DE69628909T2 - Liposomformulierung von 5-beta steroiden - Google Patents
Liposomformulierung von 5-beta steroidenInfo
- Publication number
- DE69628909T2 DE69628909T2 DE69628909T DE69628909T DE69628909T2 DE 69628909 T2 DE69628909 T2 DE 69628909T2 DE 69628909 T DE69628909 T DE 69628909T DE 69628909 T DE69628909 T DE 69628909T DE 69628909 T2 DE69628909 T2 DE 69628909T2
- Authority
- DE
- Germany
- Prior art keywords
- liposome formulation
- 5beta
- dhea
- steroid
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54208395A | 1995-10-12 | 1995-10-12 | |
PCT/US1996/015507 WO1997013500A2 (en) | 1995-10-12 | 1996-09-27 | LIPOSOME FORMULATIONS OF 5β STEROIDS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69628909D1 DE69628909D1 (de) | 2003-08-07 |
DE69628909T2 true DE69628909T2 (de) | 2003-12-24 |
Family
ID=24162270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69628909T Expired - Fee Related DE69628909T2 (de) | 1995-10-12 | 1996-09-27 | Liposomformulierung von 5-beta steroiden |
Country Status (10)
Country | Link |
---|---|
US (1) | US6436435B1 (de) |
EP (1) | EP0801557B1 (de) |
JP (1) | JPH10508322A (de) |
CN (1) | CN1173815A (de) |
AT (1) | ATE243998T1 (de) |
CA (1) | CA2208215A1 (de) |
DE (1) | DE69628909T2 (de) |
HU (1) | HUP9801834A3 (de) |
IL (1) | IL121070A (de) |
WO (1) | WO1997013500A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
CA2670236C (en) * | 1999-09-30 | 2012-06-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
FR2799645B1 (fr) | 1999-10-13 | 2004-04-30 | Oreal | Utilisation de la dhea ou de ses precurseurs ou derives metaboliques comme depigmentant |
JP2003512474A (ja) * | 1999-10-25 | 2003-04-02 | ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド | 血液細胞欠乏症の治療処置 |
FR2807323A1 (fr) | 2000-04-10 | 2001-10-12 | Oreal | Composition, notamment cosmetique, renfermant un steroide et un 2-alkyl alcanol ou un ester |
CA2439687A1 (en) * | 2001-03-01 | 2002-09-12 | Hollis-Eden Pharmaceuticals, Inc. | Use of certain steroids for treatment of blood cell deficiencies |
CA2493605A1 (en) * | 2001-07-25 | 2003-02-06 | Richard A. Haase | Processes and apparatus for the manufacture of polynuclear aluminum compounds and disinfectants, and polynuclear aluminum compounds and disinfectants from such processes and apparatus |
FR2827765B1 (fr) * | 2001-07-27 | 2003-09-19 | Oreal | Composition a base de vesicules lamellaires lipidiques incorporant au moins un compose a base de dhea |
FR2827766A1 (fr) * | 2001-07-27 | 2003-01-31 | Oreal | Composition a base de vesicules lamellaires lipidiques incorporant au moins un compose a base de dhea |
US20040034003A1 (en) * | 2002-05-01 | 2004-02-19 | Schwartz Arthur G. | 7-Hydroxy-16alpha-fluoro-5-androsten-17-ones and 7-hydroxy-16alpha-fluoro-5-androstan-17-ones and derivatives thereof |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US8268269B2 (en) | 2006-01-24 | 2012-09-18 | Clearvalue Technologies, Inc. | Manufacture of water chemistries |
US8273770B2 (en) | 2007-07-21 | 2012-09-25 | Albany Molecular Research, Inc. | 5-pyridinone substituted indazoles |
ES2558155T3 (es) | 2007-10-30 | 2016-02-02 | Indiana University Research And Technology Corporation | Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1 |
JP2011504505A (ja) | 2007-11-21 | 2011-02-10 | デコード ジェネティクス イーエイチエフ | 肺および心血管障害を治療するためのビアリールpde4抑制剤 |
JP5501251B2 (ja) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ, インコーポレイテッド | Mch拮抗薬としての(1−アジノン)置換ピリドインドール類 |
WO2010059836A1 (en) | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Substituted aza-bridged bicyclics for cardiovascular and cns disease |
PE20120332A1 (es) | 2008-12-19 | 2012-04-14 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida |
BRPI1007350B8 (pt) | 2009-01-26 | 2021-05-25 | Israel Institute For Biological Res | compostos espiro heterocíclicos bicíclicos |
AU2010273732A1 (en) | 2009-07-14 | 2012-02-09 | Albany Molecular Research, Inc. | 5-HT3 receptor modulators, methods of making, and use thereof |
EP2569000B1 (de) | 2010-05-13 | 2017-09-27 | Indiana University Research and Technology Corporation | Glucagon-superfamilien-peptide mit nuklearhormon-rezeptoraktivität |
US9237762B2 (en) | 2010-05-24 | 2016-01-19 | Swedish Oat Fiber Ab | Aqueous dispersion comprising galactolipids and method for production thereof |
MX2012014576A (es) | 2010-06-24 | 2013-02-21 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida. |
FR2979239A1 (fr) * | 2011-08-25 | 2013-03-01 | Trophos | Liposome comprenant au moins un derive de cholesterol |
US8859491B2 (en) | 2011-11-17 | 2014-10-14 | Indiana University Research And Technology Corporation | Glucagon superfamily peptides exhibiting glucocorticoid receptor activity |
EP3768267A4 (de) | 2018-03-20 | 2022-04-20 | Icahn School of Medicine at Mount Sinai | Kinaseinhibitorverbindungen und zusammensetzungen und verfahren zur verwendung |
CA3124700A1 (en) | 2018-12-31 | 2020-07-09 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522803A (en) | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
US4588578A (en) | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
US4518595A (en) | 1983-07-19 | 1985-05-21 | The Jackson Laboratory | Method for treating diabetes using DHEA compounds |
FR2551758B1 (fr) * | 1983-08-16 | 1986-01-31 | Anvar | Derives de muramyl-peptides et de steroides ayant des proprietes d'activation des macrophages |
US4666898A (en) | 1983-12-28 | 1987-05-19 | Jackson Lab. | Treatment of obesity, diabetes and other symptoms of hypercorticoidism using etiocholanolones |
US4507289A (en) | 1983-12-28 | 1985-03-26 | Progenics, Inc. | Treatment of diabetes and other symptoms of hypercorticoidism using a synergistic combination of etiocholanolones and estrogen |
US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
CA1264668C (en) | 1984-06-20 | 1990-01-23 | EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES | |
EP0231261B1 (de) | 1985-07-05 | 1994-04-06 | The Liposome Company, Inc. | Multilamellare liposome mit verbesserter einschliessungswirkung |
US5041278A (en) | 1985-10-15 | 1991-08-20 | The Liposome Company, Inc. | Alpha tocopherol-based vesicles |
US4861580A (en) | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
DE3626421A1 (de) * | 1986-08-05 | 1988-02-11 | Recipe Pharma Vertriebs Gmbh & | Peptid, pharmazeutisches mittel und verwendung desselben zur stimulierung der lipolyse |
US5006517A (en) | 1987-12-01 | 1991-04-09 | Progenics, Inc. | Treatment of Prader-Willi syndrome |
US5041287A (en) | 1989-05-22 | 1991-08-20 | Terry L. Driggers | Sprayable composition using acetone solvent |
US5126324A (en) | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
AU668934B2 (en) | 1992-04-10 | 1996-05-23 | Hisamitsu Pharmaceutical Co., Inc. | Liposome composition |
WO1994004155A1 (en) * | 1992-08-19 | 1994-03-03 | Health Resource Institute, Ltd. | Dehydroepiandrosterone therapy for the treatment of eye disorders |
US6015576A (en) * | 1997-08-29 | 2000-01-18 | Bio-Sphere Technology, Inc. | Method for inducing a systemic immune response to an antigen |
-
1996
- 1996-09-27 DE DE69628909T patent/DE69628909T2/de not_active Expired - Fee Related
- 1996-09-27 JP JP9515066A patent/JPH10508322A/ja active Pending
- 1996-09-27 HU HU9801834A patent/HUP9801834A3/hu unknown
- 1996-09-27 WO PCT/US1996/015507 patent/WO1997013500A2/en active IP Right Grant
- 1996-09-27 CA CA002208215A patent/CA2208215A1/en not_active Abandoned
- 1996-09-27 AT AT96933929T patent/ATE243998T1/de not_active IP Right Cessation
- 1996-09-27 IL IL12107096A patent/IL121070A/en not_active IP Right Cessation
- 1996-09-27 CN CN96191876A patent/CN1173815A/zh active Pending
- 1996-09-27 EP EP96933929A patent/EP0801557B1/de not_active Expired - Lifetime
-
1999
- 1999-04-27 US US09/300,819 patent/US6436435B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0801557B1 (de) | 2003-07-02 |
DE69628909D1 (de) | 2003-08-07 |
IL121070A (en) | 2004-06-20 |
CA2208215A1 (en) | 1997-04-17 |
JPH10508322A (ja) | 1998-08-18 |
WO1997013500A3 (en) | 1997-05-29 |
ATE243998T1 (de) | 2003-07-15 |
EP0801557A2 (de) | 1997-10-22 |
HUP9801834A2 (hu) | 1999-02-01 |
HUP9801834A3 (en) | 2000-06-28 |
WO1997013500A2 (en) | 1997-04-17 |
CN1173815A (zh) | 1998-02-18 |
US6436435B1 (en) | 2002-08-20 |
IL121070A0 (en) | 1997-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |