ATE115189T1 - Immunreagenzien reaktiv mit einem konservierten epitope des humanen immundefizienzviruses i (hiv- i) gp120 und verfahren zu deren verwendung. - Google Patents

Immunreagenzien reaktiv mit einem konservierten epitope des humanen immundefizienzviruses i (hiv- i) gp120 und verfahren zu deren verwendung.

Info

Publication number
ATE115189T1
ATE115189T1 AT91304840T AT91304840T ATE115189T1 AT E115189 T1 ATE115189 T1 AT E115189T1 AT 91304840 T AT91304840 T AT 91304840T AT 91304840 T AT91304840 T AT 91304840T AT E115189 T1 ATE115189 T1 AT E115189T1
Authority
AT
Austria
Prior art keywords
hiv
methods
immunodeficiency virus
human immunodeficiency
immune reagents
Prior art date
Application number
AT91304840T
Other languages
English (en)
Inventor
David Da-I Ho
James Edmun Robinson
Original Assignee
Cedars Sinai Medical Center
Univ Louisiana State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/701,129 external-priority patent/US5798251A/en
Application filed by Cedars Sinai Medical Center, Univ Louisiana State filed Critical Cedars Sinai Medical Center
Application granted granted Critical
Publication of ATE115189T1 publication Critical patent/ATE115189T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT91304840T 1990-05-29 1991-05-29 Immunreagenzien reaktiv mit einem konservierten epitope des humanen immundefizienzviruses i (hiv- i) gp120 und verfahren zu deren verwendung. ATE115189T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53085090A 1990-05-29 1990-05-29
US07/701,129 US5798251A (en) 1990-05-29 1991-05-16 Antibody and antibody derivative immunoreagents reactive with a conserved epitope of Human Immunodeficiency Virus Type 1 (HIV-1) gp 120

Publications (1)

Publication Number Publication Date
ATE115189T1 true ATE115189T1 (de) 1994-12-15

Family

ID=27063388

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91304840T ATE115189T1 (de) 1990-05-29 1991-05-29 Immunreagenzien reaktiv mit einem konservierten epitope des humanen immundefizienzviruses i (hiv- i) gp120 und verfahren zu deren verwendung.

Country Status (12)

Country Link
US (2) US6054284A (de)
EP (2) EP0614985A1 (de)
JP (1) JP2792733B2 (de)
AP (1) AP237A (de)
AT (1) ATE115189T1 (de)
AU (2) AU643285B2 (de)
DE (1) DE69105627T2 (de)
DK (1) DK0459779T3 (de)
ES (1) ES2067866T3 (de)
GR (1) GR3015269T3 (de)
OA (1) OA09499A (de)
WO (1) WO1991018928A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP237A (en) * 1990-05-29 1993-04-29 Cedars Sinai Medical Center Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use.
US5346989A (en) * 1990-08-22 1994-09-13 Syntello Vaccine Development Kb Peptides for use in induction of T cell activation against HIV-1
WO1992005800A1 (en) * 1990-09-27 1992-04-16 Syntello Vaccin Development Kb Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
HUT66445A (en) * 1990-10-26 1994-11-28 New York Health Res Inst Monoclonal antibodies specific for the v3 loop and cd-4 binding site of hiv-1 gp120
CA2109961A1 (en) * 1991-06-03 1992-12-10 Anders Vahlne Peptides for use in induction of t cell activation against hiv-1
US6261558B1 (en) * 1993-10-19 2001-07-17 The Scripps Research Institute Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus
US6428790B1 (en) 1995-04-27 2002-08-06 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
US6193982B1 (en) 1995-04-27 2001-02-27 The United States Of America As Represented By The Department Of Health & Human Services Anti-cyanovirin antibody with an internal image of gp120, a method of use thereof, and a method of using a cyanovirin to induce an immune response to gp120
US7048935B2 (en) 1995-04-27 2006-05-23 The United States Of America As Represented By The Department Of Health And Human Services Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
US6987096B1 (en) 1995-04-27 2006-01-17 The United States Of America As Represented By The Department Of Health And Human Services Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof
US6780847B2 (en) 1995-04-27 2004-08-24 The United States Of America As Represented By The Department Of Health And Human Services Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins
US5843882A (en) 1995-04-27 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Antiviral proteins and peptides
JP2003523721A (ja) 1998-12-31 2003-08-12 カイロン コーポレイション 抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用
ES2299276T3 (es) 1998-12-31 2008-05-16 Novartis Vaccines And Diagnostics, Inc. Polipeptidos env del vih modificados.
DE60221705T2 (de) 2001-03-22 2008-06-05 The United States of America, represented by the Secretary, Dept. of Health and Human Services, the Natl. Institutes of Health, Office of Technology Transfer Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirine
CA2634992C (en) 2001-07-05 2012-10-16 Novartis Vaccines And Diagnostics, Inc. Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
US20050014230A1 (en) * 2003-07-16 2005-01-20 Ccl Holding Co., Ltd. Preparation of fully human antibodies
US7572766B2 (en) 2004-06-16 2009-08-11 Affinergy, Inc. IFBMs to promote the specific attachment of target analytes to the surface of orthopedic implants
CA2623197A1 (en) * 2005-09-22 2007-03-29 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof
US20110212119A1 (en) * 2008-10-31 2011-09-01 Proteonova, Inc. Methods for making hiv vaccines and related compositions
ES2625406T3 (es) 2010-03-25 2017-07-19 Oregon Health & Science University Glicoproteínas de CMV y vectores recombinantes
ES2667425T3 (es) 2011-06-10 2018-05-10 Oregon Health & Science University Glucoproteínas y vectores recombinantes de CMV
EP2568289A3 (de) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper
EP2586461A1 (de) 2011-10-27 2013-05-01 Christopher L. Parks Von einem eingehüllten Virus abgeleitete Virenpartikel
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
EP2848937A1 (de) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Verfahren zur Identifizierung neuartiger HIV-1-Immunogene
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
EP3069730A3 (de) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59116230A (ja) * 1982-11-29 1984-07-05 ベイロ−・カレツジ・オヴ・メデイスン ウイルス性感染因子に対する免疫応答を生起する抗−イデイオタイプ抗体
US4536479A (en) * 1983-03-22 1985-08-20 E. I. Du Pont De Nemours And Company Use of anti-idiotype antibodies in immunoassays
AU609447B2 (en) * 1987-02-19 1991-05-02 Nissin Shokuhin Kabushiki Kaisha Methods and materials for hiv detection and therapy
US5215913A (en) * 1987-11-30 1993-06-01 Roger Williams General Hospital IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use
EP0349645A4 (en) * 1987-12-15 1991-11-27 Nippon Shokubai Kagaku Kogyo Co. Ltd. Photo-setting composition
WO1989005821A1 (en) * 1987-12-21 1989-06-29 Arch Development Corporation Hiv-related antigens and antibodies
WO1990002568A1 (en) * 1988-09-13 1990-03-22 Chiron Corporation Hiv-1 envelope muteins lacking hypervariable domains
AU633570B2 (en) * 1989-04-25 1993-02-04 Tanox Biosystems, Inc. Antibodies specific for cd4-binding domain of hiv
CA2066607A1 (en) * 1989-09-22 1991-03-23 Thomas Kieber-Emmons Peptides associated with the cd4 binding region of gp120 and their methods of use
AP237A (en) * 1990-05-29 1993-04-29 Cedars Sinai Medical Center Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use.
US5798251A (en) * 1990-05-29 1998-08-25 Cedars-Sinai Medical Center Antibody and antibody derivative immunoreagents reactive with a conserved epitope of Human Immunodeficiency Virus Type 1 (HIV-1) gp 120
AU651113B2 (en) * 1990-06-18 1994-07-14 Abbott Laboratories HIV GP120 monoclonal antibodies
GB9013566D0 (en) * 1990-06-18 1990-08-08 Shell Int Research Process for producing gasoline components

Also Published As

Publication number Publication date
OA09499A (en) 1992-11-15
EP0459779A1 (de) 1991-12-04
US6190871B1 (en) 2001-02-20
DE69105627D1 (de) 1995-01-19
AU5510794A (en) 1994-04-28
WO1991018928A1 (en) 1991-12-12
AU660574B2 (en) 1995-06-29
DE69105627T2 (de) 1995-04-20
EP0614985A1 (de) 1994-09-14
ES2067866T3 (es) 1995-04-01
AP237A (en) 1993-04-29
JP2792733B2 (ja) 1998-09-03
US6054284A (en) 2000-04-25
GR3015269T3 (en) 1995-06-30
EP0459779B1 (de) 1994-12-07
DK0459779T3 (da) 1995-05-29
AU7803591A (en) 1991-12-05
AP9100280A0 (en) 1991-07-31
AU643285B2 (en) 1993-11-11
JPH05500818A (ja) 1993-02-18

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