ES2085661T3 - Procedimiento para la obtencion de 2-cloro-5-metil-piridina. - Google Patents

Procedimiento para la obtencion de 2-cloro-5-metil-piridina.

Info

Publication number
ES2085661T3
ES2085661T3 ES93101948T ES93101948T ES2085661T3 ES 2085661 T3 ES2085661 T3 ES 2085661T3 ES 93101948 T ES93101948 T ES 93101948T ES 93101948 T ES93101948 T ES 93101948T ES 2085661 T3 ES2085661 T3 ES 2085661T3
Authority
ES
Spain
Prior art keywords
chloro
methylpyridine
formula
piridine
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93101948T
Other languages
English (en)
Inventor
Eric Dr Rivadeneira
Klaus Dr Jelich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2085661T3 publication Critical patent/ES2085661T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCESO DE 2 RIDINA DE LA FORMULA (I) A PARTIR DE 3 OXIDO DE LA FORMULA (II) Y FOSGENO (COCL2) PREPARADO, QUE ESTA CARACTERIZADO, PORQUE EN UNA PRIMERA ETAPA EL 3 DINA FOSGENO, EVENTUALMENTE EN PRESENCIA DE UN DILUYENTE, EN TEMPERATURAS ENTRE -30 NUEVOS PRODUCTOS INTERMEDIOS TRIMETIL 2 UCTO INTERMEDIO EN BRUTO O EVENTUALMENTE UNA PURIFICACION POSTERIOR Y EN UNA SEGUNDA ETAPA ESTE PRODUCTO INTERMEDIO DE LA FORMULA (III) SE TRANSFORMA CON FOSGENO EN UNA TEMPERATURA ENTRE 50 OCIDO COMO PRODUCTO INTERMEDIO PARA PRODUCTOS FARMACEUTICOS Y PARA INSECTICIDAS.
ES93101948T 1992-02-19 1993-02-08 Procedimiento para la obtencion de 2-cloro-5-metil-piridina. Expired - Lifetime ES2085661T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4204920 1992-02-19
DE4212595A DE4212595A1 (de) 1992-02-19 1992-04-15 Verfahren zur herstellung von 2-chlor-5-methyl-pyridin

Publications (1)

Publication Number Publication Date
ES2085661T3 true ES2085661T3 (es) 1996-06-01

Family

ID=25911972

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93101948T Expired - Lifetime ES2085661T3 (es) 1992-02-19 1993-02-08 Procedimiento para la obtencion de 2-cloro-5-metil-piridina.

Country Status (12)

Country Link
EP (1) EP0556683B1 (es)
JP (1) JP3186886B2 (es)
CN (2) CN1040431C (es)
AT (1) ATE137221T1 (es)
BR (1) BR9300596A (es)
DE (2) DE4212595A1 (es)
DK (1) DK0556683T3 (es)
ES (1) ES2085661T3 (es)
HK (1) HK1009445A1 (es)
HU (1) HU209859B (es)
IL (1) IL104737A (es)
MX (1) MX9300555A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4311247A1 (de) * 1993-04-06 1994-10-13 Bayer Ag Verfahren zur Herstellung von 2-Halogen-pyridin-derivaten
US5502194A (en) * 1992-02-19 1996-03-26 Bayer Aktiengesellschaft Process for the preparation of 2-halogeno-pyridine derivatives
WO1997009312A1 (fr) * 1995-09-08 1997-03-13 Nippon Soda Co., Ltd. Processus de production de 3-(aminomethyl)-6-chloropyridines
CN101260076B (zh) * 2007-03-08 2012-04-11 南京红太阳生物化学有限责任公司 2-氯-5-甲基吡啶的制备方法
JP5499160B2 (ja) 2010-04-06 2014-05-21 日本曹達株式会社 含窒素複素環化合物及びその製造方法
CN103270043B (zh) * 2010-12-02 2015-12-16 内尔维阿诺医学科学有限公司 用于制备吗啉基蒽环衍生物的方法
CN102219732B (zh) * 2011-04-22 2013-04-17 安徽国星生物化学有限公司 一种2-氯-5-甲基吡啶化合物的制备方法
CN102977008A (zh) * 2012-11-08 2013-03-20 安徽国星生物化学有限公司 2-氯-5-甲基吡啶化合物的合成方法
TW201605852A (zh) * 2013-09-26 2016-02-16 美國禮來大藥廠 新穎化合物及其製備ｔａｕ造影劑及ｔａｕ造影調配物之用途
CN108467357B (zh) * 2018-05-28 2020-04-17 江苏扬农化工集团有限公司 一种制备2-氯-5-甲基吡啶的方法
WO2022099692A1 (zh) * 2020-11-16 2022-05-19 单县欣润化工有限公司 一种2-氯-5-三氟甲基吡啶合成方法及系统
CN115010657B (zh) * 2022-07-18 2024-01-23 江苏瑞祥化工有限公司 一种连续流制备2-氯-5-甲基吡啶的方法
CN116354876A (zh) * 2023-03-31 2023-06-30 四川大学 一种高纯度2-氯-5-甲基吡啶的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4020055A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Verfahren zur herstellung von substituierten 2-chlor-pyridinen
DE4020053A1 (de) * 1990-01-31 1991-08-01 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin
DE4020052A1 (de) * 1990-06-23 1992-01-02 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin

Also Published As

Publication number Publication date
DK0556683T3 (da) 1996-08-12
HU9300445D0 (en) 1993-05-28
JP3186886B2 (ja) 2001-07-11
DE4212595A1 (de) 1993-08-26
IL104737A0 (en) 1993-06-10
ATE137221T1 (de) 1996-05-15
JPH07252226A (ja) 1995-10-03
HK1009445A1 (en) 1999-06-04
DE59302304D1 (de) 1996-05-30
CN1186805A (zh) 1998-07-08
MX9300555A (es) 1993-09-01
EP0556683B1 (de) 1996-04-24
IL104737A (en) 1997-02-18
BR9300596A (pt) 1993-08-24
CN1040431C (zh) 1998-10-28
HU209859B (en) 1994-11-28
CN1075476A (zh) 1993-08-25
HUT64028A (en) 1993-11-29
EP0556683A1 (de) 1993-08-25
CN1083434C (zh) 2002-04-24

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