MX2009009126A - Isomeros de niacinato de inositol y usos de los mismos. - Google Patents
Isomeros de niacinato de inositol y usos de los mismos.Info
- Publication number
- MX2009009126A MX2009009126A MX2009009126A MX2009009126A MX2009009126A MX 2009009126 A MX2009009126 A MX 2009009126A MX 2009009126 A MX2009009126 A MX 2009009126A MX 2009009126 A MX2009009126 A MX 2009009126A MX 2009009126 A MX2009009126 A MX 2009009126A
- Authority
- MX
- Mexico
- Prior art keywords
- inositol
- niacin
- esters
- chiro
- allo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe un éster que se forma a partir de un inositol o derivado de inositol y niacina, en el cual el inositol o los derivados de inositol comprenden un estereoisámero que se selecciona a partir de alo-inositol, cis-inositol, epi-inositol, muco-inositol, neo-inositol, escilo-inositol, D-quiro-inositol y L-quiro-inositol, y sales farmacéuticamente aceptables de los mismos. Los ejemplos de ésteres incluyen hexaniacinatos de inositol tales como hexaniacinato de alo-inositol y hexaniacinato de cis-inositol. Los ésteres se pueden utilizar para tratar cualquier trastorno que pueda ser tratado con terapia con niacina tales como dislipidemia, hipercolesterolemia, hiperlipidemia o enfermedad vascular. Los ésteres se pueden administrar con otros agentes tales como inhibidores de HMG CoA reductasa, estatinas, fibratos, activadores de receptores activados de proliferador de peroxisoma, policosanol, fitoesteroles, tocotrienoles, calcio, secuestrantes de ácido biliar, goma guar y niacina libre. La invención incluye composiciones farmacéuticas que contienen estos compuestos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89245607P | 2007-03-01 | 2007-03-01 | |
US96005807P | 2007-09-13 | 2007-09-13 | |
PCT/US2008/002735 WO2008106227A1 (en) | 2007-03-01 | 2008-02-29 | Isomers of inositol niacinate and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009009126A true MX2009009126A (es) | 2009-10-28 |
Family
ID=39721559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009009126A MX2009009126A (es) | 2007-03-01 | 2008-02-29 | Isomeros de niacinato de inositol y usos de los mismos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090326013A1 (es) |
EP (1) | EP2114151A4 (es) |
JP (1) | JP2010520208A (es) |
KR (1) | KR20100015343A (es) |
CN (1) | CN101686674A (es) |
AU (1) | AU2008219599A1 (es) |
CA (1) | CA2679403A1 (es) |
IL (1) | IL200589A0 (es) |
MX (1) | MX2009009126A (es) |
WO (1) | WO2008106227A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5801540B2 (ja) * | 2010-06-17 | 2015-10-28 | ロート製薬株式会社 | 医薬組成物 |
EP2584899B1 (en) * | 2010-06-24 | 2018-01-10 | Trustees Of Tufts College | Niacin mimetics, and use thereof |
CA2802952A1 (en) * | 2010-06-24 | 2011-12-29 | Arisaph Pharmaceuticals, Inc. | Niacin mimetics, and methods of use thereof |
WO2014110234A1 (en) * | 2013-01-09 | 2014-07-17 | Elan Pharmaceuticals, Llc | Methods of treating developmental and personality disorders |
CN104799299A (zh) * | 2014-01-26 | 2015-07-29 | 天津中瑞药业股份有限公司 | 一种含黄芪及肌醇烟酸酯食品营养强化剂制备方法 |
TW201618777A (zh) * | 2014-09-26 | 2016-06-01 | 興和股份有限公司 | 脂質異常症治療劑 |
CN105153025A (zh) * | 2015-09-23 | 2015-12-16 | 潍坊盛瑜药业有限公司 | 肌醇烟酸酯晶型a及其制备方法 |
CA3108838A1 (en) * | 2018-08-22 | 2020-02-27 | Societe Des Produits Nestle S.A. | Composition comprising isomers of inositol and its use |
WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
KR102377167B1 (ko) | 2022-01-17 | 2022-03-23 | 주식회사 지웨이코스메틱 | 파라고무나무 잎 추출물을 함유하는 화장료 조성물의 제조 방법 |
WO2023168329A2 (en) * | 2022-03-02 | 2023-09-07 | Mitopower, Inc. | Novel prodrugs derived from nicotinic acid and ribose |
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US3674836A (en) * | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
US4027009A (en) * | 1973-06-11 | 1977-05-31 | Merck & Co., Inc. | Compositions and methods for depressing blood serum cholesterol |
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US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
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-
2008
- 2008-02-29 MX MX2009009126A patent/MX2009009126A/es not_active Application Discontinuation
- 2008-02-29 WO PCT/US2008/002735 patent/WO2008106227A1/en active Application Filing
- 2008-02-29 JP JP2009551746A patent/JP2010520208A/ja active Pending
- 2008-02-29 AU AU2008219599A patent/AU2008219599A1/en not_active Abandoned
- 2008-02-29 KR KR1020097020635A patent/KR20100015343A/ko not_active Application Discontinuation
- 2008-02-29 CA CA002679403A patent/CA2679403A1/en not_active Abandoned
- 2008-02-29 US US12/441,628 patent/US20090326013A1/en not_active Abandoned
- 2008-02-29 EP EP08726299A patent/EP2114151A4/en not_active Withdrawn
- 2008-02-29 CN CN200880014509A patent/CN101686674A/zh active Pending
-
2009
- 2009-08-26 IL IL200589A patent/IL200589A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20090326013A1 (en) | 2009-12-31 |
EP2114151A1 (en) | 2009-11-11 |
EP2114151A4 (en) | 2010-03-17 |
KR20100015343A (ko) | 2010-02-12 |
JP2010520208A (ja) | 2010-06-10 |
IL200589A0 (en) | 2010-05-17 |
CN101686674A (zh) | 2010-03-31 |
AU2008219599A1 (en) | 2008-09-04 |
WO2008106227A1 (en) | 2008-09-04 |
CA2679403A1 (en) | 2008-09-04 |
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