ES2070522T3 - Compuestos anti-inflamatorios. - Google Patents

Compuestos anti-inflamatorios.

Info

Publication number
ES2070522T3
ES2070522T3 ES91920193T ES91920193T ES2070522T3 ES 2070522 T3 ES2070522 T3 ES 2070522T3 ES 91920193 T ES91920193 T ES 91920193T ES 91920193 T ES91920193 T ES 91920193T ES 2070522 T3 ES2070522 T3 ES 2070522T3
Authority
ES
Spain
Prior art keywords
independently selected
phenyl
alkyl
optionally substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920193T
Other languages
English (en)
Inventor
Simon Teanby Hodgson
Peter John Wates
David Evan Davies
Steven Smith
Derek Anthony Demaine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2070522T3 publication Critical patent/ES2070522T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE M ES 0 O 1; N ES UN ENTERO DE ENTRE 1 A 6 Y P ES UN ENTERO DE ENTRE 0 A 3 CON LA CONDICION DE QUE N+P NO EXCEDA DE 6; AR ES UN SISTEMA DE ANILLO AROMATICO MONO, BI O TRICICLICO DONDE UNO O MAS DE LOS ATOMOS DE CARBONO ESTAN OPCIONALMENTE SUSTITUIDOS POR HETEROATOMO(S) SELECCIONADO(S) INDEPENDIENTEMENTE DE OXIGENO, SULFURO Y NITROGENO, CUYO SISTEMA DE ANILLO ESTA OPCIONALMENTE SUSTITUIDO POR UNO O MAS ATOMOS O GRUPOS INDEPENDIENTEMENTE SELECCIONADOS DE (I) C1 MAS ATOMOS DE HIDROGENO PUEDEN ESTAR SUSTITUIDOS POR HALOGENO), C1 CARBONILO, HIDROXI, CIANO, CARBAMOILO Y ALQUILSULFONILO, Y (II) FENOXI, BENZILOXI Y NAFTILOXI, CUYOS GRUPOS ARILOXI ESTAN OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE DE LOS ESPECIFICADOS EN (I); R ES HIDROGENO, C1 ENDO C3 IL O BENZIL ESTAN OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE DE LOS ESPECIFICADOS EN (I), O NR2R3 DONDE R2 Y R3 ESTAN SELECCIONADOS INDEPENDIENTEMENTE DE HIDROGENO, C1 LQUILO), FENILO Y BENZILO, CUYOS GRUPOS FENIL O BENZIL ESTAN OPCIONALMENTE SUSTITUIDOS POR UNO O MAS SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE DE LOS ESPECIFICADOS EN (I); W ES O C(R4) DONDE R4 ES HIDROGENO, C1 OXIGENO O AZUFRE; CON LA CONDICION DE QUE N+P1 CUANDO W ES C(R4)= Y AR ES UN SISTEMA DE ANILLO CARBOCICLICO OPCIONALMENTE SUSTITUIDO; Y SALES BASES Y DERIVADOS FISIOLOGICAMENTE FUNCIONALES CONSIGUIENTES, PROCESOS PARA SU PREPARACION, FORMULACIONES FARMACEUTICAS QUE LOS CONTIENEN Y, OPCIONALMENTE, UNO O MAS INGREDIENTES FISIOLOGICAMENTE ACTIVOS Y EL USO DE ESTOS COMPUESTOS EN MEDICINA.
ES91920193T 1990-11-23 1991-11-22 Compuestos anti-inflamatorios. Expired - Lifetime ES2070522T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909025514A GB9025514D0 (en) 1990-11-23 1990-11-23 Anti-inflammatory compounds

Publications (1)

Publication Number Publication Date
ES2070522T3 true ES2070522T3 (es) 1995-06-01

Family

ID=10685879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920193T Expired - Lifetime ES2070522T3 (es) 1990-11-23 1991-11-22 Compuestos anti-inflamatorios.

Country Status (9)

Country Link
EP (1) EP0558563B1 (es)
JP (1) JPH06503081A (es)
AT (1) ATE120452T1 (es)
DE (1) DE69108564T2 (es)
DK (1) DK0558563T3 (es)
ES (1) ES2070522T3 (es)
GB (1) GB9025514D0 (es)
GR (1) GR3015565T3 (es)
WO (1) WO1992009567A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3007138B2 (ja) 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
US5187192A (en) * 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物
WO1994018158A1 (en) * 1993-02-15 1994-08-18 Pfizer Inc. Spiroalkylhydroxyureas for use as lipoxygenase inhibitors
DE69411003T2 (de) * 1993-04-07 1998-10-08 Pfizer Inc., New York, N.Y. Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren
DE69421183T2 (de) * 1993-07-20 2000-01-20 Pfizer Inc., New York Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe
TW448144B (en) * 1993-08-19 2001-08-01 Pfizer Phenoxyphenyl cyclopentenyl hydroxyureas
WO1995024894A2 (en) * 1994-03-14 1995-09-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
DE19756261A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
US20030055084A1 (en) * 2001-07-30 2003-03-20 Millennium Pharmaceutical, Inc. Pharmaceutical compounds and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors

Also Published As

Publication number Publication date
EP0558563B1 (en) 1995-03-29
EP0558563A1 (en) 1993-09-08
DE69108564T2 (de) 1995-09-14
GB9025514D0 (en) 1991-01-09
DE69108564D1 (de) 1995-05-04
DK0558563T3 (da) 1995-06-12
JPH06503081A (ja) 1994-04-07
GR3015565T3 (en) 1995-06-30
WO1992009567A1 (en) 1992-06-11
ATE120452T1 (de) 1995-04-15

Similar Documents

Publication Publication Date Title
DK602589A (da) Quinazolinonderivater
DE3777505D1 (de) 4-aminochinolin-derivate und ihre verwendung als arzneimittel.
ZA895613B (en) Chemical compounds
MX9206305A (es) Bifenilpiridonas substitutas, procedimiento para su obtencion y medicamento que los contiene.
NO900306D0 (no) Fremgangsmaate for fremstilling av nye pyrazolopyridin-forbindelser.
ES8303293A1 (es) "procedimiento de preparar derivados carboxamidicos".
FI872864A0 (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
DK0378255T3 (da) 2-aminopyrimidinoderivater
ATE251624T1 (de) Granulatimide-derivate zur behandlung von krebs
HUT62264A (en) Process for producing amidino compounds and pharmaceutical compositions comprising same as active ingredient
ES2070522T3 (es) Compuestos anti-inflamatorios.
ES2123560T3 (es) Composiciones farmaceuticas que comprenden derivados de hidroxamato para la eliminacion del hierro.
ES552593A0 (es) Un procedimiento para preparar derivados de aminoacidos
ATE18196T1 (de) 1,4-acyloxynaphthalenderivate, diese enthaltende kompositionen, verfahren fuer ihre herstellung und zwischenprodukte dafuer.
DE68904102D1 (de) Antivirale tetrahydroimidazo(1,4)benzodiazepin-2-one.
DE3787844D1 (de) Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
RO115873B1 (ro) Derivaţi de acid hidroximic, procedee de obţinere a acestora, intermediari pentru realizarea unuia dintre procedee şi compoziţie farmaceutică
AU532394B2 (en) Processes
ES547962A0 (es) Procedimiento para la fabricacion de derivados de tiadiazol activos sobre el sistema nervioso central
ATE25968T1 (de) 1,1-diphenylpropanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
AU6120199A (en) Derivatives of phenantrene for medicinal use and a process for their preparation
TH5129A (th) อนุพันธ์ของเตตราไฮโดรแนพธาลีนและอินเดน

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 558563

Country of ref document: ES