ES2087730T3 - Empleo de los derivados de fenotiazina en el tratamiento de la isquemia y/o de la hipoxia. - Google Patents

Empleo de los derivados de fenotiazina en el tratamiento de la isquemia y/o de la hipoxia.

Info

Publication number
ES2087730T3
ES2087730T3 ES93907904T ES93907904T ES2087730T3 ES 2087730 T3 ES2087730 T3 ES 2087730T3 ES 93907904 T ES93907904 T ES 93907904T ES 93907904 T ES93907904 T ES 93907904T ES 2087730 T3 ES2087730 T3 ES 2087730T3
Authority
ES
Spain
Prior art keywords
pct
hypoxia
treatment
ischemia
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93907904T
Other languages
English (en)
Inventor
Claude Garret
Jean Rataud
Jean-Marie Stutzmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2087730T3 publication Critical patent/ES2087730T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVA APLICACION TERAPEUTICA DE DERIVADOS DE LA FENOTIACINA DE FORMULA GENERAL (I) EN LA QUE R ES UN RADICAL ALQUILO QUE CONTIENE 1 A 5 ATOMOS DE CARBONO EN CADENA RECTA O RAMIFICADA Y R1 Y R2 IDENTICOS O DIFERENTES SON RADICALES ALQUILOS QUE CONTIENEN 1 O 2 ATOMOS DE CARBONO O FORMAN UN CONJUNTO CON EL ATOMO DE NITROGENO AL QUE SE UNE UN RADICAL PIRROLIDINILO, ASI COMO SUS SALES Y SUS ESTEROISOMEROS DOTADOS DE ACTIVIDAD PREVENTIVA Y/O CURATIVA EN LOS TRATAMIENTOS DE LA ISQUEMIA Y DE LA HIPOXIA.
ES93907904T 1992-03-30 1993-03-29 Empleo de los derivados de fenotiazina en el tratamiento de la isquemia y/o de la hipoxia. Expired - Lifetime ES2087730T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203793A FR2689013B1 (fr) 1992-03-30 1992-03-30 Nouvelle application thérapeutique des dérivés de la phénothiazine.

Publications (1)

Publication Number Publication Date
ES2087730T3 true ES2087730T3 (es) 1996-07-16

Family

ID=9428216

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93907904T Expired - Lifetime ES2087730T3 (es) 1992-03-30 1993-03-29 Empleo de los derivados de fenotiazina en el tratamiento de la isquemia y/o de la hipoxia.

Country Status (12)

Country Link
US (1) US5502049A (es)
EP (1) EP0633780B1 (es)
JP (1) JPH07505376A (es)
AT (1) ATE138806T1 (es)
CA (1) CA2129962A1 (es)
DE (1) DE69303015T2 (es)
DK (1) DK0633780T3 (es)
ES (1) ES2087730T3 (es)
FR (1) FR2689013B1 (es)
GR (1) GR3020149T3 (es)
MX (1) MX9301701A (es)
WO (1) WO1993019757A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2720940A1 (fr) * 1994-06-13 1995-12-15 Rhone Poulenc Rorer Sa Application du (+)-N-propyl [(pyrrolidinyl-1)-1 propyl-2]-10 phénothiazinecarboxamide comme antidépresseur.
DE4430091A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von N-substituierten Phenothiazinen
AU7576501A (en) * 2000-03-28 2001-12-03 John W. Olney Combination of adrenergic agonist and nmda antagonist for relieving chronic painwithout adverse side effects
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
CN100513407C (zh) 2003-06-27 2009-07-15 詹森药业有限公司 三环δ阿片样物质调节剂
EP1910353A1 (en) * 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
WO2006069276A2 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
BRPI0519198A2 (pt) * 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclicos
EP1846400A2 (en) * 2005-01-06 2007-10-24 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
JP2008543866A (ja) * 2005-06-16 2008-12-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式オピオイドモジュレーター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112310A (en) * 1962-01-15 1963-11-26 Searle & Co 10-alkylaminoalkylphenothiazine-2-carboxamides
US4833138A (en) * 1987-10-23 1989-05-23 Washington University Phenothiazinealkaneamines for treatment of neurotoxic injury
FR2632520B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Derives de la phenothiazine analgesiques
FR2652084B1 (fr) * 1989-09-21 1991-10-31 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
FR2689013B1 (fr) 1995-05-05
JPH07505376A (ja) 1995-06-15
EP0633780B1 (fr) 1996-06-05
US5502049A (en) 1996-03-26
CA2129962A1 (fr) 1993-10-14
ATE138806T1 (de) 1996-06-15
GR3020149T3 (en) 1996-09-30
EP0633780A1 (fr) 1995-01-18
DK0633780T3 (da) 1996-07-01
MX9301701A (es) 1993-09-01
WO1993019757A1 (fr) 1993-10-14
FR2689013A1 (fr) 1993-10-01
DE69303015T2 (de) 1996-10-31
DE69303015D1 (de) 1996-07-11

Similar Documents

Publication Publication Date Title
DE69835430D1 (de) Sulfonamidderivate, ihre herstellung und verwendung
ES2087730T3 (es) Empleo de los derivados de fenotiazina en el tratamiento de la isquemia y/o de la hipoxia.
ATE247654T1 (de) Neue heterozyklische verbindungen
ATE158288T1 (de) Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate
ATE283268T1 (de) 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
ES2062558T3 (es) Compuestos contra el cancer.
ES2063309T3 (es) Derivados de pirimidina 3-oxido halogenados, su utilizacion para el tratamiento y la prevencion de la caida de los cabellos y para estimular su crecimiento.
MY131096A (en) N-imidazolyl derivatives of substituted indole.
DK1000034T3 (da) Substituerede 6-alkylphenanthridiner
ES2150613T3 (es) Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.
DK0420121T3 (da) Antitumormiddel
ATE70182T1 (de) Therapeutische mittel zur behandlung von magengeschwueren.
ES2058849T3 (es) Benzanilidas.
ATE137759T1 (de) S'-adenosyl-methionin-decarboxylase-inhibitoren
ITMI922742A1 (it) Composti ad attivita' terapeutica utili per il trattamento di malattie connesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
DK0420224T3 (da) Anthihepatopatisk middel
WO1990008529A3 (en) 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
ES2180201T3 (es) Derivados de azetidinona para el tratamiento de infecciones por hcmv.
DE69905144T2 (de) N,N'-Diacylthiocystine
ES2075610T3 (es) Ureas y tioureas disustituidas.
TR199901102T2 (xx) Bisiklik amin t�revleri.
DE69112095T2 (de) 1-Phenoxycarbonyl-2-Pyrrolidon-Derivate und nootrope Wirkstoffe.
GT199000081A (es) Derivados de aminoacidos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 0633780

Country of ref document: ES