MX9301701A - Derivados de fenotiazina para el tratamiento de la isquema y la hipoxia, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichas composiciones farmaceuticas. - Google Patents

Derivados de fenotiazina para el tratamiento de la isquema y la hipoxia, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichas composiciones farmaceuticas.

Info

Publication number
MX9301701A
MX9301701A MX9301701A MX9301701A MX9301701A MX 9301701 A MX9301701 A MX 9301701A MX 9301701 A MX9301701 A MX 9301701A MX 9301701 A MX9301701 A MX 9301701A MX 9301701 A MX9301701 A MX 9301701A
Authority
MX
Mexico
Prior art keywords
pharmaceutical compositions
pct
hypoxia
treatment
ischema
Prior art date
Application number
MX9301701A
Other languages
English (en)
Inventor
Claude Garret
Jean Marie Stutzmann
Jean Rataud
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of MX9301701A publication Critical patent/MX9301701A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención describe una nueva aplicación terapéutica de derivados de la fenotiazina de fórmula general (I), en la cual R es un radical alquilo que contiene de 1 a 5 átomos de carbono, en cadena recta o ramificada, y R1 y R2 idénticos o diferentes, son dos radicales alquilo que contienen 1 ó 2 átomos de carbono, o forman, junto con el átomo de nitrógeno al cual están unidos un radical pirrolidinilo, así como sus sales y sus esteroisómeros, dotados de una actividad preventiva y/o curativa en el tratamiento de la isquemia de la hipoxia.
MX9301701A 1992-03-30 1993-03-26 Derivados de fenotiazina para el tratamiento de la isquema y la hipoxia, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichas composiciones farmaceuticas. MX9301701A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203793A FR2689013B1 (fr) 1992-03-30 1992-03-30 Nouvelle application thérapeutique des dérivés de la phénothiazine.

Publications (1)

Publication Number Publication Date
MX9301701A true MX9301701A (es) 1993-09-01

Family

ID=9428216

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301701A MX9301701A (es) 1992-03-30 1993-03-26 Derivados de fenotiazina para el tratamiento de la isquema y la hipoxia, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichas composiciones farmaceuticas.

Country Status (12)

Country Link
US (1) US5502049A (es)
EP (1) EP0633780B1 (es)
JP (1) JPH07505376A (es)
AT (1) ATE138806T1 (es)
CA (1) CA2129962A1 (es)
DE (1) DE69303015T2 (es)
DK (1) DK0633780T3 (es)
ES (1) ES2087730T3 (es)
FR (1) FR2689013B1 (es)
GR (1) GR3020149T3 (es)
MX (1) MX9301701A (es)
WO (1) WO1993019757A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2720940A1 (fr) * 1994-06-13 1995-12-15 Rhone Poulenc Rorer Sa Application du (+)-N-propyl [(pyrrolidinyl-1)-1 propyl-2]-10 phénothiazinecarboxamide comme antidépresseur.
DE4430091A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verwendung von N-substituierten Phenothiazinen
AU7576501A (en) * 2000-03-28 2001-12-03 John W. Olney Combination of adrenergic agonist and nmda antagonist for relieving chronic painwithout adverse side effects
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
CN100513407C (zh) 2003-06-27 2009-07-15 詹森药业有限公司 三环δ阿片样物质调节剂
EP1910353A1 (en) * 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
WO2006069276A2 (en) 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. TRICYCLIC ō-OPIOID MODULATORS
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
BRPI0519198A2 (pt) * 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclicos
EP1846400A2 (en) * 2005-01-06 2007-10-24 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
JP2008543866A (ja) * 2005-06-16 2008-12-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式オピオイドモジュレーター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112310A (en) * 1962-01-15 1963-11-26 Searle & Co 10-alkylaminoalkylphenothiazine-2-carboxamides
US4833138A (en) * 1987-10-23 1989-05-23 Washington University Phenothiazinealkaneamines for treatment of neurotoxic injury
FR2632520B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Derives de la phenothiazine analgesiques
FR2652084B1 (fr) * 1989-09-21 1991-10-31 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
FR2689013B1 (fr) 1995-05-05
JPH07505376A (ja) 1995-06-15
EP0633780B1 (fr) 1996-06-05
US5502049A (en) 1996-03-26
CA2129962A1 (fr) 1993-10-14
ATE138806T1 (de) 1996-06-15
GR3020149T3 (en) 1996-09-30
EP0633780A1 (fr) 1995-01-18
DK0633780T3 (da) 1996-07-01
WO1993019757A1 (fr) 1993-10-14
FR2689013A1 (fr) 1993-10-01
ES2087730T3 (es) 1996-07-16
DE69303015T2 (de) 1996-10-31
DE69303015D1 (de) 1996-07-11

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees