ES2093708T3 - Combinacion de la hormona de crecimiento y del factor de crecimiento de tipo i similar a la insulina que incrementa el crecimiento. - Google Patents

Combinacion de la hormona de crecimiento y del factor de crecimiento de tipo i similar a la insulina que incrementa el crecimiento.

Info

Publication number
ES2093708T3
ES2093708T3 ES91911898T ES91911898T ES2093708T3 ES 2093708 T3 ES2093708 T3 ES 2093708T3 ES 91911898 T ES91911898 T ES 91911898T ES 91911898 T ES91911898 T ES 91911898T ES 2093708 T3 ES2093708 T3 ES 2093708T3
Authority
ES
Spain
Prior art keywords
growth
combination
igf
insulin
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911898T
Other languages
English (en)
Inventor
Ross G Clark
Michael J Cronin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2093708T3 publication Critical patent/ES2093708T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTA UN METODO PARA MEJORAR EL CRECIMIENTO DE UN MAMIFERO MEDIANTE LA ADMINISTRACION DE UNA COMBINACION DE CANTIDADES EFECTIVAS DE IGF-I Y GH DE FORMA QUE MEJOREN EL CRECIMIENTO DEL MAMIFERO DE FORMA MAS EFECTIVA QUE LA LOGRADA USANDO TANTO IGF-I COMO GH SOLOS EN UNA CANTIDAD IGUAL A LA USADA PARA EL GF-I O PARA LA GH RESPECTIVAMENTE, EN LA COMBINACION. PREFERIBLEMENTE, EL MAMIFERO SERA UN NIÑO Y EL IGF-I SERA IGF-I HUMANO MADURO DE SECUENCIA NATIVA O IGF-I DEL CEREBRO HUMANO, Y LA GH SERA GH HUMANA MADURA DE SECUENCIA NATIVA CON O SIN UN TERMINAL DE METIONINA. EN OTRA CONFORMACION, EL MAMIFERO SERA UN ANIMAL NO HUMANO DE IMPORTANCIA ECONOMICA TAL COMO UNA VACA O UN CERDO.
ES91911898T 1990-06-07 1991-05-31 Combinacion de la hormona de crecimiento y del factor de crecimiento de tipo i similar a la insulina que incrementa el crecimiento. Expired - Lifetime ES2093708T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/535,005 US5126324A (en) 1990-06-07 1990-06-07 Method of enhancing growth in patients using combination therapy

Publications (1)

Publication Number Publication Date
ES2093708T3 true ES2093708T3 (es) 1997-01-01

Family

ID=24132463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91911898T Expired - Lifetime ES2093708T3 (es) 1990-06-07 1991-05-31 Combinacion de la hormona de crecimiento y del factor de crecimiento de tipo i similar a la insulina que incrementa el crecimiento.

Country Status (11)

Country Link
US (2) US5126324A (es)
EP (1) EP0536226B1 (es)
JP (1) JP2961708B2 (es)
AT (1) ATE141799T1 (es)
CA (1) CA2083159C (es)
DE (1) DE69121715T2 (es)
DK (1) DK0536226T3 (es)
ES (1) ES2093708T3 (es)
GR (1) GR3021713T3 (es)
HK (1) HK1007954A1 (es)
WO (1) WO1991018621A1 (es)

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WO1991018621A1 (en) 1991-12-12
ATE141799T1 (de) 1996-09-15
JP2961708B2 (ja) 1999-10-12
CA2083159C (en) 2005-02-01
US5126324A (en) 1992-06-30
DE69121715T2 (de) 1997-02-06
CA2083159A1 (en) 1991-12-08
HK1007954A1 (en) 1999-04-30
JPH05507278A (ja) 1993-10-21
EP0536226B1 (en) 1996-08-28
US5597797A (en) 1997-01-28
DK0536226T3 (es) 1997-02-10
GR3021713T3 (en) 1997-02-28
EP0536226A1 (en) 1993-04-14
DE69121715D1 (de) 1996-10-02

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