NO933015L - 3-piperidinylmetalkarboksylat-substituerte indoler - Google Patents

3-piperidinylmetalkarboksylat-substituerte indoler

Info

Publication number
NO933015L
NO933015L NO93933015A NO933015A NO933015L NO 933015 L NO933015 L NO 933015L NO 93933015 A NO93933015 A NO 93933015A NO 933015 A NO933015 A NO 933015A NO 933015 L NO933015 L NO 933015L
Authority
NO
Norway
Prior art keywords
alkyl
piperidinyl
metal carboxylate
group
hydrogen
Prior art date
Application number
NO93933015A
Other languages
English (en)
Other versions
NO933015D0 (no
Inventor
Alexander William Oxford
John William Frank Whitehead
John Knight
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO933015L publication Critical patent/NO933015L/no
Publication of NO933015D0 publication Critical patent/NO933015D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Indol-derivater med formel (l), hvor R1 representerer et hydrogen- eller halogenatom, hvor R1 representerer et hydrogen- eller halogenatom, eller en Cj.j-alkyl-, ClT6-alkoksy- eller hydroksygruppe; R2 representerer et hydrogenatom eller en C^6- alkyl-, -CH2C2.5-alkenyl- eller -CH2C2_5-alkynylgruppe; R3 representerer et hydrogenatom eller en Cj.j-alkyl- eller C>6- alkoksygruppe; n representerer 2 eller 3; R* representerer en gruppe valgt blant cyano, hydroksyl, C^-alkoksy, fenoksy, C(0)Ci.6-alkyl, C(0)CtHj, -CONR^OR6, -NR5COR', -S02NR5R6 eller -NR5SO2R' (hvor hver av R5 og R6 uavhengig av hverandre repre- senterer et hydrogenatom, en Cj.j-alkyl- eller fenylgruppe) ; og kvat.-ammoniumderivater, piperidin-N-oksyder og farmasoytisk akseptable salter og solvater derav, hvilke forbindelser er serke og spesifikke antagonister mot 5-hydroksytryptamin (5- HT; serotonin).
NO933015A 1991-02-25 1993-08-24 3-piperidinylmetalkarboksylat-substituerte indoler NO933015D0 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919103862A GB9103862D0 (en) 1991-02-25 1991-02-25 Chemical compounds
PCT/EP1992/000371 WO1992014727A1 (en) 1991-02-25 1992-02-21 3-piperidinylmethylcarboxylate substituted indoles
APAP/P/1992/000417A AP295A (en) 1991-02-25 1992-08-17 3-Piperidinylmethylcarboxylate substituted indoles.
CN92110050A CN1083059A (zh) 1991-02-25 1992-08-24 3-哌啶甲基羧酸酯取代的吲哚

Publications (2)

Publication Number Publication Date
NO933015L true NO933015L (no) 1993-08-24
NO933015D0 NO933015D0 (no) 1993-08-24

Family

ID=36790873

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933015A NO933015D0 (no) 1991-02-25 1993-08-24 3-piperidinylmetalkarboksylat-substituerte indoler

Country Status (18)

Country Link
EP (1) EP0501322B1 (no)
JP (1) JPH06505238A (no)
CN (1) CN1083059A (no)
AP (1) AP295A (no)
AT (1) ATE142205T1 (no)
AU (1) AU645402B2 (no)
CA (1) CA2105179A1 (no)
DE (1) DE69213276T2 (no)
ES (1) ES2091963T3 (no)
FI (1) FI933697A (no)
GB (1) GB9103862D0 (no)
HU (1) HUT65486A (no)
IE (1) IE920567A1 (no)
IL (1) IL101042A (no)
MX (1) MX9200762A (no)
NO (1) NO933015D0 (no)
NZ (1) NZ241704A (no)
WO (1) WO1992014727A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2126354C (en) * 1991-12-21 2006-07-11 Gareth John Sanger Use of 5-ht4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
US20020128172A1 (en) 1991-12-21 2002-09-12 Smithkline Beecham Plc Use of 5-HT4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
PT884319E (pt) * 1992-03-12 2004-09-30 Smithkline Beecham Plc N-¬(1-n-butil-4-piperidil)metil|-3,4-di-hidro-2h-¬1,3|oxazino¬3,2-a|indole-10-carboxamida ou um seu sal farmaceuticamente aceitavel
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
JPH07507290A (ja) * 1992-05-23 1995-08-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 不安症の治療のための医薬
JPH07508276A (ja) * 1992-06-27 1995-09-14 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ↓４受容体アンタゴニスト含有医薬品
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
GB9221468D0 (en) * 1992-10-13 1992-11-25 Smithkline Beecham Plc Pharmaceuticals
WO1994008965A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
WO1994010174A1 (en) * 1992-11-05 1994-05-11 Smithkline Beecham Plc Piperidine derivatives as 5-ht4 receptor antagonists
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
IT1275903B1 (it) * 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
GB9725933D0 (en) * 1997-12-05 1998-02-04 Smithkline Beecham Plc Pharmaceuticals
MXPA03001210A (es) * 2000-08-07 2004-08-12 Smithkline Beecham Corp Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
HUP0303801A2 (hu) * 2001-04-20 2004-03-01 Wyeth Heterociklusos alkoxi-, alkil-tio- és alkil-amino-benzazol-származékok, mint 5-hidroxi-triptamin-6 ligandumok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
JP4323810B2 (ja) * 2001-04-20 2009-09-02 ワイス ５−ヒドロキシトリプトアミン−６リガンドとしてのヘテロシクリルオキシ−、−チオキシ−および−アミノベンザゾール誘導体
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
WO2010065743A2 (en) * 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives

Also Published As

Publication number Publication date
AP295A (en) 1993-12-29
AP9200417A0 (en) 1992-10-31
ATE142205T1 (de) 1996-09-15
HU9302414D0 (en) 1993-11-29
HUT65486A (en) 1994-06-28
GB9103862D0 (en) 1991-04-10
NZ241704A (en) 1993-11-25
DE69213276T2 (de) 1997-01-23
EP0501322A1 (en) 1992-09-02
IL101042A (en) 1996-06-18
FI933697A0 (fi) 1993-08-23
DE69213276D1 (de) 1996-10-10
IE920567A1 (en) 1992-08-26
EP0501322B1 (en) 1996-09-04
WO1992014727A1 (en) 1992-09-03
AU645402B2 (en) 1994-01-13
FI933697A (fi) 1993-08-23
MX9200762A (es) 1992-08-01
ES2091963T3 (es) 1996-11-16
CA2105179A1 (en) 1992-08-26
IL101042A0 (en) 1992-11-15
AU1209492A (en) 1992-09-15
CN1083059A (zh) 1994-03-02
NO933015D0 (no) 1993-08-24
JPH06505238A (ja) 1994-06-16

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