ES2084019T3 - Profarmacos fosforilados inhibidores de la glicosidasa. - Google Patents
Profarmacos fosforilados inhibidores de la glicosidasa.Info
- Publication number
- ES2084019T3 ES2084019T3 ES90870126T ES90870126T ES2084019T3 ES 2084019 T3 ES2084019 T3 ES 2084019T3 ES 90870126 T ES90870126 T ES 90870126T ES 90870126 T ES90870126 T ES 90870126T ES 2084019 T3 ES2084019 T3 ES 2084019T3
- Authority
- ES
- Spain
- Prior art keywords
- glycosidase
- inhibitors
- propharmacs
- phosphorilated
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000005744 Glycoside Hydrolases Human genes 0.000 title abstract 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 239000003316 glycosidase inhibitor Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE PROVEE UN METODO PARA CONVERTIR INHIBIDORES DE GLICOSIDASA TERAPEUTICA EN NUEVAS PRO-DROGAS MEDIANTE FOSFORACION DE UN GRUPO HIDROXILO LIBRE SOBRE LA MOLECULA PARA REDUCIR SUSTANCIALMENTE LA ACTIVIDAD INHIBIDORA DE GLICOSIDASA SIN POR ELLO REDUCIR SUSTANCIALMENTE LA ACTIVIDAD TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/394,914 US5043273A (en) | 1989-08-17 | 1989-08-17 | Phosphorylated glycosidase inhibitor prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084019T3 true ES2084019T3 (es) | 1996-05-01 |
Family
ID=23560918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90870126T Expired - Lifetime ES2084019T3 (es) | 1989-08-17 | 1990-08-13 | Profarmacos fosforilados inhibidores de la glicosidasa. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5043273A (es) |
EP (1) | EP0413674B1 (es) |
JP (1) | JPH0791309B2 (es) |
AT (1) | ATE134639T1 (es) |
CA (1) | CA2023404C (es) |
DE (1) | DE69025515T2 (es) |
DK (1) | DK0413674T3 (es) |
ES (1) | ES2084019T3 (es) |
GR (1) | GR3019753T3 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0453692A1 (en) * | 1990-04-27 | 1991-10-30 | Merrell Dow Pharmaceuticals Inc. | Novel nojirimycin derivatives |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
GB9602080D0 (en) | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
KR20010033028A (ko) | 1997-12-11 | 2001-04-25 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 막-관련 바이러스 복제의 억제 |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
US7816560B1 (en) | 1999-08-10 | 2010-10-19 | Thomas Jefferson University | Long chain n-alkyl compounds and oxa-derivatives thereof |
SI2027137T1 (sl) | 2005-06-08 | 2015-06-30 | Amicus Therapeutics, Inc. | Čiščenje imino in amino sladkorja |
EP1909812A4 (en) | 2005-07-27 | 2009-11-25 | Univ Florida | SMALL CONNECTIONS FOR THE CORRECTION OF PROTEIN MISFAIRINGS AND USES THEREOF |
PT1968990E (pt) | 2005-12-27 | 2015-03-16 | Otsuka Pharma Co Ltd | Composto de benzoazepina solúvel em água e a sua composição farmacêutica |
JP2009545621A (ja) | 2006-08-02 | 2009-12-24 | ユナイテッド セラピューティクス コーポレーション | ウィルス感染症のリポソーム処置 |
EP2054076A2 (en) * | 2006-08-21 | 2009-05-06 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
EP1995323A1 (en) * | 2007-05-24 | 2008-11-26 | Libragen | Method for preparing C-6 phosphorylated D-aldohexoses and C-6 phosphorylated D-aldohexose derivatives |
CA2719567A1 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
KR20120042716A (ko) * | 2009-02-23 | 2012-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 바이러스성 질환을 치료하는 방법 |
KR20170117614A (ko) * | 2009-02-24 | 2017-10-23 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 아레나바이러스성 감염을 치료하는 방법 |
CN102427804A (zh) * | 2009-03-27 | 2012-04-25 | 牛津大学之校长及学者 | 降低胆固醇水平的脂质体 |
WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
EP2440205B1 (en) | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminosugars for use in the treatment of bunyaviral and togaviral diseases |
IN2012DN00352A (es) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
MX2012002486A (es) * | 2009-09-04 | 2012-09-07 | United Therapeutics Corp | Metodos para tratar infecciones ortomixovirales. |
EP2473493B1 (en) * | 2009-09-04 | 2014-04-30 | United Therapeutics Corporation | Methods of treating poxviral infections |
CA2772813A1 (en) * | 2009-09-04 | 2011-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Iminosugars and methods of treating filoviral diseases |
CN102740852A (zh) | 2009-12-07 | 2012-10-17 | 牛津大学之校长及学者 | 用于抑制破骨细胞形成和/或破骨细胞活化的n-取代的脱氧野尻霉素化合物 |
EA026121B1 (ru) | 2011-06-14 | 2017-03-31 | Бикам Фармасьютикалз, Инк. | Опсин-связывающие лиганды, композиции и способы их использования |
WO2013058809A1 (en) | 2011-10-19 | 2013-04-25 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
WO2013082000A1 (en) | 2011-11-30 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
WO2013081642A1 (en) | 2011-12-01 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
JP5876856B2 (ja) * | 2013-08-02 | 2016-03-02 | 中国医学科学院薬物研究所 | 血糖降下剤を調製するための、桑の枝由来のアルカロイドの有効画分の使用 |
US10144727B2 (en) | 2013-09-16 | 2018-12-04 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
BR112017008898B1 (pt) | 2014-11-05 | 2022-11-29 | Emergent Virology Llc | Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais |
BR112018072298A2 (pt) | 2016-05-02 | 2019-02-12 | Florida State University Research Foundation, Inc. | tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase |
WO2017220298A1 (en) * | 2016-06-22 | 2017-12-28 | Unilever N.V. | Edible fat-continuous emulsion comprising 1-deoxynojirimycin and lecithin |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
US11369592B2 (en) | 2020-02-21 | 2022-06-28 | Florida State University Research Foundation, Inc. | Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
US4847244A (en) * | 1985-09-17 | 1989-07-11 | Burroughs Wellcome Co. | Treatment of human viral infections |
GB8716918D0 (en) * | 1987-07-17 | 1987-08-26 | Inverni Della Beffa Spa | Soluble derivatives of silybin |
US4849430A (en) * | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
-
1989
- 1989-08-17 US US07/394,914 patent/US5043273A/en not_active Expired - Lifetime
-
1990
- 1990-08-13 AT AT90870126T patent/ATE134639T1/de not_active IP Right Cessation
- 1990-08-13 DK DK90870126.1T patent/DK0413674T3/da active
- 1990-08-13 ES ES90870126T patent/ES2084019T3/es not_active Expired - Lifetime
- 1990-08-13 DE DE69025515T patent/DE69025515T2/de not_active Expired - Fee Related
- 1990-08-13 EP EP90870126A patent/EP0413674B1/en not_active Expired - Lifetime
- 1990-08-16 CA CA002023404A patent/CA2023404C/en not_active Expired - Fee Related
- 1990-08-16 JP JP2216466A patent/JPH0791309B2/ja not_active Expired - Fee Related
-
1996
- 1996-04-24 GR GR960401150T patent/GR3019753T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0413674B1 (en) | 1996-02-28 |
CA2023404A1 (en) | 1991-02-18 |
EP0413674A3 (en) | 1991-07-17 |
ATE134639T1 (de) | 1996-03-15 |
DE69025515D1 (de) | 1996-04-04 |
JPH0791309B2 (ja) | 1995-10-04 |
EP0413674A2 (en) | 1991-02-20 |
JPH03118327A (ja) | 1991-05-20 |
CA2023404C (en) | 2001-10-23 |
GR3019753T3 (en) | 1996-07-31 |
DE69025515T2 (de) | 1996-10-02 |
DK0413674T3 (da) | 1996-06-10 |
US5043273A (en) | 1991-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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