ES2074532T3 - Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos. - Google Patents
Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos.Info
- Publication number
- ES2074532T3 ES2074532T3 ES90301063T ES90301063T ES2074532T3 ES 2074532 T3 ES2074532 T3 ES 2074532T3 ES 90301063 T ES90301063 T ES 90301063T ES 90301063 T ES90301063 T ES 90301063T ES 2074532 T3 ES2074532 T3 ES 2074532T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- carbon atoms
- benzopyrans
- amino
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE PRESENTA UN PROCESO PARA LA PREPARACION DE UN ISOMERO (3S,4R) PURO DE UN COMPUESTO DE FORMULA (A), EN LA QUE UNA ENTRE R1 Y R2 ES HIDROGENO Y LA OTRA SE SELECCIONA ENTRE ALKIL CARBONIL, ALCOXICARBONIL, ALKILCARBONILOXIDO, ALKIL HIDROXIMETIL, NITRO, ZIANO, CLORO, TRIFLUOROMETIL, ALKIL SULFINIL, ALKIL SULFONIL, ALCOXISULFINIL, ALCOXISULFONIL, ALKIL CARBONILAMINO, ALCOXICARBONILAMINO O AMINOSULFINIL, AMINOSULFONIL O AMINO CARBONIL, ESTANDO LA MOLECULA AMINO OPCIONALMENTE SUSTITUIDA POR UNO O DOS GRUPOS ALKIL, O ALKIL SULFINIL AMINO, ALKIL SULFONIL AMINO, ALCOXISULFONILAMINO O ALCOXISULFONILAMINO O ETILENICAMENTE SUSTITUIDO POR ALKIL CARBONIL, NITRO O CIANO O -C(ALKIL)NOH O -C(ALKIL)NNH2, TENIENDO LOS GRUPOS ALKIL O LAS MOLECULAS ALKIL DE LOS GRUPOS QUE CONTIENEN ALKIL ENTRE 1 Y 6 ATOMOS DE CARBONO; UNA DE ENTRE R3 Y R4 ES HIDROGENO O ALKIL QUE TIENE ENTRE 1 Y 4 ATOMOS DE CARBONO Y LA OTRA ES ALKIL QUE TIENE ENTRE 1 Y 4 ATOMOS DE CARBONO, R3 Y R4 JUNTAS SON POLIMETILENO C2-C5; R5 ES HIDROGENO, ALKIL QUE TIENE ENTRE 1 Y 3 ATOMOS DE CARBONO O AZIL QUE TIENE ENTRE 1 Y 8 ATOMOS DE CARBONO; Y N ES 1 O 2; EN DICHO COMPUESTO EL ANILLO PIRROLIDONIL O PIPERIDONIL SE FORMA CICLANDO UN COMPUESTO DE DIHIDROBENZOPIPIRANOL PRECURSOR APROPIADO QUE HAYA SIDO RESUELTO A LA CONFIGURACION (3S,4R) O UNA MEZCLA EN LA CUAL PREDOMINE LA CONFIGURACION (3S,4R) CON RESPECTO A LA CONFIGURACION (3R,4S)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898902118A GB8902118D0 (en) | 1989-02-01 | 1989-02-01 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2074532T3 true ES2074532T3 (es) | 1995-09-16 |
Family
ID=10650905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90301063T Expired - Lifetime ES2074532T3 (es) | 1989-02-01 | 1990-02-01 | Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5126460A (es) |
| EP (1) | EP0385584B1 (es) |
| JP (1) | JP2859348B2 (es) |
| KR (1) | KR0179364B1 (es) |
| AT (1) | ATE123029T1 (es) |
| AU (1) | AU626376B2 (es) |
| CA (1) | CA2008940C (es) |
| DE (1) | DE69019554T2 (es) |
| DK (1) | DK0385584T3 (es) |
| ES (1) | ES2074532T3 (es) |
| FI (1) | FI900499A0 (es) |
| GB (1) | GB8902118D0 (es) |
| GR (1) | GR3017077T3 (es) |
| HK (1) | HK1006308A1 (es) |
| HU (1) | HUT58074A (es) |
| IE (1) | IE66738B1 (es) |
| IL (1) | IL93229A0 (es) |
| MA (1) | MA21741A1 (es) |
| NO (1) | NO900420L (es) |
| NZ (1) | NZ232289A (es) |
| PT (1) | PT92999B (es) |
| TW (1) | TW206213B (es) |
| ZA (1) | ZA90660B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5095016A (en) * | 1989-08-11 | 1992-03-10 | Kaken Pharmaceutical Co., Ltd. | Benzopyran compounds, processes for their production and pharmaceutical compositions |
| US5276168A (en) * | 1990-06-18 | 1994-01-04 | E. R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
| US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
| US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
| US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
| US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
| AU2005316739A1 (en) * | 2004-12-13 | 2006-06-22 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
| CA2620379C (en) * | 2005-08-31 | 2015-02-24 | Aryx Therapeutics, Inc. | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1495526A (en) * | 1974-05-31 | 1977-12-21 | Beecham Group Ltd | Chroman derivatives |
| GB1548222A (en) * | 1976-12-17 | 1979-07-04 | Beecham Group Ltd | Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives |
| GB2107706A (en) * | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
| DE3368629D1 (en) * | 1982-04-28 | 1987-02-05 | Beecham Group Plc | Novel chromenes and chromans |
| GB8308062D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
| GB8308063D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
| GB8313679D0 (en) * | 1983-05-18 | 1983-06-22 | Beecham Group Plc | Active compounds |
| DE3475786D1 (de) * | 1983-09-01 | 1989-02-02 | Beecham Group Plc | Chromanol derivatives |
| US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| CH674984A5 (es) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
| FI90343C (fi) * | 1987-06-23 | 1994-01-25 | Merck Patent Gmbh | Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi |
| DE3823533A1 (de) * | 1988-07-12 | 1990-02-08 | Beiersdorf Ag | Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate |
| GB8918298D0 (en) * | 1989-08-10 | 1989-09-20 | Beecham Group Plc | Novel compounds |
-
1989
- 1989-02-01 GB GB898902118A patent/GB8902118D0/en active Pending
-
1990
- 1990-01-30 HU HU90588A patent/HUT58074A/hu unknown
- 1990-01-30 US US07/472,012 patent/US5126460A/en not_active Expired - Lifetime
- 1990-01-30 IE IE34290A patent/IE66738B1/en not_active IP Right Cessation
- 1990-01-30 NO NO90900420A patent/NO900420L/no unknown
- 1990-01-30 ZA ZA90660A patent/ZA90660B/xx unknown
- 1990-01-30 PT PT92999A patent/PT92999B/pt not_active IP Right Cessation
- 1990-01-30 NZ NZ232289A patent/NZ232289A/en unknown
- 1990-01-30 AU AU48921/90A patent/AU626376B2/en not_active Ceased
- 1990-01-30 MA MA22003A patent/MA21741A1/fr unknown
- 1990-01-30 CA CA002008940A patent/CA2008940C/en not_active Expired - Fee Related
- 1990-01-31 KR KR1019900001246A patent/KR0179364B1/ko not_active IP Right Cessation
- 1990-01-31 FI FI900499A patent/FI900499A0/fi not_active Application Discontinuation
- 1990-01-31 IL IL93229A patent/IL93229A0/xx unknown
- 1990-01-31 JP JP2019402A patent/JP2859348B2/ja not_active Expired - Fee Related
- 1990-02-01 TW TW079100668A patent/TW206213B/zh active
- 1990-02-01 DK DK90301063.5T patent/DK0385584T3/da active
- 1990-02-01 ES ES90301063T patent/ES2074532T3/es not_active Expired - Lifetime
- 1990-02-01 DE DE69019554T patent/DE69019554T2/de not_active Expired - Fee Related
- 1990-02-01 AT AT90301063T patent/ATE123029T1/de not_active IP Right Cessation
- 1990-02-01 EP EP90301063A patent/EP0385584B1/en not_active Expired - Lifetime
-
1995
- 1995-08-09 GR GR950402205T patent/GR3017077T3/el unknown
-
1998
- 1998-06-16 HK HK98105432A patent/HK1006308A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69019554D1 (de) | 1995-06-29 |
| HUT58074A (en) | 1992-01-28 |
| HK1006308A1 (en) | 1999-02-19 |
| PT92999B (pt) | 1995-12-29 |
| HU900588D0 (en) | 1990-04-28 |
| GR3017077T3 (en) | 1995-11-30 |
| EP0385584B1 (en) | 1995-05-24 |
| KR0179364B1 (ko) | 1999-03-20 |
| AU626376B2 (en) | 1992-07-30 |
| MA21741A1 (fr) | 1990-10-01 |
| TW206213B (es) | 1993-05-21 |
| FI900499A0 (fi) | 1990-01-31 |
| NO900420L (no) | 1990-08-02 |
| JPH02240079A (ja) | 1990-09-25 |
| AU4892190A (en) | 1990-08-09 |
| KR900012931A (ko) | 1990-09-03 |
| CA2008940C (en) | 2000-12-05 |
| EP0385584A1 (en) | 1990-09-05 |
| IE66738B1 (en) | 1996-02-07 |
| DE69019554T2 (de) | 1995-09-28 |
| IL93229A0 (en) | 1990-11-05 |
| IE900342L (en) | 1990-08-01 |
| PT92999A (pt) | 1990-08-31 |
| CA2008940A1 (en) | 1990-08-01 |
| GB8902118D0 (en) | 1989-03-22 |
| NZ232289A (en) | 1992-09-25 |
| ATE123029T1 (de) | 1995-06-15 |
| US5126460A (en) | 1992-06-30 |
| JP2859348B2 (ja) | 1999-02-17 |
| ZA90660B (en) | 1992-05-27 |
| DK0385584T3 (da) | 1995-07-17 |
| NO900420D0 (no) | 1990-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4446113B1 (es) | ||
| ES8607964A1 (es) | Un procedimiento para la preparacion del isomero (3s, 4r) de un compuesto | |
| DK0651737T3 (da) | O-Benzyloximetherderivater samt deres anvendelse som pesticider | |
| DK279785A (da) | Benzopyranderivater | |
| ES2074532T3 (es) | Procedimiento para la preparacion de 4-(ciclico-amido)-2h-1-benzopiranos y 4-amino-3-hidroxi-2h-1-benzopiranos. | |
| ES2033297T3 (es) | Un metodo para preparar heterociclos de 5 atomos substituidos con fenilo y pirrolidin-2-ilo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 385584 Country of ref document: ES |