ES2072993T3 - Derivados de diazina. - Google Patents

Derivados de diazina.

Info

Publication number
ES2072993T3
ES2072993T3 ES90313772T ES90313772T ES2072993T3 ES 2072993 T3 ES2072993 T3 ES 2072993T3 ES 90313772 T ES90313772 T ES 90313772T ES 90313772 T ES90313772 T ES 90313772T ES 2072993 T3 ES2072993 T3 ES 2072993T3
Authority
ES
Spain
Prior art keywords
formula
alkyl
hydrogen
compounds
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90313772T
Other languages
English (en)
Inventor
Rodney Brian Hargreaves
Bernard Joseph Mclouchlin
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2072993T3 publication Critical patent/ES2072993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Vibration Prevention Devices (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Organic Insulating Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS QUE TIENEN LA FORMULA I: EN DONDE R ELEVADO 1 ES (1-10C) ALQUILO, (3-8C) CICLOALQUILO, (3-8C) CICLOALQUILO ALQUILO TENIENDO OPCIONALMENTE LA PARTE DE FENILO DE LOS DOS ULTIMOS UNO O MAS SUSTITUYENTES; R (AL CUADRADO) ES HIDROGENO, (1-4C) ALQUILO, AMINO O (1-4C) 1-4C) ALQUILO, AMINO O (1-4C) ALQUILAMINO; Q ES UN GRUPO QUE TIENE LA FORMULA II, EN CUYO CASO R ELEVADO 3 Y R ELEVADO 4 SON INDEPENDIENTEMENTE HIDROGENO, (1-4C) ALQUILO, FENILO O BENCILO TENIENDO OPCIONALMENTE LA PARTE DE FENILO DE LOS DOS ULTIMOS UNO O MAS SUSTITUYENTES; R ELEVADO 5 ES HIDROGENO, (1-4C) ALQUILO O (2-4C) ALQUENILO A Y B SON INDEPENDIENTEMENTE ETILENO O TRIMETILENO; Z ES UN ENLACE DIRECTO ENTRE A Y B, O UN OXI, TIO, CARBONILO, METILENO, ETILENODIOXIMETILENO, ETILIDENO O UN ENLACE DE ISOPROPILIDENO, O Z ES UN GRUPO QUE TIENE LA FORMULA = N.M EN QUE M ES HIDROGENO, (1-6C) ALQUILO, FENILO O BENCILO, TENIENDO OPCIONALMENTE LA PARTE DE FENILO DE LOS DOS ULTIMOS UNO O MAS SUSTITUYENTES;O Q REPRESENTA UN GRUPO AMINO BICICLICO DE 9 O 10 MIEMBROS SATURADO, QUE ES NO SUSTITUIDO O SUSTITUIDO POR UNO O DOS SUSTITUYENTES; E Y ES UN ANION FISIOLOGICAMENTE ACEPTABLE. LA INVENCION INCLUYE TAMBIEN ALGUNOS DERIVADOS DE BASE ANHIDRO ESTRECHAMENTE RELACIONADOS QUE, COMO POR EJEMPLO LOS COMPUESTOS DE LA FORMULA I, POSEEN EFECTOS BENEFICIOSOS PARA EL SISTEMA CARDIOVASCULAR (Y EN PARTICULAR EFECTOS BENEFICIOSOS MODULADOS MEDIANTE EL NODO SINOATRIAL). TAMBIEN HAY INCLUIDOS COMPUESTOS FARMACEUTICOS QUE CONTIENEN COMPUESTOS DE LA FORMULA I (O UNA BASE ANHIDRO RELACIONADA) COMO INGREDIENTE ACTIVO Y PROCESOS PARA LA FABRICACION DE VARIOS COMPUESTOS NUEVOS.
ES90313772T 1989-12-22 1990-12-17 Derivados de diazina. Expired - Lifetime ES2072993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898929022A GB8929022D0 (en) 1989-12-22 1989-12-22 Diazine derivatives

Publications (1)

Publication Number Publication Date
ES2072993T3 true ES2072993T3 (es) 1995-08-01

Family

ID=10668392

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90313772T Expired - Lifetime ES2072993T3 (es) 1989-12-22 1990-12-17 Derivados de diazina.

Country Status (21)

Country Link
US (1) US5252567A (es)
EP (1) EP0434341B1 (es)
JP (1) JPH03291277A (es)
KR (1) KR910011838A (es)
AT (1) ATE122672T1 (es)
AU (1) AU641960B2 (es)
CA (1) CA2032743A1 (es)
DE (1) DE69019489T2 (es)
DK (1) DK0434341T3 (es)
ES (1) ES2072993T3 (es)
FI (1) FI906306A7 (es)
GB (2) GB8929022D0 (es)
HU (1) HU207511B (es)
IE (1) IE904391A1 (es)
IL (1) IL96609A0 (es)
NO (1) NO905378L (es)
NZ (1) NZ236417A (es)
PT (1) PT96315B (es)
TW (1) TW215088B (es)
ZA (1) ZA909852B (es)
ZW (1) ZW19290A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022644D0 (en) * 1990-10-18 1990-11-28 Ici Plc Heterocyclic compounds
JP2007501781A (ja) * 2003-08-07 2007-02-01 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 駆虫及び殺虫ピリミジン誘導体
US7741976B2 (en) * 2005-12-16 2010-06-22 Hunt Power, L.P. Server and method for processing meter data into a common format
SG11201700777VA (en) 2014-08-04 2017-02-27 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
US11447479B2 (en) 2019-12-20 2022-09-20 Nuevolution A/S Compounds active towards nuclear receptors
TWI872177B (zh) 2019-12-20 2025-02-11 丹麥商紐韋盧森公司 對核受體具有活性之化合物
JP7713953B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
CA3174176A1 (en) 2020-03-31 2021-10-07 Sanne Schroder Glad Compounds active towards nuclear receptors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB815833A (en) * 1956-09-26 1959-07-01 Boots Pure Drug Co Ltd Phenanthridine compounds
BE492034A (es) * 1948-11-05
DE1445740A1 (de) * 1963-09-04 1968-11-28 Bayer Ag Verfahren zur Herstellung von Bispyrimidinium-Verbindungen
US4339453A (en) * 1979-07-23 1982-07-13 Merck & Co., Inc. Antimicrobial aminopyrimidinium salts
US4287338A (en) * 1980-03-10 1981-09-01 The Upjohn Company Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts
FR2524467A1 (fr) * 1982-03-30 1983-10-07 Adir Polymethylene-imines disubstituees, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
US4503050A (en) * 1983-06-02 1985-03-05 Riker Laboratories, Inc. Substituted imidazo[1,2-c]pyrimidines
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
DE3703633A1 (de) * 1986-02-14 1987-08-20 Sandoz Ag Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4729995A (en) * 1986-04-21 1988-03-08 Toyo Boseki Kabushiki Kaisha Pyrimidine 2,4-dioxamate compounds and pharmaceutical compositions
DE3629563A1 (de) * 1986-08-02 1988-02-04 Mildenberger & Willing Verpack Tragbarer verpackungsbeutel aus kunststoffolie und verfahren zu dessen herstellung
DE3639563A1 (de) * 1986-11-20 1988-06-01 Basf Ag N-arylsulfonyl-n'-pyrimidyl(triazinyl) -harnstoffe
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0434341A1 (en) 1991-06-26
PT96315A (pt) 1991-09-30
CA2032743A1 (en) 1991-06-23
DK0434341T3 (da) 1995-10-09
TW215088B (es) 1993-10-21
ZW19290A1 (en) 1991-09-18
AU6791490A (en) 1991-06-27
IE904391A1 (en) 1991-07-03
NO905378D0 (no) 1990-12-12
KR910011838A (ko) 1991-08-07
AU641960B2 (en) 1993-10-07
FI906306A0 (fi) 1990-12-20
ZA909852B (en) 1991-10-30
DE69019489T2 (de) 1995-09-21
NZ236417A (en) 1994-04-27
DE69019489D1 (de) 1995-06-22
JPH03291277A (ja) 1991-12-20
GB9025810D0 (en) 1991-01-09
FI906306A7 (fi) 1991-06-23
NO905378L (no) 1991-06-24
GB8929022D0 (en) 1990-02-28
HUT56087A (en) 1991-07-29
HU908115D0 (en) 1991-06-28
US5252567A (en) 1993-10-12
EP0434341B1 (en) 1995-05-17
PT96315B (pt) 1998-06-30
HU207511B (en) 1993-04-28
ATE122672T1 (de) 1995-06-15
IL96609A0 (en) 1991-09-16

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