ES2087964T3 - Contraceptivos orales bajos en estrogenos. - Google Patents
Contraceptivos orales bajos en estrogenos.Info
- Publication number
- ES2087964T3 ES2087964T3 ES91203182T ES91203182T ES2087964T3 ES 2087964 T3 ES2087964 T3 ES 2087964T3 ES 91203182 T ES91203182 T ES 91203182T ES 91203182 T ES91203182 T ES 91203182T ES 2087964 T3 ES2087964 T3 ES 2087964T3
- Authority
- ES
- Spain
- Prior art keywords
- dosage units
- equivalent
- desogestrel
- phase
- progestogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
SE DESCRIBE UN REGIMEN ANTICONCEPTIVO, Y UN METODO DE UTILIZACION DEL REGIMEN, QUE CONSTA DE 24 UNIDADES DE DOSIFICACION DE SECUENCIA DIARIA DE : UNA PRIMERA FASE QUE INCLUYE APROXIMADAMENTE ENTRE 7 Y 9 PRIMERAS UNIDADES DE DOSIFICACION QUE CONTIENEN UN PROGESTOGENO EN UNA DOSIS DIARIA EQUIVALENTE EN ACTIVIDAD PROGESTOGENICA A 100 (MU)G DE DESOGESTREL Y UN ESTROGENO EN UNADOSIS DIARIA EQUIVALENTE EN ACTIVIDAD ESTROGENICA A 25 (MU)G DE ETININIL ESTRADIOL ("EE"). UNA SEGUNDA FASE DE 7 A 9 SEGUNDAS UNIDADES DE DOSIFICACION, CADA UNA DE LAS SEGUNDAS UNIDADES DE DOSIFICACION CONTIENE UN PROGESTOGENO EQUIVALENTE A 125 (MU)G DE DESOGESTREL Y UN ESTROGENO EQUIVALENTE A 20 (MU)G DE EE. UNA TERCERA FASE DE 7 A 9 TERCERAS UNIDADES DE DOSIFICACION, CADA UNIDAD CONTIENE UN PROGESTOGENO EQUIVALENTE A 150 (MU)G DESOGESTREL Y UN ESTROGENO EQUIVALENTE A 20 (MU)G DE EE. EL CONJUNTO TIENE GENERALMENTE 28 UNIDADES DE DOSIFICACION DIARIAS DE LAS QUE CUATRO DE LAS UNIDADES DE DOSIFICACION DIARIAS NO CONTIENEN ESTEROIDES ANTICONCEPTIVOS, O, COMO ALTERNATIVA, TIENE SOLO 24 UNIDADES DE DOSIFICACION CON UN PERIODO DE CUATRO DIAS "LIBRE DE PILDORAS". LA CUARTA FASE PUEDEN SER TAMBIEN CUATRO UNIDADES DE DOSIFICACION QUE CONTENGAN UN PROGESTOGENO EQUIVALENTE A 25-35 (MU)G DE DESOGESTREL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90203309 | 1990-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2087964T3 true ES2087964T3 (es) | 1996-08-01 |
Family
ID=8205195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91203182T Expired - Lifetime ES2087964T3 (es) | 1990-12-13 | 1991-12-05 | Contraceptivos orales bajos en estrogenos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5262408A (es) |
EP (1) | EP0491415B1 (es) |
JP (1) | JPH04290828A (es) |
KR (1) | KR100187316B1 (es) |
CN (1) | CN1036835C (es) |
AT (1) | ATE136218T1 (es) |
AU (1) | AU645382B2 (es) |
CA (1) | CA2057528C (es) |
DE (1) | DE69118493T2 (es) |
DK (1) | DK0491415T3 (es) |
ES (1) | ES2087964T3 (es) |
FI (1) | FI99083C (es) |
GR (1) | GR3020179T3 (es) |
IE (1) | IE71203B1 (es) |
NO (1) | NO179234C (es) |
NZ (1) | NZ240944A (es) |
PT (1) | PT99782B (es) |
ZA (1) | ZA919731B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
US5516769A (en) * | 1993-02-19 | 1996-05-14 | The Medical College Of Hampton Roads | Method of inhibiting fertilization |
US6407082B1 (en) | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
DE4344462C2 (de) * | 1993-12-22 | 1996-02-01 | Schering Ag | Zusammensetzung für die Empfängnisverhütung |
DE4411585A1 (de) * | 1994-03-30 | 1995-10-05 | Schering Ag | Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption |
US5552394A (en) * | 1994-07-22 | 1996-09-03 | The Medical College Of Hampton Roads | Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy |
CA2159419C (en) * | 1994-10-17 | 2006-07-04 | Pieter De Haan | Solid pharmaceutical composition comprising an excipient capable of binding water |
US5747480A (en) * | 1996-05-08 | 1998-05-05 | American Home Products Corporation | Oral contraceptive |
US5888543A (en) * | 1996-07-26 | 1999-03-30 | American Home Products Corporation | Oral contraceptives |
EP0917466B1 (en) * | 1996-07-26 | 2004-10-06 | Wyeth | Oral contraceptive |
US5858405A (en) * | 1996-07-26 | 1999-01-12 | American Home Products Corporation | Oral contraceptive |
US6479475B1 (en) | 1996-07-26 | 2002-11-12 | Wyeth | Oral contraceptive |
AU3888697A (en) * | 1996-07-26 | 1998-02-20 | American Home Products Corporation | Progestin/estrogen oral contraceptive |
KR100518102B1 (ko) * | 1996-07-26 | 2005-10-04 | 와이어쓰 | 프로게스틴과 에스트로겐의 혼합물을 포함하는 단일상 피임약 키트 |
US6451778B1 (en) | 1996-07-26 | 2002-09-17 | Wyeth | Oral contraceptive |
US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
WO2001030355A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Medicament contraceptif a base d'un progestatif et d'un estrogene et son mode de preparation |
FR2754179B1 (fr) | 1996-10-08 | 1998-12-24 | Theramex | Nouvelle composition hormononale et son utilisation |
US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
US7989436B2 (en) | 2003-07-23 | 2011-08-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and pharmaceutical formulations comprising the same |
US6855703B1 (en) | 2000-03-10 | 2005-02-15 | Endeavor Pharmaceuticals | Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds |
US6660726B2 (en) | 2000-03-10 | 2003-12-09 | Endeavor Pharmaceuticals | Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same |
US7459445B2 (en) * | 2000-03-10 | 2008-12-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and topical pharmaceutical formulations of the same |
US20040176336A1 (en) * | 2000-03-21 | 2004-09-09 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
US20050113351A1 (en) * | 2000-03-21 | 2005-05-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
HU230759B1 (hu) * | 2001-12-05 | 2018-03-28 | Teva Women's Health, Inc. | Teherbeesés megakadályozására és menstruációs tünetek enyhítésére vagy kiküszöbölésére alkalmas orális készítmények |
US20030225048A1 (en) * | 2002-03-11 | 2003-12-04 | Caubel Patrick Michel | Sulfatase inhibiting continuous progestogen contraceptive regimens |
TW200403075A (en) * | 2002-05-29 | 2004-03-01 | Akzo Nobel Nv | Progestagenic dosage units |
JP2004140323A (ja) * | 2002-08-20 | 2004-05-13 | Sharp Corp | 半導体レーザ装置およびその製造方法 |
US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
US20040259851A1 (en) * | 2003-04-11 | 2004-12-23 | Leonard Thomas W. | Methods of administering estrogens and progestins |
SI1820494T1 (sl) * | 2003-06-13 | 2010-08-31 | Skendi Finance Ltd | Mikrodelci, ki sestojijo iz estradiola in holesterola |
EP1648382A4 (en) * | 2003-07-16 | 2009-09-16 | Duramed Pharmaceuticals Inc | HORMONE TREATMENT METHODS USING CONTRACEPTIVE DOSAGES WITH CONTINUOUS ADMINISTRATION OF ESTROGENES |
EP1535618A1 (en) * | 2003-11-26 | 2005-06-01 | Schering Aktiengesellschaft | Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions |
DE102004019743B4 (de) * | 2004-04-20 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens |
US20060135496A1 (en) * | 2004-10-07 | 2006-06-22 | Duramed Pharmaceuticals, Inc. | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens |
US20070111975A1 (en) | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
US8153616B2 (en) | 2005-10-17 | 2012-04-10 | Bayer Pharma Aktiengesellschaft | Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same |
EP1930010A1 (de) | 2006-10-20 | 2008-06-11 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Estradiolvalerat oder 17ß-Estradiol in Kombination mit Dienogest zur oralen Therapie für den Erhalt und/oder die Steigerung der weiblichen Libido |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2431704A1 (de) * | 1974-07-02 | 1976-01-22 | Asche Ag | Stufenkombinationspraeparate per kontrazeption |
NL8001593A (nl) * | 1980-03-18 | 1981-10-16 | Akzo Nv | Meerfasisch combinatiepreparaat voor orale anticonceptie. |
US4628051A (en) * | 1983-09-26 | 1986-12-09 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
US4544554A (en) * | 1983-09-26 | 1985-10-01 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
US4616006A (en) * | 1983-09-26 | 1986-10-07 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
DK174724B1 (da) * | 1986-07-15 | 2003-10-06 | Wyeth Corp | Anvendelse af et præparat omfattende et østrogen og et progestogen til fremstilling af en dosisform til tilvejebringelse af hormonerstatningsterapi og kontraception til kvinder i præmenopausen samt pakning til tilvejebringelse af præparatet |
-
1991
- 1991-12-04 IE IE422191A patent/IE71203B1/en not_active IP Right Cessation
- 1991-12-05 DE DE69118493T patent/DE69118493T2/de not_active Expired - Fee Related
- 1991-12-05 EP EP91203182A patent/EP0491415B1/en not_active Expired - Lifetime
- 1991-12-05 DK DK91203182.0T patent/DK0491415T3/da active
- 1991-12-05 AT AT91203182T patent/ATE136218T1/de not_active IP Right Cessation
- 1991-12-05 ES ES91203182T patent/ES2087964T3/es not_active Expired - Lifetime
- 1991-12-10 ZA ZA919731A patent/ZA919731B/xx unknown
- 1991-12-11 NZ NZ240944A patent/NZ240944A/xx not_active IP Right Cessation
- 1991-12-11 AU AU89647/91A patent/AU645382B2/en not_active Ceased
- 1991-12-12 NO NO914900A patent/NO179234C/no unknown
- 1991-12-12 FI FI915855A patent/FI99083C/fi not_active IP Right Cessation
- 1991-12-12 KR KR1019910022726A patent/KR100187316B1/ko not_active IP Right Cessation
- 1991-12-12 US US07/806,966 patent/US5262408A/en not_active Expired - Lifetime
- 1991-12-12 PT PT99782A patent/PT99782B/pt not_active IP Right Cessation
- 1991-12-12 CN CN91111089A patent/CN1036835C/zh not_active Expired - Fee Related
- 1991-12-12 CA CA002057528A patent/CA2057528C/en not_active Expired - Fee Related
- 1991-12-13 JP JP3330885A patent/JPH04290828A/ja active Pending
-
1996
- 1996-06-07 GR GR960401541T patent/GR3020179T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI99083C (fi) | 1997-10-10 |
AU645382B2 (en) | 1994-01-13 |
AU8964791A (en) | 1992-06-18 |
CA2057528C (en) | 2003-02-04 |
EP0491415A1 (en) | 1992-06-24 |
JPH04290828A (ja) | 1992-10-15 |
US5262408A (en) | 1993-11-16 |
NO914900L (no) | 1992-06-15 |
IE71203B1 (en) | 1997-02-12 |
CN1036835C (zh) | 1997-12-31 |
DE69118493D1 (de) | 1996-05-09 |
NZ240944A (en) | 1994-05-26 |
NO179234C (no) | 1996-09-04 |
DK0491415T3 (da) | 1996-07-08 |
NO179234B (no) | 1996-05-28 |
KR100187316B1 (ko) | 1999-05-01 |
FI915855A0 (fi) | 1991-12-12 |
ATE136218T1 (de) | 1996-04-15 |
CA2057528A1 (en) | 1992-06-14 |
IE914221A1 (en) | 1992-06-17 |
KR920011517A (ko) | 1992-07-24 |
CN1062290A (zh) | 1992-07-01 |
PT99782B (pt) | 2001-05-31 |
GR3020179T3 (en) | 1996-09-30 |
FI99083B (fi) | 1997-06-30 |
FI915855A (fi) | 1992-06-14 |
ZA919731B (en) | 1992-09-30 |
EP0491415B1 (en) | 1996-04-03 |
NO914900D0 (no) | 1991-12-12 |
DE69118493T2 (de) | 1996-08-22 |
PT99782A (pt) | 1992-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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