ES2089709T3 - Derivados de pirrolidina y procedimiento para prepararlos. - Google Patents

Derivados de pirrolidina y procedimiento para prepararlos.

Info

Publication number
ES2089709T3
ES2089709T3 ES93300101T ES93300101T ES2089709T3 ES 2089709 T3 ES2089709 T3 ES 2089709T3 ES 93300101 T ES93300101 T ES 93300101T ES 93300101 T ES93300101 T ES 93300101T ES 2089709 T3 ES2089709 T3 ES 2089709T3
Authority
ES
Spain
Prior art keywords
base
prepare
procedure
pirrolidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93300101T
Other languages
English (en)
Inventor
Makoto Sunagawa
Haruki Matsumura
Takashi Bando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of ES2089709T3 publication Critical patent/ES2089709T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LOS DERIVADOS DE LA PIRROLIDINA DE FORMULA (1): EN DONDE R ES UN GRUPO PROTECTOR DEL GRUPO AMINO, INTERMEDIARIOS EN LA SINTESIS DE LA CADENA LATERAL DE DOS RESTOS DE COMPUESTOS PENEM Y CARBAPENEM ANTIBACTERIANOS, SE PREPARAN PERMITIENDO QUE REACIONEN CON AGENTES ESTERIFICANTES ACTIVOS EN PRESENCIA DE UNA BASE Y DESPUES QUE EL PRODUCTO FORMADO REACCIONE CON SULFURO DE HIDROGENO EN PRESENCIA DE UNA BASE Y LUEGO TRATANDO EL PRODUCTO RESULTANTE CON UNA BASE.
ES93300101T 1992-01-10 1993-01-07 Derivados de pirrolidina y procedimiento para prepararlos. Expired - Lifetime ES2089709T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP04022104A JP3091297B2 (ja) 1992-01-10 1992-01-10 ピロリジン誘導体およびその製造方法

Publications (1)

Publication Number Publication Date
ES2089709T3 true ES2089709T3 (es) 1996-10-01

Family

ID=12073586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93300101T Expired - Lifetime ES2089709T3 (es) 1992-01-10 1993-01-07 Derivados de pirrolidina y procedimiento para prepararlos.

Country Status (7)

Country Link
US (1) US5322952A (es)
EP (1) EP0551993B1 (es)
JP (1) JP3091297B2 (es)
KR (1) KR930016425A (es)
CA (1) CA2086649A1 (es)
DE (1) DE69303497T2 (es)
ES (1) ES2089709T3 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0842166T3 (da) * 1995-08-04 2000-11-27 Merck & Co Inc Fremgangsmåde til syntese af carbapenemsidekædemellemprodukter
US5648501A (en) * 1995-08-04 1997-07-15 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US5721368A (en) * 1996-07-22 1998-02-24 Merck & Co. Inc. Process for synthesizing carbapenem side chain intermediates
US6063931A (en) * 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
WO1999002531A1 (en) * 1997-07-09 1999-01-21 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US6060607A (en) * 1998-06-29 2000-05-09 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
JP4068452B2 (ja) 2000-07-19 2008-03-26 エフ．ホフマン−ラ ロシュ アーゲー エンドセリン変換酵素阻害剤としてのピロリジン誘導体
KR100825243B1 (ko) * 2000-11-20 2008-04-25 상꾜 가부시키가이샤 카르바페넴계 항균제의 제조방법
JP2004035507A (ja) * 2002-07-05 2004-02-05 Nippon Soda Co Ltd ピロール誘導体及びその製造方法
JP2006522028A (ja) * 2003-04-04 2006-09-28 アルファーマ エーピーエス ステロイド性カルボチオ酸誘導体の製造方法および中間体
CN101367812B (zh) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物
WO2009143153A1 (en) * 2008-05-23 2009-11-26 Janssen Pharmaceutica Nv Substituted pyrrolidine amides as modulators of the histamine h3 receptor
WO2010073706A1 (ja) * 2008-12-25 2010-07-01 株式会社カネカ カルバペネム側鎖中間体の改良された製造方法
CN102002069A (zh) * 2010-11-12 2011-04-06 上海巴迪生物医药科技有限公司 一种合成培南类侧链的双环中间体的制备方法及其应用
CN102134249B (zh) * 2010-12-30 2015-11-25 天津市敬业精细化工有限公司 一种手性5-保护-2-硫杂-5-氮杂双环[2.2.1]庚-3-酮的制备方法
CN102351861A (zh) * 2011-08-16 2012-02-15 湖南欧亚生物有限公司 一种厄他培南的工业化制备方法
CN104130262B (zh) * 2014-08-12 2017-06-09 湖南凯米尔生物科技有限公司 一种厄他培南、厄他培南侧链及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991076A (en) * 1974-06-07 1976-11-09 American Hoechst Corporation Aminoalkylthiopyranopyrroles
US4321383A (en) * 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
FR2537974A1 (fr) * 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
CA2036163C (en) * 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
JP3005045B2 (ja) * 1990-02-14 2000-01-31 住友製薬株式会社 新規なβ―ラクタム化合物及びその製造法

Also Published As

Publication number Publication date
DE69303497D1 (de) 1996-08-14
EP0551993B1 (en) 1996-07-10
EP0551993A1 (en) 1993-07-21
CA2086649A1 (en) 1993-07-11
JP3091297B2 (ja) 2000-09-25
JPH05186476A (ja) 1993-07-27
US5322952A (en) 1994-06-21
DE69303497T2 (de) 1997-01-23
KR930016425A (ko) 1993-08-26

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