ES2075222T3 - 1,4-bis(alquilamino)-2,3-diaza-antraceno-9,10-dionas. - Google Patents

1,4-bis(alquilamino)-2,3-diaza-antraceno-9,10-dionas.

Info

Publication number
ES2075222T3
ES2075222T3 ES90915454T ES90915454T ES2075222T3 ES 2075222 T3 ES2075222 T3 ES 2075222T3 ES 90915454 T ES90915454 T ES 90915454T ES 90915454 T ES90915454 T ES 90915454T ES 2075222 T3 ES2075222 T3 ES 2075222T3
Authority
ES
Spain
Prior art keywords
sub
compounds
formula
groups
dionas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90915454T
Other languages
English (en)
Inventor
Carmelo A Gandolfi
Francis Johnson
Ernesto Menta
Silvano Spinelli
Sergio Tognella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Application granted granted Critical
Publication of ES2075222T3 publication Critical patent/ES2075222T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

SE DESCRIBEN LOS COMPUESTOS DE LA FORMULA (1), EN DONDE R SUB 1 Y R SUB 2, QUE PUEDEN SER IGUALES O DIFERENTES, SON HIDROGENO O GRUPOS ACILO; R SUB 3 Y R SUB 4, QUE PUEDEN SER IGUALES O DIFERENTES, SON HIDROGENO O GRUPOS ALQUILO OPCIONALMENTE SUSTITUIDOS. LOS COMPUESTOS DE LA FORMULA (I) SE PREPARAN MEDIANTE LA OXIDACION DE LOS COMPUESTOS DE LA FORMULA (II), EN DONDE LOS GRUPOS R'' SUB 1, R'' SUB 2, R'' SUB 3 Y R'' SUB 4 TIENEN LOS MISMOS SIGNIFICADOS QUE R SUB 1, R SUB 2, R SUB 3 Y R SUB 4 O LOS GRUPOS CONVERTIBLES AL ULTIMO. LOS COMPUESTOS DE LA FORMULA (I) TIENEN UNA CONSIDERABLE ACTIVIDAD ANTITUMORES.
ES90915454T 1989-10-27 1990-10-23 1,4-bis(alquilamino)-2,3-diaza-antraceno-9,10-dionas. Expired - Lifetime ES2075222T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02217589A IT1237506B (it) 1989-10-27 1989-10-27 Derivati amminici di 2,3-diaza-antracene-9,10-dioni come farmaci antitumorali

Publications (1)

Publication Number Publication Date
ES2075222T3 true ES2075222T3 (es) 1995-10-01

Family

ID=11192611

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90915454T Expired - Lifetime ES2075222T3 (es) 1989-10-27 1990-10-23 1,4-bis(alquilamino)-2,3-diaza-antraceno-9,10-dionas.

Country Status (9)

Country Link
US (1) US5162320A (es)
EP (1) EP0497809B1 (es)
JP (1) JPH05504124A (es)
AT (1) ATE124402T1 (es)
AU (1) AU6548190A (es)
DE (1) DE69020576T2 (es)
ES (1) ES2075222T3 (es)
IT (1) IT1237506B (es)
WO (1) WO1991006540A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719282A (en) * 1989-05-19 1998-02-17 Consejo Superior De Investigaciones Cientificas 1,4-bis(amino) benzo g!phthalazine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE687916A (es) * 1965-10-12 1967-03-16
US3880881A (en) * 1971-08-03 1975-04-29 American Cyanamid Co Azomethinimine dyes
US4428882A (en) * 1979-05-29 1984-01-31 American Cyanamid Company 1-(Aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones
US4275009A (en) * 1979-05-29 1981-06-23 American Cyanamid Company 1-(Aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones
US4278605A (en) * 1980-06-30 1981-07-14 American Cyanamid Company Heteroalkylenebisanthraquinones

Also Published As

Publication number Publication date
DE69020576D1 (de) 1995-08-03
IT8922175A0 (it) 1989-10-27
AU6548190A (en) 1991-05-31
EP0497809B1 (en) 1995-06-28
JPH05504124A (ja) 1993-07-01
EP0497809A1 (en) 1992-08-12
US5162320A (en) 1992-11-10
DE69020576T2 (de) 1996-01-18
IT1237506B (it) 1993-06-08
ATE124402T1 (de) 1995-07-15
IT8922175A1 (it) 1991-04-27
WO1991006540A1 (en) 1991-05-16

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