ES2074153T3 - Acidos fosfonicos, procedimiento para su obtencion y empleo como productos activos para medicamentos. - Google Patents
Acidos fosfonicos, procedimiento para su obtencion y empleo como productos activos para medicamentos.Info
- Publication number
- ES2074153T3 ES2074153T3 ES90810712T ES90810712T ES2074153T3 ES 2074153 T3 ES2074153 T3 ES 2074153T3 ES 90810712 T ES90810712 T ES 90810712T ES 90810712 T ES90810712 T ES 90810712T ES 2074153 T3 ES2074153 T3 ES 2074153T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- aliphatically
- protected
- amino
- acylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- 150000003009 phosphonic acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 239000004215 Carbon black (E152) Substances 0.000 abstract 3
- 229930195733 hydrocarbon Natural products 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 102000018899 Glutamate Receptors Human genes 0.000 abstract 1
- 108010027915 Glutamate Receptors Proteins 0.000 abstract 1
- HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
DERIVADOS SUSTITUIDOS DE FORMULA I (FORMULA). PROCEDIMIENTO DE PRODUCCION DE DERIVADOS DE AMINOACIDOS INSATURADOS DE FORMULA I EN EL QUE R1 SIGNIFICA UN RESTO DE HIDROCARBURO ACILADO O UN HIDROXI ETERIFICADO ALIFATICAMENTE, O HALOGENO O UN AMINO ACILADO Y/O SUSTITUIDO ALIFATICAMENTE, O UN RESTO AZA, DIAZA, AZOXA O OXACILCICLOALIFATICO, UNIDO A TRAVES DE UN ATOMO DE C A UN HIDROCARBURO AZACICLOALIFATICO N-SUSTITUIDO O N-ACILADO; R2 SIGNIFICA UN CARBOXI LIBRE O ESTERIFICADO. ESTOS COMPUESTOS ASI COMO SUS SALES, POSEEN UNA ACTIVIDAD ANTAGONICA SELECTIVA DE LOS RECEPTORES DE AMINOACIDOS FRENTE AL ACIDO N-METIL-D-ASPARGICO (SENSITIVO AL NMDA).SE OBTIENEN POR EJEMPLO MEDIANTE UN COMPUESTO DE FORMULA II (FORMULA), EN LA QUE Z1 Y Z2 SIGNIFICAN UN HIDROXI, EVENTUALMENTE PROTEGIDO, O UN RESTO DE HIDROCARBURO SUSTITUIDO POR UN HIDROXI EVENTUALMENTE PROTEGIDO O ACILADO O ETERIFICADO ALIFATICA O ARALIFATICAMENTE, POR HALOGENO, POR AMINO, EVENTUALMENTE PROTEGIDO O ACILADO Y/O SUSTITUIDO ALIFATICAMENTE, OUN RESTO AZA-, DIAZA-, AZOXA UNIDO A TRAVES DE UN ATOMO DE C A UN HIDROCARBURO AZACICLOALIFATICO N-SUSTITUIDO O N-ACILADO; Z4 SIGNIFICA UN AMINO PROTEGIDO. POR LIBERACION DE LOS GRUPOS PROTEGIDOS SE OBTIENE, SEGUN EL INVENTO, UNA MEZCLA DE ISOMEROS, QUE SE SEPARAN EN SUS COMPONENTES, OBTENIENDOSE A CONTINUACION EL COMPUESTO LIBRE O TRANSFORMADO EN UNA SAL FISIOLOGICAMENTE TOLERABLE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH347989 | 1989-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2074153T3 true ES2074153T3 (es) | 1995-09-01 |
Family
ID=4256862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90810712T Expired - Lifetime ES2074153T3 (es) | 1989-09-26 | 1990-09-18 | Acidos fosfonicos, procedimiento para su obtencion y empleo como productos activos para medicamentos. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0420806B1 (es) |
| JP (1) | JPH03130296A (es) |
| KR (1) | KR910006312A (es) |
| AT (1) | ATE124700T1 (es) |
| AU (1) | AU638057B2 (es) |
| CA (1) | CA2026038A1 (es) |
| DD (1) | DD298105A5 (es) |
| DE (1) | DE59009368D1 (es) |
| DK (1) | DK0420806T3 (es) |
| ES (1) | ES2074153T3 (es) |
| FI (1) | FI97231C (es) |
| HU (1) | HUT56110A (es) |
| IE (1) | IE67873B1 (es) |
| IL (1) | IL95729A (es) |
| MX (1) | MX22528A (es) |
| NO (1) | NO179450C (es) |
| NZ (1) | NZ235427A (es) |
| PT (1) | PT95401B (es) |
| ZA (1) | ZA907641B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE112282T1 (de) * | 1989-04-07 | 1994-10-15 | Ciba Geigy Ag | Ungesättigte aminodicarbonsäurederivate. |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
| WO2018193999A1 (ja) * | 2017-04-17 | 2018-10-25 | 国立大学法人京都大学 | 光学活性な２－アミノ－ホスホノアルカン酸、光学活性な２－アミノ－ホスホノアルカン酸塩、及びこれらの水和物 |
| EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3775229D1 (de) * | 1986-02-13 | 1992-01-30 | Ciba Geigy Ag | Ungesaettigte aminosaeuren. |
| EP0302826A3 (de) * | 1987-08-04 | 1991-04-03 | Ciba-Geigy Ag | Verfahren zur Herstellung neuer ungesättigter Aminosäureverbindungen |
-
1990
- 1990-09-18 EP EP90810712A patent/EP0420806B1/de not_active Expired - Lifetime
- 1990-09-18 DK DK90810712.1T patent/DK0420806T3/da not_active Application Discontinuation
- 1990-09-18 IL IL95729A patent/IL95729A/en not_active IP Right Cessation
- 1990-09-18 DE DE59009368T patent/DE59009368D1/de not_active Expired - Fee Related
- 1990-09-18 AT AT90810712T patent/ATE124700T1/de not_active IP Right Cessation
- 1990-09-18 ES ES90810712T patent/ES2074153T3/es not_active Expired - Lifetime
- 1990-09-24 FI FI904690A patent/FI97231C/fi not_active IP Right Cessation
- 1990-09-24 CA CA002026038A patent/CA2026038A1/en not_active Abandoned
- 1990-09-24 PT PT95401A patent/PT95401B/pt not_active IP Right Cessation
- 1990-09-24 NZ NZ235427A patent/NZ235427A/en unknown
- 1990-09-24 MX MX2252890A patent/MX22528A/es unknown
- 1990-09-25 AU AU63152/90A patent/AU638057B2/en not_active Ceased
- 1990-09-25 DD DD90344183A patent/DD298105A5/de not_active IP Right Cessation
- 1990-09-25 HU HU906210A patent/HUT56110A/hu unknown
- 1990-09-25 JP JP2252073A patent/JPH03130296A/ja active Pending
- 1990-09-25 IE IE345290A patent/IE67873B1/en not_active IP Right Cessation
- 1990-09-25 KR KR1019900015186A patent/KR910006312A/ko not_active Application Discontinuation
- 1990-09-25 NO NO904169A patent/NO179450C/no unknown
- 1990-09-25 ZA ZA907641A patent/ZA907641B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE67873B1 (en) | 1996-05-01 |
| JPH03130296A (ja) | 1991-06-04 |
| AU638057B2 (en) | 1993-06-17 |
| ZA907641B (en) | 1991-05-29 |
| FI97231C (fi) | 1996-11-11 |
| CA2026038A1 (en) | 1991-03-27 |
| NO179450C (no) | 1996-10-09 |
| DD298105A5 (de) | 1992-02-06 |
| FI904690A0 (fi) | 1990-09-24 |
| AU6315290A (en) | 1991-04-11 |
| EP0420806A1 (de) | 1991-04-03 |
| NO904169L (no) | 1991-03-27 |
| NZ235427A (en) | 1992-10-28 |
| IL95729A (en) | 1998-02-22 |
| EP0420806B1 (de) | 1995-07-05 |
| KR910006312A (ko) | 1991-04-29 |
| PT95401A (pt) | 1991-05-22 |
| PT95401B (pt) | 1997-07-31 |
| NO179450B (no) | 1996-07-01 |
| IE903452A1 (en) | 1991-04-10 |
| HUT56110A (en) | 1991-07-29 |
| DK0420806T3 (da) | 1995-10-16 |
| FI97231B (fi) | 1996-07-31 |
| DE59009368D1 (de) | 1995-08-10 |
| ATE124700T1 (de) | 1995-07-15 |
| MX22528A (es) | 1994-02-28 |
| NO904169D0 (no) | 1990-09-25 |
| HU906210D0 (en) | 1991-03-28 |
| IL95729A0 (en) | 1991-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT88944A (pt) | Processo para a preparacao de novos derivados de benzociclohepteno e de composicoes farmaceuticas que os contem | |
| ES2096614T3 (es) | Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento. | |
| ES516311A0 (es) | "procedimiento para la preparacion de nuevos derivados de acidos carboxilicos". | |
| SE8803570L (sv) | 4h-1-bensopyran-4-on-derivat eller dess salt, foerfarande foer framstaellning daerav samt farmaceutisk komposition innehaallande detsamma som aktiv komponent | |
| FI960504A0 (fi) | Menetelmä terapeuttisten yhdisteiden ja rasvahappojen muodostamien konjugaattien valmistamiseksi | |
| ES2074153T3 (es) | Acidos fosfonicos, procedimiento para su obtencion y empleo como productos activos para medicamentos. | |
| ES2108772T3 (es) | Derivados de aminofosfonato substituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| MX9301268A (es) | Procedimiento para la preparacion de la beta-fenilisoserina y sus analogos y productos obtenidos mediante el mismo. | |
| ES2060122T3 (es) | Derivados insaturados de acidos aminodicarboxilicos. | |
| KR880009989A (ko) | 글루탐산유도체, 이들의 염, 제조방법, 약제로서의 사용 및 이들을 함유하는 조성물 | |
| JPS6466116A (en) | Antiemetic containing specific substituted phenylalkylamino and amino acid derivatives and compound selected from other serotonin drying drugs | |
| PT91051A (pt) | Processo para a preparacao de novos derivados de glicerina e de composicoes farmaceuticas que os contem | |
| FR2408617A1 (fr) | Derives d'acide n-(phosphonoacetyl)-l-aspartique et procedes pour leur preparation | |
| TH1461B (th) | ขบวนการเตรียม 15-ไฮดรอกซีอิมิ โน-อี-โฮโมอีเบอร์เนน ดีริเวทีฟ | |
| RU94028711A (ru) | Производные пиррол- или пирролидин-2-борной кислоты, смесь их изомеров или отдельные изомеры и их соли и способ их получения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 420806 Country of ref document: ES |