ES2085627T3 - Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents
Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen.Info
- Publication number
- ES2085627T3 ES2085627T3 ES92911474T ES92911474T ES2085627T3 ES 2085627 T3 ES2085627 T3 ES 2085627T3 ES 92911474 T ES92911474 T ES 92911474T ES 92911474 T ES92911474 T ES 92911474T ES 2085627 T3 ES2085627 T3 ES 2085627T3
- Authority
- ES
- Spain
- Prior art keywords
- alcoil
- new derivatives
- halogen
- perhydroisoindol
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- -1 CYCLOHEXADIENYL Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
NUEVOS DERIVADOS DE PERIDROISOINDOLA DE FORMULA GENERAL (I), EN LA QUE LOS RADICALES R SON ATOMOS DE HIDROGENO, O FORMAN EN CONJUNTO UN ENLACE, LOS SIMBOLOS R'' SON RADICALES DE FENILO, PUDIENDO SER SUSTITUIDOS POR UN ATOMO DE HALOGENO O UN RADICAL DE METILO, EN POSICION 2 O 3, X ES UN ATOMO DE OXIGENO O UN RADICAL NH, R1 ES FENILO EVENTUALMENTE SUSTITUIDO, CICLOHEXADIENILO, NAFTILO O HETEROCICLILO, R2 ES H, HALOGENO, OH, ALCOILO, AMINOALCOILO, ALCOILAMINOALCOILO, DIALCOILAMINOALCOILO, ALCOILOXI, ALCOITIO, ACILOXI, CARBOXI, ALCOILOXICARBONILO EVENTUALMENTE SUSTITUIDO, BENZILOXICARBONILO, AMINO O ACILAMINO, R3 ES HALOGENO O OH Y R4 ES H O HALOGENO, SI R3 ES HALOGENO BAJO SUS FORMAS ISOMERAS O SUS MEZCLAS, EVENTUALMENTE SUS SALES CUANDO EXISTEN Y SU PREPARACION. LOS NUEVOS DERIVADOS CONFORME A LA INVENCION RESULTAN DE ESPECIAL INTERES COMO ANTAGONISTAS DE LA SUSTANCIA P.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9106035A FR2676442B1 (fr) | 1991-05-17 | 1991-05-17 | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2085627T3 true ES2085627T3 (es) | 1996-06-01 |
Family
ID=9412907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92911474T Expired - Lifetime ES2085627T3 (es) | 1991-05-17 | 1992-05-15 | Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5451601A (es) |
| EP (2) | EP0514273A1 (es) |
| JP (1) | JPH06507627A (es) |
| AT (1) | ATE135687T1 (es) |
| AU (1) | AU1883692A (es) |
| CA (1) | CA2109298A1 (es) |
| CZ (1) | CZ244793A3 (es) |
| DE (1) | DE69209290T2 (es) |
| DK (1) | DK0586490T3 (es) |
| ES (1) | ES2085627T3 (es) |
| FI (1) | FI935071A0 (es) |
| FR (1) | FR2676442B1 (es) |
| GR (1) | GR3019386T3 (es) |
| HU (1) | HUT67649A (es) |
| IE (1) | IE921578A1 (es) |
| IL (1) | IL101866A0 (es) |
| MX (1) | MX9202287A (es) |
| NO (1) | NO933964L (es) |
| NZ (1) | NZ242772A (es) |
| SK (1) | SK126793A3 (es) |
| TW (1) | TW200459B (es) |
| WO (1) | WO1992020653A1 (es) |
| ZA (1) | ZA923540B (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689888B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| US5508424A (en) * | 1993-03-26 | 1996-04-16 | Ortho Pharmaceutical Corporation | 4-arylisoindole analgesics |
| FR2703679B1 (fr) * | 1993-04-05 | 1995-06-23 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2710913B1 (fr) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2709752B1 (fr) * | 1993-07-30 | 1995-10-06 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| TW365603B (en) * | 1993-07-30 | 1999-08-01 | Rhone Poulenc Rorer Sa | Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them |
| FR2710842B1 (fr) * | 1993-10-07 | 1995-11-24 | Rhone Poulenc Rorer Sa | Nouvelle application thérapeutique de dérivés de perhydroisoindole. |
| FR2719476B1 (fr) * | 1994-05-05 | 1997-05-23 | Oreal | Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue. |
| US6203803B1 (en) | 1994-12-14 | 2001-03-20 | Societe L'oreal S.A. | Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained |
| FR2719474B1 (fr) | 1994-05-05 | 1996-05-31 | Oreal | Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue. |
| FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2728166A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Composition topique contenant un antagoniste de substance p |
| FR2728165A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene |
| FR2728169A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales |
| FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
| US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| EP1246806B1 (en) | 1999-11-03 | 2008-02-27 | AMR Technology, Inc. | Arly- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| WO2002004455A2 (en) | 2000-07-11 | 2002-01-17 | Albany Molecular Research, Inc | 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
| KR101389246B1 (ko) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
| KR101594898B1 (ko) | 2005-07-15 | 2016-02-18 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| GEP20115337B (en) | 2007-01-10 | 2011-11-25 | St Di Ricerche Di Biologia Molecolare P Angeletti Spa | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
| EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| AR071997A1 (es) | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| EA020553B1 (ru) | 2009-05-12 | 2014-12-30 | Олбани Молекьюлар Рисерч, Инк. | 7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ |
| WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| MX2012004377A (es) | 2009-10-14 | 2012-06-01 | Merck Sharp & Dohme | Piperidinas sustituidas que aumentan la actividad de p53 y sus usos. |
| EP2601293B1 (en) | 2010-08-02 | 2017-12-06 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| AU2011292261B2 (en) | 2010-08-17 | 2015-05-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| EP2615916B1 (en) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel erk inhibitors |
| EP3327125B1 (en) | 2010-10-29 | 2020-08-05 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| US20140045832A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Insulin-Like Growth Factor-1 Receptor Inhibitors |
| WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| EP3453762B1 (en) | 2012-05-02 | 2021-04-21 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| MX2015004041A (es) | 2012-09-28 | 2015-07-06 | Merck Sharp & Dohme | Compuestos novedosos que son inhibidores de erk. |
| RU2660349C2 (ru) | 2012-11-28 | 2018-07-05 | Мерк Шарп И Доум Корп. | Композиции и способы для лечения злокачественной опухоли |
| US8846657B2 (en) | 2012-12-20 | 2014-09-30 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
| EP2951180B1 (en) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
| FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
-
1991
- 1991-05-17 FR FR9106035A patent/FR2676442B1/fr not_active Expired - Fee Related
-
1992
- 1992-05-14 IL IL101866A patent/IL101866A0/xx unknown
- 1992-05-15 SK SK1267-93A patent/SK126793A3/sk unknown
- 1992-05-15 ZA ZA923540A patent/ZA923540B/xx unknown
- 1992-05-15 TW TW081103795A patent/TW200459B/zh active
- 1992-05-15 DE DE69209290T patent/DE69209290T2/de not_active Expired - Fee Related
- 1992-05-15 DK DK92911474.2T patent/DK0586490T3/da active
- 1992-05-15 NZ NZ242772A patent/NZ242772A/en unknown
- 1992-05-15 ES ES92911474T patent/ES2085627T3/es not_active Expired - Lifetime
- 1992-05-15 HU HU9303249A patent/HUT67649A/hu unknown
- 1992-05-15 US US08/146,143 patent/US5451601A/en not_active Expired - Fee Related
- 1992-05-15 CA CA002109298A patent/CA2109298A1/fr not_active Abandoned
- 1992-05-15 EP EP92401329A patent/EP0514273A1/fr active Pending
- 1992-05-15 AT AT92911474T patent/ATE135687T1/de active
- 1992-05-15 MX MX9202287A patent/MX9202287A/es unknown
- 1992-05-15 JP JP4510462A patent/JPH06507627A/ja active Pending
- 1992-05-15 CZ CS932447A patent/CZ244793A3/cs unknown
- 1992-05-15 EP EP92911474A patent/EP0586490B1/fr not_active Expired - Lifetime
- 1992-05-15 AU AU18836/92A patent/AU1883692A/en not_active Abandoned
- 1992-05-15 WO PCT/FR1992/000429 patent/WO1992020653A1/fr active IP Right Grant
- 1992-07-01 IE IE157892A patent/IE921578A1/en not_active Application Discontinuation
-
1993
- 1993-11-02 NO NO933964A patent/NO933964L/no unknown
- 1993-11-16 FI FI935071A patent/FI935071A0/fi unknown
-
1996
- 1996-03-21 GR GR950403441T patent/GR3019386T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3019386T3 (en) | 1996-06-30 |
| JPH06507627A (ja) | 1994-09-01 |
| DK0586490T3 (da) | 1996-04-15 |
| MX9202287A (es) | 1993-02-01 |
| FR2676442A1 (fr) | 1992-11-20 |
| ZA923540B (en) | 1993-01-27 |
| DE69209290T2 (de) | 1996-10-31 |
| HUT67649A (en) | 1995-04-28 |
| EP0586490A1 (fr) | 1994-03-16 |
| IE921578A1 (en) | 1992-11-18 |
| NZ242772A (en) | 1994-04-27 |
| IL101866A0 (en) | 1992-12-30 |
| TW200459B (es) | 1993-02-21 |
| CA2109298A1 (fr) | 1992-11-18 |
| NO933964D0 (no) | 1993-11-02 |
| AU1883692A (en) | 1992-12-30 |
| EP0514273A1 (fr) | 1992-11-19 |
| SK126793A3 (en) | 1994-11-09 |
| FI935071A (fi) | 1993-11-16 |
| WO1992020653A1 (fr) | 1992-11-26 |
| FI935071A0 (fi) | 1993-11-16 |
| US5451601A (en) | 1995-09-19 |
| EP0586490B1 (fr) | 1996-03-20 |
| NO933964L (no) | 1993-11-02 |
| DE69209290D1 (de) | 1996-04-25 |
| FR2676442B1 (fr) | 1993-08-06 |
| CZ244793A3 (en) | 1994-03-16 |
| HU9303249D0 (en) | 1994-03-28 |
| ATE135687T1 (de) | 1996-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2085627T3 (es) | Nuevos derivados de perhidroisoindol, su preparacion y las composiciones farmaceuticas que les contienen. | |
| ES2066620T3 (es) | Nuevos derivados de perhidroisoindol y su preparacion. | |
| DK165108C (da) | 3-phenyluraciler og enolethere og salte deraf, fremgangsmaade til fremstilling deraf, ukrudtsbekaempelsesmiddel indeholdende disse forbindelser samt anvendelse af forbindelserne til bekaempelse af ukrudt | |
| HUP0001192A2 (hu) | Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására | |
| DK1019368T3 (da) | Acylsulfamoylbenzoesyreamider, nytteplantebeskyttelsesmidler indeholdende disse samt fremgangsmåder til deres fremstilling | |
| MX9301986A (es) | Derivados de perhidroisoindol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| HUP0303037A2 (hu) | Alzheimer-kór kezelésére alkalmas vegyületek és ezeket tartalmazó gyógyszerkészítmények | |
| MX9207074A (es) | Piperazinil- y piperidinil -ciclohexanoles y composicion farmaceutica que los comprende | |
| AR015211A1 (es) | Amidas aromaticas, su procedimiento de preparacion, composicion farmaceutica y productos quimicos que las contienen | |
| IS3504A7 (is) | Alpha-alpha-dísúbstitúeruð N-cycloalkylalkylbenzylamín, aðferð við framleiðslu þeirra, notkun þeirra til lækninga og efni til nýmyndunar þeirra | |
| ES2115904T3 (es) | Derivados amino ramificados del tiazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. | |
| ES2036213T3 (es) | Procedimiento para preparar derivados tetrahidroisoquinolin-1-ilicos de acidos carboxilicos. | |
| DK83789D0 (da) | Substituerede 1,2,4-triazindioner, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse | |
| DE69006707D1 (de) | Verwendung von Fluorochinolon-Derivaten zur Behandlung der Pneumocystis carinii Pneumonie. | |
| DK177589D0 (da) | Fremgangsmaade til fremstilling af 2,5-diamino-6-nitro-pyridinderivater, derivaternes anvendelse i haarfarvemidler samt hidtil ukendte 2,5-diamino-6-nitro-pyridinderivater | |
| SE7712733L (sv) | Substituerade o-fenylendiaminderivat, sett for framstellning samt anvendning derav som lekemedel | |
| FR2616433B1 (fr) | Nouveaux derives piperazinyl alkyl piperazine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
| DE3772909D1 (de) | 3-methylphthalimide. | |
| SE8100946L (sv) | Nya indanderivat, sett att framstella dem, anvendning derav som farmaceutika och farmaceutiska kompositioner som innehaller dess derivat | |
| ES520312A0 (es) | Procedimiento para la preparacion de 2-aminometilfenoles. | |
| JPS57185270A (en) | Novel cyclic sulfenamides, manufacture and use as drug | |
| ES2052206T3 (es) | Procedimiento de preparacion de nuevos derivados de benzotiazolinona y las composiciones farmaceuticas que los contienen. | |
| DE3865656D1 (de) | Trizyklische derivate, agonistn von cholinergetischen rezeptoren und diese enthaltende arzneimittel. | |
| MX9207395A (es) | Tiazoles novedosos. | |
| DK104488D0 (da) | Acetamider afledt af 2,3-dihydro-3-phenyl-2-benzofuranon, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 586490 Country of ref document: ES |