ES2079417T3 - Procedimiento de preparacion de derivados de la partricina. - Google Patents
Procedimiento de preparacion de derivados de la partricina.Info
- Publication number
- ES2079417T3 ES2079417T3 ES90121400T ES90121400T ES2079417T3 ES 2079417 T3 ES2079417 T3 ES 2079417T3 ES 90121400 T ES90121400 T ES 90121400T ES 90121400 T ES90121400 T ES 90121400T ES 2079417 T3 ES2079417 T3 ES 2079417T3
- Authority
- ES
- Spain
- Prior art keywords
- amines
- polyene
- derivatives
- prepared
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NVJUPMZQNWDHTL-BGZDCYLNSA-N 3-[(2s,3r,4r,5r,6s)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-23,27,29,31,33,35,37-heptahydroxy-18-methyl-21,25-dioxo-20,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylic acid Chemical class O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)C=CC=CC=CC=CC=CC=CC=CC(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-BGZDCYLNSA-N 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- -1 POLYENE CARBOXYL Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 230000000416 anti-micotic effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 230000001969 hypertrophic effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- NVJUPMZQNWDHTL-MJODAWFJSA-N partricin Chemical compound O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-MJODAWFJSA-N 0.000 abstract 1
- 229950007355 partricin Drugs 0.000 abstract 1
- 238000011422 pharmacological therapy Methods 0.000 abstract 1
- 150000004291 polyenes Chemical class 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003334 secondary amides Chemical class 0.000 abstract 1
- 239000003270 steroid hormone Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000003511 tertiary amides Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Steroid Compounds (AREA)
Abstract
SE HAN PREPARADO UNA SERIE DE DERIVADOS DE AMIDAS SECUNDARIAS Y TERCIARIAS DEL PARTRICIN ANTIBIOTICO DE POLIENO ASI COMO SUS COMPUESTOS SENCILLOS, PARTRICIN A Y B, QUE TIENEN RADICALES SOBRE EL NITROGENO DE AMIDA, SIENDO DICHOS RADICALES PREFERIBLEMENTE SUSTITUIDOS, POR TURNO, POR VARIOS GRUPOS DE AMINA. LA SINTESIS SE HA LLEVADO A CABO HACIENDO REACCIONAR EL CARBOXILO C-18 DEL POLIENO CON AMINAS ADECUADAS, ANTE LA PRESENCIA DE FOSFORACIDATO DE DIFENILO COMO ACTIVADOR. DE DICHAS AMINAS, SOBRE TODO DE AQUELLAS SUSTITUIDAS POR GRUPOS BASICOS, SE HAN PREPARADO MUCHAS SALES CON UNA BUENA DISOLUBILIDAD EN AGUA AL HABERLAS HECHO REACCIONAR CON ACIDOS COMPATIBLES FARMACOLOGICAMENTE. SE HA MOSTRADO QUE MUCHAS AMINAS Y SALES RELACIONADAS SON MAS ACTIVAS QUE, O TAN ACTIVAS COMO, EL PRODUCTO INICIAL COMO AGENTES ANTIMICOTICOS Y ANTIPROTOZOICOS, AL TIEMPO QUE SON MENOS TOXICAS Y MENOS HEMOLITICAS CON LO QUE SE LES PUEDE ENCONTRAR UNA APLICACION UTIL EN TERAPIAS CLINICAS Y VETERINARIAS. LOS COMPUESTOS PUEDEN SER UTILIZADOS TAMBIEN EN EL TRATAMIENTO DE HIPERCOLESTEREMIA E HIPERLIPEMIA Y DE ALGUNOS DESEQUILIBRIOS DE HORMONAS ESTEROIDES, ASI COMO EN LA TERAPIA FARMACOLOGICA DE PROSTATA HIPERTROFICA Y EN EL TRATAMIENTO DE INFECCIONES VIRICAS DE SOBRE LIPIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02239689A IT1237772B (it) | 1989-11-16 | 1989-11-16 | Derivati di macrolidi polienici. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2079417T3 true ES2079417T3 (es) | 1996-01-16 |
Family
ID=11195729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90121400T Expired - Lifetime ES2079417T3 (es) | 1989-11-16 | 1990-11-08 | Procedimiento de preparacion de derivados de la partricina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5296597A (es) |
EP (1) | EP0434943B1 (es) |
JP (1) | JP3094065B2 (es) |
KR (1) | KR0185200B1 (es) |
AT (1) | ATE127471T1 (es) |
DE (1) | DE69022196T2 (es) |
ES (1) | ES2079417T3 (es) |
IT (1) | IT1237772B (es) |
PT (1) | PT95910B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1243404B (it) * | 1990-12-03 | 1994-06-10 | Prodotti Antibiotici Spa | Derivati della partricina |
IT1283149B1 (it) * | 1996-07-12 | 1998-04-07 | Prodotti Antibiotici Spa | Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato |
IT1294740B1 (it) * | 1997-09-16 | 1999-04-12 | Prospa Bv | Derivati della partricina per il trattamento profilattico e/o curativo delle contaminazioni fungine di colture cellulari e di tessuti |
US6121244A (en) * | 1997-09-19 | 2000-09-19 | Prospa B.V. | Antitumoral method by administration of partricin derivatives |
EP1278527A4 (en) | 2000-01-14 | 2003-04-09 | Intrabiotics Pharmaceuticals | DERIVATIVES OF POLYEN MACROLIDES, THEIR PRODUCTION AND USE |
US6664241B2 (en) | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
ITMI20032280A1 (it) * | 2003-11-24 | 2005-05-25 | Tiberio Bruzzese | Formulazioni farmaceutiche contenenti derivati della partricina e loro uso orale per il trattamento di infezioni fungine e protozoarie localizzate |
MX365184B (es) * | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
GB201409451D0 (en) * | 2014-05-28 | 2014-07-09 | Ipabc Ltd | Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1406774A (en) * | 1973-02-15 | 1975-09-17 | Prodotti Antibiotici Spa | Esters of patricin and of partricin derivatives |
PL122086B1 (en) * | 1979-04-09 | 1982-06-30 | Politechnika Gdanska | Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh |
-
1989
- 1989-11-16 IT IT02239689A patent/IT1237772B/it active IP Right Grant
-
1990
- 1990-11-08 DE DE69022196T patent/DE69022196T2/de not_active Expired - Lifetime
- 1990-11-08 ES ES90121400T patent/ES2079417T3/es not_active Expired - Lifetime
- 1990-11-08 AT AT90121400T patent/ATE127471T1/de not_active IP Right Cessation
- 1990-11-08 EP EP90121400A patent/EP0434943B1/en not_active Expired - Lifetime
- 1990-11-14 US US07/612,912 patent/US5296597A/en not_active Expired - Lifetime
- 1990-11-15 PT PT95910A patent/PT95910B/pt not_active IP Right Cessation
- 1990-11-16 JP JP02308956A patent/JP3094065B2/ja not_active Expired - Fee Related
- 1990-11-16 KR KR1019900018555A patent/KR0185200B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3094065B2 (ja) | 2000-10-03 |
IT8922396A0 (it) | 1989-11-16 |
KR910009638A (ko) | 1991-06-28 |
ATE127471T1 (de) | 1995-09-15 |
JPH03188096A (ja) | 1991-08-16 |
EP0434943B1 (en) | 1995-09-06 |
US5296597A (en) | 1994-03-22 |
PT95910A (pt) | 1991-09-13 |
EP0434943A1 (en) | 1991-07-03 |
IT1237772B (it) | 1993-06-17 |
DE69022196T2 (de) | 1996-02-01 |
DE69022196D1 (de) | 1995-10-12 |
PT95910B (pt) | 1998-01-30 |
KR0185200B1 (ko) | 1999-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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