ES2075099T3 - Heterohibridoma de perro-raton y fragmento genico que codifica para la region constante de inmunoglobulinas caninas. - Google Patents

Heterohibridoma de perro-raton y fragmento genico que codifica para la region constante de inmunoglobulinas caninas.

Info

Publication number
ES2075099T3
ES2075099T3 ES90116258T ES90116258T ES2075099T3 ES 2075099 T3 ES2075099 T3 ES 2075099T3 ES 90116258 T ES90116258 T ES 90116258T ES 90116258 T ES90116258 T ES 90116258T ES 2075099 T3 ES2075099 T3 ES 2075099T3
Authority
ES
Spain
Prior art keywords
dog
amino acid
constant region
acid sequence
mouse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116258T
Other languages
English (en)
Inventor
Hiroaki Maeda
Yasuyuki Eda
Kazuhiko Kimachi
Yoichi Ono
Sachio Tokiyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1219889A external-priority patent/JP2811089B2/ja
Priority claimed from JP25542589A external-priority patent/JP2811096B2/ja
Priority claimed from JP2150673A external-priority patent/JP2837240B2/ja
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Application granted granted Critical
Publication of ES2075099T3 publication Critical patent/ES2075099T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN FRAGMENTO DE GEN COMPRENDE UN CODIFICADOR SECUENCIA DE ADN PARA SECUENCIAS DE AMINO ACIDO DE UNA REGION CONSTANTE DE LA CADENA LAMBDA DE INMUNOGLOBULINA; CODIFICADOR DE LA MOLECULA RECOMBINANTE DE ADN PARA LA SECUENCIA AMINOACIDA DE UN ANTICUERPO QUINERICO PERRO DEL FREGAMENTO DE GEN PARA UNA SECUENCIA AMINO ACIDA DE UNA REGION VARIABLE DE LA INMUNOGLOBULINA DEL RATON, Y UN CODIFICADOR DEL GRAFMENTO DE QUE PARA UNA SECUENCIA AMINO ACIDA DE UNA REGION VARIABLE DE LA INMUNOGLOBULINA DEL RATON, Y UN CODIFICADOR DEL FRAGMENTO DE QUE PARA UNA SECUENCIA AMINO ACIDA DE UNA REGION CONSTANTE DE LA INMUNOGLOBULINA CANINA. UN POLIPEPTIDO DEL ANTICUERPO QUINERICO PERRO CELULA TRANSFORMADORA POR UN VECTOR DE EXPRESION DE CELULAS DONDE DICHO CODIFICADOR DE LA MOLECULA RECOMBINANTE DE ADN PARA LA SECUENCIA AMINO ACIDA DEL ANTICUERPO QUINERICO PERRO NOGLOBULINA CANINA.
ES90116258T 1989-08-25 1990-08-24 Heterohibridoma de perro-raton y fragmento genico que codifica para la region constante de inmunoglobulinas caninas. Expired - Lifetime ES2075099T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1219889A JP2811089B2 (ja) 1989-08-25 1989-08-25 イヌ×マウスヘテロハイブリドーマおよびイヌ免疫グロブリンλ鎖の定常領域をコードする遺伝子断片
JP25542589A JP2811096B2 (ja) 1989-09-30 1989-09-30 イヌ免疫グロブリンκ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体
JP2150673A JP2837240B2 (ja) 1990-06-07 1990-06-07 イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体

Publications (1)

Publication Number Publication Date
ES2075099T3 true ES2075099T3 (es) 1995-10-01

Family

ID=27319982

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116258T Expired - Lifetime ES2075099T3 (es) 1989-08-25 1990-08-24 Heterohibridoma de perro-raton y fragmento genico que codifica para la region constante de inmunoglobulinas caninas.

Country Status (8)

Country Link
US (2) US5593861A (es)
EP (1) EP0419858B1 (es)
AT (1) ATE122716T1 (es)
AU (1) AU640397B2 (es)
CA (1) CA2023894C (es)
DE (1) DE69019447T2 (es)
DK (1) DK0419858T3 (es)
ES (1) ES2075099T3 (es)

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US7393529B2 (en) 1998-04-09 2008-07-01 Idexx Laboratories, Inc. Methods and compositions for inhibiting binding of IgE to a high affinity receptor
US6537781B1 (en) 1999-08-10 2003-03-25 Idexx Laboratories, Inc. Methods and compositions concerning canine interleukin 5
WO2001077332A2 (en) * 2000-04-07 2001-10-18 Heska Corporation Compositions and methods related to canine igg and canine il-13 receptors
CA2469833C (en) * 2001-12-21 2008-05-20 Idexx Laboratories, Inc. Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
US20030163618A1 (en) * 2002-02-27 2003-08-28 Vishal Anand Shared queue for multiple input-streams
MX2011000116A (es) 2008-07-10 2011-02-25 Toray Industries Agente inductor de inmunidad y metodo para la deteccion de cancer.
CN102089004B (zh) 2008-07-10 2018-06-01 东丽株式会社 癌的治疗及预防用药物组合物
WO2010027488A2 (en) * 2008-09-04 2010-03-11 Vet Therapeutics, Inc. Monoclonal antibodies
US8313915B2 (en) * 2009-01-21 2012-11-20 Gundersen Lutheran Medical Foundation, Inc. Early detection of canine lyme disease by specific peptides and antibodies
US8569460B2 (en) 2009-03-25 2013-10-29 Vet Therapeutics, Inc. Antibody constant domain regions and uses thereof
EP2413969A4 (en) * 2009-03-30 2012-09-05 Boehringer Ingelheim Int FUSION PROTEINS WITH DOG FC ELEMENTS
WO2010117448A2 (en) * 2009-04-05 2010-10-14 Provenance Biopharmaceuticals Corp. Chimeric immunocytokines and methods of use thereof
EP2496604B1 (en) 2009-11-06 2017-08-23 IDEXX Laboratories, Inc. Canine anti-cd20 antibodies
US9616120B2 (en) 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
US8652470B2 (en) 2010-03-04 2014-02-18 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD52
RS63063B1 (sr) 2010-08-19 2022-04-29 Zoetis Belgium S A Anti-ngf antitela i njihova upotreba
GB201114858D0 (en) 2011-08-29 2011-10-12 Nvip Pty Ltd Anti-nerve growth factor antibodies and methods of using the same
EP2723380B1 (en) 2011-06-24 2019-08-21 Stephen D. Gillies Light chain immunoglobulin fusion proteins and methods of use thereof
CA2847020A1 (en) 2011-08-30 2013-03-07 Nvip Pty Ltd Caninised tumour necrosis factor antibodies and methods of using the same
AU2012328819B2 (en) 2011-10-26 2017-08-03 Elanco Tiergesundheit Ag Monoclonal antibodies and methods of use
EP2817326A1 (en) 2012-02-22 2014-12-31 NVIP Pty Ltd Tumour necrosis factor receptor fusion proteins and methods of using the same
CN104364264B (zh) 2012-06-06 2018-07-24 硕腾服务有限责任公司 犬源化抗ngf抗体和其方法
CN108779172B (zh) 2016-01-06 2022-02-08 定制药品研究株式会社 抑制vegf与nrp1结合的抗体
US11007259B2 (en) * 2016-01-06 2021-05-18 Order-Made Medical Research Inc. High-affinity anti-VEGF antibody
KR102569068B1 (ko) * 2016-08-15 2023-08-21 국립대학법인 홋가이도 다이가쿠 항pd-l1 항체
GB2561352B (en) * 2017-04-10 2023-01-18 Genome Res Ltd Animal models and therapeutic molecules
EP3765499A1 (en) 2018-03-12 2021-01-20 Zoetis Services LLC Anti-ngf antibodies and methods thereof
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4842999A (en) * 1986-08-11 1989-06-27 Adi Diagnostics Inc. Canine heartworm vaccine and diagnostic test
CA1340898C (en) * 1987-04-30 2000-02-15 The Wistar Institute Monoclonal antibodies against lymphoma-associated antigens, hybrid cell lines producing these antibodies, and use therefore

Also Published As

Publication number Publication date
DK0419858T3 (da) 1995-07-10
CA2023894A1 (en) 1991-02-26
US5593861A (en) 1997-01-14
DE69019447T2 (de) 1995-10-26
AU6120490A (en) 1991-02-28
US5852183A (en) 1998-12-22
CA2023894C (en) 2001-09-18
EP0419858A1 (en) 1991-04-03
EP0419858B1 (en) 1995-05-17
DE69019447D1 (de) 1995-06-22
AU640397B2 (en) 1993-08-26
ATE122716T1 (de) 1995-06-15

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