ES2090140T3 - Peptidos terapeuticos. - Google Patents
Peptidos terapeuticos.Info
- Publication number
- ES2090140T3 ES2090140T3 ES90913117T ES90913117T ES2090140T3 ES 2090140 T3 ES2090140 T3 ES 2090140T3 ES 90913117 T ES90913117 T ES 90913117T ES 90913117 T ES90913117 T ES 90913117T ES 2090140 T3 ES2090140 T3 ES 2090140T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- active site
- acid residue
- peptide
- peptide bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57572—Gastrin releasing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
UN ANALOGO LINEAL (ES DECIR, NO CICLICO) DE UN PEPTIDO DE LIBERACION DE LA GASTRINA DE MAMIFEROS (GRP) O DE LA BOMBESINA DE ANFIBIOS BIOLOGICAMENTE ACTIVO QUE TIENE UN LADO ACTIVO Y UN LADO ENLAZANTE RESPONSABLE DEL ENLACE DEL PEPTIDO A UN RECEPTOR SOBRE UNA CELULA BLANCA. LA DIVISION DE UN ENLACE PEPTIDO EN EL LADO ACTIVO DE LA BOMBOSINA QUE OCURRE DE MANERA NATURAL O DEL GRP ES INNECESARIA PARA UNA ACTIVIDAD BIOLOGICA IN VIVO. EL ANALOGO TIENE UNO DE LOS CAMBIOS SIGUIENTES: (A) UNA ELIMINACION DEL RESIDUO AMINOACIDO DENTRO DEL LADO ACTIVO Y UN CAMBIO DE UN RESIDUO AMINOACIDO FUERA DEL LADO ACTIVO, (B) UNA SUSTITUCION DE LOS DOS RESIDUOS AMINOACIDOS DENTRO DEL LADO ACTIVO CON UN AMINOACIDO SINTETICO, UN BETA-AMINOACIDO O UN RESIDUO GAMMA-AMINOACIDO, O (C) UN ENLACE NO PEPTIDO EN LUGAR DE UN ENLACE PEPTIDO ENTRE UN RESIDUO AMINOACIDO DEL LADO ACTIVO Y UN RESIDUO AMINOACIDO ADYACENTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39716989A | 1989-08-21 | 1989-08-21 | |
US07/502,438 US5084555A (en) | 1989-08-21 | 1990-03-30 | An octapeptide bombesin analog |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2090140T3 true ES2090140T3 (es) | 1996-10-16 |
Family
ID=27015776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90913117T Expired - Lifetime ES2090140T3 (es) | 1989-08-21 | 1990-08-17 | Peptidos terapeuticos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5084555A (es) |
EP (1) | EP0489089B1 (es) |
JP (1) | JPH04506664A (es) |
AT (1) | ATE139540T1 (es) |
AU (1) | AU648037B2 (es) |
CA (1) | CA2064896A1 (es) |
DE (1) | DE69027533T2 (es) |
DK (1) | DK0489089T3 (es) |
ES (1) | ES2090140T3 (es) |
FI (1) | FI920737A0 (es) |
NO (1) | NO302619B1 (es) |
WO (1) | WO1991002746A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5877277A (en) * | 1987-09-24 | 1999-03-02 | Biomeasure, Inc. | Octapeptide bombesin analogs |
US5830863A (en) * | 1988-06-20 | 1998-11-03 | Merrell Pharmaceuticals Inc. | Neurokinin A antagonists |
US6218364B1 (en) | 1988-06-20 | 2001-04-17 | Scott L. Harbeson | Fluorinated neurokinin A antagonists |
US5767236A (en) * | 1990-05-09 | 1998-06-16 | Biomeasure, Inc. | Linear therapeutic peptides |
US5620959A (en) * | 1990-07-31 | 1997-04-15 | Glaxo Wellcome Inc. | Bombesin antagonists |
US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
AU4238493A (en) * | 1992-05-08 | 1993-12-13 | Thomas Jefferson University | IGF-1 analogs |
US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
US5650395A (en) * | 1995-03-13 | 1997-07-22 | Hurel; Steven | Treatment of pulmonary hypertension |
FR2739553B1 (fr) * | 1995-10-06 | 1998-01-02 | Oreal | Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
US6989371B1 (en) | 1996-08-16 | 2006-01-24 | Dabur Research Foundation | Bombesin analogs for treatment of cancer |
GB0009918D0 (en) * | 2000-04-20 | 2000-06-07 | Rose Keith | Covalent capture facilitating purification of polypeptides |
US20030013637A1 (en) * | 2001-05-18 | 2003-01-16 | Hideto Ikushima | Novel anti-autoimmune composition by inhibition of GRF action |
AU2003262878A1 (en) * | 2002-08-26 | 2004-03-11 | Wisconsin Alumni Research Foundation | HETEROGENEOUS FOLDAMERS CONTAINING Alpha, Beta, AND/OR Gamma-AMINO ACIDS |
US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7611692B2 (en) | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US20060239923A1 (en) * | 2003-01-13 | 2006-10-26 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
US8420050B2 (en) | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
AU2004232314B2 (en) | 2003-04-22 | 2007-11-22 | Ipsen Pharma S.A.S. | Peptide vectors |
JPWO2006115135A1 (ja) | 2005-04-21 | 2008-12-18 | アステラス製薬株式会社 | 過敏性腸症候群治療剤 |
KR20090058553A (ko) * | 2006-09-08 | 2009-06-09 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 18f 표지된 작용제에 대한 화합물 및 방법 |
MX2009003617A (es) * | 2006-10-02 | 2009-04-22 | Bayer Schering Pharma Ag | Derivados de silicio para obtencion de imagenes por tomografia de emision de positrones (pet). |
BRPI0721424A2 (pt) * | 2007-03-01 | 2014-03-25 | Bayer Schering Pharma Ag | Métodos de radiofluoração |
US8691942B2 (en) | 2008-03-28 | 2014-04-08 | University Of Miami | N- and C- terminal substituted antagonistic analogs of GH-RH |
US10240138B2 (en) | 2008-06-12 | 2019-03-26 | Ipsen Bioinnovation Limited | Polypeptides that bind to and inhibit secretion from growth hormone secreting cells |
AU2009259033B2 (en) | 2008-06-12 | 2013-11-07 | Ipsen Bioinnovation Limited | Suppression of neuroendocrine diseases |
GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
EP2198878A1 (en) | 2008-12-18 | 2010-06-23 | University Of Miami | Polypeptide bombesin antagonists |
WO2020163833A2 (en) | 2019-02-08 | 2020-08-13 | United States Government As Represented By The Department Of Veterans Affairs | Growth hormone-releasing hormone antagonists and uses thereof |
WO2020235932A1 (ko) * | 2019-05-21 | 2020-11-26 | 주식회사 아이바이오코리아 | 신규한 펩타이드 화합물 또는 이의 약제학적으로 허용 가능한 염 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4207311A (en) * | 1977-07-18 | 1980-06-10 | The Salk Institute For Biological Studies | Peptides having analgesic and thermoregulative properties |
US4650661A (en) * | 1982-09-15 | 1987-03-17 | Aktiebolaget Hassle | Enzyme inhibitors |
ATE37552T1 (de) * | 1982-10-18 | 1988-10-15 | Ici Plc | Peptid- und pseudopeptid-derivate. |
IT1190389B (it) * | 1985-09-19 | 1988-02-16 | Eniricerche Spa | Esapeptidi ad attivita' ipotensiva |
US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
WO1989002897A1 (en) * | 1987-09-24 | 1989-04-06 | The Administrators Of The Tulane Educational Fund | Therapeutic peptides |
GB8813356D0 (en) * | 1988-06-06 | 1988-07-13 | Ici Plc | Polypeptide compounds |
-
1990
- 1990-03-30 US US07/502,438 patent/US5084555A/en not_active Expired - Lifetime
- 1990-08-17 ES ES90913117T patent/ES2090140T3/es not_active Expired - Lifetime
- 1990-08-17 EP EP90913117A patent/EP0489089B1/en not_active Expired - Lifetime
- 1990-08-17 DE DE69027533T patent/DE69027533T2/de not_active Expired - Fee Related
- 1990-08-17 WO PCT/US1990/004646 patent/WO1991002746A1/en active IP Right Grant
- 1990-08-17 AU AU62940/90A patent/AU648037B2/en not_active Ceased
- 1990-08-17 AT AT90913117T patent/ATE139540T1/de not_active IP Right Cessation
- 1990-08-17 JP JP2512265A patent/JPH04506664A/ja active Pending
- 1990-08-17 CA CA002064896A patent/CA2064896A1/en not_active Abandoned
- 1990-08-17 DK DK90913117.9T patent/DK0489089T3/da active
-
1992
- 1992-02-20 NO NO920678A patent/NO302619B1/no unknown
- 1992-02-20 FI FI920737A patent/FI920737A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO920678D0 (no) | 1992-02-20 |
EP0489089A1 (en) | 1992-06-10 |
WO1991002746A1 (en) | 1991-03-07 |
DE69027533T2 (de) | 1996-12-19 |
CA2064896A1 (en) | 1991-02-22 |
US5084555A (en) | 1992-01-28 |
DE69027533D1 (de) | 1996-07-25 |
AU648037B2 (en) | 1994-04-14 |
AU6294090A (en) | 1991-04-03 |
ATE139540T1 (de) | 1996-07-15 |
EP0489089A4 (en) | 1992-06-24 |
FI920737A0 (fi) | 1992-02-20 |
NO302619B1 (no) | 1998-03-30 |
DK0489089T3 (da) | 1996-07-29 |
NO920678L (no) | 1992-04-06 |
JPH04506664A (ja) | 1992-11-19 |
EP0489089B1 (en) | 1996-06-19 |
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Legal Events
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