ES2084019T3 - Profarmacos fosforilados inhibidores de la glicosidasa. - Google Patents

Profarmacos fosforilados inhibidores de la glicosidasa.

Info

Publication number
ES2084019T3
ES2084019T3 ES90870126T ES90870126T ES2084019T3 ES 2084019 T3 ES2084019 T3 ES 2084019T3 ES 90870126 T ES90870126 T ES 90870126T ES 90870126 T ES90870126 T ES 90870126T ES 2084019 T3 ES2084019 T3 ES 2084019T3
Authority
ES
Spain
Prior art keywords
glycosidase
inhibitors
propharmacs
phosphorilated
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90870126T
Other languages
English (en)
Inventor
Peter Richard Scudder
Raymond Allen Dwek
Thomas William Rademacher
Gary Steven Jacob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2084019T3 publication Critical patent/ES2084019T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PROVEE UN METODO PARA CONVERTIR INHIBIDORES DE GLICOSIDASA TERAPEUTICA EN NUEVAS PRO-DROGAS MEDIANTE FOSFORACION DE UN GRUPO HIDROXILO LIBRE SOBRE LA MOLECULA PARA REDUCIR SUSTANCIALMENTE LA ACTIVIDAD INHIBIDORA DE GLICOSIDASA SIN POR ELLO REDUCIR SUSTANCIALMENTE LA ACTIVIDAD TERAPEUTICA.
ES90870126T 1989-08-17 1990-08-13 Profarmacos fosforilados inhibidores de la glicosidasa. Expired - Lifetime ES2084019T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/394,914 US5043273A (en) 1989-08-17 1989-08-17 Phosphorylated glycosidase inhibitor prodrugs

Publications (1)

Publication Number Publication Date
ES2084019T3 true ES2084019T3 (es) 1996-05-01

Family

ID=23560918

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90870126T Expired - Lifetime ES2084019T3 (es) 1989-08-17 1990-08-13 Profarmacos fosforilados inhibidores de la glicosidasa.

Country Status (9)

Country Link
US (1) US5043273A (es)
EP (1) EP0413674B1 (es)
JP (1) JPH0791309B2 (es)
AT (1) ATE134639T1 (es)
CA (1) CA2023404C (es)
DE (1) DE69025515T2 (es)
DK (1) DK0413674T3 (es)
ES (1) ES2084019T3 (es)
GR (1) GR3019753T3 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
EP0453692A1 (en) * 1990-04-27 1991-10-30 Merrell Dow Pharmaceuticals Inc. Novel nojirimycin derivatives
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US6465488B1 (en) 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
JP2001525367A (ja) 1997-12-11 2001-12-11 ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード 膜関連ウイルス複製の阻害
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
DE60037664T2 (de) 1999-08-10 2008-12-24 The Chancellor, Masters And Scholars Of The University Of Oxford Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel
ES2537089T3 (es) 2005-06-08 2015-06-02 Amicus Therapeutics, Inc. Purificación de imino- y amino-azúcares
NZ565953A (en) 2005-07-27 2012-01-12 Univ Florida Small compounds that correct protein misfolding and uses thereof
AU2006330277B2 (en) 2005-12-27 2011-10-06 Otsuka Pharmaceutical Co., Ltd. Water-soluble benzoazepine compound and its pharmaceutical composition
EP2356990A3 (en) 2006-08-02 2011-10-19 University of Oxford Liposome treatment of viral infections
US20080131398A1 (en) * 2006-08-21 2008-06-05 United Therapeutics Corporation Combination therapy for treatment of viral infections
EP1995323A1 (en) * 2007-05-24 2008-11-26 Libragen Method for preparing C-6 phosphorylated D-aldohexoses and C-6 phosphorylated D-aldohexose derivatives
WO2009118658A2 (en) * 2008-03-26 2009-10-01 University Of Oxford Endoplasmic reticulum targeting liposomes
US8450345B2 (en) 2009-02-23 2013-05-28 The Chancellor, Masters And Scholars Of The University Of Oxford Iminosugars and methods of treating viral diseases
US20100222384A1 (en) * 2009-02-24 2010-09-02 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
JP2012521981A (ja) * 2009-03-27 2012-09-20 ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード コレステロールレベル低下リポソーム
US20100298335A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and Methods for Ameliorating or Reducing Presbyopia
CA2765086C (en) 2009-06-12 2015-12-15 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases
IN2012DN00352A (es) 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
JP5575246B2 (ja) * 2009-09-04 2014-08-20 ユナイテッド セラピューティクス コーポレイション ポックスウイルス感染の治療方法
WO2011028779A1 (en) 2009-09-04 2011-03-10 United Therapeutics Corporation Iminosugars and methods of treating filoviral diseases
DK2473482T3 (en) * 2009-09-04 2014-05-12 United Therapeutics Corp Methods of treating orthomyxoviral infections
CA2783405A1 (en) 2009-12-07 2011-06-16 The Chancellor, Masters And Scholars Of The University Of Oxford N-substituted deoxynojirimycin compounds for use in inhibiting osteoclastogenesis and/or osteoclast activation
CN103917093B (zh) 2011-06-14 2017-08-11 比卡姆药品公司 视蛋白结合配体、组合物及使用方法
AU2012325341B2 (en) 2011-10-19 2017-01-05 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
BR112014012997A2 (pt) 2011-11-30 2017-06-13 Bikam Pharmaceuticals Inc ligantes que se ligam à opsina, composições e métodos de uso
JP6322142B2 (ja) 2011-12-01 2018-05-09 ビカム ファーマスーティカルス，インコーポレイテッド オプシン結合性リガンド、組成物、及び使用方法
JP5876856B2 (ja) * 2013-08-02 2016-03-02 中国医学科学院薬物研究所 血糖降下剤を調製するための、桑の枝由来のアルカロイドの有効画分の使用
US10144727B2 (en) 2013-09-16 2018-12-04 Emergent Virology Llc Deoxynojirimycin derivatives and methods of their using
SG11201703330YA (en) 2014-11-05 2017-05-30 Emergent Virology Llc Iminosugars useful for the treatment of viral diseases
BR112018072298A2 (pt) 2016-05-02 2019-02-12 Florida State University Research Foundation, Inc. tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase
WO2017220298A1 (en) * 2016-06-22 2017-12-28 Unilever N.V. Edible fat-continuous emulsion comprising 1-deoxynojirimycin and lecithin
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases
WO2021168483A2 (en) 2020-02-21 2021-08-26 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
US4847244A (en) * 1985-09-17 1989-07-11 Burroughs Wellcome Co. Treatment of human viral infections
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
CA2023404C (en) 2001-10-23
JPH03118327A (ja) 1991-05-20
ATE134639T1 (de) 1996-03-15
GR3019753T3 (en) 1996-07-31
EP0413674B1 (en) 1996-02-28
US5043273A (en) 1991-08-27
DE69025515D1 (de) 1996-04-04
DK0413674T3 (da) 1996-06-10
DE69025515T2 (de) 1996-10-02
EP0413674A2 (en) 1991-02-20
JPH0791309B2 (ja) 1995-10-04
EP0413674A3 (en) 1991-07-17
CA2023404A1 (en) 1991-02-18

Similar Documents

Publication Publication Date Title
ES2084019T3 (es) Profarmacos fosforilados inhibidores de la glicosidasa.
ES2038251T3 (es) Un procedimiento para producir un derivado de benzamida.
ES476955A1 (es) Un procedimiento para la preparacion de derivados se imida- zoquinazolina.
ES2058347T3 (es) Nuevos acidos percarboxilicos imido-aromaticos.
ES2038679T3 (es) Un procedimiento para preparar derivados de dihidrobenzofurano- y cromano-carboxamidas.
ATE78465T1 (de) Kathartica.
ES557076A0 (es) Un procedimiento para la preparacion de nuevas benzamidas sustituidas.
FR2361328A1 (fr) Nouvelles benzophenones utiles notamment a la preparation d'oximes et d'hydrazones
ES548799A0 (es) Procedimiento para incrementar la velocidad de asentamiento de un cemento hidraulico.
ES542163A0 (es) Un procedimiento para preparar nuevas benzamidas con actividada antagonista de 5-ht.
ES549200A0 (es) Procedimiento para preparar una solucion antigenica libre decelulas
ES2032428T3 (es) Procedimiento para preparar (+)-biotina.
DE3768586D1 (de) Fundament fuer sicherheitsgebaeude eines kernreaktors.
NO161953C (no) Anvendelse av en langkjedet alkylester som en temporaer mikrobicid.
ATE66137T1 (de) Haartonikum.
AT383396B (de) Niederdruckzylinder einer dampfturbine
ES8607247A1 (es) Procedimiento para preparar nuevos compuestos de 3-(aminoal-quilaminocarbonilmetoxi)-5-fenilpirazol
ES546732A0 (es) Dispositivo para producir un empalme de torones, especialmente de torones telefonicos.
ES2052925T3 (es) Compuestos de pirazol, metodo para su produccion, su uso, y compuestos intermedios para la produccion de los mismos.
ES546687A0 (es) Un procedimiento para preparacion de nuevos analogos de mitomicina.
ES540757A0 (es) Un procedimiento para activar peroxido de hidrogeno
GB1509454A (en) 2-amino-tetralins
ES8802496A1 (es) Procedimiento para preparar dihidropiridinas
ES544241A0 (es) Un procedimiento para producir un derivado de 4h-3,1-benzo- xazina
UA8233A1 (uk) Гамма-гідроглутамінат літію, що проявляє седативну антидепресивну дію

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 413674

Country of ref document: ES