es)
AT (1) ATE142018T1 (es)
AU (2) AU655577B2 (es)
CA (1) CA2069887C (es)
DE (1) DE69028312T2 (es)
DK (1) DK0502983T3 (es)
ES (1) ES2095310T3 (es)
FI (1) FI101575B (es)
GR (1) GR3021261T3 (es)
IE (1) IE75698B1 (es)
WO (1) WO1991008461A1 (es)

Families Citing this family (28)

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US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
ES2121011T3 (es) * 1991-02-15 1998-11-16 Formulogics Inc Determinacion de contaminantes.
US5580744A (en) * 1992-04-27 1996-12-03 Avocet Medical, Inc. Test article and method for performing blood coagulation assays
US5344036A (en) * 1992-06-04 1994-09-06 Akzo N.V. Container system
US5447838A (en) * 1992-08-05 1995-09-05 Hybritech Incorporated Protein-dye conjugate for confirmation of correct dilution of calibrators
US5919707A (en) * 1994-12-22 1999-07-06 Nalco Chemical Company Monitoring of rolling oil emulsions
US6830934B1 (en) 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
DE10257716B4 (de) 2002-12-11 2005-12-29 Institut für Textilchemie der Deutschen Institute für Textil- und Faserforschung Stuttgart Optischer Sensor zur Bestimmung von Farbstoffkonzentrationen in flüssigen Medien und Verfahren zu dessen Betrieb
US7283245B2 (en) * 2004-01-20 2007-10-16 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
US20060000710A1 (en) 2004-06-30 2006-01-05 Klaus Peter Weidenhaupt Fluid handling methods
US20060001551A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US20060000709A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Methods for modulation of flow in a flow pathway
US20060002817A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US8081303B2 (en) 2008-03-21 2011-12-20 Abbott Point Of Care, Inc. Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching
ES2464572T3 (es) * 2008-03-21 2014-06-03 Abbott Point Of Care, Inc. Método y aparato para determinar los índices de células sanguíneas rojas en una muestra de sangre utilizando la pigmentación intrínseca de la hemoglobina contenida en las células sanguíneas rojas
CN102027369B (zh) * 2008-03-21 2018-10-26 艾博特健康公司 单独和在聚合凝块中检测和计数血小板的方法及设备
ES2392380T3 (es) 2008-03-21 2012-12-10 Abbott Point Of Care, Inc. Procedimiento y aparato para determinar el hematocrito de una muestra de sangre utilizando la pigmentación intrínseca de la hemoglobina contenida en los glóbulos rojos
CA2719004C (en) * 2008-03-21 2013-06-18 Abbott Point Of Care, Inc. Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
CN102027370B (zh) 2008-04-02 2016-06-08 艾博特健康公司 用于对包括全血的生物流体执行免疫测定的配体分析中的结合标记和游离标记的虚拟分离
CA2720072C (en) * 2008-04-09 2013-11-19 Abbott Point Of Care, Inc. Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber
JP5734838B2 (ja) * 2008-04-09 2015-06-17 アボット ポイント オブ ケア インコーポレイテッド 分析チャンバ内に置かれた試料の面積を計測するための方法
US20100255605A1 (en) * 2009-04-02 2010-10-07 Abbott Point Of Care, Inc. Method and device for transferring biologic fluid samples
US20100323343A1 (en) * 2009-05-11 2010-12-23 Nexus Dx, Inc. Methods and compositions for analyte detection
WO2011082342A1 (en) * 2009-12-31 2011-07-07 Abbott Point Of Care, Inc. Method and apparatus for determining mean cell volume of red blood cells
WO2011116305A1 (en) 2010-03-18 2011-09-22 Abbott Point Of Care, Inc. Method and apparatus for optically determining at least one hemoglobin related parameter of a whole blood sample
CN102128796B (zh) * 2010-12-07 2012-07-25 桂林理工大学 一种测定硫酸庆大霉素的方法
US9476871B2 (en) 2012-05-02 2016-10-25 Diatech Oncology Llc System and method for automated determination of the relative effectiveness of anti-cancer drug candidates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3059524A (en) * 1958-06-04 1962-10-23 Grassmann Wolfgang Method and apparatus for the continuous colorimetric determination of the individualcomponents of a mixture
US4204839A (en) * 1978-08-09 1980-05-27 Eastman Kodak Company Fluorimetric analysis method for bilirubin
US4274744A (en) * 1978-11-21 1981-06-23 Medico Electronic, Inc. Direct reading digital colorimeter
US4329149A (en) * 1980-03-06 1982-05-11 Hach Chemical Company Method for spectrophotometric compensation for colorimetric reagent variation
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
JPS5832168A (ja) * 1981-08-19 1983-02-25 Olympus Optical Co Ltd 分析装置
US4506626A (en) * 1981-11-02 1985-03-26 Schurman Richard H Apparatus for controlling the proportions of a fluid
US4543335A (en) * 1982-12-20 1985-09-24 Miles Laboratories, Inc. Device and method for the quantitative determination of heparin in mammalian blood plasma
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4911549A (en) * 1988-04-05 1990-03-27 Baxter International Inc. Heparin monitoring system and methodology

Also Published As

Publication number Publication date
JPH05502723A (ja) 1993-05-13
CA2069887A1 (en) 1991-06-02
IE75698B1 (en) 1997-09-10
EP0502983B1 (en) 1996-08-28
EP0502983A4 (en) 1993-05-05
ATE142018T1 (de) 1996-09-15
DE69028312T2 (de) 1997-01-16
KR100210736B1 (ko) 1999-07-15
DK0502983T3 (es) 1997-01-20
FI922478A0 (fi) 1992-05-29
FI101575B1 (fi) 1998-07-15
JP2902108B2 (ja) 1999-06-07
AU6951291A (en) 1991-06-26
FI101575B (fi) 1998-07-15
CA2069887C (en) 2004-02-10
FI922478A (fi) 1992-05-29
WO1991008461A1 (en) 1991-06-13
AU655577B2 (en) 1995-01-05
AU1628795A (en) 1995-06-29
IE904276A1 (en) 1991-06-05
KR920704118A (ko) 1992-12-19
US5068181A (en) 1991-11-26
EP0502983A1 (en) 1992-09-16
GR3021261T3 (en) 1997-01-31
DE69028312D1 (de) 1996-10-02

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