ES2067866T3 - Reactivos inmunologicos que reaccionan con un epitopo constante del virus inmunodeficiente humano del tipo i (vih-1)gp120 y metodos de utilizacion. - Google Patents
Reactivos inmunologicos que reaccionan con un epitopo constante del virus inmunodeficiente humano del tipo i (vih-1)gp120 y metodos de utilizacion.Info
- Publication number
- ES2067866T3 ES2067866T3 ES91304840T ES91304840T ES2067866T3 ES 2067866 T3 ES2067866 T3 ES 2067866T3 ES 91304840 T ES91304840 T ES 91304840T ES 91304840 T ES91304840 T ES 91304840T ES 2067866 T3 ES2067866 T3 ES 2067866T3
- Authority
- ES
- Spain
- Prior art keywords
- hiv
- virus type
- react
- methods
- celulas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 4
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 206010001513 AIDS related complex Diseases 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A INMUNOREACTIVOS QUE NEUTRALIZAN EL VIRUS DE INMUNODEFICIENCIA HUMANA TIPO 1 (HIV-1) AL ENLAZARSE A UN NUEVO EPITOPE CONSERVADO DEL HIV OREACTIVOS PRESENTAN UN AMPLIO EFECTO NEUTRALIZADOR A LA UNION DEL HIV A CELULAS RECEPTORAS Y SON POR LO TANTO UTILES EN LA DETECCION, PREVENCION, MEJORA Y TRATAMIENTO DE LA ENFERMEDAD PRODUCIDA POR EL HIV, PRINCIPALMENTE EL SIDA (SINDROME DE INMUNODEFICIENCIA ADQUIRIDA) Y EL ARC (COMPLEJO RELACIONADO CON EL SIDA). DE MANERA MAS PARTICULAR, LA INVENCION SE REFIERE A NUEVOS ANTICUERPOS MONOCLONALES HUMANOS SELECTIVAMENTE REACTIVOS A UN DETERMINANTE DEPENDIENTE DE LA CONFORMACION CONSERVADA DEL HIV-1 GP120, DERIVADOS DE LOS MISMOS, LINEAS DE CELULAS QUE PRODUCEN ESTOS ANTICUERPOS Y EL USO DE ANTICUERPOS MONOCLONALES Y SUS DERIVADOS PARA LA DETECCION, PREVENCION, MEJORA Y TRATAMIENTO DE LA ENFERMEDAD RELACIONADA CON EL HIV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53085090A | 1990-05-29 | 1990-05-29 | |
US07/701,129 US5798251A (en) | 1990-05-29 | 1991-05-16 | Antibody and antibody derivative immunoreagents reactive with a conserved epitope of Human Immunodeficiency Virus Type 1 (HIV-1) gp 120 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2067866T3 true ES2067866T3 (es) | 1995-04-01 |
Family
ID=27063388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91304840T Expired - Lifetime ES2067866T3 (es) | 1990-05-29 | 1991-05-29 | Reactivos inmunologicos que reaccionan con un epitopo constante del virus inmunodeficiente humano del tipo i (vih-1)gp120 y metodos de utilizacion. |
Country Status (12)
Country | Link |
---|---|
US (2) | US6054284A (es) |
EP (2) | EP0614985A1 (es) |
JP (1) | JP2792733B2 (es) |
AP (1) | AP237A (es) |
AT (1) | ATE115189T1 (es) |
AU (2) | AU643285B2 (es) |
DE (1) | DE69105627T2 (es) |
DK (1) | DK0459779T3 (es) |
ES (1) | ES2067866T3 (es) |
GR (1) | GR3015269T3 (es) |
OA (1) | OA09499A (es) |
WO (1) | WO1991018928A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP237A (en) * | 1990-05-29 | 1993-04-29 | Cedars Sinai Medical Center | Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use. |
US5346989A (en) * | 1990-08-22 | 1994-09-13 | Syntello Vaccine Development Kb | Peptides for use in induction of T cell activation against HIV-1 |
WO1992005800A1 (en) * | 1990-09-27 | 1992-04-16 | Syntello Vaccin Development Kb | Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus |
JPH06502539A (ja) * | 1990-10-26 | 1994-03-24 | ザ・パブリック・ヘルス・リサーチ・インスティチュート・オブ・ザ・シティ・オブ・ニューヨーク・インコーポレーテッド | Hiv−1 gp120のv3ループおよびcd−4結合部位に特異的な中和ヒトモノクローナル抗体 |
WO1992021377A1 (en) * | 1991-06-03 | 1992-12-10 | Syntello Inc. | Peptides for use in induction of t cell activation against hiv-1 |
US6261558B1 (en) | 1993-10-19 | 2001-07-17 | The Scripps Research Institute | Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus |
US5843882A (en) | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
US6193982B1 (en) | 1995-04-27 | 2001-02-27 | The United States Of America As Represented By The Department Of Health & Human Services | Anti-cyanovirin antibody with an internal image of gp120, a method of use thereof, and a method of using a cyanovirin to induce an immune response to gp120 |
US6780847B2 (en) | 1995-04-27 | 2004-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins |
US6987096B1 (en) | 1995-04-27 | 2006-01-17 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof |
US6428790B1 (en) | 1995-04-27 | 2002-08-06 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use |
US7048935B2 (en) | 1995-04-27 | 2006-05-23 | The United States Of America As Represented By The Department Of Health And Human Services | Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use |
ES2299276T3 (es) | 1998-12-31 | 2008-05-16 | Novartis Vaccines And Diagnostics, Inc. | Polipeptidos env del vih modificados. |
EP1141314A2 (en) | 1998-12-31 | 2001-10-10 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
AU2002254382B2 (en) | 2001-03-22 | 2007-02-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glycosylation-resistant and nonglycosylated cyanovirins |
CA2452015C (en) | 2001-07-05 | 2012-07-03 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
US20050014230A1 (en) * | 2003-07-16 | 2005-01-20 | Ccl Holding Co., Ltd. | Preparation of fully human antibodies |
EP2255832A3 (en) | 2004-06-16 | 2011-02-09 | Affinergy, Inc. | IFBM's to promote attachment of target analytes |
CN101313216A (zh) * | 2005-09-22 | 2008-11-26 | 普洛茨股份有限公司 | 酵母突变体中产生的糖基化多肽及其使用方法 |
US20110212119A1 (en) * | 2008-10-31 | 2011-09-01 | Proteonova, Inc. | Methods for making hiv vaccines and related compositions |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
AU2012216792A1 (en) | 2011-09-12 | 2013-03-28 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies |
EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59116230A (ja) * | 1982-11-29 | 1984-07-05 | ベイロ−・カレツジ・オヴ・メデイスン | ウイルス性感染因子に対する免疫応答を生起する抗−イデイオタイプ抗体 |
US4536479A (en) * | 1983-03-22 | 1985-08-20 | E. I. Du Pont De Nemours And Company | Use of anti-idiotype antibodies in immunoassays |
AU609447B2 (en) * | 1987-02-19 | 1991-05-02 | Nissin Shokuhin Kabushiki Kaisha | Methods and materials for hiv detection and therapy |
US5215913A (en) * | 1987-11-30 | 1993-06-01 | Roger Williams General Hospital | IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use |
EP0349645A4 (en) * | 1987-12-15 | 1991-11-27 | Nippon Shokubai Kagaku Kogyo Co. Ltd. | Photo-setting composition |
WO1989005821A1 (en) * | 1987-12-21 | 1989-06-29 | Arch Development Corporation | Hiv-related antigens and antibodies |
EP0434713B1 (en) * | 1988-09-13 | 1994-10-12 | Chiron Corporation | Hiv-1 envelope muteins lacking hypervariable domains |
JPH0768276B2 (ja) * | 1989-04-25 | 1995-07-26 | タノックス バイオシステムズ インコーポレイテッド | Hivのcd4結合領域に特異的な抗体 |
EP0493508A1 (en) * | 1989-09-22 | 1992-07-08 | Idec Pharmaceuticals Corporation | Novel peptides associated with the cd4 binding region of gp120 and their methods of use |
AP237A (en) * | 1990-05-29 | 1993-04-29 | Cedars Sinai Medical Center | Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use. |
US5798251A (en) * | 1990-05-29 | 1998-08-25 | Cedars-Sinai Medical Center | Antibody and antibody derivative immunoreagents reactive with a conserved epitope of Human Immunodeficiency Virus Type 1 (HIV-1) gp 120 |
GB9013566D0 (en) * | 1990-06-18 | 1990-08-08 | Shell Int Research | Process for producing gasoline components |
KR920000333A (ko) * | 1990-06-18 | 1992-01-29 | 챨스 엠. 브룩 | HIV gp120 모노클로날 항체 |
-
1991
- 1991-04-24 AP APAP/P/1991/000280A patent/AP237A/en active
- 1991-05-17 JP JP3510450A patent/JP2792733B2/ja not_active Expired - Lifetime
- 1991-05-17 WO PCT/US1991/003508 patent/WO1991018928A1/en unknown
- 1991-05-24 OA OA60005A patent/OA09499A/xx unknown
- 1991-05-29 DK DK91304840.1T patent/DK0459779T3/da active
- 1991-05-29 EP EP94106208A patent/EP0614985A1/en not_active Withdrawn
- 1991-05-29 AT AT91304840T patent/ATE115189T1/de active
- 1991-05-29 DE DE69105627T patent/DE69105627T2/de not_active Expired - Fee Related
- 1991-05-29 EP EP91304840A patent/EP0459779B1/en not_active Expired - Lifetime
- 1991-05-29 AU AU78035/91A patent/AU643285B2/en not_active Ceased
- 1991-05-29 ES ES91304840T patent/ES2067866T3/es not_active Expired - Lifetime
-
1994
- 1994-02-11 AU AU55107/94A patent/AU660574B2/en not_active Ceased
-
1995
- 1995-03-03 GR GR940403884T patent/GR3015269T3/el unknown
-
1997
- 1997-06-06 US US08/870,531 patent/US6054284A/en not_active Expired - Fee Related
-
1999
- 1999-03-11 US US09/267,941 patent/US6190871B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AP9100280A0 (en) | 1991-07-31 |
DE69105627T2 (de) | 1995-04-20 |
EP0614985A1 (en) | 1994-09-14 |
AU7803591A (en) | 1991-12-05 |
JPH05500818A (ja) | 1993-02-18 |
OA09499A (en) | 1992-11-15 |
GR3015269T3 (en) | 1995-06-30 |
AU660574B2 (en) | 1995-06-29 |
US6054284A (en) | 2000-04-25 |
AP237A (en) | 1993-04-29 |
US6190871B1 (en) | 2001-02-20 |
ATE115189T1 (de) | 1994-12-15 |
EP0459779A1 (en) | 1991-12-04 |
AU643285B2 (en) | 1993-11-11 |
EP0459779B1 (en) | 1994-12-07 |
JP2792733B2 (ja) | 1998-09-03 |
DK0459779T3 (da) | 1995-05-29 |
AU5510794A (en) | 1994-04-28 |
WO1991018928A1 (en) | 1991-12-12 |
DE69105627D1 (de) | 1995-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2067866T3 (es) | Reactivos inmunologicos que reaccionan con un epitopo constante del virus inmunodeficiente humano del tipo i (vih-1)gp120 y metodos de utilizacion. | |
ES2194015T3 (es) | Anticuerpos monoclonales humanos neutralizantes del virus de inmunodeficiencia humana. | |
ATE405679T1 (de) | Synthetische humane neutralisierende monoklonale antikörper gegen hiv | |
ATE122237T1 (de) | Hiv-1 neutralisierende monoklonale antikörper. | |
DK0512112T3 (da) | Anti-CD4-antistoffer, som blokerer HIV-inducerede syncytier | |
DK0589004T4 (da) | Fremgangsmåde til bestemmelse af peptider, som hörer til immunologisk vigtige epitoper af HCV | |
NO169844C (no) | Htlv-iii (env)-peptider | |
ATE135743T1 (de) | Monoklonale menschliche antikörper gegen hiv-i | |
ES2139607T3 (es) | Anticuerpos monoclonales contra las proteinas e2/ns1 supuestas vhc y procedimientos de utilizacion de estos anticuerpos. | |
DE69332911T2 (de) | Rekombinanter humanisierter Antikörper gegen menschlichen Immunschwächevirus | |
FI931393A (fi) | Peptider foer anvaendning vid vaccinering och induktion av neutraliserande motkroppar mot humant immunbristvirus | |
ES2066887T3 (es) | Anticuerpo monoclonal para diferenciar individuos seropositivos hiv-2 de los hiv-1. | |
ES2147195T3 (es) | Metodo para la deteccion de anticuerpos en individuos seronegativos. | |
ATE151078T1 (de) | Verfahren und zwischenprodukte synthetischer antikörperderivate | |
BRPI9709524B8 (pt) | processo para a produção de um anticorpo para células t que expressam cd4 | |
ES2059577T3 (es) | Fragmentos genicos que codifican para las regiones variables de un anticuerpo anti-hiv, anticuerpos anti-hiv quimericos expresados utilizando los mismos y procedimiento para su preparacion. | |
FI861966A (fi) | Renad och tre gaonger klonad hepatit-a-virus. | |
ES2132115T3 (es) | Anticuerpos monoclonales contra el virus de la hepatitis c y su procedimiento de utilizacion. | |
KR920000333A (ko) | HIV gp120 모노클로날 항체 | |
OA09634A (fr) | Antigenes de la glycoproteine transmembranaire d'enveloppe d'un retrovirus humain du type HIV-2 antigenes presentant avec eux une parente immunologique | |
DE68926454D1 (de) | Gegen hiv 1 gp48 spezifische antikörper | |
ATE134649T1 (de) | Arzneimittel und verfahren zur behandlung von erworbenem immundefizienzsyndrom (aids) und aids- verwandtem komplex unter verwendung von karbohydratspezifischen antikörpern | |
ES2060162T3 (es) | Utilizacion de los anticuerpos monoclonales anti-b2 microglobulina. | |
AR001840A1 (es) | Composiciones y métodos para detectar y tratar el sindrome de inmunodeficiencia adquirida | |
ATE126238T1 (de) | Monoklonale antikörper gegen gag-protein- vorläufer-p55 von hiv-virus. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 459779 Country of ref document: ES |