ES2093651T3 - Purinas sustituidas, procedimiento para su preparacion asi como su empleo como agentes antiviricos. - Google Patents

Purinas sustituidas, procedimiento para su preparacion asi como su empleo como agentes antiviricos.

Info

Publication number
ES2093651T3
ES2093651T3 ES91104126T ES91104126T ES2093651T3 ES 2093651 T3 ES2093651 T3 ES 2093651T3 ES 91104126 T ES91104126 T ES 91104126T ES 91104126 T ES91104126 T ES 91104126T ES 2093651 T3 ES2093651 T3 ES 2093651T3
Authority
ES
Spain
Prior art keywords
ch2ph
alkyl
dialkylamino
antiviric
employment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91104126T
Other languages
English (en)
Inventor
Gerhard Dr Jahne
Manfred Dr Rosner
Irvin Dr Winkler
Matthias Dr Helsberg
Thomas Dr Scholl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2093651T3 publication Critical patent/ES2093651T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS COMPUESTOS CON FORMULA (I) EN LA QUE LOS SUSTITUYENTES R SUB 1 A R SUB 5 TIENEN EL SIGNIFICADO MENCIONADO, POSEEN ACCION ANTIVIRAL.
ES91104126T 1990-03-20 1991-03-18 Purinas sustituidas, procedimiento para su preparacion asi como su empleo como agentes antiviricos. Expired - Lifetime ES2093651T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4008858A DE4008858A1 (de) 1990-03-20 1990-03-20 Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel

Publications (1)

Publication Number Publication Date
ES2093651T3 true ES2093651T3 (es) 1997-01-01

Family

ID=6402601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91104126T Expired - Lifetime ES2093651T3 (es) 1990-03-20 1991-03-18 Purinas sustituidas, procedimiento para su preparacion asi como su empleo como agentes antiviricos.

Country Status (19)

Country Link
EP (1) EP0452680B1 (es)
JP (1) JP3146423B2 (es)
KR (1) KR910016751A (es)
CN (1) CN1054982A (es)
AT (1) ATE144984T1 (es)
AU (1) AU644414B2 (es)
CA (1) CA2038589A1 (es)
CS (1) CS70891A2 (es)
DE (2) DE4008858A1 (es)
DK (1) DK0452680T3 (es)
ES (1) ES2093651T3 (es)
FI (1) FI911310A (es)
GR (1) GR3021591T3 (es)
HU (1) HUT57764A (es)
IE (1) IE910908A1 (es)
IL (1) IL97586A0 (es)
NO (1) NO911081L (es)
PT (1) PT97080A (es)
ZA (1) ZA912015B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4210221A1 (de) * 1992-03-28 1993-09-30 Hoechst Ag Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
DE59310344D1 (de) * 1992-09-24 2003-07-24 Hoechst Ag N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
DE4311801A1 (de) * 1993-04-09 1994-10-13 Hoechst Ag Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5891881A (en) * 1997-11-21 1999-04-06 Clarion Pharmaceuticals Inc. Aminoheterocycle-substituted glycerols
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides

Also Published As

Publication number Publication date
PT97080A (pt) 1991-11-29
JPH04217984A (ja) 1992-08-07
AU7351491A (en) 1991-09-26
ATE144984T1 (de) 1996-11-15
KR910016751A (ko) 1991-11-05
FI911310A0 (fi) 1991-03-18
IL97586A0 (en) 1992-06-21
EP0452680B1 (de) 1996-11-06
CA2038589A1 (en) 1991-09-21
NO911081D0 (no) 1991-03-19
CN1054982A (zh) 1991-10-02
JP3146423B2 (ja) 2001-03-19
HUT57764A (en) 1991-12-30
NO911081L (no) 1991-09-23
CS70891A2 (en) 1991-11-12
EP0452680A1 (de) 1991-10-23
AU644414B2 (en) 1993-12-09
GR3021591T3 (en) 1997-02-28
FI911310A (fi) 1991-09-21
DE59108319D1 (de) 1996-12-12
IE910908A1 (en) 1991-09-25
DE4008858A1 (de) 1991-09-26
ZA912015B (en) 1991-12-24
HU910928D0 (en) 1991-10-28
DK0452680T3 (da) 1997-04-07

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