ES2091963T3 - Indoles 3-piperidinilmetilcarboxilato sustituidos. - Google Patents

Indoles 3-piperidinilmetilcarboxilato sustituidos.

Info

Publication number
ES2091963T3
ES2091963T3 ES92102900T ES92102900T ES2091963T3 ES 2091963 T3 ES2091963 T3 ES 2091963T3 ES 92102900 T ES92102900 T ES 92102900T ES 92102900 T ES92102900 T ES 92102900T ES 2091963 T3 ES2091963 T3 ES 2091963T3
Authority
ES
Spain
Prior art keywords
sub
elevated
group
elevado
alkoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92102900T
Other languages
English (en)
Inventor
Alexander William Oxford
John William Frank Whitehead
John Knight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2091963T3 publication Critical patent/ES2091963T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

INDOLES DERIVADOS DE LA FORMULA (I): DONDE R ELEVADO 1 REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO, O UN GRUPO C SUB 1-6 ALKOXI O HIDROXILO; R (AL CUADRADO) REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO C SUB 1-6 ALCALINO, -CH SUB 2 C SUB 2-5 ALKENILO O -CH SUB 2 C SUB 2-5 ALKINILO; R ELEVADO 3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO C SUB 1-6 ALCALINO O C SUB 1-6 ALKOXI; N REPRESENTA 2 O 3; R ELEVADO 4 REPRESENTA UN GRUPO SELECCIONADO DEL CIANO, HIDROXILO, C SUB 1 -6 ALKOXI, FENOXI, C(O)C SUB 1-6 ALCALINO, C(O) C SUB 6 H SUB 5, -CONR ELEVADO 5 R ELEVADO 6, -NR ELEVADO 5 COR ELEVADO 6, -SO SUB 2 NR ELEVADO 5 R ELEVADO 6 O -NR ELEVADO 5 SO SUB 2 R ELEVADO 6 (DONDE CADA UNO DE R ELEVADO 5 Y R ELEVADO 6 INDEPENDIENTEMENTE REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO C SUB 1-6 ALCALINO O FENILO); Y DERIVADOS DE AMONIACO QUATERNARIO, OXIDOS DE PIPERIDINA N Y SALES FARMACEUTICAMENTE ACEPTABLES Y SOLVATES DEL MISMO; CUYOS COMPUESTOS SON ANTAGONISTAS FUERTES Y ESPECIFICOS DE LA 5-HIDROXITRIPTAMINA (5-HT, SERETONINA).
ES92102900T 1991-02-25 1992-02-21 Indoles 3-piperidinilmetilcarboxilato sustituidos. Expired - Lifetime ES2091963T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919103862A GB9103862D0 (en) 1991-02-25 1991-02-25 Chemical compounds
APAP/P/1992/000417A AP295A (en) 1991-02-25 1992-08-17 3-Piperidinylmethylcarboxylate substituted indoles.
CN92110050A CN1083059A (zh) 1991-02-25 1992-08-24 3-哌啶甲基羧酸酯取代的吲哚

Publications (1)

Publication Number Publication Date
ES2091963T3 true ES2091963T3 (es) 1996-11-16

Family

ID=36790873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92102900T Expired - Lifetime ES2091963T3 (es) 1991-02-25 1992-02-21 Indoles 3-piperidinilmetilcarboxilato sustituidos.

Country Status (18)

Country Link
EP (1) EP0501322B1 (es)
JP (1) JPH06505238A (es)
CN (1) CN1083059A (es)
AP (1) AP295A (es)
AT (1) ATE142205T1 (es)
AU (1) AU645402B2 (es)
CA (1) CA2105179A1 (es)
DE (1) DE69213276T2 (es)
ES (1) ES2091963T3 (es)
FI (1) FI933697A (es)
GB (1) GB9103862D0 (es)
HU (1) HUT65486A (es)
IE (1) IE920567A1 (es)
IL (1) IL101042A (es)
MX (1) MX9200762A (es)
NO (1) NO933015L (es)
NZ (1) NZ241704A (es)
WO (1) WO1992014727A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU671430B2 (en) * 1991-12-21 1996-08-29 Smithkline Beecham Plc Use of 5-HT4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
US20020128172A1 (en) 1991-12-21 2002-09-12 Smithkline Beecham Plc Use of 5-HT4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
HU219121B (hu) * 1992-03-12 2001-02-28 Smithkline Beecham Plc. Kondenzált indolszármazékok, eljárás előállításukra és ezeket tartalmazó 5-HT4-receptor antagonista hatású gyógyászati készítmények
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
JPH07507290A (ja) * 1992-05-23 1995-08-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 不安症の治療のための医薬
AU4350493A (en) * 1992-06-27 1994-01-24 Smithkline Beecham Plc Medicaments containing 5-ht4 receptor antagonists
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
GB9221468D0 (en) * 1992-10-13 1992-11-25 Smithkline Beecham Plc Pharmaceuticals
EP0664794A1 (en) * 1992-10-16 1995-08-02 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
AU680453B2 (en) * 1992-11-05 1997-07-31 Smithkline Beecham Plc Piperidine derivatives as 5-HT4 receptor antagonists
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
IT1275903B1 (it) * 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
GB9725933D0 (en) * 1997-12-05 1998-02-04 Smithkline Beecham Plc Pharmaceuticals
CZ2003366A3 (en) * 2000-08-07 2004-04-14 Laboratoire Glaxosmithkline S. A. S. Use of 5ht4 receptor antagonists in the manufacture of a medicament for the prophylaxis or treatment of atrial fibrillation
US6815456B2 (en) * 2001-04-20 2004-11-09 Wyeth Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
JP2004526781A (ja) * 2001-04-20 2004-09-02 ワイス ５−ヒドロキシトリプトアミン−６リガンドとしてのヘテロシクリルアルコキシ−、−アルキルチオ−および−アルキルアミノベンザゾール誘導体
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
WO2010065743A2 (en) * 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives

Also Published As

Publication number Publication date
FI933697A0 (fi) 1993-08-23
DE69213276D1 (de) 1996-10-10
MX9200762A (es) 1992-08-01
NO933015D0 (no) 1993-08-24
AP9200417A0 (en) 1992-10-31
AU645402B2 (en) 1994-01-13
JPH06505238A (ja) 1994-06-16
DE69213276T2 (de) 1997-01-23
AU1209492A (en) 1992-09-15
EP0501322A1 (en) 1992-09-02
IE920567A1 (en) 1992-08-26
HUT65486A (en) 1994-06-28
WO1992014727A1 (en) 1992-09-03
AP295A (en) 1993-12-29
IL101042A (en) 1996-06-18
EP0501322B1 (en) 1996-09-04
IL101042A0 (en) 1992-11-15
HU9302414D0 (en) 1993-11-29
CN1083059A (zh) 1994-03-02
FI933697A (fi) 1993-08-23
CA2105179A1 (en) 1992-08-26
GB9103862D0 (en) 1991-04-10
NO933015L (no) 1993-08-24
NZ241704A (en) 1993-11-25
ATE142205T1 (de) 1996-09-15

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