DE69108564D1 - Entzündungshemmende verbindungen. - Google Patents
Entzündungshemmende verbindungen.Info
- Publication number
- DE69108564D1 DE69108564D1 DE69108564T DE69108564T DE69108564D1 DE 69108564 D1 DE69108564 D1 DE 69108564D1 DE 69108564 T DE69108564 T DE 69108564T DE 69108564 T DE69108564 T DE 69108564T DE 69108564 D1 DE69108564 D1 DE 69108564D1
- Authority
- DE
- Germany
- Prior art keywords
- independently selected
- phenyl
- alkyl
- optionally substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010061218 Inflammation Diseases 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- -1 nitro, amino, carboxy Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000005186 naphthyloxy group Chemical group C1(=CC=CC2=CC=CC=C12)O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Color Electrophotography (AREA)
- Electrostatic Charge, Transfer And Separation In Electrography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909025514A GB9025514D0 (en) | 1990-11-23 | 1990-11-23 | Anti-inflammatory compounds |
| PCT/GB1991/002067 WO1992009567A1 (en) | 1990-11-23 | 1991-11-22 | Anti-inflammatory compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69108564D1 true DE69108564D1 (de) | 1995-05-04 |
| DE69108564T2 DE69108564T2 (de) | 1995-09-14 |
Family
ID=10685879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69108564T Expired - Fee Related DE69108564T2 (de) | 1990-11-23 | 1991-11-22 | Entzündungshemmende verbindungen. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0558563B1 (de) |
| JP (1) | JPH06503081A (de) |
| AT (1) | ATE120452T1 (de) |
| DE (1) | DE69108564T2 (de) |
| DK (1) | DK0558563T3 (de) |
| ES (1) | ES2070522T3 (de) |
| GB (1) | GB9025514D0 (de) |
| GR (1) | GR3015565T3 (de) |
| WO (1) | WO1992009567A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3007138B2 (ja) | 1990-11-27 | 2000-02-07 | ファイザー製薬株式会社 | 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物 |
| US5187192A (en) * | 1992-03-13 | 1993-02-16 | Abbott Laboratories | Cyclobutyl derivatives having lipoxygenase inhibitory activity |
| JPH05294921A (ja) * | 1992-04-17 | 1993-11-09 | Pfizer Pharmaceut Co Ltd | 新規なフェニル置換シクロアルキル尿素誘導体および組成物 |
| WO1994018158A1 (en) * | 1993-02-15 | 1994-08-18 | Pfizer Inc. | Spiroalkylhydroxyureas for use as lipoxygenase inhibitors |
| US5681858A (en) * | 1993-04-07 | 1997-10-28 | Pfizer Inc. | Cycloalkyl hydroxyureas |
| CA2167715C (en) * | 1993-07-20 | 1998-10-06 | Akiyoshi Kawai | Heteroaryl cycloalkenyl hydroxyureas |
| TW418089B (en) * | 1993-08-19 | 2001-01-11 | Pfizer | Pharmaceutical composition comprising phenoxyphenyl cyclopentenyl hydroxyureas (the dextrorotary isomers) |
| CA2185448A1 (en) * | 1994-03-14 | 1995-09-21 | James L. Mulshine | Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
| DE19756261A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| WO2003011848A1 (en) * | 2001-07-30 | 2003-02-13 | Millennium Pharmaceuticals, Inc. | Benzoheterocycles as lipoxygenase inhitibors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120752A (en) * | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
-
1990
- 1990-11-23 GB GB909025514A patent/GB9025514D0/en active Pending
-
1991
- 1991-11-22 EP EP91920193A patent/EP0558563B1/de not_active Expired - Lifetime
- 1991-11-22 JP JP4500449A patent/JPH06503081A/ja active Pending
- 1991-11-22 DE DE69108564T patent/DE69108564T2/de not_active Expired - Fee Related
- 1991-11-22 AT AT91920193T patent/ATE120452T1/de not_active IP Right Cessation
- 1991-11-22 ES ES91920193T patent/ES2070522T3/es not_active Expired - Lifetime
- 1991-11-22 DK DK91920193.9T patent/DK0558563T3/da active
- 1991-11-22 WO PCT/GB1991/002067 patent/WO1992009567A1/en not_active Ceased
-
1995
- 1995-03-30 GR GR940403844T patent/GR3015565T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69108564T2 (de) | 1995-09-14 |
| ATE120452T1 (de) | 1995-04-15 |
| DK0558563T3 (da) | 1995-06-12 |
| EP0558563A1 (de) | 1993-09-08 |
| GB9025514D0 (en) | 1991-01-09 |
| EP0558563B1 (de) | 1995-03-29 |
| WO1992009567A1 (en) | 1992-06-11 |
| GR3015565T3 (en) | 1995-06-30 |
| JPH06503081A (ja) | 1994-04-07 |
| ES2070522T3 (es) | 1995-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB8827988D0 (en) | Chemical compounds | |
| DE3777505D1 (de) | 4-aminochinolin-derivate und ihre verwendung als arzneimittel. | |
| ZA895613B (en) | Chemical compounds | |
| FI884879A0 (fi) | Terapeutiskt anvaendbara heterocykliska foereningar. | |
| IS3156A7 (is) | Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar | |
| MXPA05007496A (es) | Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes. | |
| ATE170510T1 (de) | 3-(hydroxybenzylidenyl)-indolin-2-one und diese enthaltende arzneimittel | |
| NZ226125A (en) | Substituted n(1-alkyl-3-hydroxy-4-piperidinyl) benzamides and pharmaceutical compositions | |
| HUT62264A (en) | Process for producing amidino compounds and pharmaceutical compositions comprising same as active ingredient | |
| MXPA05007494A (es) | Nuevos compuestos. | |
| DE69108564D1 (de) | Entzündungshemmende verbindungen. | |
| ATE251624T1 (de) | Granulatimide-derivate zur behandlung von krebs | |
| ES2123560T3 (es) | Composiciones farmaceuticas que comprenden derivados de hidroxamato para la eliminacion del hierro. | |
| IL148875A0 (en) | Sulfonyl hydrazide derivatives, their preparation and pharmaceutical compositions containing them | |
| ATE84035T1 (de) | Antivirale tetrahydroimidazo(1,4)benzodiazepin-2- one. | |
| ATE18196T1 (de) | 1,4-acyloxynaphthalenderivate, diese enthaltende kompositionen, verfahren fuer ihre herstellung und zwischenprodukte dafuer. | |
| ES2081777A6 (es) | Nuevos derivados de acido d,l-glutamico y acido d,l-aspartico | |
| DK661088A (da) | N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre, fremgangsmaade til deres fremstilling og farmaceutiske midelr indeholdende dem | |
| RO115873B1 (ro) | Derivaţi de acid hidroximic, procedee de obţinere a acestora, intermediari pentru realizarea unuia dintre procedee şi compoziţie farmaceutică | |
| DE3787844D1 (de) | Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen. | |
| AU532394B2 (en) | Processes | |
| ATE25968T1 (de) | 1,1-diphenylpropanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| DK288775A (da) | Alkalimetalsalte af eddikesyrederivater og fremgangsmade til fremstilling deraf | |
| DK0412015T3 (da) | Hidtil ukendte N-(23-vincristinoyl)- og N-(5-noranhydro-23-vinblastinoyl)-1-aminomethylphosphon- syrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
| AU6120199A (en) | Derivatives of phenantrene for medicinal use and a process for their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |