AU7351491A - Substituted purines, processes for their preparation and their use as antiviral agents - Google Patents

Substituted purines, processes for their preparation and their use as antiviral agents

Info

Publication number
AU7351491A
AU7351491A AU73514/91A AU7351491A AU7351491A AU 7351491 A AU7351491 A AU 7351491A AU 73514/91 A AU73514/91 A AU 73514/91A AU 7351491 A AU7351491 A AU 7351491A AU 7351491 A AU7351491 A AU 7351491A
Authority
AU
Australia
Prior art keywords
ch2ph
alkyl
dialkylamino
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU73514/91A
Other versions
AU644414B2 (en
Inventor
Matthias Helsberg
Gerhard Jahne
Manfred Rosner
Thomas Scholl
Irvin Winkler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU7351491A publication Critical patent/AU7351491A/en
Application granted granted Critical
Publication of AU644414B2 publication Critical patent/AU644414B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.
AU73514/91A 1990-03-20 1991-03-19 Substituted purines, processes for their preparation and their use as antiviral agents Ceased AU644414B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4008858 1990-03-20
DE4008858A DE4008858A1 (en) 1990-03-20 1990-03-20 New substd. purine antiviral cpds.

Publications (2)

Publication Number Publication Date
AU7351491A true AU7351491A (en) 1991-09-26
AU644414B2 AU644414B2 (en) 1993-12-09

Family

ID=6402601

Family Applications (1)

Application Number Title Priority Date Filing Date
AU73514/91A Ceased AU644414B2 (en) 1990-03-20 1991-03-19 Substituted purines, processes for their preparation and their use as antiviral agents

Country Status (19)

Country Link
EP (1) EP0452680B1 (en)
JP (1) JP3146423B2 (en)
KR (1) KR910016751A (en)
CN (1) CN1054982A (en)
AT (1) ATE144984T1 (en)
AU (1) AU644414B2 (en)
CA (1) CA2038589A1 (en)
CS (1) CS70891A2 (en)
DE (2) DE4008858A1 (en)
DK (1) DK0452680T3 (en)
ES (1) ES2093651T3 (en)
FI (1) FI911310A (en)
GR (1) GR3021591T3 (en)
HU (1) HUT57764A (en)
IE (1) IE910908A1 (en)
IL (1) IL97586A0 (en)
NO (1) NO911081L (en)
PT (1) PT97080A (en)
ZA (1) ZA912015B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4210221A1 (en) * 1992-03-28 1993-09-30 Hoechst Ag Carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use
DE59310344D1 (en) * 1992-09-24 2003-07-24 Hoechst Ag N1-Substituted 1H-1,2,3-triazolo [4,5-d] pyrimidines, processes for their preparation and their use as antivirals
DE4311801A1 (en) * 1993-04-09 1994-10-13 Hoechst Ag New carboxylic acid esters of 2-amino-7- (1,3-dihydroxy-2-propoxymethyl) purine, their preparation and their use
DE19536164A1 (en) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Improved Process for the Production of 9 - [(2-Hydroxyethoxy) methyl] guanine (Acyclovir)
US5891881A (en) * 1997-11-21 1999-04-06 Clarion Pharmaceuticals Inc. Aminoheterocycle-substituted glycerols
FR2793794B1 (en) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc NOVEL PURINE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NEW USE
PE20030008A1 (en) 2001-06-19 2003-01-22 Bristol Myers Squibb Co DUAL INHIBITORS OF PDE 7 AND PDE 4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
DE3627024A1 (en) * 1985-09-24 1987-04-02 Hoechst Ag 2-AMINOPURINS SUBSTITUTED IN 6 AND 9 POSITIONS, THEIR USE, MEDICINAL PRODUCTS CONTAINING THESE PURINES AND METHOD FOR THE PRODUCTION OF THE PURINS
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.

Also Published As

Publication number Publication date
CN1054982A (en) 1991-10-02
AU644414B2 (en) 1993-12-09
JPH04217984A (en) 1992-08-07
CA2038589A1 (en) 1991-09-21
DE4008858A1 (en) 1991-09-26
NO911081L (en) 1991-09-23
HUT57764A (en) 1991-12-30
FI911310A (en) 1991-09-21
ES2093651T3 (en) 1997-01-01
GR3021591T3 (en) 1997-02-28
ZA912015B (en) 1991-12-24
PT97080A (en) 1991-11-29
FI911310A0 (en) 1991-03-18
CS70891A2 (en) 1991-11-12
EP0452680A1 (en) 1991-10-23
IE910908A1 (en) 1991-09-25
JP3146423B2 (en) 2001-03-19
IL97586A0 (en) 1992-06-21
DE59108319D1 (en) 1996-12-12
KR910016751A (en) 1991-11-05
EP0452680B1 (en) 1996-11-06
HU910928D0 (en) 1991-10-28
NO911081D0 (en) 1991-03-19
DK0452680T3 (en) 1997-04-07
ATE144984T1 (en) 1996-11-15

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