ES2077124T3 - Empleo de lactonas de 10 atomos en el anillo como reguladores de lipidos. - Google Patents

Empleo de lactonas de 10 atomos en el anillo como reguladores de lipidos.

Info

Publication number
ES2077124T3
ES2077124T3 ES91114331T ES91114331T ES2077124T3 ES 2077124 T3 ES2077124 T3 ES 2077124T3 ES 91114331 T ES91114331 T ES 91114331T ES 91114331 T ES91114331 T ES 91114331T ES 2077124 T3 ES2077124 T3 ES 2077124T3
Authority
ES
Spain
Prior art keywords
elevated
lactones
atoms
ring
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91114331T
Other languages
English (en)
Inventor
Ernold Dr Dr Granzer
Peter Dr Hammann
Joachim Dr Wink
Susanne Dr Grabley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2077124T3 publication Critical patent/ES2077124T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

EL COMPUESTO CON FORMULA GENERAL, EN LA QUE, INDEPENDIENTEMENTE ENTRE SI, SIGNIFICAN: R ELEVADO 1 Y R ELEVADO 4 HIDROGENO E HIDROXILO, R (AL CUADRADO) Y R ELEVADO 3 HIDROXILO, R ELEVADO 5 HIDROGENO, HIDROXILO Y UN GRUPO OXO Y EN LA QUE R (AL CUADRADO) Y R ELEVADO 3 ASI COMO R ELEVADO 3 Y R ELEVADO 4 PUEDEN FORMAR UN ENLACE DOBLE, POSEE PROPIEDADES HIPOLIPEMICAS Y SE UTILIZA PARA LA FABRICACION DE UN MEDICAMENTO PARA LA REDUCCION DEL COLESTEROL EN SUERO.
ES91114331T 1990-08-28 1991-08-27 Empleo de lactonas de 10 atomos en el anillo como reguladores de lipidos. Expired - Lifetime ES2077124T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4027100 1990-08-28

Publications (1)

Publication Number Publication Date
ES2077124T3 true ES2077124T3 (es) 1995-11-16

Family

ID=6413028

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91114331T Expired - Lifetime ES2077124T3 (es) 1990-08-28 1991-08-27 Empleo de lactonas de 10 atomos en el anillo como reguladores de lipidos.

Country Status (9)

Country Link
US (1) US5200424A (es)
EP (1) EP0477552B1 (es)
JP (1) JPH04230628A (es)
DE (1) DE59106261D1 (es)
DK (1) DK0477552T3 (es)
ES (1) ES2077124T3 (es)
GR (1) GR3017592T3 (es)
IE (1) IE913017A1 (es)
PT (1) PT98785A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753262A (en) * 1995-06-07 1998-05-19 Aronex Pharmaceuticals, Inc. Cationic lipid acid salt of 3beta N- (N', N'-dimethylaminoethane) - carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US20090069275A1 (en) * 2006-02-17 2009-03-12 Rocca Jose G Low flush niacin formulation
MX2009009126A (es) * 2007-03-01 2009-10-28 Concourse Health Sciences Llc Isomeros de niacinato de inositol y usos de los mismos.
KR100836960B1 (ko) * 2007-09-07 2008-06-10 주식회사 서울제약 새로운 나이아신 제어방출형 제제

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333024B1 (de) * 1988-03-15 1994-10-19 Hoechst Aktiengesellschaft Neue 10-Ring-Lactone, Verfahren zu ihrer Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
DE59106261D1 (de) 1995-09-21
JPH04230628A (ja) 1992-08-19
IE913017A1 (en) 1992-03-11
EP0477552A1 (de) 1992-04-01
EP0477552B1 (de) 1995-08-16
GR3017592T3 (en) 1995-12-31
DK0477552T3 (da) 1995-12-18
US5200424A (en) 1993-04-06
PT98785A (pt) 1992-07-31

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